Abstract:
:Mandibular first molars of 17-day-old mouse embryos were cultured in vitro to examine the histological effects of various concentrations of parathyroid hormone (PTH) on odontogenesis of the molars. PTH did not affect the cytodifferentiation of mesenchymal cells into preodontoblasts but inhibited that of preodontoblasts into odontoblasts. Consequently, the odontoblasts failed to undergo dentinogenesis. On the other hand, inner enamel epithelium achieved terminal cytodifferentiation into secretory ameloblasts and these cells partially formed enamel in spite of the absence of dentin. All treated molars showed the same histological disturbances and these effects were independent of PTH dose. The present study indicated that PTH had an influence on mesenchyme-derived cells, inhibiting both the differentiation of odontoblasts and the formation of predentin and dentin.
journal_name
Calcif Tissue Intjournal_title
Calcified tissue internationalauthors
Sakakura Ydoi
10.1007/BF02555728subject
Has Abstractpub_date
1987-01-01 00:00:00pages
49-54issue
1eissn
0171-967Xissn
1432-0827journal_volume
40pub_type
杂志文章abstract::The purpose of this study is to evaluate degenerative factors in a postmenopausal patient group and differentiate the influence on bone mineral density (BMD) measurements by dual-energy X-ray absorptiometry (DXA). The patients and methods included an investigation of 144 postmenopausal women (mean 63.3 years) with PA-...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900258
更新日期:1997-05-01 00:00:00
abstract::The effect of ascorbic acid deficiency on bone metabolism was evaluated using the ascorbate-requiring Osteogenic Disorder Shionogi (ODS) rat model. Ascorbic acid (Asc)-deficient rats gained body weight in a manner similar to Asc-supplemented rats (control) during 3 weeks, but began to lose weight during the 4th week o...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-002-2040-3
更新日期:2003-08-01 00:00:00
abstract::Cortical bone can be modeled as a complex hierarchical composite interrelating both structure and material properties on four levels of structural organization: molecular, ultrastructural, microscopic, and macroscopic. In young animals, the microstructural systems are long parallel lamellar units, plexiform bone, whic...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02406131
更新日期:1984-01-01 00:00:00
abstract::Amelogenins, the major protein components of the enamel extracellular matrix, are postulated to be involved in controlling the elongated and oriented growth of enamel carbonated apatite crystals. In order to clarify the functional role of amelogenin during the early stage of enamel biomineralization, octacalcium phosp...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-002-0011-3
更新日期:2004-06-01 00:00:00
abstract::The drawbacks of estrogen restrict the clinical use of hormone replacement therapy, and it would be most helpful to explore new estrogenic substances that could prevent bone loss and be free from any adverse effects. We synthesized a new compound named bone-seeking estrogen (SE2) by combining 17β-estradiol (E2) with i...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-013-9739-1
更新日期:2013-08-01 00:00:00
abstract::We describe a tall-statured 14-year-old boy who illustrated the full phenotypic and radiographic features of Stickler syndrome type I. A bone biopsy showed evidence of reduced bone mass and bone turnover, such as reduced BV/TV (-43%), TbTh (-29%), and OS/BS (-48%), Ob.S/BS (-27%), and Oc/BS (-47%) compared to "age-mat...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-009-9324-9
更新日期:2010-02-01 00:00:00
abstract::Vascular calcification (VC), which is associated with high cardiovascular morbidity and mortality in patients with chronic kidney disease, is promoted by the osteoblastic differentiation of vascular smooth muscle cells (VSMCs). The present study explored the functional roles and molecular mechanisms of the long noncod...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-020-00696-1
更新日期:2020-07-01 00:00:00
abstract::Teriparatide (TPTD) is the most widely used anabolic agent in the treatment of patients with osteoporosis although its use is restricted in many countries. A recent randomised trial confirmed that TPTD was superior to risedronate at preventing vertebral fractures over a 2-year period. There is limited information on t...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-019-00563-8
更新日期:2019-08-01 00:00:00
