当前位置： SCI文献检索 > CALCIFIED TISSUE INTERNATIONAL期刊下所有文献 > Increased fracture risk in normocalcemic postmenopausal women with high parathyroid hormone levels: a 16-year follow-up study.

Increased fracture risk in normocalcemic postmenopausal women with high parathyroid hormone levels: a 16-year follow-up study.

Abstract：

:High PTH levels increase bone turnover and decrease bone mineral density (BMD). Low plasma 25-hydroxyvitamin D (25OHD) levels cause secondary hyperparathyroidism, but the relative contribution of low 25OHD and high PTH levels on risk of fracture is largely unknown. Within the cohort of women (n = 2,016) included in the Danish Osteoporosis Prevention Study (DOPS), we studied risk of fracture according to parathyroid status. Analyses were performed on effects of high PTH levels (i.e., in the upper tertile, ≥4.5 pmol/L) on risk of incident fractures at different 25OHD levels during 16 years of follow-up. Incident fractures were assessed using a nationwide hospital discharge register. In addition, effects of high PTH levels on BMD and vertebral fractures were assessed by DXA scans and spinal X-ray examination after 10 years of follow-up. High PTH levels were associated with a decreased body mass index, adjusted BMD, and an increased risk of any fracture (HR = 1.41, 95% CI 1.11-1.79) as well as an increased risk of osteoporotic fractures (HR = 1.59, 95% CI 1.20-2.10). Plasma 25OHD levels per se did not affect fracture risk, but high PTH levels were associated with an increased fracture risk only at 25OHD levels <50 nmol/L and 50-80 nmol/L. High PTH levels did not increase risk of fracture at 25OHD levels >80 nmol/L. In conclusion, PTH levels in the upper part or above the upper level of the reference interval increase risk of fracture in the presence of low vitamin D levels.

journal_name

Calcif Tissue Int

journal_title

Calcified tissue international

authors

Rejnmark L,Vestergaard P,Brot C,Mosekilde L

doi

10.1007/s00223-010-9454-0

subject

Has Abstract

pub_date

2011-03-01 00:00:00

pages

238-45

issue

3

eissn

0171-967X

issn

1432-0827

journal_volume

88

pub_type

杂志文章,多中心研究

相关文献

CALCIFIED TISSUE INTERNATIONAL文献大全
  • Bone Structural Changes and Estimated Strength After Gastric Bypass Surgery Evaluated by HR-pQCT.

    abstract：:Roux-en-Y gastric bypass surgery (RYGB) is an effective treatment of morbid obesity, with positive effects on obesity-related complications. The treatment is associated with bone loss, which in turn might increase fracture risk. The aim of this study was to evaluate changes in bone mineral density (BMD) and bone archi...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s00223-015-0091-5

    authors： Frederiksen KD,Hanson S,Hansen S,Brixen K,Gram J,Jørgensen NR,Støving RK

    更新日期：2016-03-01 00:00:00

  • Specific effects of gamma-linolenic, eicosapentaenoic, and docosahexaenoic ethyl esters on bone post-ovariectomy in rats.

    abstract：:Long chain polyunsaturated fatty acids (LCPUFAs) are involved in the regulation of bone metabolism. Increased dietary consumption of n-3, and possibly some n-6, LCPUFAs may limit postmenopausal bone loss. The aim of this study was to determine the effects on bone of specific fatty acids within the n-3 and n-6 LCPUFA f...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s00223-007-9080-7

    authors： Poulsen RC,Firth EC,Rogers CW,Moughan PJ,Kruger MC

    更新日期：2007-12-01 00:00:00

  • High Serum Insulin-Like Growth Factor-Binding Protein 1 (IGFBP-1) is Associated with High Fracture Risk Independent of Insulin-Like Growth Factor 1 (IGF-I).

