当前位置： SCI文献检索 > CALCIFIED TISSUE INTERNATIONAL期刊下所有文献 > Antiidiotypic PTH antibodies as a cause of elevated immunoreactive parathyroid hormone in idiopathic hypoparathyroidism, a second case: another manifestation of autoimmune endocrine disease?

Antiidiotypic PTH antibodies as a cause of elevated immunoreactive parathyroid hormone in idiopathic hypoparathyroidism, a second case: another manifestation of autoimmune endocrine disease?

Abstract：

:A 69-year-old man became hypocalcemic under medical observation. The hypocalcemia occurred in the presence of circulating immunoreactive parathyroid hormone (PTH). Common causes of secondary hyperparathyroidism were excluded, as was PTH resistance using PTH infusions. The immunoreactive PTH was examined in detail. PTH immunoreactivity (1) was not retained on a C18 SPE-column, suggesting unusual molecular or physicochemical properties, unlike bona fide PTH; (2) was precipitated with 15% PEG, indicating a molecular size far in excess of native PTH; (3) had an apparent molecular size similar to immunoglobulins on size exclusion chromatography; (4) was retained on affinity chromatography with both Protein A and anti-hIgG antibodies. These data lead us to conclude that the immunoreactive PTH was due to antiidiotypic PTH autoantibodies. No significant quantities of true PTH were found in the patient's serum suggesting that his hypoparathyroidism was a result of PTH deficiency. Autoimmunity might explain the occurrence of both processes if an arrested antiidiotypic antibody cascade is assumed.

journal_name

Calcif Tissue Int

journal_title

Calcified tissue international

authors

McElduff A,Lackmann M,Wilkinson M

doi

10.1007/BF00298499

subject

Has Abstract

pub_date

1992-08-01 00:00:00

pages

121-6

issue

2

eissn

0171-967X

issn

1432-0827

journal_volume

51

pub_type

杂志文章

相关文献

CALCIFIED TISSUE INTERNATIONAL文献大全
  • Bone metabolism in endurance trained athletes: a comparison to population-based controls based on DXA, SXA, quantitative ultrasound, and biochemical markers.

    abstract：:In general, physical exercise appears to have favorable effects on the skeleton. However, a few recent reports have described negative effects, including reduced bone density (BMD) and high bone turnover in runners. The aim of our study was to compare endurance runners to controls with respect to BMD at different site...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s002239900366

    authors： Brahm H,Ström H,Piehl-Aulin K,Mallmin H,Ljunghall S

    更新日期：1997-12-01 00:00:00

  • Plasma leptin concentration and change in bone density among elderly men and women: the Hertfordshire Cohort Study.

    abstract：:Several studies have shown an association between circulating leptin concentration and bone mineral density. but most studies are cross-sectional in design and report findings in women only. We per-formed a population-based longitudinal study relating baseline plasma leptin concentration to bone mass at the lumbar spi...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s00223-002-0017-x

    authors： Dennison EM,Syddall HE,Fall CH,Javaid MK,Arden NK,Phillips DI,Cooper C

    更新日期：2004-05-01 00:00:00

  • Isolation and characterization of human embryonic osteoblasts.

    abstract：:Human osteoblasts were obtained by migration and proliferation of cells from embryonic membranous bone on glass fragments. Light and electron microscopy analyses revealed a typical osteoblast-like appearance with high protein synthesis activity. The cells showed high alkaline phosphatase activity that was associated w...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/BF00316880

    authors： Oliva A,Marrone G,Della Ragione F,Riccio V,Palumbo R,Rossano F,Zappia V

    更新日期：1992-11-01 00:00:00

  • Increase in tartrate-resistant acid phosphatase of bone at the early stage of ascorbic acid deficiency in the ascorbate-requiring Osteogenic Disorder Shionogi (ODS) rat.

    abstract：:The effect of ascorbic acid deficiency on bone metabolism was evaluated using the ascorbate-requiring Osteogenic Disorder Shionogi (ODS) rat model. Ascorbic acid (Asc)-deficient rats gained body weight in a manner similar to Asc-supplemented rats (control) during 3 weeks, but began to lose weight during the 4th week o...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s00223-002-2040-3

    authors： Goto A,Tsukamoto I

    更新日期：2003-08-01 00:00:00

  • Icariin Stimulates Differentiation and Suppresses Adipocytic Transdifferentiation of Primary Osteoblasts Through Estrogen Receptor-Mediated Pathway.

    abstract：:Icariin, the main constituent of Herba Epimedii, appears to be a promising alternative to classic drugs used to treat osteoporosis. However, the detailed molecular mechanisms of its action and the role of icariin in the cross-talk between osteoblasts and adipocytes remain unclear. The present study was designed to inv...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s00223-016-0138-2

    authors： Zhang D,Fong C,Jia Z,Cui L,Yao X,Yang M

    更新日期：2016-08-01 00:00:00

  • Unanticipated changes in steady-state mRNA levels for glyceraldehyde-3-phosphate dehydrogenase in rat tibiae.