abstract::Cartilage oligomeric matrix protein (COMP) is a macromolecule of yet unknown function with restricted distribution among tissues. In the present study, the ultrastructural localization of COMP in porcine immature joint cartilage and growth plate cartilage was semiquantitatively delineated. Tissues were fixed in a mixt...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900278
更新日期:1997-06-01 00:00:00
abstract::Bone mineral content (BMC) and bone mineral density (BMD) are common but imperfect surrogate measures of bone strength. The mechanical response tissue analyzer is a device that measures long bone bending stiffness (EI), which strongly predicts bone breaking strength. We hypothesized that isokinetic resistance training...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-009-9247-5
更新日期:2009-06-01 00:00:00
abstract::Bone involvement, mainly osteoporosis but also osteosclerosis, is frequent in patients with indolent systemic mastocytosis (ISM). The recent characterization of the canonical Wnt/β-catenin pathway in the regulation of bone remodeling provided important insights for our understanding of the pathophysiology of a number ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-015-9969-5
更新日期:2015-05-01 00:00:00
abstract::This study examines the efficacy of using radiolabeled thymidine as a measure of bone cell DNA synthesis. The effect of a bone-active peptide on cell proliferation is assessed under different labeling conditions and it is shown that the apparent stimulation in DNA synthesis is due to an increase in participating cells...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02553298
更新日期:1986-08-01 00:00:00
abstract::Pregnancy and lactation-associated osteoporosis (PAO) is a rare condition with little known pathophysiology. Most cases are diagnosed in the third trimester of pregnancy or in the first weeks postpartum, particularly in first pregnancies. Vertebral fractures are most commonly observed and characterised by prolonged se...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-015-0028-z
更新日期:2015-10-01 00:00:00
abstract::We have recently reported that risedronate preserves normal bone formation and decreases bone remodeling in women with postmenopausal osteoporosis after 3 years of treatment. We report now the results of a 2-year extension study. The primary objective of this study was to determine the effect of 5 years of risedronate...
journal_title:Calcified tissue international
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00223-004-0039-7
更新日期:2004-12-01 00:00:00
abstract::Men and women (n = 518) receiving moderate-to-high doses of corticosteroids were enrolled in two studies with similar protocols and randomly assigned to receive either placebo or risedronate (2.5 or 5 mg) for 1 year. All patients received daily calcium supplementation (500-1000 mg), and most also received supplemental...
journal_title:Calcified tissue international
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1007/s002230001146
更新日期:2000-10-01 00:00:00
abstract::Aluminum ions (Al) and chromium (III) ions (Cr), as they exist in aqueous solution at neutral pH, adsorb onto calcium hydroxyapatite crystals (HAP) and severely inhibit their dissolution process, when present in concentrations less than 1 microM. Iron (III) ions (Fe), at concentrations up to 10 microM, have no effect ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02555127
更新日期:1987-07-01 00:00:00
abstract::The calcium ion binding properties of a high molecular weight bovine phosphophoryn preparation have been studied at high ionic strength (0.5 M KCl as supporting electrolyte). Surprisingly, even under these conditions at which intermolecular ionic interactions are effectively screened, phosphophoryn was capable of bind...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02555712
更新日期:1987-02-01 00:00:00
abstract::Vitamin D supplements are often recommended to restore sufficiency, although the adherence to treatment is low. This study assessed vitamin D status at different time intervals following the cessation of treatment. The database of Clalit-Health-Services (CHS), a not-for-profit HMO covering more than half of the Israel...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-011-9536-7
更新日期:2011-11-01 00:00:00
abstract::The purpose of the present work was to investigate the appearance of ossification centers in human femur by Dual-energy X-ray Absorptiometry (DXA), comparing densitometric data with morphogenetic events. Posteroanterior scans were performed on 31 dried femora (from 11.5 weeks of conceptual age to 1 year of postnatal l...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/pl00005841
更新日期:2000-04-01 00:00:00
