Effects of cyclosporins and transforming growth factor beta 1 on thyroid hormone action in cultured fetal rat limb bones.

abstract：:Healing trabecular microfractures are a common feature in cancellous bone. These lesions, when observed in macerated cancellous bone slices, measure about 500 microns in diameter and surround fractures in trabeculae with microcallus. Whether microcallus is a structure acting primarily as a transient brace, preventing ...

journal_title：Calcified tissue international

authors： Fazzalari NL

更新日期：1993-01-01 00:00:00

abstract：:Several rare inherited disorders have been described that show phenotypic overlap with Paget's disease of bone (PDB) and in which PDB is a component of a multisystem disorder affecting muscle and the central nervous system. These conditions are the subject of this review article. Insertion mutations within exon 1 of t...

journal_title：Calcified tissue international

authors： Ralston SH,Taylor JP

更新日期：2019-05-01 00:00:00

abstract：:The mineral in bone is located primarily within the collagen fibril, and during mineralization the fibril is formed first and then water within the fibril is replaced with mineral. Our goal is to understand the mechanism of fibril mineralization, and as a first step we recently determined the size exclusion characteri...

journal_title：Calcified tissue international

authors： Toroian D,Price PA

更新日期：2008-02-01 00:00:00

abstract：:Cytochemical staining of normal human bone cells in monolayer cultures for alkaline phosphatase (ALP) indicated that the cultures contained mixed-cell populations. Time course evaluations of the cytochemical staining revealed, in addition to the ALP-negative cell population, at least two subpopulations of ALP-positive...

journal_title：Calcified tissue international

authors： Matsuyama T,Lau KH,Wergedal JE

更新日期：1990-11-01 00:00:00

abstract：:SUMMARY. The high variation often observed in the ex vivo fibroblastic-colony forming unit (CFU-f) assay is likely to be due to both biological and experimental variation. To determine whether we could improve experimental methods we developed an alternative method of bone marrow cell (BMC) isolation employing a centr...

journal_title：Calcified tissue international

authors： Dobson KR,Reading L,Haberey M,Marine X,Scutt A

更新日期：1999-11-01 00:00:00

abstract：:Bone formation in a variety of contexts depends on angiogenesis; however, there are few reports of the vascular response to osteogenic skeletal loading. We used the rat forelimb compression model to characterize vascular changes after fatigue loading. The right forelimbs of 72 adult rats were loaded cyclically in vivo...

journal_title：Calcified tissue international

authors： Matsuzaki H,Wohl GR,Novack DV,Lynch JA,Silva MJ

更新日期：2007-06-01 00:00:00

abstract：:It is generally accepted that bone formation is depressed during corticosteroid treatment, but the effects of glucocorticoids on bone resorption are less well characterized. We have investigated the effects of short-term treatment with high-dose oral glucocorticoids on biochemical markers of bone turnover in 20 consec...

journal_title：Calcified tissue international

authors： Bornefalk E,Dahlén I,Michaëlsson K,Ljunggren,Ljunghall S

更新日期：1998-07-01 00:00:00

abstract：:We treated four hypercalcemic cancer patients by nasal hCT, 3 x 2 mg daily, which has been reported to be active in Paget's disease at lower doses. Only one patient became normocalcemic and mean (+/- SEM) calcium levels fell from 11.6 +/- 0.2 mg/dl before therapy to 10.7 +/- 0.6 mg/dl 2-3 days after starting hCT. The ...

journal_title：Calcified tissue international

authors： Dumon JC,Magritte A,Body JJ

更新日期：1992-07-01 00:00:00

abstract：:Bone loss occurs as early as the third decade and its cumulative effect throughout adulthood may impact risk for osteoporosis in later life, however, the genes and environmental factors influencing early bone loss are largely unknown. We investigated the role of genes in the change in bone mineral density (BMD) in par...

journal_title：Calcified tissue international

authors： Shaffer JR,Kammerer CM,Bruder JM,Cole SA,Dyer TD,Almasy L,Maccluer JW,Blangero J,Bauer RL,Mitchell BD

更新日期：2009-02-01 00:00:00

abstract：:The aim of this study was to test whether the nitric oxide (NO) donor sodium nitroprusside (SNP) has an effect on mineralization in ATDC5 cells. Mineralization in ATDC5 cell culture was induced by addition of beta-glycerophosphate or inorganic phosphate, visualized by staining precipitated calcium with an alizarin red...

journal_title：Calcified tissue international

authors： Huitema LF,Vaandrager AB,van Weeren PR,Barneveld A,Helms JB,van de Lest CH

更新日期：2006-03-01 00:00:00

abstract：:Transcriptional regulation of the postnatal skeleton is incompletely understood. Here, we determined the consequence of loss of early growth response gene 1 (EGR-1) on bone properties. Analyses were performed on both the microscopic and molecular levels utilizing micro-computed tomography (micro-CT) and Fourier transf...

