Abstract:
:The present study reports on the separation of fluid from soft, "cheeselike" enamel of porcine permanent teeth in the secretory stage, and the determination of its chemical composition. The enamel tissues were dissected from mandibles of 5 to 6-month-old piglets and pooled under mineral oil in centrifuge tubes, and then centrifuged at 1.9-2.4 X 10(5) g for 1-1.5 hours. The yields of the fluid were 44.8 +/- 2.3 (mean +/- standard error) microliter/g of enamel tissue at 1.9 X 10(5) g, and 53.9 +/- 1.9 microliter/g at 2.4 X 10(5) g. A significant finding was that the total Ca concentration of the enamel fluid (3.9-6.0 X 10(-4) M) was lower than that of porcine serum (2.9 X 10(-3) M), reflecting a distinct, compartmentalized microenvironment, isolated from the circulating blood. Another significant finding was that the ionic calcium activity (5.3 X 10(-5) M) in the enamel fluid was one order of magnitude lower than the total Ca concentration. The averaged results of other determinations were: pH, 7.26; total [P], 3.9 mM; [Mg2+], 0.8 mM; [Na+], 140 mM; [K+], 20 mM; [Cl-], 150 mM; [F-], 5 X 10(-3) mM; and osmolality of the fluid, 312 mosmol/kg H2O (in the same range as that of the serum, 310 mosmol/kg H2O). The apparent electrical unbalance of the analytical data, 8.65 meq excess of positive charges, was ascribed to the presence of HCO3- in the fluid; the computed ionic strength was 164 mM.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Calcif Tissue Intjournal_title
Calcified tissue internationalauthors
Aoba T,Moreno ECdoi
10.1007/BF02555250subject
Has Abstractpub_date
1987-08-01 00:00:00pages
86-94issue
2eissn
0171-967Xissn
1432-0827journal_volume
41pub_type
杂志文章abstract::Enamel of intact human teeth laser irradiated in vitro under certain conditions is known to have less subsurface demineralization than unirradiated enamel on exposure to acid; consequently, the potential use of laser irradiance to reduce caries is apparent. The laser-induced physical and/or chemical changes that cause...
journal_title:Calcified tissue international
pub_type: 杂志文章,评审
doi:10.1007/BF02556711
更新日期:1986-04-01 00:00:00
abstract::Undesirable changes in health-related parameters are thought to occur in retiring female athletes, but this has not been examined in longitudinal studies. The purpose of this study was to examine longitudinal changes in bone mineral density (BMD), body composition, and dietary intake in gymnasts and controls. Nonathle...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-004-0228-4
更新日期:2004-12-01 00:00:00
abstract::Methotrexate (MTX) is one of the most commonly prescribed drugs for autoimmune rheumatic diseases. As there is no consensus on its negative effects on bone, the purpose of this investigation was to determine the clinical spectrum of patients with stress fractures due to long-term MTX treatment (i.e., MTX osteopathy). ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-020-00765-5
更新日期:2021-02-01 00:00:00
abstract::Test implant plates surgically retrieved from distal femurs of dogs were studied by Raman spectroscopy in order to characterize the bone-implant interface. The implant surface consisted of phosphate mineral, plasma sprayed on a titanium substrate. On the basis of its spectroscopic signature, the phosphate mineral of b...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02556157
更新日期:1991-05-01 00:00:00
abstract::We hypothesized that reactive oxygen species play an important role in avascular/ischemic osteonecrosis. When isolated chick osteocytes were cultured with hydrogen peroxide, annexin V binding, which is the earliest marker of apoptosis, increased in a dose-dependent fashion. Hydrogen peroxide also induced the activatio...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-001-1110-2
更新日期:2002-09-01 00:00:00
abstract::Experimental analysis with paired femurs provides the opportunity to study within-person differences in fracture type and associated structural side differences. We hypothesized that different fracture types in the hips of a subject are associated with structural asymmetry. Bone mineral density (BMD) and structural me...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-010-9388-6
更新日期:2010-09-01 00:00:00
abstract::Sustained exposure to high levels of parathyroid hormone (PTH), as observed in hyperparathyroidism, is catabolic to bone. The increase in the RANKL/OPG ratio in response to continuous PTH, resulting in increased osteoclastogenesis, is well established. However, the effects of prolonged PTH exposure on key regulators o...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-016-0176-9
更新日期:2016-11-01 00:00:00
