Factors influencing the enhanced hypocalcemic action of liposome-entrapped calcitonin.

abstract：:The aim of this work was to explore the reduction of fluoride concentrations in the skeleton after stopping experimental fluoride administration. Fluoride was administered to the rats at varying doses (0, 50, 100 ppm in drinking water) and for different lengths of time (4, 13, 25 weeks). A series of fluoride concentra...

journal_title：Calcified tissue international

authors： Li J,Nakagaki H,Kato K,Tsuboi S,Kato S,Morita I,Ohno N,Kameyama Y,Chen R,Robinson C

更新日期：1995-04-01 00:00:00

abstract：:The aim of the investigation was to measure the effect of fluoride on vertebral trabecular bone compressive strength and to correlate this with fluoride-induced changes in bone density. This correlation would express changes in the quality of bone during fluoride treatment. Pigs were used in the experiment because the...

journal_title：Calcified tissue international

authors： Mosekilde L,Kragstrup J,Richards A

更新日期：1987-06-01 00:00:00

abstract：:The purpose of this study was to investigate the mineral induction capacity in vitro of polyanionic proteins covalently bound to a surface. Rat dentin gamma-carboxyglutamate-containing protein of the osteocalcin type (Gla-protein), proteoglycan (PG), and phosphoprotein (PP-H), as well as phosvitin (PhV) and bovine ser...

journal_title：Calcified tissue international

authors： Linde A,Lussi A,Crenshaw MA

更新日期：1989-04-01 00:00:00

abstract：:Pregnancy and lactation-associated osteoporosis (PAO) is a rare condition with little known pathophysiology. Most cases are diagnosed in the third trimester of pregnancy or in the first weeks postpartum, particularly in first pregnancies. Vertebral fractures are most commonly observed and characterised by prolonged se...

journal_title：Calcified tissue international

authors： Grizzo FM,da Silva Martins J,Pinheiro MM,Jorgetti V,Carvalho MD,Pelloso SM

更新日期：2015-10-01 00:00:00

abstract：:The method of heat-denaturation and trypsin digestion was used to dissect bone biochemically into mineral-protected and mineral-unprotected pools of collagenous matrix. It was found that varying the particle size of the bone powder had a profound effect on the results. Using mature bovine cortical bone, the observed p...

journal_title：Calcified tissue international

authors： Wu JJ,Eyre DR

更新日期：1988-04-01 00:00:00

abstract：:Lumbar spine bone mass and density were measured with Dual photon absorptiometry (DPA) in 60 patients with crush fractures and 60 age-matched normal women. Short-term reproducibility of bone mineral density (BMD) was 1.3% in normal women and 2.5% in osteoporotic women; long-term reproducibility in normal women was 2.2...

journal_title：Calcified tissue international

authors： Pouilles JM,Tremollieres F,Louvet JP,Fournie B,Morlock G,Ribot C

更新日期：1988-12-01 00:00:00

abstract：:This study sought to confirm that osteoblasts of C3H/HeJ (C3H) mice, which have higher differentiation status and bone-forming ability compared to C57BL/6J (B6) osteoblasts, also have a lower apoptosis level and to test whether the higher differentiation status and bone-forming ability of C3H osteoblasts were related ...

journal_title：Calcified tissue international

authors： Sheng MH,Lau KH,Mohan S,Baylink DJ,Wergedal JE

更新日期：2006-05-01 00:00:00

abstract：:Bone collagen undergoes a series of enzymatic and nonenzymatic posttranslational modifications with maturation. The aim of this study was to analyze the collagenolytic efficiency of cathepsin K in relation to the extent of bone collagen age. Bone collagen posttranslational maturation was induced in vitro by preincubat...

journal_title：Calcified tissue international

authors： Borel O,Gineyts E,Bertholon C,Garnero P

更新日期：2012-07-01 00:00:00

abstract：:The aim of this study was to investigate bone mineral density (BMD) and bone turnover in patients with primary knee osteoarthritis (KOA) and to compare them with generalized OA (GOA) and nonGOA patients. A total of 88 postmenopausal primary KOA patients were studied. OA was graded by using knee radiographs. BMD of the...

journal_title：Calcified tissue international

authors： Naitou K,Kushida K,Takahashi M,Ohishi T,Inoue T

更新日期：2000-05-01 00:00:00

abstract：:Osteoarthritis (OA), the most prevalent chronic joint disease, increases in prevalence with age, and affects majority of individuals over the age of 65 and is a leading musculoskeletal cause of impaired mobility in the elderly. Because the precise molecular mechanisms which are involved in the degradation of cartilage...

