Abstract:
:Calcium-acidic phospholipid-phosphate complexes (Ca-PL-PO4) cause hydroxyapatite (HA) deposition in vitro. The acidic phospholipids--phosphatidylserine (PS), phosphatidylinositol (PI), phosphatidylglycerol (PG), and diphosphatidylglycerol (DPG)--all form Ca-PL-PO4 complexes: Nonacidic phospholipids--sphingomyelin (SPL), phosphatidylcholine (PC) and phosphatidylethanolamine (PE)--do not form Ca-PL-PO4 and do not induce hydroxyapatite (HA) deposition in low ionic strength metastable calcium phosphate solution or in synthetic lymph. The extent to which each of the acidic phospholipids reacts with calcium and inorganic phosphate, and the chemical composition of the Ca-PL-PO4 complexes is a function of pH, solution composition, the nature of the phospholipid, and the method of isolation. The addition of inorganic phosphate prior to or in combination with calcium appears to be an absolute requirement for Ca-PL-PO4 formation.
journal_name
Calcif Tissue Intjournal_title
Calcified tissue internationalauthors
Boskey AL,Posner ASsubject
Has Abstractpub_date
1982-01-01 00:00:00pages
S1-7eissn
0171-967Xissn
1432-0827journal_volume
34 Suppl 2pub_type
杂志文章abstract::It is generally accepted that bone formation is depressed during corticosteroid treatment, but the effects of glucocorticoids on bone resorption are less well characterized. We have investigated the effects of short-term treatment with high-dose oral glucocorticoids on biochemical markers of bone turnover in 20 consec...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900482
更新日期:1998-07-01 00:00:00
abstract::The relationship between bisphosphonate-induced bone mineral density (BMD) gains and antifracture efficacy remains to be fully elucidated. Data from two antifracture studies were analyzed. Postmenopausal osteoporotic women received oral (2.5 mg daily, 20 mg intermittent) or intravenous (0.5 mg, 1 mg quarterly) ibandro...
journal_title:Calcified tissue international
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00223-010-9403-y
更新日期:2010-10-01 00:00:00
abstract::The aim of this work was to explore the reduction of fluoride concentrations in the skeleton after stopping experimental fluoride administration. Fluoride was administered to the rats at varying doses (0, 50, 100 ppm in drinking water) and for different lengths of time (4, 13, 25 weeks). A series of fluoride concentra...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00318049
更新日期:1995-04-01 00:00:00
abstract::The binding of prostaglandin E2 (PGE2) to bone cells was studied to provide direct evidence for the existence of specific receptors in bone. Bone cells were isolated by collagenase digestion of fetal and newborn rat calvaria. Isolated cells were incubated with 3H-PGE2 and collected on Millipore filters. Specific bindi...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02405038
更新日期:1983-01-01 00:00:00
abstract::1,25 Dihydroxyvitamin D3 (1,25(OH)2D3) (2.0 micrograms) was given intramuscularly to 6 healthy adult males. Twenty-four circadian patterns of blood-ionized calcium (Ca2+), serum phosphate (Pi), and total calcium (CaT) were assessed pre- and posthormone administration. Correlations of mean mineral rhythms with normativ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02553700
更新日期:1985-07-01 00:00:00
abstract::The increased uptake of bone-seeking radionuclides following a fracture has been stated to be due to an increase in bone blood flow, resulting in an increase in capillary surface area available for exchange. This paper examines the relationship between the maximum instantaneous extraction of 99mTc-MDP and blood flow i...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02405085
更新日期:1983-07-01 00:00:00
abstract::Until 2006 the only mutations known to cause osteogenesis imperfecta (OI) were in the two genes coding for type I collagen chains. These dominant mutations affecting the expression or primary sequence of collagen α1(I) and α2(I) chains account for over 90% of OI cases. Since then a growing list of mutant genes causing...