abstract::Long-term use of hydrochlorothiazide (HCTZ), a common diuretic agent for hypertension, has been associated with increased bone density and reduced hip fracture rates in patients. In this study, we sought to examine whether HCTZ has an anabolic effect on the proliferation of human osteoblasts (derived from either verte...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00369219
更新日期:1996-12-01 00:00:00
abstract::Inorganic phosphate (P(i)) can regulate the level of skeletal alkaline phosphatase (ALP) activity in human osteoblast-like cells, but not by means of changes in transcription or release from the cell surface. The current studies were intended to determine whether (1) P(i) affected the inactivation of ALP activity in h...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00302073
更新日期:1995-11-01 00:00:00
abstract::X-linked hypophosphatemia (XLH) is a rare, inheritable disorder manifesting as rickets in children and osteomalacia in adults. While conventional medical treatment with oral phosphate and alfacalcidol is recommended in childhood, it is undecided whether adults should continue therapy. The aim of this 6-year prospectiv...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-017-0363-3
更新日期:2018-03-01 00:00:00
abstract::The purpose of this study was to determine whether total serum calcium, parathyroid gland structure, and/or levels of parathyroid hormone, 1,25 and 24,25 DHCC, are altered in pigs with dental and skeletal fluorosis. Eight experimental animals receiving 2 mg F-/kg b.w. per day from age 8-14 months were compared with ei...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02556714
更新日期:1986-04-01 00:00:00
abstract::The mineral of cortical bones has been studied in newborn, growing, and adult rats and in the calf and cow, using X-ray diffraction and infrared spectroscopy during the thermal decomposition of bones and by microassay of carbonate. The mineral of all the bone samples, regardless of species or age, was found to be a ca...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02563793
更新日期:1987-09-01 00:00:00
abstract::The mineral in bone is located primarily within the collagen fibril, and during mineralization the fibril is formed first and then water within the fibril is replaced with mineral. Our goal is to understand the mechanism of fibril mineralization, and as a first step we recently determined the size exclusion characteri...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-007-9085-2
更新日期:2008-02-01 00:00:00
abstract::The purpose of this study was to determine whether human parathyroid hormone (h-PTH) enhances trabecular bone mass and connectivities that were reduced by streptozotocin (STZ)-induced diabetes in rats. Seven-month-old female Wistar rats were injected with STZ or its vehicle intraperitoneally. All vehicle-injected norm...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/pl00005838
更新日期:2000-03-01 00:00:00
abstract::We have examined the effect of the anti-tumor compound taxol, on osteoclastic bone resorption. In the bone slice assay, taxol (0.1-0.001 microM) dose-dependently inhibited bone resorption with an IC50 of 0.08 microM. Osteoclast survival on bone slices was unaffected by 0.01-1 microM taxol, but 10 microM was cytotoxic....
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00301951
更新日期:1995-12-01 00:00:00
abstract::The native human parathyroid hormone, hPTH-(1-84), and certain carboxyl truncated analogs such as hPTH-(1-34) and even smaller fragments such as hPTH-(1-31)NH2, [Leu27]cyclo(Glu22-Lys26)hPTH-(1-31)NH2, and hPTH-(1-30)NH2 stimulate femoral trabecular and cortical bone growth in ovariectomized (OVX) rats. Here we show t...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002230010061
更新日期:2000-04-01 00:00:00
abstract::This randomized, double-blind study assessed the antifracture efficacy and safety of intermittent intravenous (IV) ibandronate versus oral daily risedronate in Japanese patients with primary osteoporosis. Ambulatory patients aged ≥60 years were randomized to receive 0.5 or 1 mg/month IV ibandronate plus oral daily pla...
journal_title:Calcified tissue international
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00223-013-9734-6
更新日期:2013-08-01 00:00:00
abstract::The primary aim of the project was to determine the combined effect of whole-body electromyostimulation (WB-EMS) and protein supplements on local and overall muscle/fat distribution in older man with sarcopenic obesity (SO). Community-dwelling (cdw) men ≥ 70 years with SO were randomly allocated to a WB-EMS and protei...
journal_title:Calcified tissue international
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00223-018-0424-2
更新日期:2018-09-01 00:00:00