    abstract：:High serum levels of IGFBP-1 are related both to low body mass index (BMI) and to low insulin-like growth factor 1 (IGF-I), which both in turn are related to low bone mineral density (BMD) and to increased fracture risk. However, we have found no previous prospective studies on IGFBP-1 and fracture risk. Despite its n...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s00223-016-0152-4

    authors： Lundin H,Sääf M,Strender LE,Nyren S,Johansson SE,Salminen H

    更新日期：2016-10-01 00:00:00

  • The mandibular condylar growth center: separation and characterization of the cellular elements.

    abstract：:The developing mandibular condylar growth center consists of a number of histologically distinct cell types. There is an increase in cell volume that takes place from the condylar surface layer through the center of ossification, resulting in a disorganized, irregular cellular pattern. Consequently, the isolation and ...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/BF00298747

    authors： Landesberg R,Proctor RL,Rosier RN,Puzas JE

    更新日期：1995-01-01 00:00:00

  • The effect of intravenous pamidronate on bone mineral density, bone histomorphometry, and parameters of bone turnover in adults with type IA osteogenesis imperfecta.

    abstract：:The type IA osteogenesis imperfecta (OI) phenotype is characterized by multiple fractures, blue sclerae, and minimal skeletal deformity without dentinogenesis imperfecta. The object of this study was to determine the effect of treatment with intravenous pamidronate (30 mg) every 3 months on bone density and bone histo...

    journal_title：Calcified tissue international

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00223-001-1055-5

    authors： Shapiro JR,McCarthy EF,Rossiter K,Ernest K,Gelman R,Fedarko N,Santiago HT,Bober M

    更新日期：2003-02-01 00:00:00

  • Bone collagen: new clues to its mineralization mechanism from recessive osteogenesis imperfecta.

    abstract：:Until 2006 the only mutations known to cause osteogenesis imperfecta (OI) were in the two genes coding for type I collagen chains. These dominant mutations affecting the expression or primary sequence of collagen α1(I) and α2(I) chains account for over 90% of OI cases. Since then a growing list of mutant genes causing...

    journal_title：Calcified tissue international

    pub_type： 杂志文章,评审

    doi：10.1007/s00223-013-9723-9

    authors： Eyre DR,Weis MA

    更新日期：2013-10-01 00:00:00

  • Damaging fatigue loading stimulates increases in periosteal vascularity at sites of bone formation in the rat ulna.

    abstract：:Bone formation in a variety of contexts depends on angiogenesis; however, there are few reports of the vascular response to osteogenic skeletal loading. We used the rat forelimb compression model to characterize vascular changes after fatigue loading. The right forelimbs of 72 adult rats were loaded cyclically in vivo...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s00223-007-9031-3

    authors： Matsuzaki H,Wohl GR,Novack DV,Lynch JA,Silva MJ

    更新日期：2007-06-01 00:00:00

  • Severe bone deformities in young children from vitamin D deficiency and fluorosis in Bihar-India.

    abstract：:A case-control study was undertaken to understand the etiopathology of the bone deformities among young children in a fluoride-affected village of the Bihar State. Two villages were selected: one village with high fluoride in drinking water (7.9 +/- 4.15 ppm), and the other village with normal levels of fluoride (0.6 ...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s00223-005-0233-2

    authors： Khandare AL,Harikumar R,Sivakumar B

    更新日期：2005-06-01 00:00:00

  • A controlled study of the effects of alendronate in a growing mouse model of osteogenesis imperfecta.

    abstract：:Recent studies have reported that bisphosphonates reduce fracture incidence and improve bone density in children with osteogenesis imperfecta (OI). However, questions still persist concerning the effect of these drugs on bone properties such as ultrastructure and quality, particularly in the growing patient. To addres...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s002230010045

    authors： Camacho NP,Raggio CL,Doty SB,Root L,Zraick V,Ilg WA,Toledano TR,Boskey AL

    更新日期：2001-08-01 00:00:00

  • Temporal variations in iliac trabecular bone formation in vertebral osteoporosis.

