Abstract：
:Calcium and phosphate were allowed to diffuse into gelatin and Type I collagen gels which were then cut into slices and analyzed for ion concentrations. Solutions of calcium and phosphate were then prepared, with ion concentrations equivalent to the highest levels in the slices, and mixed together, whereupon a rapid and copious precipitation of hydroxyapatite (HA) was observed. In contrast, HA bands were not visible in the gels until 1 to 2 1/2 days after analysis. These results indicate that Type I collagen exerts a considerable inhibitory effect on HA proliferation, probably by steric blockage of nuclei and crystal formation and growth. It thus appears that Type I collagen should be added to the list of agents that perform a regulatory role in bone mineral formation.
journal_name
Calcif Tissue Intjournal_title
Calcified tissue internationalauthors
Blumenthal NC,Cosma V,Gomes Edoi
10.1007/BF02556459subject
Has Abstractpub_date
1991-06-01 00:00:00pages
440-2issue
6eissn
0171-967Xissn
1432-0827journal_volume
48pub_type
杂志文章abstract：:The relationship between bisphosphonate-induced bone mineral density (BMD) gains and antifracture efficacy remains to be fully elucidated. Data from two antifracture studies were analyzed. Postmenopausal osteoporotic women received oral (2.5 mg daily, 20 mg intermittent) or intravenous (0.5 mg, 1 mg quarterly) ibandro...
journal_title：Calcified tissue international
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00223-010-9403-y
更新日期：2010-10-01 00:00:00
abstract：:Plasma osteocalcin (BGP), growth hormone (GH), and somatomedin C(SmC) were measured in 12 patients with acromegaly [7 clinically active (aA), 5 cured (cA)] and 9 control subjects (C). Basal plasma values for the three parameters were higher in aA than in C and in cA. No significant difference was found between cA and ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02555167
更新日期：1988-07-01 00:00:00
abstract：:Unfixed, undecalcified sections from closed fractures of rat metatarsals have been studied by quantitative cytochemistry from the first week after fracture to late in the fracture-healing process. Alkaline phosphatase activity appeared to be related to calcification. Glucose 6-phosphate dehydrogenase activity was asso...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02405007
更新日期：1983-01-01 00:00:00
abstract：:The effect of ipriflavone (IP), a synthetic isoflavonoid derivative, on in vivo bone formation was studied in rat perialveolar bone by surgically producing a hole in the mandibular bone. The holes were filled either with powdered IP or with compounds containing no osteoinductive properties such as biostite and Htr (ha...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900533
更新日期：1998-10-01 00:00:00
abstract：:The small proteoglycan decorin had been localized previously at the d-band in the gap zone of collagen fibrils in nonmineralizing tissues. In bone matrix this zone is proteoglycan free and is at least in some species the place where mineralization along collagen fibrils starts. To study the metabolism of the small pro...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900279
更新日期：1997-06-01 00:00:00
abstract：:We had shown that aromatic amino acid (phenylalanine, tyrosine, and tryptophan) supplementation prevented bone loss in an aging C57BL/6 mice model. In vivo results from the markers of bone breakdown suggested an inhibition of osteoclastic activity or differentiation. To assess osteoclastic differentiation, we examined...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-014-9878-z
更新日期：2014-08-01 00:00:00
abstract：:The orientation of nanoscale mineral platelets was quantitatively evaluated in relation to the shape of lacunae associated with partially embedded osteocytes (osteoblastic-osteocytes) on the surface of deproteinised trabecular bone of adult sheep. By scanning electron microscopy and image analysis, the mean orientatio...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-015-0072-8
更新日期：2016-02-01 00:00:00
abstract：:Five years ago we reported results from a cross-sectional study of the effect of nutritional factors on calcium-regulating hormones and bone loss in perimenopausal women. We found an inverse correlation between serum 25-hydroxyvitamin D (25OHD) and immunoreactive parathyroid hormone (PTH), and we postulated that over ...
