Vitamin D Status in Israeli subjects before the initiation and after the cessation of vitamin D supplements.

Abstract:

:Vitamin D supplements are often recommended to restore sufficiency, although the adherence to treatment is low. This study assessed vitamin D status at different time intervals following the cessation of treatment. The database of Clalit-Health-Services (CHS), a not-for-profit HMO covering more than half of the Israeli population, was retrospectively searched for all members with available serum 25OHD test results in 2009 (245,493). We then identified those who filled any cholecalciferol prescription in 2008-2009 (121,817). Subjects were included in the final analysis only if they started treatment in 2009, had serum 25OHD < 50 nmol/l before the first prescription in 2009, and had at least one additional test result after the last dated prescription in 2009 (5,461). Serum 25OHD increased from 32 ± 11 nmol/l at baseline to 58.6 ± 22.3 nmol/l after treatment (P < 0.001). The proportion of subjects with sufficient vitamin D after treatment increased with increasing cholecalciferol daily dose and treatment duration (P < 0.001) and decreased with increasing time from cessation of treatment (P < 0.001). The effect of time from treatment cessation persisted after controlling for baseline serum 25OHD, daily cholecalciferol dose, treatment duration, seasonality, gender, age, ethnicity, and BMI; the ORs for sufficient vitamin D were 2.02 (95% CI 1.66-2.45), 1.67 (1.39-2.01), and 1.23 (1.04-1.47) for >30-60, 61-99, and 100-155 days compared to >155 days, respectively. Long-term vitamin D treatment is needed to maintain sufficient levels in those with baseline serum 25OHD below 50 nmol/l.

journal_name

Calcif Tissue Int

authors

Saliba W,Barnett O,Rennert HS,Lavi I,Rennert G

doi

10.1007/s00223-011-9536-7

subject

Has Abstract

pub_date

2011-11-01 00:00:00

pages

419-25

issue

5

eissn

0171-967X

issn

1432-0827

journal_volume

89

pub_type

杂志文章
  • Integrated therapies for osteoporosis and sarcopenia: from signaling pathways to clinical trials.

    abstract::Sarcopenia and osteoporosis are two sides of the same coin. They represent different aspects of the same age-related process of musculoskeletal atrophy and together culminate in falls, fractures, deconditioning, and increased mortality in older individuals. However, the current therapeutic approach to the prevention o...

    journal_title:Calcified tissue international

    pub_type: 杂志文章,评审

    doi:10.1007/s00223-015-9956-x

    authors: Girgis CM

    更新日期:2015-03-01 00:00:00

  • Pharmacological Regulation of Primary Cilium Formation Affects the Mechanosensitivity of Osteocytes.

    abstract::Primary cilia are responsible for sensing mechanical loading in osteocytes. However, the underlying working mechanism of cilia remains elusive. An osteocyte model is necessary to reveal the role of cilia. Furthermore, the osteocyte model should be with upregulated or downregulated primary cilium expression. Herein, we...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/s00223-020-00756-6

    authors: Ding D,Yang X,Luan HQ,Wu XT,He C,Sun LW,Fan YB

    更新日期:2020-12-01 00:00:00

  • Rare Inherited forms of Paget's Disease and Related Syndromes.

    abstract::Several rare inherited disorders have been described that show phenotypic overlap with Paget's disease of bone (PDB) and in which PDB is a component of a multisystem disorder affecting muscle and the central nervous system. These conditions are the subject of this review article. Insertion mutations within exon 1 of t...

    journal_title:Calcified tissue international

    pub_type: 杂志文章,评审

    doi:10.1007/s00223-019-00520-5

    authors: Ralston SH,Taylor JP

    更新日期:2019-05-01 00:00:00

  • The stimulation of vertebral and tibial bone growth by the parathyroid hormone fragments, hPTH-(1-31)NH2, [Leu27]cyclo(Glu22-Lys26)hPTH-(1-31)NH2, and hPTH-(1-30)NH2.

