Abstract:
:The primary aim of the project was to determine the combined effect of whole-body electromyostimulation (WB-EMS) and protein supplements on local and overall muscle/fat distribution in older man with sarcopenic obesity (SO). Community-dwelling (cdw) men ≥ 70 years with SO were randomly allocated to a WB-EMS and protein supplementation (n = 33) or a non-intervention control group (CG: n = 34). WB-EMS was conducted 1.5 sessions of 20 min/week for 16 weeks. Whey protein supplementation aimed to ensure a daily intake of 1.8 g/kg body mass. The primary study endpoint was muscle/fat distribution of the total intra-fascial volume of the mid-thigh as determined by MRI. The core secondary endpoint was appendicular muscle mass (ASMM) and trunk fat; subordinate secondary endpoint was lower-leg performance. Thigh lean muscle volume increased significantly in the WB-EMS&P (p < 0.001) and increased slightly in the CG (p = 0.435). In parallel, fat volume increased significantly in the CG (p < 0.001) and was maintained in the WB-EMS&P group (p = 0.728). Group differences for both parameters were significant (p = 0.033 and p = 0.002). ASMM and trunk fat also differed significantly (p < 0.001) between WB-EMS and CG, with significant positive changes in the WB-EMS&P (p < 0.001) and no relevant changes in the CG (p ≥ 0.458). Finally, changes of gait velocity, leg-extensor strength, and advanced lower extremity function of the WB-EMS&P group differed significantly from the CG (p ≤ 0.002). WB-EMS combined with whey protein supplements favorably affects local and overall muscle/fat distribution and lower limb functioning in cdw men 70+ with SO. Thus, this time-saving, joint-friendly, and highly customizable approach may be an option for people either unable or unmotivated to conduct intense (resistance) exercise protocols.Trial registration number NCT02857660 on http://www.clinicaltrials.gov .
journal_name
Calcif Tissue Intjournal_title
Calcified tissue internationalauthors
Kemmler W,Grimm A,Bebenek M,Kohl M,von Stengel Sdoi
10.1007/s00223-018-0424-2subject
Has Abstractpub_date
2018-09-01 00:00:00pages
266-277issue
3eissn
0171-967Xissn
1432-0827pii
10.1007/s00223-018-0424-2journal_volume
103pub_type
杂志文章,随机对照试验abstract::Tartrate resistant acid phosphatase (TRAP) has been proposed as a new biochemical marker for bone resorption. We have compared this new marker, TRAP, with the classical biochemical markers of bone remodelling, serum alkaline phosphatase (sAP), serum osteocalcin (sBGP), and with the urinary hydroxyproline/creatinine ra...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02555896
更新日期:1991-07-01 00:00:00
abstract::The bone mineral status of 17 girls with Turner's syndrome was evaluated by single photon absorptiometry. Bone mineral content (BMC) was 25.4% below that predicted by normalization for age, sex, height, weight, and bone width. Only 25% of this demineralization could be attributed to delayed skeletal maturation. Bones ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02411296
更新日期:1982-01-01 00:00:00
abstract::We studied the influence of age, gender, latitude, season, diet and ethnicity on plasma 25-hydroxyvitamin D 25 OHD, PTH, 1,25-dihydroxyvitamin D, vitamin D-binding protein, bone-specific alkaline phosphatase, and osteocalcin levels in 46 Greenlanders living in Nuuk (64 degrees N) on a traditional fare (group A), 45 Gr...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-003-0110-9
更新日期:2004-03-01 00:00:00
abstract::The aim of our study was to compare the results provided by the measurement of vertebral and femoral bone mineral density (BMD) for assessing the individual risk of osteoporosis as defined by either low BMD and/or rapid bone loss. Vertebral and femoral BMD were measured twice at a mean interval of 21 months in 85 norm...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00310196
更新日期:1993-05-01 00:00:00
abstract::A 69-year-old man became hypocalcemic under medical observation. The hypocalcemia occurred in the presence of circulating immunoreactive parathyroid hormone (PTH). Common causes of secondary hyperparathyroidism were excluded, as was PTH resistance using PTH infusions. The immunoreactive PTH was examined in detail. PTH...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00298499
更新日期:1992-08-01 00:00:00
abstract::Alkaline phosphatase is detected in both soluble and particulate fractions of rat bone. The concentration of alkaline phosphatase in the particulate fraction of rat skull cap bone and femur is high during the peak period of calcification of these bones suggesting the possibility of using it as a marker for the rate of...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02555116
更新日期:1986-09-01 00:00:00
abstract::The prevalence rates of ossification of the posterior longitudinal ligament (OPLL) in the Korean population were reported as 3.4 and 0.6%. However, these studies were performed before the era of three-dimensional computed tomography (3D CT). We investigated the prevalence of cervical OPLL on the basis of 3D CT and fea...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-014-9846-7
