Pregnancy and Lactation-Associated Osteoporosis: Bone Histomorphometric Analysis and Response to Treatment with Zoledronic Acid.

Abstract:

:Pregnancy and lactation-associated osteoporosis (PAO) is a rare condition with little known pathophysiology. Most cases are diagnosed in the third trimester of pregnancy or in the first weeks postpartum, particularly in first pregnancies. Vertebral fractures are most commonly observed and characterised by prolonged severe pain, functional limitations and a loss of height. Measurements of bone mineral density and biochemical markers of bone remodelling are the clinical methods most commonly used for the management of these patients. However, a bone biopsy with histomorphometric analysis has been considered to be the gold-standard. Few studies have evaluated the histomorphometry in patients with this clinical condition and none of them performed the procedure at the beginning of the clinical assessment. In this study, we report a case of PAO in a 31-year-old postpartum patient who had undergone a twin pregnancy. We describe the clinical, laboratory tests and imaging features. Bone histomorphometry showed a high resorption rate and excellent evolution after 1 year of treatment with intravenous zoledronic acid. Our data suggest that osteoclastogenesis plays a central role in the pathophysiological processes of this disease.

journal_name

Calcif Tissue Int

authors

Grizzo FM,da Silva Martins J,Pinheiro MM,Jorgetti V,Carvalho MD,Pelloso SM

doi

10.1007/s00223-015-0028-z

subject

Has Abstract

pub_date

2015-10-01 00:00:00

pages

421-5

issue

4

eissn

0171-967X

issn

1432-0827

pii

10.1007/s00223-015-0028-z

journal_volume

97

pub_type

杂志文章
  • Is There Causal Relationship of Smoking and Alcohol Consumption with Bone Mineral Density? A Mendelian Randomization Study.

    abstract::Observational studies examining associations of smoking and alcohol consumption with bone mineral density (BMD) have generated inconsistent results and suffer from several methodological limitations. We aim to evaluate whether there are causal associations between smoking, alcohol consumption, and BMD using a Mendelia...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/s00223-018-0452-y

    authors: Guo R,Wu L,Fu Q

    更新日期:2018-11-01 00:00:00

  • Temporal relationship between bone loss and increased bone turnover in ovariectomized rats.

    abstract::To characterize osteopenic changes in ovariectomized (OVX) rats as a function of time, female Sprague Dawley rats (240 g body weight, 90 days old) were subjected to bilateral ovariectomy or sham surgery and killed at various times from 14-180 days postovariectomy. The proximal tibial metaphysis was processed undecalci...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/BF02571317

    authors: Wronski TJ,Cintrón M,Dann LM

    更新日期:1988-09-01 00:00:00

  • Bone mineral density and muscle strength in young men with mental retardation (with and without Down syndrome).

    abstract::The objective of this study was to compare the bone mineral density (BMD) of men with Down syndrome (DS) to otherwise mentally retarded (MR) men and to investigate whether leg muscle strength of these patients is related to BMD. Two groups with MR (with and without DS) participated in the study, having met the followi...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/s002230010035

    authors: Angelopoulou N,Matziari C,Tsimaras V,Sakadamis A,Souftas V,Mandroukas K

    更新日期:2000-03-01 00:00:00

  • Vitamin K1 supplementation retards bone loss in postmenopausal women between 50 and 60 years of age.

    abstract::Although several observational studies have demonstrated an association between vitamin K status and bone mineral density (BMD) in postmenopausal women, no placebo-controlled intervention trials of the effect of vitamin K1 supplementation on bone loss have been reported thus far. In the trial presented here we have in...

    journal_title:Calcified tissue international

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/s00223-002-2084-4

    authors: Braam LA,Knapen MH,Geusens P,Brouns F,Hamulyák K,Gerichhausen MJ,Vermeer C

    更新日期:2003-07-01 00:00:00

  • Three-Dimensional Porous Gelapin-Simvastatin Scaffolds Promoted Bone Defect Healing in Rabbits.

    abstract::Treatment of large bone defects (LBDs) is technically demanding. Tissue engineering is an option. A bioactive graft may be produced by combining tissue scaffolds and healing promotive factors in order to accelerate bone repair. We investigated the role of Simvastatin (Sim)-embedded porous Gelapin (Gel) scaffold on exp...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/s00223-015-9981-9

    authors: Moshiri A,Shahrezaee M,Shekarchi B,Oryan A,Azma K

    更新日期:2015-06-01 00:00:00

  • Effects of parathyroid hormone on odontogenesis of the mouse embryonic molar tooth in vitro.