    abstract::The native human parathyroid hormone, hPTH-(1-84), and certain carboxyl truncated analogs such as hPTH-(1-34) and even smaller fragments such as hPTH-(1-31)NH2, [Leu27]cyclo(Glu22-Lys26)hPTH-(1-31)NH2, and hPTH-(1-30)NH2 stimulate femoral trabecular and cortical bone growth in ovariectomized (OVX) rats. Here we show t...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/s002230010061

    authors: Whitfield JF,Morley P,Fraher L,Hodsman AB,Holdsworth DW,Watson PH,Willick GE,Barbier JR,Gulam M,Isaacs RJ,MacLean S,Ross V

    更新日期:2000-04-01 00:00:00

  • Coordinate inhibition of alkaline phosphatase and type X collagen syntheses by 1,25-dihydroxyvitamin D3 in primary cultured hypertrophic chondrocytes.

    abstract::The effects of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) (2.3 x 10(-12) - 1.4 x 10(-6) [M]) on alkaline phosphatase, collagen, and cell proliferation were examined in primary cultured hypertrophic chondrocytes prepared from the distal epiphyseal growth plate of the tibias of 12-day chick embryos. 1,25(OH)2D3 showed time-...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/BF00296776

    authors: Inao S,Conrad HE

    更新日期:1992-05-01 00:00:00

  • Magnetic resonance imaging measurements of bone density and cross-sectional geometry.

    abstract::Magnetic resonance imaging (MRI) is commonly used in the assessment of the musculoskeletal system and associated pathology. The ability of MRI to measure the signals from water and lipid protons enables quantitative measurements of bone porosity. The goal of this investigation was to demonstrate that the density and c...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/s002230050015

    authors: Hong J,Hipp JA,Mulkern RV,Jaramillo D,Snyder BD

    更新日期:2000-01-01 00:00:00

  • Long-Term Effects of Teriparatide Followed by Antiresorptive Therapy on Clinical Outcomes in Patients with Severe Spinal Osteoporosis.

    abstract::Teriparatide (TPTD) is the most widely used anabolic agent in the treatment of patients with osteoporosis although its use is restricted in many countries. A recent randomised trial confirmed that TPTD was superior to risedronate at preventing vertebral fractures over a 2-year period. There is limited information on t...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/s00223-019-00563-8

    authors: Oswald AJ,Berg K,Ralston SH,Riches PL

    更新日期:2019-08-01 00:00:00

  • Skeletal demineralization in Turner's syndrome.

    abstract::The bone mineral status of 17 girls with Turner's syndrome was evaluated by single photon absorptiometry. Bone mineral content (BMC) was 25.4% below that predicted by normalization for age, sex, height, weight, and bone width. Only 25% of this demineralization could be attributed to delayed skeletal maturation. Bones ...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/BF02411296

    authors: Shore RM,Chesney RW,Mazess RB,Rose PG,Bargman GJ

    更新日期:1982-01-01 00:00:00

  • Regional measurement of bone calcium accretion rate and exchangeable pool with a whole-body counter: method and studies in subjects without bone disease.

    abstract::A whole-body counter was used to measure the retention and distribution of radioactivity along the longitudinal axis of the body during 10 days after the intravenous injection of 50 microCi of 47Ca. These data and the simultaneous measurements of the serum specific activity allowed us to calculate, by the Bauer-Carlss...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/BF02405001

    authors: Bergmann P,Paternot T,Schoutens A

    更新日期:1983-01-01 00:00:00

  • Vitamin D reduces musculoskeletal pain after infusion of zoledronic acid for postmenopausal osteoporosis.

    abstract::The acute-phase response (APR) is a frequent occurrence after infusion of zoledronic acid and is caused by activation of γδ T cells. Vitamin D receptor is expressed in immune cells, and vitamin D has immunomodulatory properties. The aim of this prospective study was to test the effect of vitamin D (cholecalciferol) on...

