Abstract：
:This study investigated whether bone turnover influences the response to alendronate in women with postmenopausal osteoporosis. One hundred postmenopausal osteoporotic women were randomized to receive either alendronate (10 mg/day) plus calcium (1000 mg/day) (n = 50) or calcium alone (n = 50). Vertebral and radial bone density, measured by DXA, and markers of bone turnover were assessed at baseline and after 1 and 2 years. At the end of treatment, alendronate users showed an increase of 5.0% and 2.3%, respectively, at the lumbar spine and ultradistal radius; in the group treated only with calcium, bone mineral density (BMD) decreased by 1.6% at the lumbar spine and 1.3% at the ultradistal radius. The difference between the two groups was significant (P < 0.001). The patients were divided into high (HT) or low (LT) bone turnover groups, as assessed by 24-hour whole body retention (WBR%) of (99m)Tc-methylene-diphosphonate. The response to alendronate treatment was greater in HT patients compared with LT patients. In fact, at the end of the study period, BMD at the lumbar spine had increased by 7.9% in HT patients and by 3.0% in LT patients; the difference between the two groups was significant (P < 0.001). No significant difference between the two groups was found for BMD at the ultradistal radius. In conclusion, the present study demonstrates that 2-year treatment with alendronate has highly positive effects on bone mass at both the lumbar spine and ultradistal radius. The increase in bone mass, especially at the axial level, is influenced by bone turnover. Therefore, the evaluation of bone turnover may be useful in predicting the response to alendronate treatment.
journal_name
Calcif Tissue Intjournal_title
Calcified tissue internationalauthors
Gonnelli S,Cepollaro C,Pondrelli C,Martini S,Montagnani A,Monaco R,Gennari Cdoi
10.1007/s002239900713subject
Has Abstractpub_date
1999-11-01 00:00:00pages
359-64issue
5eissn
0171-967Xissn
1432-0827pii
CT90-98journal_volume
65pub_type
临床试验,杂志文章,随机对照试验abstract：:Vit-D-Dependent calcium binding protein and parvalbumin have both been detected in ameloblasts and calcified cartilage by immunohistochemical techniques. These two Ca2+ binding proteins may play a crucial role in the local accumulation of Ca2+ ions during the process of mineralization. The mechanisms underlying the de...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02405306
更新日期：1984-01-01 00:00:00
abstract：:The bone mineral status of 17 girls with Turner's syndrome was evaluated by single photon absorptiometry. Bone mineral content (BMC) was 25.4% below that predicted by normalization for age, sex, height, weight, and bone width. Only 25% of this demineralization could be attributed to delayed skeletal maturation. Bones ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02411296
更新日期：1982-01-01 00:00:00
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journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF00305529
更新日期：1994-05-01 00:00:00
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journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-020-00770-8
更新日期：2020-10-17 00:00:00
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journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02556459
更新日期：1991-06-01 00:00:00
abstract：:Osteoporosis is commonly associated with estrogen deficiency. However, the mechanisms by which the lack of this hormone causes bone loss are poorly understood. The bone structure of the oral cavity seems to be affected by estrogen deficiency, since a delayed healing process after tooth extraction has been observed aft...
journal_title：Calcified tissue international
pub_type： 杂志文章
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journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-004-0275-x
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journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900621
更新日期：1999-04-01 00:00:00
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journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02556606
更新日期：1986-05-01 00:00:00
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journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF00302073
更新日期：1995-11-01 00:00:00
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journal_title：Calcified tissue international
pub_type： 杂志文章
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更新日期：1995-12-01 00:00:00
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journal_title：Calcified tissue international
pub_type： 杂志文章
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更新日期：2016-08-01 00:00:00
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journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-020-00674-7
更新日期：2020-06-01 00:00:00
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journal_title：Calcified tissue international
pub_type： 杂志文章
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更新日期：2018-03-01 00:00:00
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journal_title：Calcified tissue international
pub_type： 杂志文章
doi：
更新日期：1993-12-01 00:00:00
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journal_title：Calcified tissue international
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2002-12-01 00:00:00
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journal_title：Calcified tissue international
pub_type： 杂志文章
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更新日期：2016-11-01 00:00:00
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journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-015-0074-6
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journal_title：Calcified tissue international
pub_type： 杂志文章
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journal_title：Calcified tissue international
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journal_title：Calcified tissue international
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journal_title：Calcified tissue international
pub_type： 杂志文章
doi：
更新日期：1982-01-01 00:00:00
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journal_title：Calcified tissue international
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journal_title：Calcified tissue international
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Calcified tissue international
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journal_title：Calcified tissue international
pub_type： 杂志文章
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journal_title：Calcified tissue international
pub_type： 临床试验,杂志文章
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journal_title：Calcified tissue international
pub_type： 杂志文章
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journal_title：Calcified tissue international
pub_type： 杂志文章
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journal_title：Calcified tissue international
pub_type： 杂志文章,评审
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