    abstract::Mandibular first molars of 17-day-old mouse embryos were cultured in vitro to examine the histological effects of various concentrations of parathyroid hormone (PTH) on odontogenesis of the molars. PTH did not affect the cytodifferentiation of mesenchymal cells into preodontoblasts but inhibited that of preodontoblast...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/BF02555728

    authors: Sakakura Y

    更新日期:1987-01-01 00:00:00

  • Effects of Combined Whole-Body Electromyostimulation and Protein Supplementation on Local and Overall Muscle/Fat Distribution in Older Men with Sarcopenic Obesity: The Randomized Controlled Franconia Sarcopenic Obesity (FranSO) Study.

    abstract::The primary aim of the project was to determine the combined effect of whole-body electromyostimulation (WB-EMS) and protein supplements on local and overall muscle/fat distribution in older man with sarcopenic obesity (SO). Community-dwelling (cdw) men ≥ 70 years with SO were randomly allocated to a WB-EMS and protei...

    journal_title:Calcified tissue international

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00223-018-0424-2

    authors: Kemmler W,Grimm A,Bebenek M,Kohl M,von Stengel S

    更新日期:2018-09-01 00:00:00

  • Inhibition of calcium pyrophosphate dihydrate crystal formation: effects of carboxylate ions.

    abstract::Proteoglycans are recognized to inhibit calcium pyrophosphate dihydrate (CPPD) crystal formation but the mechanisms are not known. To study the role of carboxylate (-CO2-) ligands, the possible inhibitor effects of sodium acetate, sodium D-glucuronate, disodium malate, and trisodium citrate were studied using solution...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/BF02555838

    authors: Cheng PT,Pritzker KP

    更新日期:1988-01-01 00:00:00

  • Ultrasonic velocity as a predictor of strength in bovine cancellous bone.

    abstract::Ultrasonic methods measure properties intrinsic to bone's structure that are not necessarily dependent on bone mass. Therefore, ultrasound may prove to be a useful tool for diagnosing bone fragility and osteoporosis. The goal of this study was to determine the relationship between apparent velocity of ultrasound (AVU)...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/BF02565132

    authors: Turner CH,Eich M

    更新日期:1991-08-01 00:00:00

  • Bone Disease in CKD in Children.

    abstract::This manuscript discusses mineral and bone disorders of chronic kidney disease (MBD-CKD) in pediatric patients with special emphasis on the underlying pathophysiology, the causes and clinical profile of growth retardation, the alterations in the growth plate, the strategies to optimize growth and the medical recommend...

    journal_title:Calcified tissue international

    pub_type: 杂志文章,评审

    doi:10.1007/s00223-020-00787-z

    authors: Santos F,Díaz-Anadón L,Ordóñez FA,Haffner D

    更新日期:2021-01-16 00:00:00

  • Recombinant Human Bone Morphogenetic Protein 7 Exerts Osteo-Catabolic Effects on Bone Grafts That Outweigh Its Osteo-Anabolic Capacity.

    abstract::This study aimed to investigate the effects of recombinant human bone morphogenetic protein (rhBMP-7) on human cancellous bone grafts (BGs) while differentiating between anabolic and catabolic events. Human BGs alone or supplemented with rhBMP-7 were harvested 14 weeks after subcutaneous implantation into NOD/Scid mic...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/s00223-019-00574-5

    authors: Lahr CA,Wagner F,Shafiee A,Rudert M,Hutmacher DW,Holzapfel BM

    更新日期:2019-09-01 00:00:00

  • A mechanism for incorporation of carbonate into apatite.

    abstract::Octacalcium phosphate (Ca8H2(PO4)6 . 5H2O) is considered to be precursor in the formation of apatite in bones and teeth; a crucial step for incorporation of impurities appears to occur during its hydrolysis. The present study examines the role that octacalcium phosphate plays in the process of incorporation of carbona...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/BF02408521

    authors: Chickerur NS,Tung MS,Brown WE

    更新日期:1980-01-01 00:00:00

  • Establishment of the relative antiinflammatory potency of deflazacort and prednisone in polymyalgia rheumatica.

    abstract::Conventional glucocorticoids exert a negative influence on calcium balance, and long-term treatment with these agents leads to osteopenia. Deflazacort is an oxazoline derivative of prednisolone with documented calcium-sparing properties when compared to prednisone on a weight basis. The purpose of the present study wa...

    journal_title:Calcified tissue international

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF02556669

    authors: Lund B,Egsmose C,Jørgensen S,Krogsgaard MR

    更新日期:1987-12-01 00:00:00

  • Radioimmunoassay for human osteocalcin using an antibody raised against the synthetic human (h37-49) sequence.