    journal_title:Calcified tissue international

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00223-012-9577-6

    authors: Catalano A,Morabito N,Atteritano M,Basile G,Cucinotta D,Lasco A

    更新日期:2012-04-01 00:00:00

  • Serum triiodothyronine, bone turnover, and bone mass changes in euthyroid pre- and postmenopausal women.

    abstract::Hyperthyroidism and thyroid hormone substitutive therapy with serum iT3 in the normal range of values are known to lead to increased bone remodeling and loss of bone mass. We looked for a relationship between serum iT3 and bone metabolic or bone mass parameters in 402 euthyroid women aged 44-60. In a group of 93 preme...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/BF02565128

    authors: Schoutens A,Laurent E,Markowicz E,Lisart J,De Maertelaer V

    更新日期:1991-08-01 00:00:00

  • Vertebral fractures and osteopenia in chronic alcoholic patients.

    abstract::To assess whether vertebral fractures are associated with osteopenia in chronic alcoholic patients, a transversal study was carried out in 76 chronic alcoholic males and 62 age-matched healthy males. Lumbar bone mineral density (BMD) by dual photon absorptiometry and spinal chest X-ray films were done in all patients....

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/BF00298430

    authors: Peris P,Guañabens N,Parés A,Pons F,del Rio L,Monegal A,Surís X,Caballería J,Rodés J,Muñoz-Gómez J

    更新日期:1995-08-01 00:00:00

  • Hydrogen peroxide induces apoptosis of osteocytes: involvement of calcium ion and caspase activity.

    abstract::We hypothesized that reactive oxygen species play an important role in avascular/ischemic osteonecrosis. When isolated chick osteocytes were cultured with hydrogen peroxide, annexin V binding, which is the earliest marker of apoptosis, increased in a dose-dependent fashion. Hydrogen peroxide also induced the activatio...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/s00223-001-1110-2

    authors: Kikuyama A,Fukuda K,Mori S,Okada M,Yamaguchi H,Hamanishi C

    更新日期:2002-09-01 00:00:00

  • The Distinct Role of the Extra-Large G Protein ɑ-Subunit XLɑs.

    abstract::GNAS is one of the most complex gene loci in the human genome and encodes multiple gene products including Gsα, XLαs, NESP55, A/B, and AS transcripts. XLαs, the extra-large G protein ɑ-subunit, is paternally expressed. XLɑs and Gsɑ share the common 2-13 exons with different promoters and first exons. Therefore, XLɑs c...

    journal_title:Calcified tissue international

    pub_type: 杂志文章,评审

    doi:10.1007/s00223-020-00714-2

    authors: Wang Y,Tian H,Chen X

    更新日期:2020-09-01 00:00:00

  • Human amelogenins: sequences of "TRAP" molecules.

    abstract::The extracellular protein matrix of developing enamel includes a major class of proteins, the amelogenins, which are believed to be concerned in regulating enamel biomineralization. Previous studies have shown the amelogenins of the extracellular matrix to be a complex of proline-rich hydrophobic proteins which, it is...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/BF02556044

    authors: Fincham AG,Hu YY,Pavlova Z,Slavkin HC,Snead ML

    更新日期:1989-10-01 00:00:00

  • Anxiolytics and sedatives and risk of fractures: effects of half-life.

    abstract::To study the risk of fractures associated with anxiolytics, sedatives, and hypnotics, we conducted a case-control study. Cases were all subjects with any fracture during the year 2000 (n = 124,655). For each case, three controls (n = 373,962) matched on age and gender were randomly drawn from the background population...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/s00223-007-9095-0

    authors: Vestergaard P,Rejnmark L,Mosekilde L

    更新日期:2008-01-01 00:00:00

  • The effects of remodeling on the elastic properties of bone.

    abstract::Cortical bone can be modeled as a complex hierarchical composite interrelating both structure and material properties on four levels of structural organization: molecular, ultrastructural, microscopic, and macroscopic. In young animals, the microstructural systems are long parallel lamellar units, plexiform bone, whic...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/BF02406131

    authors: Katz JL,Yoon HS,Lipson S,Maharidge R,Meunier A,Christel P

    更新日期:1984-01-01 00:00:00

  • MEPE's diverse effects on mineralization.