journal_title：Calcified tissue international

authors： Xia B,Di Chen,Zhang J,Hu S,Jin H,Tong P

更新日期：2014-12-01 00:00:00

abstract：:Patients with systemic lupus erythematosus (SLE), a chronic inflammatory disease characterized by loss of T- and B-cell tolerance to autoantigens, are at increased risk for osteoporosis and fractures. Mice deficient in Fc gamma receptor IIb (FcγRIIB) exhibit spontaneous SLE and its restoration rescues the disease. To ...

journal_title：Calcified tissue international

authors： Saiworn W,Thim-Uam A,Visitchanakun P,Atjanasuppat K,Chantaraaumporn J,Mokdara J,Chungchatupornchai S,Pisitkun P,Leelahavanichkul A,Poolthong S,Baron R,Lotinun S

更新日期：2018-12-01 00:00:00

abstract：:Impact activity is an important contributor to bone accrual. Children engaging in such activity have been shown to have greater bone mineral density (BMD) than their peers. This cross-sectional study was designed to quantify the association between BMD and impact activity in pre-pubescent girls, specifically examining...

journal_title：Calcified tissue international

authors： Scerpella TA,Davenport M,Morganti CM,Kanaley JA,Johnson LM

更新日期：2003-01-01 00:00:00

abstract：:Disturbances in mineral and bone metabolism are common in patients with chronic kidney disease (CKD), especially those undergoing dialysis. Renal osteodystrophy, which describes an alteration of bone morphology, is an important component of this systemic disorder and may explain the elevated risk of fracture which adv...

journal_title：Calcified tissue international

authors： Komaba H,Ketteler M,Cunningham J,Fukagawa M

更新日期：2021-01-02 00:00:00

abstract：:Vitamin D supplementation is recommended for women with osteoporosis. In the FOCUS-D trial comparing the combination tablet alendronate plus vitamin D3 5,600 IU (ALN/D) with standard care (SC) prescribed by patients' personal physicians, ALN/D was more effective in improving serum 25(OH)D and bone turnover markers by ...

journal_title：Calcified tissue international

authors： Roux C,Binkley N,Boonen S,Kiel DP,Ralston SH,Reginster JY,Pong A,Rosenberg E,Santora A,FOCUS-D Investigators.

更新日期：2014-02-01 00:00:00

abstract：:We assessed the bone mineral density (BMD) of 16 matched sets of cadaveric proximal femurs and feet using dual-energy x-ray absorptiometry (DXA). We also estimated the femoral neck length from the DXA scans. Quantitative ultrasound densitometry was used to measure the velocity of sound and broadband ultrasound attenua...

journal_title：Calcified tissue international

authors： Bouxsein ML,Courtney AC,Hayes WC

更新日期：1995-02-01 00:00:00

abstract：:The aim of this study was to test whether the nitric oxide (NO) donor sodium nitroprusside (SNP) has an effect on mineralization in ATDC5 cells. Mineralization in ATDC5 cell culture was induced by addition of beta-glycerophosphate or inorganic phosphate, visualized by staining precipitated calcium with an alizarin red...

journal_title：Calcified tissue international

authors： Huitema LF,Vaandrager AB,van Weeren PR,Barneveld A,Helms JB,van de Lest CH

更新日期：2006-03-01 00:00:00

abstract：:This report describes a method using direct photon absorptiometry (DPA) for determination in vivo of the bone mineral content to bone width ratio (BMC/W) in the rat femur. A significant correlation was noted between measurements by DPA and whole femur dry weight and ash weight. Measurements were reproducible within re...

journal_title：Calcified tissue international

authors： Sanchez TV,Myers RC,Bond JT,Mayor GH

更新日期：1981-01-01 00:00:00

abstract：:The association of dietary patterns and bone health is not yet well known, and findings from the rare previous studies conducted on this issue are contradictory. We assessed the dietary patterns in relation to bone mineral density (BMD) in a sample of menopausal Iranian women. In this cross-sectional study, 160 menopa...

journal_title：Calcified tissue international

authors： Karamati M,Jessri M,Shariati-Bafghi SE,Rashidkhani B

更新日期：2012-07-01 00:00:00

abstract：:The effect of ascorbic acid deficiency on bone metabolism was evaluated using the ascorbate-requiring Osteogenic Disorder Shionogi (ODS) rat model. Ascorbic acid (Asc)-deficient rats gained body weight in a manner similar to Asc-supplemented rats (control) during 3 weeks, but began to lose weight during the 4th week o...

journal_title：Calcified tissue international

authors： Goto A,Tsukamoto I

更新日期：2003-08-01 00:00:00

abstract：:The purpose of the present work was to investigate the appearance of ossification centers in human femur by Dual-energy X-ray Absorptiometry (DXA), comparing densitometric data with morphogenetic events. Posteroanterior scans were performed on 31 dried femora (from 11.5 weeks of conceptual age to 1 year of postnatal l...