更新日期:2014-06-01 00:00:00
abstract::A strategy based on high pressure liquid chromatography (HPLC) techniques for the isolation or a principal amelogenin molecule from a single human dentition is described. A partial sequence (33 residues) for this 24 kDa amelogenin is presented and related to earlier studies of human 5 kDa tyrosine-rich amelogenin poly...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02555993
更新日期:1990-08-01 00:00:00
abstract::Osteoclasts are multinucleated cells that carry out bone resorption. Analysis of the direct effect of hormones on the bone-resorbing activity of human osteoclasts has been limited by difficulties in isolating these cells from the human skeleton. In this study, human osteoclasts formed from cultures of peripheral blood...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-001-2128-1
更新日期:2002-12-01 00:00:00
abstract::Bone mineralization density distribution (BMDD) is an important determinant of bone mechanical properties. The most available skeletal site for access to the BMDD is the iliac crest. Compared to cancellous bone much less information on BMDD is available for cortical bone. Hence, we analyzed complete transiliac crest b...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-014-9901-4
更新日期:2014-10-01 00:00:00
abstract::The acute-phase response (APR) is a frequent occurrence after infusion of zoledronic acid and is caused by activation of γδ T cells. Vitamin D receptor is expressed in immune cells, and vitamin D has immunomodulatory properties. The aim of this prospective study was to test the effect of vitamin D (cholecalciferol) on...
journal_title:Calcified tissue international
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00223-012-9577-6
更新日期:2012-04-01 00:00:00
abstract::The presence of lipids in urinary stones was determined by histochemical and biochemical methods. When crystals of calcium oxalate, made by mixing calcium chloride and potassium oxalate solutions and sections of human calcium oxalate urinary stones, were exposed to osmium vapors, there was no staining of the pure crys...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02556340
更新日期:1988-02-01 00:00:00
abstract::The purpose of this study was to examine the effects of green tea extract (GTE) intake on bone structural and physiological properties, such as bone mass, trabecular bone microarchitecture, cortical bone geometry, and bone mechanical strength, in growing rats. Four-week-old male Wistar rats were divided into the follo...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-017-0358-0
更新日期:2018-03-01 00:00:00
abstract::To experimentally examine the participation of amelogenins in controlled mineral-phase maturation of mammalian enamel, the identification of the individual proteins and their corresponding gene(s) is required. For this purpose, cDNAs were constructed from polyadenylated RNA from 2-day postnatal murine teeth, molecular...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02556627
更新日期:1987-04-01 00:00:00
abstract::Newly developed fuzzy logic-derived structural parameters were used to characterize trabecular bone architecture in high-resolution magnetic resonance imaging (HR-MRI) of human cadaver calcaneus specimens. These parameters were compared to standard histomorphological structural measures and analyzed concerning perform...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-007-9058-5
更新日期:2007-10-01 00:00:00
abstract::It has long been thought that collagen fibers within the bone matrix are deposited in an aligned pattern that channels mineral growth. If this model of bone structure is correct, both organic and inorganic phases of bone should have similar elastic anisotropy. Using an acoustic microscope, we measured longitudinal and...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00299319
更新日期:1994-11-01 00:00:00
abstract::Bone and mineral metabolism has been reported to affect the development of the ossification of the posterior longitudinal ligament (OPLL). The aim of this study was to compare bone mineral densities (BMD) and rate of osteoporosis between cervical OPLL and a matched control group. We also investigated the correlation o...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-012-9662-x
更新日期:2013-01-01 00:00:00
abstract::Measurement of areal bone mineral density (aBMD) in intravertebral subregions may increase the diagnostic sensitivity of dual-energy X-ray absorptiometry (DXA)-derived parameters for vertebral fragility. This study investigated whether DXA-derived bone parameters in vertebral subregions were better predictors of verte...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-014-9866-3
更新日期:2014-08-01 00:00:00