    abstract::Radioiodination of synthetic human 37-49 osteocalcin requires optimal labeling conditions in order to obtain a maximum of mono- and di-iodinated tracer with little contamination by tri- and tetra-iodinated products or "radio-damage." The antibody raised against osteocalcin(h37-49) had the highest affinity for the C-te...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/BF02555196

    authors: Jüppner H,Schettler T,Giebel G,Wenner S,Hesch RD

    更新日期:1986-11-01 00:00:00

  • The effect of lipopolysaccharide from bacteroides gingivalis and muramyl dipeptide on osteoblast collagenase release.

    abstract::In order to determine whether the bacterial bone resorbing agents lipopolysaccharide (LPS) and muramyl dipeptide (MDP) interact with osteoblasts, their effect on the synthesis of collagenase and tissue inhibitor or metalloproteinases (TIMP) from monolayer cultures of mouse osteoblast-like cells was investigated. All c...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/BF02556318

    authors: Sismey-Durrant HJ,Atkinson SJ,Hopps RM,Heath JK

    更新日期:1989-05-01 00:00:00

  • Osteoporosis Changes Collagen/Apatite Orientation and Young's Modulus in Vertebral Cortical Bone of Rat.

    abstract::This study revealed the distinguished changes of preferential orientation of collagen and apatite and Young's modulus in two different types of osteoporotic bones compared with the normal bone. Little is known about the bone material properties of osteoporotic bones; therefore, we aimed to assess material properties i...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/s00223-018-0508-z

    authors: Ozasa R,Ishimoto T,Miyabe S,Hashimoto J,Hirao M,Yoshikawa H,Nakano T

    更新日期:2019-04-01 00:00:00

  • Compressive strength, ash weight, and volume of vertebral trabecular bone in experimental fluorosis in pigs.

    abstract::The aim of the investigation was to measure the effect of fluoride on vertebral trabecular bone compressive strength and to correlate this with fluoride-induced changes in bone density. This correlation would express changes in the quality of bone during fluoride treatment. Pigs were used in the experiment because the...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/BF02556693

    authors: Mosekilde L,Kragstrup J,Richards A

    更新日期:1987-06-01 00:00:00

  • Dietary patterns in relation to bone mineral density among menopausal Iranian women.

    abstract::The association of dietary patterns and bone health is not yet well known, and findings from the rare previous studies conducted on this issue are contradictory. We assessed the dietary patterns in relation to bone mineral density (BMD) in a sample of menopausal Iranian women. In this cross-sectional study, 160 menopa...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/s00223-012-9608-3

    authors: Karamati M,Jessri M,Shariati-Bafghi SE,Rashidkhani B

    更新日期:2012-07-01 00:00:00

  • Total body and regional bone mineral by dual-photon absorptiometry in metabolic bone disease.

    abstract::Dual-photon absorptiometry (153Gd) was used to measure bone mineral of the total body and major anatomical areas. Patients with osteoporosis (male = 11, female = 18) and with renal osteodystrophy (n = 17) were significantly below (20%) normal females (n = 72) and males (n = 13) at most sites. In the osteoporotic patie...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/BF02405287

    authors: Mazess RB,Peppler WW,Chesney RW,Lange TA,Lindgren U,Smith E Jr

    更新日期:1984-01-01 00:00:00

  • Ultrastructural changes accompanying the mechanical deformation of bone tissue: a Raman imaging study.

    abstract::Raman spectroscopy and imaging are known to be valuable tools for the analysis of bone, the determination of protein secondary structure, and the study of the composition of crystalline materials. We have utilized all of these attributes to examine how mechanical loading and the resulting deformation affects bone ultr...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/s00223-002-1039-0

    authors: Carden A,Rajachar RM,Morris MD,Kohn DH

    更新日期:2003-02-01 00:00:00

  • Determinants of bone turnover markers in healthy premenopausal women.

    abstract::Bone turnover markers (BTMs) are widely used for the management of osteoporosis, and the premenopausal reference range is the target value for the treatment of postmenopausal osteoporosis with antiresorbing agents. Three serum BTMs (serum C-telopeptide of type I collagen [CTX], osteocalcin [OC], and N-terminal propept...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/s00223-008-9126-5

    authors: Adami S,Bianchi G,Brandi ML,Giannini S,Ortolani S,DiMunno O,Frediani B,Rossini M,BONTURNO study group.