journal_title：Calcified tissue international
pub_type： 临床试验,杂志文章
doi：10.1007/BF00334543
更新日期：1992-09-01 00:00:00
abstract：:The increased uptake of bone-seeking radionuclides following a fracture has been stated to be due to an increase in bone blood flow, resulting in an increase in capillary surface area available for exchange. This paper examines the relationship between the maximum instantaneous extraction of 99mTc-MDP and blood flow i...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02405085
更新日期：1983-07-01 00:00:00
abstract：:The aims of this study were to compare the response to therapy in disease activity in pagetic patients with and without skull involvement and the usefulness of bone markers in the evaluation of these patients. Forty patients with Paget's disease treated with tiludronate and 26 healthy controls were included. Serum tot...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-005-0247-9
更新日期：2006-07-01 00:00:00
abstract：:The purpose of this study was to examine the effects of green tea extract (GTE) intake on bone structural and physiological properties, such as bone mass, trabecular bone microarchitecture, cortical bone geometry, and bone mechanical strength, in growing rats. Four-week-old male Wistar rats were divided into the follo...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-017-0358-0
更新日期：2018-03-01 00:00:00
abstract：:Regular tennis play is associated with impressive asymmetries in bone strength in favor of the racquet arm, particularly in the humerus. However, the relative effects of service and ground strokes are not known. Serendipitously, we encountered a 46-year-old regular tennis player who has played service and ground strok...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-015-9995-3
更新日期：2015-08-01 00:00:00
abstract：:This study examined effects of bone bonding and nonbonding implants on parameters associated with matrix vesicle-mediated primary bone formation, matrix vesicle alkaline phosphatase and phospholipase A2 specific activities, and phosphatidylserine content. Tibia marrow ablation followed by implantation of KG-Cera, Mina...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF00296676
更新日期：1992-12-01 00:00:00
abstract：:Transcriptional regulation of the postnatal skeleton is incompletely understood. Here, we determined the consequence of loss of early growth response gene 1 (EGR-1) on bone properties. Analyses were performed on both the microscopic and molecular levels utilizing micro-computed tomography (micro-CT) and Fourier transf...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-011-9486-0
更新日期：2011-07-01 00:00:00
abstract：:Proton pump inhibitors are taken by millions of patients for prevention and treatment of gastroesophageal diseases. Case-control studies have suggested that use of omeprazole is associated with an increased risk of hip fractures. The aim of this prospective study was to assess the risk of vertebral fractures in postme...
journal_title：Calcified tissue international
pub_type： 杂志文章,多中心研究
doi：10.1007/s00223-008-9188-4
更新日期：2009-01-01 00:00:00
abstract：:Age-related loss of skeletal muscle is associated with increased risk of functional limitation and cardiovascular (CV) mortality. In the elderly abdominal aortic calcification (AAC) can increase CV risk by altering aortic properties which may raise blood pressure and increase cardiac workload. This study investigated ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-016-0157-z
更新日期：2016-10-01 00:00:00
abstract：:Psoriatic arthritis (PsA) is an inflammatory rheumatic disorder that occurs in patients with psoriasis and predominantly affects musculoskeletal structures, skin, and nails. The etiology of PsA is not well understood but evidence supports an interplay of genetic, immunologic, and environmental factors which promote pa...
journal_title：Calcified tissue international
pub_type： 杂志文章,评审
doi：10.1007/s00223-017-0380-2
更新日期：2018-05-01 00:00:00
abstract：:Atomic force microscopy (AFM) was used to obtain three-dimensional images of isolated mineralites extracted from young postnatal bovine bone. The mean mineralite size is 9 nm x 6 nm x 2.0 nm, significantly shorter and thicker than the mineralites of mature bovine bone measured by the same technique. Mineralites of the...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-002-1077-7
更新日期：2003-05-01 00:00:00
abstract：:The present study reports on the separation of fluid from soft, "cheeselike" enamel of porcine permanent teeth in the secretory stage, and the determination of its chemical composition. The enamel tissues were dissected from mandibles of 5 to 6-month-old piglets and pooled under mineral oil in centrifuge tubes, and th...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02555250
更新日期：1987-08-01 00:00:00
abstract：:Mature dental enamel is the most mineralized of all mammalian tissues and considered to be free of collagen. Hydroxylysylpyridinoline (HP) and lysylpyridinoline (LP) are two nonreducible cross-links of mature collagen. Hydroxyproline (Hyp) is an amino acid that is believed to be indicative of the presence of collagen....