    abstract::Matrix extracellular phosphoglycoprotein (MEPE) is an inhibitor of mineralization in situ and in cell cultures where altered expression is associated with oncogenic osteomalacia and hypophosphatemic rickets. The purpose of this study was to determine whether the intact protein or the peptide(s) originating from this p...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/s00223-009-9313-z

    authors: Boskey AL,Chiang P,Fermanis A,Brown J,Taleb H,David V,Rowe PS

    更新日期:2010-01-01 00:00:00

  • Misoprostol, a prostaglandin E1 analogue, inhibits basic calcium phosphate crystal-induced mitogenesis and collagenase accumulation in human fibroblasts.

    abstract::Synovial fluid basic calcium phosphate (BCP) crystals are associated with severe destructive arthropathy. BCP crystals induce the secretion of matrix-degrading enzymes such as collagenase. No prophylactic or therapeutic agents are recognized to ameliorate the cartilage damage associated with BCP deposits in joints. As...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/BF00571332

    authors: McCarthy GM,Mitchell PG,Cheung HS

    更新日期:1993-06-01 00:00:00

  • In vitro and in vivo effects of ipriflavone on bone formation and bone biomechanics.

    abstract::Ipriflavone (i.p.) positively affects bone density in postmenopausal osteoporosis, primarily by inhibiting bone resorption. Using in vitro models of human osteoblast differentiation, we have observed that i.p. and some of its metabolites stimulate the expression of bone sialoprotein, decorin, and type I collagen, and ...

    journal_title:Calcified tissue international

    pub_type: 杂志文章,评审

    doi:10.1007/s002239900378

    authors: Civitelli R

    更新日期:1997-01-01 00:00:00

  • Once-Weekly Teriparatide Treatment Prevents Microdamage Accumulation in the Lumbar Vertebral Trabecular Bone of Ovariectomized Cynomolgus Monkeys.

    abstract::The effect of teriparatide treatment on microdamage accumulation has yet to be examined in animal studies. The purpose of this study was to investigate the effect of once-weekly teriparatide treatment on bone microdamage accumulation and the relationship between microdamage parameters and bone mass, architecture, turn...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/s00223-018-0500-7

    authors: Yoshitake S,Mashiba T,Saito M,Fujihara R,Iwata K,Takao-Kawabata R,Yamamoto T

    更新日期:2019-04-01 00:00:00

  • Impaired bone health in inflammatory bowel disease: a case-control study in 80 pediatric patients.

    abstract::Previous studies have indicated that children with inflammatory bowel disease (IBD) may not achieve optimal bone mass. We evaluated the skeletal characteristics in children and adolescents with IBD. This cross-sectional cohort study comprised 80 IBD patients (median age 14.9 years, range 5-20) with a median disease du...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/s00223-012-9617-2

    authors: Laakso S,Valta H,Verkasalo M,Toiviainen-Salo S,Viljakainen H,Mäkitie O

    更新日期:2012-08-01 00:00:00

  • Comparison of the effects of vitamin D metabolites on collagen synthesis and resportion of fetal rat bone in organ culture.

    abstract::We compared the effects of four vitamin D metabolites, 1 alpha,25 dihydroxy vitamin D3 (1 alpha,25(OH)2D3), 1 alpha hydroxy vitamin D3 (1 alpha OH D3), 25 hydroxy vitamin D3 (25 OH D3), and 24R,25 dihydroxy vitamin D (24R,25(OH)sD3) on resorption and collagen synthesis in fetal rat bone maintained in organ culture. Re...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/BF02408532

    authors: Raisz LG,Kream BE,Smith MD,Simmons HA

    更新日期:1980-01-01 00:00:00

  • Vitamin D deficiency in mothers of rachitic infants.

    abstract::The existence of nutritional deficiency rickets among infants in sunny Riyadh was confirmed radiologically. Most of the rachitic infants were breast-fed, some received unsupplemented infant feeding formulae, and all live in an environment that is devoid of sunlight. Their mean age at the time of onset was 10.5 months....