    abstract：:The histologic heterogeneity of osteoporosis relative to normal controls has attracted great interest. There has been controversy as to whether patients with high turnover osteoporosis may convert to a normal or low turnover form, and vice versa. We have studied 44 patients over 12 years by dynamic histomorphometry an...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/BF00675620

    authors： Arlot ME,Bradbeer JN,Edouard C,Green JR,Hesp R,Roux JP,Meunier PJ,Reeve J

    更新日期：1993-01-01 00:00:00

  • Immunohistochemical localization of alpha 2HS glycoprotein in dentin.

    abstract：:Monoclonal antibody against bovine serum alpha 2HS glycoprotein was raised in mice and the localization of this glycoprotein in bovine and human teeth was examined by immunohistochemical techniques on undemineralized ground sections after surface etching with dilute HCl. Positive reactions were found in both bovine an...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/BF02555864

    authors： Takagi Y,Shimokawa H,Suzuki M,Nagai H,Sasaki S

    更新日期：1990-07-01 00:00:00

  • Normal maturational changes in bone matrix, mineral, and crystal size in the rat.

    abstract：:Normal rat bone maturation has been studied using biochemical methods and hydrazine separation of matrix and mineral for X-ray diffraction. In the bone, the amount of mineral increases between 4 and 22 weeks of age, while in the matrix, the ratio of noncollagenous protein to collagen progressively decreases. In minera...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/BF02407162

    authors： Burnell JM,Teubner EJ,Miller AG

    更新日期：1980-01-01 00:00:00

  • Vitamin D Status in Israeli subjects before the initiation and after the cessation of vitamin D supplements.

    abstract：:Vitamin D supplements are often recommended to restore sufficiency, although the adherence to treatment is low. This study assessed vitamin D status at different time intervals following the cessation of treatment. The database of Clalit-Health-Services (CHS), a not-for-profit HMO covering more than half of the Israel...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s00223-011-9536-7

    authors： Saliba W,Barnett O,Rennert HS,Lavi I,Rennert G

    更新日期：2011-11-01 00:00:00

  • The essential role of fetuin in the serum-induced calcification of collagen.

    abstract：:The mineral in bone is located primarily within the collagen fibril, and during mineralization the fibril is formed first and then water within the fibril is replaced with mineral. Our goal is to understand the mechanism of fibril mineralization, and as a first step we recently determined the size exclusion characteri...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s00223-007-9085-2

    authors： Toroian D,Price PA

    更新日期：2008-02-01 00:00:00

  • Magnetic resonance imaging measurements of bone density and cross-sectional geometry.

    abstract：:Magnetic resonance imaging (MRI) is commonly used in the assessment of the musculoskeletal system and associated pathology. The ability of MRI to measure the signals from water and lipid protons enables quantitative measurements of bone porosity. The goal of this investigation was to demonstrate that the density and c...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s002230050015

    authors： Hong J,Hipp JA,Mulkern RV,Jaramillo D,Snyder BD

    更新日期：2000-01-01 00:00:00

  • Alterations in collagen and mineral nanostructure observed in osteoporosis and pharmaceutical treatments using simultaneous small- and wide-angle X-ray scattering.

    abstract：:The influence of the macroscale material properties of bone on its mechanical competence has been extensively investigated, but less is known about possible contributions from bone's nanoscale material properties. These nanoscale properties, particularly the collagen network and the size and shape of hydroxyapatite mi...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s00223-014-9913-0

    authors： Acerbo AS,Kwaczala AT,Yang L,Judex S,Miller LM

    更新日期：2014-11-01 00:00:00

  • Increase in tartrate-resistant acid phosphatase of bone at the early stage of ascorbic acid deficiency in the ascorbate-requiring Osteogenic Disorder Shionogi (ODS) rat.