journal_title:Calcified tissue international
pub_type: 杂志文章,评审
doi:10.1007/s00223-013-9723-9
更新日期:2013-10-01 00:00:00
abstract::Radiation therapy (RT) is an established treatment modality for malignant neoplasms. RT induces tissue damage that may lead to osteoradionecrosis in more severe cases. Suitable animal models to study RT-induced changes in membranous craniofacial bone are currently not available. The aim of this study was therefore to ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-009-9217-y
更新日期:2009-05-01 00:00:00
abstract::Radioimmunoassay of the carboxyterminal propeptide of human type I procollagen has been recently introduced to measure in vitro synthesis of type I collagen by osteoblasts and fibroblasts. However, it has not been assessed whether the equivalent results are obtained with this new assay and with tritiated proline incor...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900607
更新日期:1999-03-01 00:00:00
abstract::Osteoclasts are large, multinucleated, terminally differentiated cells formed by the fusion of mononuclear hemopoietic precursors. Their function is the resorption of bone, which is an essential part of the growth, modeling and remodeling of the skeleton. Though some osteoclast differentiation factors have recently be...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-002-2098-y
更新日期:2003-10-01 00:00:00
abstract::Identifying persons with a high risk of osteoporotic fractures remains a challenge. DXA uptake in women with elevated risk of osteoporosis seems to be depending on distance to scanning facilities. This study aimed to investigate the ability of a small portable scanner in identifying women with reduced bone mineral den...
journal_title:Calcified tissue international
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00223-015-0084-4
更新日期:2016-03-01 00:00:00
abstract::Ascorbic acid is a required cofactor in the hydroxylations of lysine and proline necessary for collagen formation; its role in bone cell differentiation and formation is less well characterized. This study examines the cross-sectional relation between dietary vitamin C intake and bone mineral density (BMD) in women fr...
journal_title:Calcified tissue international
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1007/s002239900512
更新日期:1998-09-01 00:00:00
abstract::A 69-year-old man became hypocalcemic under medical observation. The hypocalcemia occurred in the presence of circulating immunoreactive parathyroid hormone (PTH). Common causes of secondary hyperparathyroidism were excluded, as was PTH resistance using PTH infusions. The immunoreactive PTH was examined in detail. PTH...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00298499
更新日期:1992-08-01 00:00:00
abstract::Biochemical markers applicable to the ovariectomized rat model can provide important tools for studying the bone remodeling process in this animal model of postmenopausal osteoporosis. We describe the development and application of two biochemical markers, a C-telopeptide (of type-I collagen) enzyme-linked immunosorbe...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002230010088
更新日期:2000-06-01 00:00:00
abstract::The purpose of the present work was to investigate the appearance of ossification centers in human femur by Dual-energy X-ray Absorptiometry (DXA), comparing densitometric data with morphogenetic events. Posteroanterior scans were performed on 31 dried femora (from 11.5 weeks of conceptual age to 1 year of postnatal l...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/pl00005841
更新日期:2000-04-01 00:00:00
abstract::We compared the effects of four vitamin D metabolites, 1 alpha,25 dihydroxy vitamin D3 (1 alpha,25(OH)2D3), 1 alpha hydroxy vitamin D3 (1 alpha OH D3), 25 hydroxy vitamin D3 (25 OH D3), and 24R,25 dihydroxy vitamin D (24R,25(OH)sD3) on resorption and collagen synthesis in fetal rat bone maintained in organ culture. Re...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02408532
更新日期:1980-01-01 00:00:00
abstract::This study sought to develop a noninvasive, reliable, clinically relevant, and easy-to-implement mouse model that can be used for investigation of the pathophysiology of PTOA and for preclinical testing of new therapies of PTOA. Accordingly, we have established a closed intraarticular tibial plateau compression loadin...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-019-00614-0
更新日期:2020-02-01 00:00:00
abstract::The effect of ipriflavone (IP), a synthetic isoflavonoid derivative, on in vivo bone formation was studied in rat perialveolar bone by surgically producing a hole in the mandibular bone. The holes were filled either with powdered IP or with compounds containing no osteoinductive properties such as biostite and Htr (ha...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900533
更新日期:1998-10-01 00:00:00
abstract::Various studies have investigated the serum sclerostin and bone morphogenetic protein-2 (BMP-2) levels in patients with ankylosing spondylitis (AS), but the results were inconsistent. The aim of this meta-analysis was to synthetically assess the associations of serum levels of sclerostin and BMP-2 with AS. Multiple el...