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/BF02405328

    authors: Elidrissy AT,Sedrani SH,Lawson DE

    更新日期:1984-05-01 00:00:00

  • A histochemical method for the demonstration of calcifying cartilage.

    abstract::The demonstration of histochemical characteristics in calcifying cartilage is fraught with methodological difficulties including the distinction of mineralized from unmineralized cartilage and the demonstration of cell detail in relatively hard tissue. This study uses the decalcified bone matrix-induced enchondral (en...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/BF02555141

    authors: Aaron RK,Jolly G,Ciombor DM,Barrach HJ

    更新日期:1988-10-01 00:00:00

  • No association between dietary vitamin K intake and fracture risk in chinese community-dwelling older men and women: a prospective study.

    abstract::Data on the association between dietary vitamin K intake and fracture risk are limited among Chinese. This study examined such an association in community-dwelling elderly in Hong Kong. We present data from 2,944 subjects (1,605 men, 1,339 women) who participated in a prospective cohort study. Baseline dietary intakes...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/s00223-012-9586-5

    authors: Chan R,Leung J,Woo J

    更新日期:2012-05-01 00:00:00

  • Serum Sclerostin and Bone Morphogenetic Protein-2 Levels in Patients with Ankylosing Spondylitis: A Meta-Analysis.

    abstract::Various studies have investigated the serum sclerostin and bone morphogenetic protein-2 (BMP-2) levels in patients with ankylosing spondylitis (AS), but the results were inconsistent. The aim of this meta-analysis was to synthetically assess the associations of serum levels of sclerostin and BMP-2 with AS. Multiple el...

    journal_title:Calcified tissue international

    pub_type: 杂志文章,meta分析

    doi:10.1007/s00223-019-00542-z

    authors: Yang J,Xu S,Chen M,Yuan Y,Zhang X,Ma Y,Wu M,Han R,Hu X,Liu R,Deng J,Guan S,Gao X,Pan M,Xu S,Shuai Z,Jiang S,Guan S,Chen L,Pan F

    更新日期:2019-07-01 00:00:00

  • Molecular structure at the bone-implant interface: a vibrational spectroscopic characterization.

    abstract::Test implant plates surgically retrieved from distal femurs of dogs were studied by Raman spectroscopy in order to characterize the bone-implant interface. The implant surface consisted of phosphate mineral, plasma sprayed on a titanium substrate. On the basis of its spectroscopic signature, the phosphate mineral of b...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/BF02556157

    authors: Walters MA,Blumenthal NC,Leung Y,Wang Y,Ricci JL,Spivak JM

    更新日期:1991-05-01 00:00:00

  • Soy affects trabecular microarchitecture and favorably alters select bone-specific gene expressions in a male rat model of osteoporosis.

    abstract::We have recently reported that soy isoflavones particularly when provided in the context of soy protein are capable of preventing loss of bone mineral density due to orchidectomy in F344 rats. We hypothesize, that soy isoflavones also exert beneficial effects on bone microstructural properties, in part, by enhancing b...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/s00223-005-0069-9

    authors: Soung DY,Devareddy L,Khalil DA,Hooshmand S,Patade A,Lucas EA,Arjmandi BH

    更新日期:2006-06-01 00:00:00

  • Biochemical response to bisphosphonate therapy in pagetic patients with skull involvement.

    abstract::The aims of this study were to compare the response to therapy in disease activity in pagetic patients with and without skull involvement and the usefulness of bone markers in the evaluation of these patients. Forty patients with Paget's disease treated with tiludronate and 26 healthy controls were included. Serum tot...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/s00223-005-0247-9

    authors: Peris P,Alvarez L,Vidal S,Kasper D,Leeming DJ,Monegal A,Angeles Martínez M,Pons F,Guañabens N

    更新日期:2006-07-01 00:00:00