abstract::There is considerable interest in determining whether hypergravity can be used as a countermeasure for microgravity-induced bone loss. This study was conducted on 20 immature male rats in order to investigate possible elastic adaptations of cortical bone in rapidly growing rats exposed to chronic hypergravity. Ten rat...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900111
更新日期:1996-09-01 00:00:00
abstract::The purpose of the present work was to investigate the appearance of ossification centers in human femur by Dual-energy X-ray Absorptiometry (DXA), comparing densitometric data with morphogenetic events. Posteroanterior scans were performed on 31 dried femora (from 11.5 weeks of conceptual age to 1 year of postnatal l...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/pl00005841
更新日期:2000-04-01 00:00:00
abstract::We investigated the effects of conjugated estrogens as an add-back replacement drug, incadronate sodium as a bisphosphonate, and alfacalcidol as a vitamin D(3) analog on femoral bone mineral density (BMD) and bone mineral content (BMC) in female rats chronically treated with the gonadotropin-releasing hormone (GnRH) a...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900675
更新日期:1999-08-01 00:00:00
abstract::The mechanism whereby liposomal entrapment enhances the hypocalcemic effect of calcitonin (CT) was evaluated in the rat. Phosphatidylcholine (PC) and PC plus cholesterol (PCC) preparations of large multilammelar vesicles (MLV) and small unilammelar vesicles (SUV) were used to entrap human calcitonin (hCT). The effect ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02555889
更新日期:1990-12-01 00:00:00
abstract::Insulin is a potent stimulator of collagen synthesis and other osteoblastic cell functions. In various insulin-sensitive tissues, stimulation of glucose transport and glycolytic metabolism are hallmarks of insulin action and may play a role in insulin regulation of cellular function. However, the effects of insulin on...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02556657
更新日期:1989-07-01 00:00:00
abstract::Pyrolyzed scales, fin spines, and bone from the ray-finned bony fish Polypterus (Actinopterygii) showed two mineral phases on X-ray diffraction: hydroxyapatite (HA), Ca5(PO4)3OH, and whitlockite, Ca3(PO4)2. The ratio of HA/whitlockite varied with the structure (scale, spine, bone) within each individual fish. The rela...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02441216
更新日期:1979-08-24 00:00:00
abstract::To determine the relationships among nutrients intake, bone mass, and bone turnover in women we have investigated these issues in a population-based, cross-sectional, observational study in one county in central Sweden. A total of 175 women aged 28-74 at entry to the study were included. Dietary assessment was made by...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00298425
更新日期:1995-08-01 00:00:00
abstract::Teriparatide (TPTD) is known to increase the cortical thickness and porosity. The purpose of the present study was to determine whether switching from TPTD to ibandronate (IBN) would be useful for improving cortical bone parameters as assessed using high-resolution quantitative computed tomography (HR-QCT) analyses in...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-016-0180-0
更新日期:2016-11-01 00:00:00
abstract::The effect of SrCl(2) treatment on bone nanostructure in a rat ovariectomy model was studied using scanning small-angle X-ray scattering (sSAXS). Twelve 6-month-old female Wistar rats were used. Six animals were ovariectomized (+ovx) and six were left intact after sham surgery (-ovx). Six animals, three +ovx and three...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-010-9341-8
更新日期:2010-04-01 00:00:00
abstract::There is increasing interest in identifying new pathways and candidate genes that confer susceptibility to osteoporosis. There is evidence that adipogenesis and osteogenesis may be related, including a common bone marrow progenitor cell for both adipocytes and osteoblasts. Perilipin 1 (PLIN1) and Perilipin 4 (PLIN4) a...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-011-9552-7
更新日期:2012-02-01 00:00:00
abstract::We treated four hypercalcemic cancer patients by nasal hCT, 3 x 2 mg daily, which has been reported to be active in Paget's disease at lower doses. Only one patient became normocalcemic and mean (+/- SEM) calcium levels fell from 11.6 +/- 0.2 mg/dl before therapy to 10.7 +/- 0.6 mg/dl 2-3 days after starting hCT. The ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00296210
更新日期:1992-07-01 00:00:00
abstract::Proton pump inhibitors are taken by millions of patients for prevention and treatment of gastroesophageal diseases. Case-control studies have suggested that use of omeprazole is associated with an increased risk of hip fractures. The aim of this prospective study was to assess the risk of vertebral fractures in postme...