    abstract：:The effect of ascorbic acid deficiency on bone metabolism was evaluated using the ascorbate-requiring Osteogenic Disorder Shionogi (ODS) rat model. Ascorbic acid (Asc)-deficient rats gained body weight in a manner similar to Asc-supplemented rats (control) during 3 weeks, but began to lose weight during the 4th week o...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s00223-002-2040-3

    authors： Goto A,Tsukamoto I

    更新日期：2003-08-01 00:00:00

  • Increased Turnover of Small Proteoglycans Synthesized by Human Osteoblasts During Cultivation with Ascorbate and β-Glycerophosphate.

    abstract：:The small proteoglycan decorin had been localized previously at the d-band in the gap zone of collagen fibrils in nonmineralizing tissues. In bone matrix this zone is proteoglycan free and is at least in some species the place where mineralization along collagen fibrils starts. To study the metabolism of the small pro...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s002239900279

    authors： Blumberg P,Brenner R,Budny S,Kresse H

    更新日期：1997-06-01 00:00:00

  • Ultrasonic velocity as a predictor of strength in bovine cancellous bone.

    abstract：:Ultrasonic methods measure properties intrinsic to bone's structure that are not necessarily dependent on bone mass. Therefore, ultrasound may prove to be a useful tool for diagnosing bone fragility and osteoporosis. The goal of this study was to determine the relationship between apparent velocity of ultrasound (AVU)...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/BF02565132

    authors： Turner CH,Eich M

    更新日期：1991-08-01 00:00:00

  • Absence of glutamine supplementation prevents differentiation of murine calvarial osteoblasts to a mineralizing phenotype.

    abstract：:Osteoblasts in vitro differentiate from a proliferating to a mineralizing phenotype upon transfer to a medium rich in beta-glycerophosphate and ascorbic acid. The nutritional requirements of the cells at different stages of this differentiation process are not known. In other cell types, nutritional supplementation du...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s00223-011-9537-6

    authors： Brown PM,Hutchison JD,Crockett JC

    更新日期：2011-12-01 00:00:00

  • Increases in hip and spine bone mineral density are predictive for vertebral antifracture efficacy with ibandronate.

    abstract：:The relationship between bisphosphonate-induced bone mineral density (BMD) gains and antifracture efficacy remains to be fully elucidated. Data from two antifracture studies were analyzed. Postmenopausal osteoporotic women received oral (2.5 mg daily, 20 mg intermittent) or intravenous (0.5 mg, 1 mg quarterly) ibandro...

    journal_title：Calcified tissue international

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00223-010-9403-y

    authors： Miller PD,Delmas PD,Huss H,Patel KM,Schimmer RC,Adami S,Recker RR

    更新日期：2010-10-01 00:00:00

  • Regional variations in histomorphometric bone dynamics from the skeleton of an osteoporotic woman.

    abstract：:Histomorphometric evaluation of bone formation in an intravital tetracycline-labeled skeleton of a suddenly deceased osteoporotic woman is presented. The 24 skeletal sites investigated displayed substantial regional variations which, for two out of four cortical bone dynamics and all trabecular bone dynamics, were sig...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/BF02556619

    authors： Pødenphant J,Engel U

    更新日期：1987-04-01 00:00:00

  • Effects of SP500263, a novel selective estrogen receptor modulator, on bone, uterus, and serum cholesterol in the ovariectomized rat.

    abstract：:We describe here the activity of a novel selective estrogen receptor modulator, SP500263. When given to adult ovariectomized (OVX) rats for 28 days at doses of 0.3, 1, or 3 mg/kg/day, we found that SP500263 partially protected against OVX-induced loss of bone mineral content in the distal ends of femurs and in the who...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s00223-002-1029-2

    authors： Sutherland MK,Brady H,Gayo-Fung LM,Leisten J,Lipps SG,McKie JA,O'Leary E,Patnaik N,Anderson DW,Bhagwat SS,Stein B