    更新日期:2008-05-01 00:00:00

  • Ultrasound and dual X-ray absorptiometry densitometry in women with hip fracture.

    abstract::To assess the usefulness of the measurement of the os calcis by ultrasound, a method that probably reflects bone quality as well as density, we have studied 54 women with hip fracture of the proximal femur and a control group. Ultrasound evaluation of the os calcis [broadband ultrasound attenuation (BUA), speed of the...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/BF00310252

    authors: Mautalen C,Vega E,González D,Carrilero P,Otaño A,Silberman F

    更新日期:1995-09-01 00:00:00

  • Effect of 1 alpha-hydroxycholecalciferol on psoriasis vulgaris: a pilot study.

    abstract::We carried out a clinical trial of 1 alpha-hydroxycholecalciferol [1 alpha(OH)D3] at a dose of 1.0 microgram a day on 7 patients with psoriasis vulgaris. These patients had been treated by topical applications of corticosteroids before this study without improvement, and during the clinical trial, treatment of topical...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/BF02555172

    authors: Takamoto S,Onishi T,Morimoto S,Imanaka S,Yukawa S,Kozuka T,Kitano Y,Seino Y,Kumahara Y

    更新日期:1986-12-01 00:00:00

  • Expression patterns of Raf-1 suggest multiple roles in tooth development.

    abstract::Raf-1, the product of proto-oncogene c-raf-1, has key roles in the signal transduction pathways within the cell. The molecular mechanisms of tooth development in the mouse embryo are not known in detail. We examined the expression of Raf-1 during subsequent tooth development by immunohistochemical analysis. In mouse e...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/BF02509547

    authors: Sunohara M,Tanzawa H,Kaneko Y,Fuse A,Sato K

    更新日期:1996-01-01 00:00:00

  • Longitudinal study of the effect of calcium pidolate on bone mass in eugonadal women.

    abstract::Seventy-two eugonadal women, mean age 39 +/- 4 years, with a z score for total body bone mineral content (BMC) of less than -1.5 (mean -1.80 +/- 0.12) were selected from a previous screening study of normal values of total body and regional BMC in women using dual-energy X-ray absorptiometry. The women were distribute...

    journal_title:Calcified tissue international

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF00334327

    authors: Rico H,Revilla M,Villa LF,Alvarez de Buergo M,Arribas I

    更新日期:1994-06-01 00:00:00

  • Increased Risk of Hip Fracture in Patients with Lymphoma, a Swedish Population Study of 37,236 Lymphoma Patients.

    abstract::Increased bone loss has been noted in lymphoma patients; however, the incidence of hip fracture is not known. The aim of our study was to explore the risk for hip fracture in patients with lymphoma compared with the entire Swedish population. The risk of hip fracture was determined in a retrospective population cohort...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/s00223-020-00674-7

    authors: Johansson P,Lind Kristjansdottir H,Johansson H,Jakir A,Mellström D,Lewerin C

    更新日期:2020-06-01 00:00:00

  • Spine and femur densitometry at the menopause: are both sites necessary in the assessment of the risk of osteoporosis?

    abstract::The aim of our study was to compare the results provided by the measurement of vertebral and femoral bone mineral density (BMD) for assessing the individual risk of osteoporosis as defined by either low BMD and/or rapid bone loss. Vertebral and femoral BMD were measured twice at a mean interval of 21 months in 85 norm...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/BF00310196

    authors: Pouilles JM,Tremollieres F,Ribot C

    更新日期:1993-05-01 00:00:00

  • Signaling between tumor cells and the host bone marrow microenvironment.

    abstract::Tumor cells with high skeletal homing affinity express numerous cell surface receptors that bind ligands produced in bone. Upon arrival, these cells survive in the host environment, encompassed in close proximity to bone marrow cells. Interactions between tumor cells and cells of the host microenvironment are essentia...

    journal_title:Calcified tissue international

    pub_type: 杂志文章,评审

    doi:10.1007/s00223-013-9794-7

    authors: Kovacic N,Croucher PI,McDonald MM

    更新日期:2014-01-01 00:00:00

  • Integrated therapies for osteoporosis and sarcopenia: from signaling pathways to clinical trials.

    abstract::Sarcopenia and osteoporosis are two sides of the same coin. They represent different aspects of the same age-related process of musculoskeletal atrophy and together culminate in falls, fractures, deconditioning, and increased mortality in older individuals. However, the current therapeutic approach to the prevention o...

    journal_title:Calcified tissue international

    pub_type: 杂志文章,评审

    doi:10.1007/s00223-015-9956-x

    authors: Girgis CM

    更新日期:2015-03-01 00:00:00

  • Human amelogenesis. I: High resolution electron microscopy study of ribbon-like crystals.

    abstract::Ribbon-like crystals, from developing enamel of human fetuses, were studied by high resolution electron microscopy. These crystals were classically described as the first organized mineral formed during amelogenesis. They were characterized by a mean width-to-thickness ratio (W.T-1) of 9.5, and 40% were bent. On latti...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/BF00334485

    authors: Cuisinier FJ,Steuer P,Senger B,Voegel JC,Frank RM

    更新日期:1992-10-01 00:00:00