journal_title:Calcified tissue international
pub_type: 杂志文章,多中心研究
doi:10.1007/s00223-008-9188-4
更新日期:2009-01-01 00:00:00
abstract::Calcium and phosphate were allowed to diffuse into gelatin and Type I collagen gels which were then cut into slices and analyzed for ion concentrations. Solutions of calcium and phosphate were then prepared, with ion concentrations equivalent to the highest levels in the slices, and mixed together, whereupon a rapid a...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02556459
更新日期:1991-06-01 00:00:00
abstract::Lumbar spine bone mass and density were measured with Dual photon absorptiometry (DPA) in 60 patients with crush fractures and 60 age-matched normal women. Short-term reproducibility of bone mineral density (BMD) was 1.3% in normal women and 2.5% in osteoporotic women; long-term reproducibility in normal women was 2.2...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02553274
更新日期:1988-12-01 00:00:00
abstract::The peptide hormone calcitonin is a potent inhibitor of osteoclastic resorption, but it is unstable and poorly absorbed following oral administration. Conjugates of salmon calcitonin covalently linked to low-molecular-weight amphiphilic polymers show improved stability and absorption. The purpose of this study was to ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-002-1051-4
更新日期:2003-09-01 00:00:00
abstract::Osteoarthritis (OA) is a chronic, debilitating disease affecting millions of people worldwide. Management of OA involves pharmacological and non-pharmacological approaches. Conventional pharmacological treatments have limited efficacy and are associated with a number of side-effects, restricting the number of patients...
journal_title:Calcified tissue international
pub_type: 杂志文章,评审
doi:10.1007/s00223-020-00672-9
更新日期:2020-02-13 00:00:00
abstract::The accompanying article by Drs. Lian and Stein describes current thinking on how genes are organized in the nucleus and suggests that subnuclear localization is critical for the control of gene expression in bone. In particular, it is proposed that a major function of the osteoblast transcription factor, Runx2, is to...
journal_title:Calcified tissue international
pub_type: 评论,杂志文章,评审
doi:10.1007/s00223-002-1053-2
更新日期:2003-06-01 00:00:00
abstract::Mandibular first molars of 17-day-old mouse embryos were cultured in vitro to examine the histological effects of various concentrations of parathyroid hormone (PTH) on odontogenesis of the molars. PTH did not affect the cytodifferentiation of mesenchymal cells into preodontoblasts but inhibited that of preodontoblast...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02555728
更新日期:1987-01-01 00:00:00
abstract::Sarcopenia and osteoporosis are two sides of the same coin. They represent different aspects of the same age-related process of musculoskeletal atrophy and together culminate in falls, fractures, deconditioning, and increased mortality in older individuals. However, the current therapeutic approach to the prevention o...
journal_title:Calcified tissue international
pub_type: 杂志文章,评审
doi:10.1007/s00223-015-9956-x
更新日期:2015-03-01 00:00:00
abstract::Calcium-acidic phospholipid-phosphate complexes (Ca-PL-PO4) cause hydroxyapatite (HA) deposition in vitro. The acidic phospholipids--phosphatidylserine (PS), phosphatidylinositol (PI), phosphatidylglycerol (PG), and diphosphatidylglycerol (DPG)--all form Ca-PL-PO4 complexes: Nonacidic phospholipids--sphingomyelin (SPL...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:
更新日期:1982-01-01 00:00:00
abstract::A continuous flow organ culture system (CFCS) was used to determine the effect of ascorbic acid on the synthesis of collagen and noncollagenous protein by bone of the alveolar process and periodontal ligament in organ cultures of adult mouse periodontium. For the last 24 h of 2 day cultures, 5 microCi/ml 3H-proline wa...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02411276
更新日期:1982-07-01 00:00:00
abstract::Inorganic phosphate (P(i)) can regulate the level of skeletal alkaline phosphatase (ALP) activity in human osteoblast-like cells, but not by means of changes in transcription or release from the cell surface. The current studies were intended to determine whether (1) P(i) affected the inactivation of ALP activity in h...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00302073
更新日期:1995-11-01 00:00:00
abstract::Psoriatic arthritis (PsA) is an inflammatory rheumatic disorder that occurs in patients with psoriasis and predominantly affects musculoskeletal structures, skin, and nails. The etiology of PsA is not well understood but evidence supports an interplay of genetic, immunologic, and environmental factors which promote pa...
journal_title:Calcified tissue international
pub_type: 杂志文章,评审
doi:10.1007/s00223-017-0380-2
更新日期:2018-05-01 00:00:00