journal_title：Calcified tissue international

authors： Reumann MK,Strachna O,Lukashova L,Verdelis K,Donnelly E,Boskey AL,Mayer-Kuckuk P

更新日期：2011-07-01 00:00:00

abstract：:ATP is as effective as inorganic pyrophosphate in retarding the rate of dissolution of calcium hydroxyapatite at pH 7, ADP is less effective, and AMP is without effect. The inhibition is due to the adsorption of ATP and ADP units on the crystal surface. ...

journal_title：Calcified tissue international

authors： Christoffersen MR,Christoffersen J

更新日期：1984-12-01 00:00:00

abstract：:To investigate the effect of low doses of intranasal salmon calcitonin on plasma cyclic AMP (cAMP) and serum ionized calcium, 40 healthy postmenopausal women were randomized to receive a single dose of either placebo or 50, 100, or 200 IU of salmon calcitonin as a nasal spray. Blood samples were collected throughout a...

journal_title：Calcified tissue international

authors： Thamsborg G,Storm TL,Brinch E,Sykulski R,Fogh-Andersen N,Holmegaard SN,Sørensen OH

更新日期：1990-01-01 00:00:00

abstract：:The effect of SrCl(2) treatment on bone nanostructure in a rat ovariectomy model was studied using scanning small-angle X-ray scattering (sSAXS). Twelve 6-month-old female Wistar rats were used. Six animals were ovariectomized (+ovx) and six were left intact after sham surgery (-ovx). Six animals, three +ovx and three...

journal_title：Calcified tissue international

authors： Bünger MH,Oxlund H,Hansen TK,Sørensen S,Bibby BM,Thomsen JS,Langdahl BL,Besenbacher F,Pedersen JS,Birkedal H

更新日期：2010-04-01 00:00:00

abstract：:Bone collagen undergoes a series of enzymatic and nonenzymatic posttranslational modifications with maturation. The aim of this study was to analyze the collagenolytic efficiency of cathepsin K in relation to the extent of bone collagen age. Bone collagen posttranslational maturation was induced in vitro by preincubat...

journal_title：Calcified tissue international

authors： Borel O,Gineyts E,Bertholon C,Garnero P

更新日期：2012-07-01 00:00:00

abstract：:The effect of the degree of carboxylation of osteocalcin (OC) on the properties of bone is unclear. The aim of this study was to relate serum concentrations of total OC (tOC) and undercarboxylated OC (ucOC), measured with a two-site immunoassay, to bone mineral density (BMD) at the femoral neck and ultrasonic transmit...

journal_title：Calcified tissue international

authors： Liu G,Peacock M

更新日期：1998-04-01 00:00:00

abstract：:A number of osteoporotic patients under bisphosphonate treatment present persistent fragility fractures and bone loss despite good compliance. The objective of this 18-month prospective study was to investigate the effect of teriparatide [rhPTH(1-34)] in 25 female osteoporotics who were inadequate responders to oral b...

journal_title：Calcified tissue international

authors： Jobke B,Muche B,Burghardt AJ,Semler J,Link TM,Majumdar S

更新日期：2011-08-01 00:00:00

abstract：:Hip fracture may cause and/or complicate institutionalization. We undertook this study to define its overall prevalence among the residents of four nursing homes in Central Italy as well as its latency and impact on mobility when it occurred within institutions. We also performed a case control analysis with the aim o...

journal_title：Calcified tissue international

authors： Maggio D,Ubaldi E,Simonelli G,Cenci S,Pedone C,Cherubini A

更新日期：2001-06-01 00:00:00

abstract：:During endochondral ossification, proliferative activity of chondrocytes is arrested and the cells undergo terminal hypertrophic differentiation. We examined the expression of the cyclin-dependent kinase inhibitor, p21(CIP1/WAF1) in permanent cartilage (xyphoid and articular cartilage) and in cartilage undergoing endo...

journal_title：Calcified tissue international

authors： Stewart MC,Farnum CE,MacLeod JN

更新日期：1997-09-01 00:00:00

abstract：:Even though indirect evidence indicates that PTH exerts an anabolic effect on dentinogenesis, the existence of PTH receptors and any second-messenger response in odontoblasts have not been demonstrated. The aim of this study was to investigate whether rat incisor odontoblasts express PTH receptors, and to identify whi...

journal_title：Calcified tissue international

authors： Lundgren T,Stenport V,Wetter A,Linde A

更新日期：1998-03-01 00:00:00

abstract：:Parathyroid Hormone (PTH) stimulates calcium entry into bone cells in vitro, and this effect has been proposed to mediate the actions of PTH on bone. Using cells harvested from infant rat calvaria by collagenase digestion, we evaluated the sensitivity and specificity of this phenomenon. Calcium uptake was temperature ...