journal_title:Calcified tissue international
pub_type: 杂志文章,meta分析
doi:10.1007/s00223-019-00542-z
更新日期:2019-07-01 00:00:00
abstract::Yerba mate (Ilex paraguariensis) is a xanthine-containing beverage, which is also rich in caffeine. Because caffeine has a negative impact on bone mineral density (BMD) mainly associated with low calcium (Ca) diets, there would be expected a negative effect of yerba mate on bone. In this study, Sprague-Dawley rats wer...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-015-0043-0
更新日期:2015-11-01 00:00:00
abstract::The main congenital conditions of hypophosphatemia expressed in adulthood include several forms of hereditary hypophosphatemic rickets and a congenital disorder of vitamin D metabolism characterized by osteomalacia and hypophosphatemia in adult patients. Hypophosphatemia in adults is defined as serum phosphate concent...
journal_title:Calcified tissue international
pub_type: 杂志文章,评审
doi:10.1007/s00223-020-00695-2
更新日期:2021-01-01 00:00:00
abstract::Quantitative ultrasound measurement (QUS) and bone mineral density (BMD) have each been shown to predict fracture risk in women. The present study examined whether a combination of QUS and BMD could improve the predictive accuracy of fracture risk. This is a population-based prospective study which involved 454 women ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-011-9556-3
更新日期:2012-02-01 00:00:00
abstract::Proton pump inhibitors are taken by millions of patients for prevention and treatment of gastroesophageal diseases. Case-control studies have suggested that use of omeprazole is associated with an increased risk of hip fractures. The aim of this prospective study was to assess the risk of vertebral fractures in postme...
journal_title:Calcified tissue international
pub_type: 杂志文章,多中心研究
doi:10.1007/s00223-008-9188-4
更新日期:2009-01-01 00:00:00
abstract::We measured serum concentrations of bone Gla-protein (osteocalcin, BGP) and carboxyterminal propeptide of type I procollagen (PICP) in 14 patients with active acromegaly. Blood was collected at 0800 for measurement of bone Gla-protein (BGP), carboxyterminal propeptide of type I procollagen (PICP), and insulin-like gro...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00298716
更新日期:1993-03-01 00:00:00
abstract::It has recently been demonstrated that calcium ionophore A23187 mimics certain of the effects of parathyroid hormone (PTH) on bone in vitro, including stimulation of 45Ca release and cAMP formation. To further examine the relative effects of these two agents on bone cell metabolism, we compared the effects of syntheti...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02411291
更新日期:1982-09-01 00:00:00
abstract::We have previously shown that cyclosporin A (CsA) produces high bone remodeling with resorption exceeding formation and loss of bone volume in the rat. This may have important clinical implications where CsA is widely used in organ transplantation. 1,25 dihydroxyvitamin D3 (1,25(OH)2D3) is a bone mineralizing hormone ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02555980
更新日期:1990-09-01 00:00:00
abstract::Formalin fixation of hard tissues alters the levels of some, but not all, of the parameters routinely measured by bone researchers. Although mineral parameters (ash weight, particle size (beta 1/2 002) and Ca/PO4 ratio) and lipid parameters (total lipid content and composition, extractability, and Ca-acidic phospholip...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02411262
更新日期:1982-07-01 00:00:00
abstract::The present study examined calcium phosphate precipitation in aqueous suspensions of multilamellar liposomes as a possible in vitro model for matrix vesicle mineralization. Liposomes were prepared by dispersing CHCl3-evaporated thin films of 7:2:1 and 7:1:1 molar mixtures of phosphatidylcholine, dicetyl phosphate, and...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02405354
更新日期:1984-07-01 00:00:00
abstract::The hypophosphatemic male mouse (Hyp/y), the proposed model for human vitamin D-resistant rickets (VDRR), is characterized by chronic hypophosphatemia, dwarfism, and rachitic and osteomalacic bone lesions. We have reported that treatment of Hyp/y mice with phosphate salts (Pi) heals rickets but does not correct the de...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02411227
更新日期:1982-03-01 00:00:00
abstract::The influence of the macroscale material properties of bone on its mechanical competence has been extensively investigated, but less is known about possible contributions from bone's nanoscale material properties. These nanoscale properties, particularly the collagen network and the size and shape of hydroxyapatite mi...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-014-9913-0
更新日期:2014-11-01 00:00:00