Abstract：
:X-linked hypophosphatemia (XLH) is a rare, inheritable disorder manifesting as rickets in children and osteomalacia in adults. While conventional medical treatment with oral phosphate and alfacalcidol is recommended in childhood, it is undecided whether adults should continue therapy. The aim of this 6-year prospective study was to determine the impact of conventional medical treatment on areal bone mineral density (aBMD), bone turnover markers (BTMs) and measures of calcium homeostasis in 27 adult patients with XLH, 11 of whom received medical treatment. Lumbar spine and total hip aBMD, as assessed by DXA, and biochemical measures of calcium, phosphate, PTH, 1,25 dihydroxyvitamin D2+3 (1,25(OH)2D), fibroblast growth factor 23 (FGF23), P1NP and CTX were measured at baseline and at follow-up. The renal tubular reabsorption of PO4 (TmPO4/GFR) was calculated at both time points. Multilevel mixed-effects linear regression models were used for analyses. During the study period, spine and hip aBMD did not change significantly between treated and non-treated XLH patients. There was a trend towards a decrease in calcium, phosphate and TmPO4/GFR in the treatment group (p = 0.057, p = 0.080 and p = 0.063, respectively), whereas PTH, FGF23, 1,25(OH)2D and P1NP did not change significantly in either groups. However, CTX increased significantly in the treated compared to non-treated group (p = 0.044). Continuing conventional medical therapy in adulthood, although associated with increased bone resorption, does not promote or prevent loss of bone mass as evidenced from the stable aBMD of the hip and spine in XLH patients.
journal_name
Calcif Tissue Intjournal_title
Calcified tissue internationalauthors
Shanbhogue VV,Hansen S,Jørgensen NR,Beck-Nielsen SSdoi
10.1007/s00223-017-0363-3subject
Has Abstractpub_date
2018-03-01 00:00:00pages
321-328issue
3eissn
0171-967Xissn
1432-0827pii
10.1007/s00223-017-0363-3journal_volume
102pub_type
杂志文章abstract：:Low-grade inflammation negatively affects bone. Resveratrol is a natural compound proven to possess both anti-inflammatory and bone protective properties. However, it is uncertain if the bone effects are mediated though anti-inflammatory effects. Firstly, we investigated if resveratrol affects proliferation and differ...
journal_title：Calcified tissue international
pub_type： 杂志文章
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journal_title：Calcified tissue international
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abstract：:The DMS Lexxos is the first cone-beam dual X-ray absorptiometry (DXA) system capable of performing bone mineral density (BMD) measurements of the spine and hip. By using a two-dimensional (2-D) detector array rather than the linear array used with conventional fan-beam DXA systems, image acquisition time on Lexxos is ...
journal_title：Calcified tissue international
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journal_title：Calcified tissue international
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doi：10.1007/s00223-008-9197-3
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journal_title：Calcified tissue international
pub_type： 临床试验,杂志文章
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journal_title：Calcified tissue international
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journal_title：Calcified tissue international
pub_type： 杂志文章
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journal_title：Calcified tissue international
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journal_title：Calcified tissue international
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journal_title：Calcified tissue international
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journal_title：Calcified tissue international
pub_type： 杂志文章
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journal_title：Calcified tissue international
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Calcified tissue international
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journal_title：Calcified tissue international
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journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02411276
更新日期：1982-07-01 00:00:00
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journal_title：Calcified tissue international
pub_type： 杂志文章
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journal_title：Calcified tissue international
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Calcified tissue international
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journal_title：Calcified tissue international
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journal_title：Calcified tissue international
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
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journal_title：Calcified tissue international
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