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-004-0122-0
更新日期：2005-02-01 00:00:00
abstract：:This cross-sectional, observational study was designed to identify clinical risk factors of osteoporosis and fractures in Korean women to validate the probability of osteoporosis and subsequent fractures. A total of 1541 Korean women were recruited nationally. Fracture history of any site, risk factors of osteoporosis...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-008-9182-x
更新日期：2008-12-01 00:00:00
abstract：:Osteoclasts are multinucleated cells that carry out bone resorption. Analysis of the direct effect of hormones on the bone-resorbing activity of human osteoclasts has been limited by difficulties in isolating these cells from the human skeleton. In this study, human osteoclasts formed from cultures of peripheral blood...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-001-2128-1
更新日期：2002-12-01 00:00:00
abstract：:The bone mineral status of 17 girls with Turner's syndrome was evaluated by single photon absorptiometry. Bone mineral content (BMC) was 25.4% below that predicted by normalization for age, sex, height, weight, and bone width. Only 25% of this demineralization could be attributed to delayed skeletal maturation. Bones ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02411296
更新日期：1982-01-01 00:00:00
abstract：:Calcium-acidic phospholipid-phosphate complexes (Ca-PL-PO4) cause hydroxyapatite (HA) deposition in vitro. The acidic phospholipids--phosphatidylserine (PS), phosphatidylinositol (PI), phosphatidylglycerol (PG), and diphosphatidylglycerol (DPG)--all form Ca-PL-PO4 complexes: Nonacidic phospholipids--sphingomyelin (SPL...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：
更新日期：1982-01-01 00:00:00
abstract：:The prevalence rates of ossification of the posterior longitudinal ligament (OPLL) in the Korean population were reported as 3.4 and 0.6%. However, these studies were performed before the era of three-dimensional computed tomography (3D CT). We investigated the prevalence of cervical OPLL on the basis of 3D CT and fea...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-014-9846-7
更新日期：2014-06-01 00:00:00
abstract：:Although radiogenic free radicals are widely used as molecular probes in biological calcified tissues, their nature and their location remain controversial. In the present study we have synthesized and irradiated apatites in which 13CO3(2-) ions substitute hydroxyl or phosphate ions in hydroxyapatite. The 13C-coupling...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：
更新日期：1982-01-01 00:00:00
abstract：:Observational studies examining associations of smoking and alcohol consumption with bone mineral density (BMD) have generated inconsistent results and suffer from several methodological limitations. We aim to evaluate whether there are causal associations between smoking, alcohol consumption, and BMD using a Mendelia...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-018-0452-y
更新日期：2018-11-01 00:00:00
abstract：:Normative bone mineral density (BMD) and bone mineral content (BMC) values for the total body (TB), proximal femur (PF), and antero-posterior lumbar spine (LS) were obtained from a large cross-sectional sample of children and adolescents who were 8-17 years of age. There were 977 scans for the TB, 892 for the PF, and ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900138
更新日期：1996-11-01 00:00:00
abstract：:This study aims to test the hypothesis that noninvasive bone mass measurements can be used to predict bone strength in a piglet model. Dual energy X-ray absorptiometry measurements of bone mineral content (BMC), bone mineral density (BMD), and bone area (BA) were obtained from four sets of bones (left and right humeri...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002230010006
更新日期：2001-04-01 00:00:00
abstract：:The present study further characterizes an extract from immature, human tooth apicies from which an intact dentin phosphoprotein has been identified. Third molar apicies from developing roots were decalcified in 10% EDTA until Ca2+ was undetectable in the decalcifying solution. The crude extract was run on 7.5% SDS-PA...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900101
更新日期：1996-09-01 00:00:00