    更新日期：2003-06-01 00:00:00

  • hard tissue biochemistry: a comparison of fresh-frozen and formalin-fixed tissue samples.

    abstract：:Formalin fixation of hard tissues alters the levels of some, but not all, of the parameters routinely measured by bone researchers. Although mineral parameters (ash weight, particle size (beta 1/2 002) and Ca/PO4 ratio) and lipid parameters (total lipid content and composition, extractability, and Ca-acidic phospholip...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/BF02411262

    authors： Boskey AL,Cohen ML,Bullough PG

    更新日期：1982-07-01 00:00:00

  • The effect of lipopolysaccharide from bacteroides gingivalis and muramyl dipeptide on osteoblast collagenase release.

    abstract：:In order to determine whether the bacterial bone resorbing agents lipopolysaccharide (LPS) and muramyl dipeptide (MDP) interact with osteoblasts, their effect on the synthesis of collagenase and tissue inhibitor or metalloproteinases (TIMP) from monolayer cultures of mouse osteoblast-like cells was investigated. All c...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/BF02556318

    authors： Sismey-Durrant HJ,Atkinson SJ,Hopps RM,Heath JK

    更新日期：1989-05-01 00:00:00

  • Absorption of intranasal salmon calcitonin in normal subjects and hypogonadic men.

    abstract：:The absorption kinetics of intranasal salmon calcitonin were assessed in 4 normal subjects and 9 patients with Klinefelter's syndrome. After administration, absorption occurred within 5 minutes. There was a highly significant correlation between the amount administered and the amount absorbed (r = -0.83, P less than 0...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/BF02556097

    authors： Pun KK,Chan LW,Lau P,Ho PW,Wang C

    更新日期：1990-02-01 00:00:00

  • Serum triiodothyronine, bone turnover, and bone mass changes in euthyroid pre- and postmenopausal women.

    abstract：:Hyperthyroidism and thyroid hormone substitutive therapy with serum iT3 in the normal range of values are known to lead to increased bone remodeling and loss of bone mass. We looked for a relationship between serum iT3 and bone metabolic or bone mass parameters in 402 euthyroid women aged 44-60. In a group of 93 preme...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/BF02565128

    authors： Schoutens A,Laurent E,Markowicz E,Lisart J,De Maertelaer V

    更新日期：1991-08-01 00:00:00

  • Influence of Teriparatide and Ibandronate on Cortical Bone in New Zealand White Rabbits: A HR-QCT Study.

    abstract：:Teriparatide (TPTD) is known to increase the cortical thickness and porosity. The purpose of the present study was to determine whether switching from TPTD to ibandronate (IBN) would be useful for improving cortical bone parameters as assessed using high-resolution quantitative computed tomography (HR-QCT) analyses in...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s00223-016-0180-0

    authors： Iwamoto J,Seki A,Nango N

    更新日期：2016-11-01 00:00:00

  • Bone progenitor cell deficits and the age-associated decline in bone repair capacity.

    abstract：:Aging bone shows a progressive decline in mass and strength. Previous studies have suggested that bone marrow stem cells are reduced with aging and that this could be responsible, in part, for age-associated bone deficits. We measured the number of osteoprogenitor cells present in the bone marrow from adult and aged r...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/BF00296343

    authors： Quarto R,Thomas D,Liang CT

    更新日期：1995-02-01 00:00:00

  • Local bone mineral density, muscle strength, and exercise in adolescent boys: a comparative study of two groups with different muscle strength and exercise levels.

    abstract：:The primary objective of the present study was to evaluate the impact of physical activity and muscle strength on bone mineral density (BMD) of the tuberositas tibiae in adolescent boys. Two groups with different exercise levels were compared. The high activity group consisted of 20 subjects (age 15.9 +/- 0.3) from a ...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/BF02509438

    authors： Nordström P,Nordström G,Thorsen K,Lorentzon R

    更新日期：1996-06-01 00:00:00