journal_title：Calcified tissue international

authors： Panattoni GL,D'Amelio P,Di Stefano M,Isaia GC

更新日期：2000-04-01 00:00:00

abstract：:We have previously noted that a relatively large load (150 N) is required to induce a strain on the cortex of rat vertebrae similar to that induced on weight-bearing bones by normal mechanical usage. It seems unlikely that the musculature of the tail normally imposes loads of this magnitude, and this suggests that the...

journal_title：Calcified tissue international

authors： Chow JW,Jagger CJ,Chambers TJ

更新日期：1996-08-01 00:00:00

abstract：:High PTH levels increase bone turnover and decrease bone mineral density (BMD). Low plasma 25-hydroxyvitamin D (25OHD) levels cause secondary hyperparathyroidism, but the relative contribution of low 25OHD and high PTH levels on risk of fracture is largely unknown. Within the cohort of women (n = 2,016) included in th...

journal_title：Calcified tissue international

authors： Rejnmark L,Vestergaard P,Brot C,Mosekilde L

更新日期：2011-03-01 00:00:00

abstract：:Ultrasonic methods measure properties intrinsic to bone's structure that are not necessarily dependent on bone mass. Therefore, ultrasound may prove to be a useful tool for diagnosing bone fragility and osteoporosis. The goal of this study was to determine the relationship between apparent velocity of ultrasound (AVU)...

journal_title：Calcified tissue international

authors： Turner CH,Eich M

更新日期：1991-08-01 00:00:00

abstract：:Polymorphisms in the region of the gene for the vitamin D receptor (VDR) (chromosome 12q12-14) have been associated with differences in bone mineral density (BMD) in some studies but not in others. Because linkage analysis assesses allele sharing identical-by-descent among relatives instead of the association of a par...

journal_title：Calcified tissue international

authors： Zee RY,Myers RH,Hannan MT,Wilson PW,Ordovas JM,Schaefer EJ,Lindpaintner K,Kiel DP

更新日期：2000-12-01 00:00:00

abstract：:Dickkopf-1 (DKK1) and sclerostin are antagonists of the Wnt/β-catenin pathway and decreased expression of either results in increased bone formation and mass. As both affect the same signaling pathway, we aimed to elucidate the redundancy and/or compensation of sclerostin and DKK1. Weekly sclerostin antibody (Scl-Ab) ...

journal_title：Calcified tissue international

authors： Morse A,Cheng TL,Schindeler A,McDonald MM,Mohanty ST,Kneissel M,Kramer I,Little DG

更新日期：2018-09-01 00:00:00

abstract：:A morphological and electron microscopic study of bone from patients with osteogenesis imperfecta (OI) has been performed. Bone from OI patients from various anatomical sites has been compared with that from normal, age-, site-, and sex-matched controls. The morphology of OI bone appeared variable among patients and s...

journal_title：Calcified tissue international

authors： Cassella JP,Stamp TC,Ali SY

更新日期：1996-03-01 00:00:00

abstract：:The aim of this study was to determine whether forearm bone mineral density (BMD) measurements are affected by clinical risk factors for osteoporosis to the same extent as spine and hip BMD. The study population consisted of 1,009 female patients and volunteers, of whom 238 were premenopausal. Women were placed into s...

journal_title：Calcified tissue international

authors： Patel R,Blake GM,Fogelman I

更新日期：2007-02-01 00:00:00

abstract：:Interleukin (IL)-6 is a bone-resorbing cytokine that acts primarily on osteoclast progenitors to stimulate both proliferation and differentiation. Glucocorticoids (GC) down-regulate IL-6 synthesis in different cell types, including osteoblasts. Given the fact that bone remodeling is a tightly controlled process, it is...

journal_title：Calcified tissue international

authors： Dovio A,Masera RG,Sartori ML,Racca S,Angeli A

更新日期：2001-11-01 00:00:00

abstract：:The present study examined calcium phosphate precipitation in aqueous suspensions of multilamellar liposomes as a possible in vitro model for matrix vesicle mineralization. Liposomes were prepared by dispersing CHCl3-evaporated thin films of 7:2:1 and 7:1:1 molar mixtures of phosphatidylcholine, dicetyl phosphate, and...

journal_title：Calcified tissue international

authors： Eanes ED,Hailer AW,Costa JL

更新日期：1984-07-01 00:00:00

abstract：:Icariin, the main constituent of Herba Epimedii, appears to be a promising alternative to classic drugs used to treat osteoporosis. However, the detailed molecular mechanisms of its action and the role of icariin in the cross-talk between osteoblasts and adipocytes remain unclear. The present study was designed to inv...

journal_title：Calcified tissue international

authors： Zhang D,Fong C,Jia Z,Cui L,Yao X,Yang M

更新日期：2016-08-01 00:00:00