当前位置： SCI文献检索 > CALCIFIED TISSUE INTERNATIONAL期刊下所有文献 > Coordinate inhibition of alkaline phosphatase and type X collagen syntheses by 1,25-dihydroxyvitamin D3 in primary cultured hypertrophic chondrocytes.

Coordinate inhibition of alkaline phosphatase and type X collagen syntheses by 1,25-dihydroxyvitamin D3 in primary cultured hypertrophic chondrocytes.

Abstract：

:The effects of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) (2.3 x 10(-12) - 1.4 x 10(-6) [M]) on alkaline phosphatase, collagen, and cell proliferation were examined in primary cultured hypertrophic chondrocytes prepared from the distal epiphyseal growth plate of the tibias of 12-day chick embryos. 1,25(OH)2D3 showed time- and dose-dependent inhibitory effects on the alkaline phosphatase and collagen levels. The inhibition of alkaline phosphatase activity became detectable at 2 x 10(-11) [M] and reached 10% of control at 10(-7) [M]. The concentration of 1,25(OH)2D3 giving a 50% inhibition of the enzyme level was approximately 3 x 10(-10) [M]. Of the two extracellular collagen pools, a cell-associated matrix pool showed a more dramatic decrease (to 10% of control) than a culture medium pool (to 50% of control) at increased 1,25(OH)2D3 concentrations. The degree of inhibition was different for each type of chondrocyte-specific collagen (types II, IX, X, and XI). Types II and IX were inhibited in a parallel manner to only 60-80% of control. On the other hand, types X and XI were more greatly reduced up to 10% of control, and their dose-dependent inhibitory curves were similar to that of alkaline phosphatase. On cell proliferation, 1,25(OH)2D3 had a biphasic effect: stimulation at 10(-10)-10(-8) [M] and inhibition at higher levels. The results revealed the significant involvement of 1,25(OH)2D3 in the metabolism of two probable calcification-related products, alkaline phosphatase and type X collagen.

journal_name

Calcif Tissue Int

journal_title

Calcified tissue international

authors

Inao S,Conrad HE

doi

10.1007/BF00296776

subject

Has Abstract

pub_date

1992-05-01 00:00:00

pages

445-50

issue

5

eissn

0171-967X

issn

1432-0827

journal_volume

50

pub_type

杂志文章

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