abstract::In order to study in detail the processes leading to the resorption and ankylosis of teeth after trauma, the effects of cold application on the periodontal tissues were studied in the mouse. Liquid nitrogen was applied locally to the outer surface of the lower jaw which resulted in a freezing of the incisor and its su...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02555735
更新日期:1986-07-01 00:00:00
abstract::Periodic fringes corresponding to six different lattice planes have been observed in apatite crystals of human normal alveolar bone by transmission electron microscopy. Three of these sets of fringes have spacings less than 3.5 A corresponding to the Scherzer resolution of the microscope used. The (0002) lattice plane...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02556695
更新日期:1987-06-01 00:00:00
abstract::Micro-computed tomography (microCT) has become a standard tool for the evaluation of bone morphology in preclinical studies. Unfortunately, the user-dependent definition of contour lines that separate trabecular from cortical bone is not only extremely time-consuming but may also represent a source of data bias and in...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-007-9063-8
更新日期:2007-10-01 00:00:00
abstract::Mature dental enamel is the most mineralized of all mammalian tissues and considered to be free of collagen. Hydroxylysylpyridinoline (HP) and lysylpyridinoline (LP) are two nonreducible cross-links of mature collagen. Hydroxyproline (Hyp) is an amino acid that is believed to be indicative of the presence of collagen....
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-004-0122-0
更新日期:2005-02-01 00:00:00
abstract::The small leucine-rich bone proteoglycans, biglycan and decorin, can be purified by chromatography on hydroxyapatite columns, demonstrating their potential affinities for bone apatite. To determine their effects on in vitro apatite formation and growth, a mixture of the chondroitin-sulfate (CS) bone proteoglycans, or ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900339
更新日期:1997-10-01 00:00:00
abstract::X-linked hypophosphatemia (XLH) is a rare, inheritable disorder manifesting as rickets in children and osteomalacia in adults. While conventional medical treatment with oral phosphate and alfacalcidol is recommended in childhood, it is undecided whether adults should continue therapy. The aim of this 6-year prospectiv...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-017-0363-3
更新日期:2018-03-01 00:00:00
abstract::Ectopic calcification of diseased tissues or around prosthetic implants can lead to serious disability. Therefore, calcification of implants of glutaraldehyde-cross-linked collagenous tissues and reconstituted collagen was compared with mineralization induced by demineralized bone matrix (DBM). Whereas implants of DBM...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02556366
更新日期:1988-05-01 00:00:00
abstract::Amelogenins are the most abundant secreted proteins in developing dental enamel. These evolutionarily-conserved proteins have important roles in enamel mineral formation, as mutations within the amelogenin gene coding region lead to defects in enamel thickness or mineral structure. Because of extensive alternative spl...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-002-0036-7
更新日期:2003-11-01 00:00:00
abstract::To define the quantitative aspects of ossification of human fetal spine, we performed a high resolution densitometric study by lateral and postero-anterior scanning of five fetal spines (18-36 weeks of conceptual age) and one spine of a 4-month-old infant. The data were plotted against developmental age for each spine...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00299001
更新日期:1995-07-01 00:00:00
abstract::In humans, gastric surgery results in in osteopenia via mechanisms that are insufficiently understood; surgery-induced changes in the hormonal axes involving the stomach, thyroid, and the parathyroids may play a role. To study this in more detail, we evaluated calcium (Ca), magnesium (Mg), and phosphorus (P) metabolis...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900553
更新日期:1998-11-01 00:00:00
abstract::Acute spinal cord injury is associated with rapid bone loss and an increased risk of fracture. In this double-blind, randomized, placebo-controlled trial, 17 patients were followed for 1 year after administration of either 4 or 5 mg of zoledronic acid or placebo. Bone mineral density (BMD) and structural analyses of t...
journal_title:Calcified tissue international
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00223-007-9012-6
更新日期:2007-05-01 00:00:00
abstract::The tumor-suppressor p53 is a transcription factor that regulates a number of genes in the process of cell-cycle inhibition, apoptosis, and DNA damage. Recent studies have revealed a crucial role for p53 in bone remodeling. In our previous studies we have shown that p53 is an important regulator of osteoblast differen...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-011-9533-x
更新日期:2011-11-01 00:00:00