Abstract:
:Several phosphoprotein preparations (phosvitin, rat incisor and fetal calf molar dentin phosphoproteins) all inhibit apatite growth/replication from pre-existing crystal seeds in metastable solutions. Two stages of the crystal growth process were inhibited by these phosphoproteins. First an initial lag period was induced, probably associated with seed surface phenomena. This period was prolonged indefinitely when a combination of phosphoprotein precoated seeds was used together with soluble phosphoproteins in the crystal growth reaction. Second, the phosphoproteins prolonged that stage of the reaction where octacalcium phosphate is the predominant mineral phase present prior to its conversion to the final apatite product. Pre-treatment of the phosphoproteins with calcium diminished their inhibitory activity to seeded crystal growth as well as towards de novo apatite formation in synthetic extracellular fluids. The presence of collagen diminished the inhibitory activity of the phosphoproteins towards de novo precipitation but had no effect on phosphoprotein-modulated apatite crystal growth in the seeded systems. These results suggest a potential regulatory role for phosphoproteins in dentin mineralization.
journal_name
Calcif Tissue Intjournal_title
Calcified tissue internationalauthors
Termine JD,Eanes ED,Conn KMdoi
10.1007/BF02407188subject
Has Abstractpub_date
1980-01-01 00:00:00pages
247-51issue
3eissn
0171-967Xissn
1432-0827journal_volume
31pub_type
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journal_title:Calcified tissue international
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journal_title:Calcified tissue international
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