journal_title：Calcified tissue international

authors： Marcus R,Orner FB

更新日期：1980-01-01 00:00:00

abstract：:The crystallinity of bone mineral at different stages of maturation has been measured by quantitative X-ray diffraction methods. Crystallinity measurements were made on tibial mid-diaphyses from 17-day embryonic chicks, newly-formed periosteal bone from embryonic chicks, and density-fractionated bone from post-hatch c...

journal_title：Calcified tissue international

authors： Bonar LC,Roufosse AH,Sabine WK,Grynpas MD,Glimcher MJ

更新日期：1983-01-01 00:00:00

abstract：:Octacalcium phosphate (Ca8H2(PO4)6 . 5H2O) is considered to be precursor in the formation of apatite in bones and teeth; a crucial step for incorporation of impurities appears to occur during its hydrolysis. The present study examines the role that octacalcium phosphate plays in the process of incorporation of carbona...

journal_title：Calcified tissue international

authors： Chickerur NS,Tung MS,Brown WE

更新日期：1980-01-01 00:00:00

abstract：:We examined the role of sleep, growth hormone (GH), and parathyroid hormone [PTH(1-84)] as regulators of the diurnal rhythm of the osteoblastic bone marker, serum osteocalcin (OC). Nine normal subjects were followed with hourly blood sampling during one 24-hour period with normal sleep pattern, and one 24-hour period ...

journal_title：Calcified tissue international

authors： Nielsen HK,Brixen K,Kassem M,Christensen SE,Mosekilde L

更新日期：1991-12-01 00:00:00

abstract：:This study investigated whether bone turnover influences the response to alendronate in women with postmenopausal osteoporosis. One hundred postmenopausal osteoporotic women were randomized to receive either alendronate (10 mg/day) plus calcium (1000 mg/day) (n = 50) or calcium alone (n = 50). Vertebral and radial bon...

journal_title：Calcified tissue international

authors： Gonnelli S,Cepollaro C,Pondrelli C,Martini S,Montagnani A,Monaco R,Gennari C

更新日期：1999-11-01 00:00:00

abstract：:The primary aim of the project was to determine the combined effect of whole-body electromyostimulation (WB-EMS) and protein supplements on local and overall muscle/fat distribution in older man with sarcopenic obesity (SO). Community-dwelling (cdw) men ≥ 70 years with SO were randomly allocated to a WB-EMS and protei...

journal_title：Calcified tissue international

authors： Kemmler W,Grimm A,Bebenek M,Kohl M,von Stengel S

更新日期：2018-09-01 00:00:00

abstract：:Prior exposure to PTH markedly decreased the responsiveness of isolated, cultured bone cells to the stimulatory effect of the hormone on cyclic AMP formation. This process of desensitization developed within 30 min, persisted during prolonged incubation of the cells in PTH-free medium, and could not be attributed to e...

journal_title：Calcified tissue international

authors： Peck WA,Kohler G

更新日期：1980-01-01 00:00:00

abstract：:The mechanism whereby liposomal entrapment enhances the hypocalcemic effect of calcitonin (CT) was evaluated in the rat. Phosphatidylcholine (PC) and PC plus cholesterol (PCC) preparations of large multilammelar vesicles (MLV) and small unilammelar vesicles (SUV) were used to entrap human calcitonin (hCT). The effect ...

journal_title：Calcified tissue international

authors： Fukunaga M,Miller MM,Deftos LJ

更新日期：1990-12-01 00:00:00

abstract：:Toxicological studies have demonstrated that intermittent PTH1-34 treatment is associated with an increased incidence of osteosarcoma in Fischer 344 rats. Comet and micronucleus (MN) tests, standard methods to evaluate genotoxic potential of drugs, were used to detect DNA and chromosome breaks, respectively, after PTH...

journal_title：Calcified tissue international

authors： Alves de Oliveira EC,Szejnfeld VL,Pereira da Silva N,Coelho Andrade LE,Heldan de Moura Castro C

更新日期：2010-11-01 00:00:00

abstract：:The low interference with growth expected in child for a cortisol analogue, deflazacort (DFZ), prompted us to verify if DFZ could affect growth less than prednisone (PDN). An interim analysis relative to 27 girls and 38 boys (out of 100 expected) aged 3-12 yrs, after a median period of 14 mo.s is reported. Children wi...

journal_title：Calcified tissue international

authors： Aicardi G,Milani S,Imbimbo B,Vignolo M,Di Battista E,Gusmano R,Terragna A,Cordone G,Cottafava F,Coppo R

更新日期：1991-04-01 00:00:00