    abstract：:Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) mRNA levels are commonly used as an internal control to normalize gene expression data based on the belief that this gene is constitutively expressed. However, GAPDH mRNA levels increased by more than 2.5-fold in tibiae of hindlimb unloaded female rats compared to L32 m...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s00223-002-1098-2

    authors： Maran A,Hefferan TE,Zhang M,Turner RT

    更新日期：2004-02-01 00:00:00

  • Pregnancy and Lactation-Associated Osteoporosis: Bone Histomorphometric Analysis and Response to Treatment with Zoledronic Acid.

    abstract：:Pregnancy and lactation-associated osteoporosis (PAO) is a rare condition with little known pathophysiology. Most cases are diagnosed in the third trimester of pregnancy or in the first weeks postpartum, particularly in first pregnancies. Vertebral fractures are most commonly observed and characterised by prolonged se...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s00223-015-0028-z

    authors： Grizzo FM,da Silva Martins J,Pinheiro MM,Jorgetti V,Carvalho MD,Pelloso SM

    更新日期：2015-10-01 00:00:00

  • Permeabilization of cells of hemopoietic origin by extracellular ATP4-: elimination of osteoclasts, macrophages, and their precursors from isolated bone cell populations and fetal bone rudiments.

    abstract：:Skeletal tissues contain, apart from cells of the osteogenic and chondrogenic lineage, cells of hemopoietic origin, e.g., macrophages, osteoclasts, and their precursors. In the present study we examined the sensitivity for extracellular ATP4- of the above-mentioned cell types in freshly isolated, bone-derived cell pop...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/BF00297190

    authors： Modderman WE,Weidema AF,Vrijheid-Lammers T,Wassenaar AM,Nijweide PJ

    更新日期：1994-08-01 00:00:00

  • Local bone mineral density, muscle strength, and exercise in adolescent boys: a comparative study of two groups with different muscle strength and exercise levels.

    abstract：:The primary objective of the present study was to evaluate the impact of physical activity and muscle strength on bone mineral density (BMD) of the tuberositas tibiae in adolescent boys. Two groups with different exercise levels were compared. The high activity group consisted of 20 subjects (age 15.9 +/- 0.3) from a ...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/BF02509438

    authors： Nordström P,Nordström G,Thorsen K,Lorentzon R

    更新日期：1996-06-01 00:00:00

  • The Orientation of Nanoscale Apatite Platelets in Relation to Osteoblastic-Osteocyte Lacunae on Trabecular Bone Surface.

    abstract：:The orientation of nanoscale mineral platelets was quantitatively evaluated in relation to the shape of lacunae associated with partially embedded osteocytes (osteoblastic-osteocytes) on the surface of deproteinised trabecular bone of adult sheep. By scanning electron microscopy and image analysis, the mean orientatio...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s00223-015-0072-8

    authors： Shah FA,Zanghellini E,Matic A,Thomsen P,Palmquist A

    更新日期：2016-02-01 00:00:00

  • Histomorphometric evaluation of the recovering effect of human parathyroid hormone (1-34) on bone structure and turnover in streptozotocin-induced diabetic rats.

    abstract：:The purpose of this study was to determine whether human parathyroid hormone (h-PTH) enhances trabecular bone mass and connectivities that were reduced by streptozotocin (STZ)-induced diabetes in rats. Seven-month-old female Wistar rats were injected with STZ or its vehicle intraperitoneally. All vehicle-injected norm...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/pl00005838

    authors： Tsuchida T,Sato K,Miyakoshi N,Abe T,Kudo T,Tamura Y,Kasukawa Y,Suzuki K

    更新日期：2000-03-01 00:00:00

  • Effects of cyclosporins and transforming growth factor beta 1 on thyroid hormone action in cultured fetal rat limb bones.

    abstract：:To study the mechanism of action of thyroid hormones on bone, we examined the effects of immunosuppressive and nonimmunosuppressive cyclosporins, as well as of transforming growth factor beta 1 (TGF beta 1), 17 beta-estradiol (E2), and dihydroxytestosterone (DHT) on thyroxine (T4)- and triiodothyronine (T3)-stimulated...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/BF00298788

    authors： Lakatos P,Stern PH

    更新日期：1992-02-01 00:00:00

  • Effect of a hypergravity environment on cortical bone elasticity in rats.

    abstract：:There is considerable interest in determining whether hypergravity can be used as a countermeasure for microgravity-induced bone loss. This study was conducted on 20 immature male rats in order to investigate possible elastic adaptations of cortical bone in rapidly growing rats exposed to chronic hypergravity. Ten rat...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s002239900111

    authors： Kohles SS,Bowers JR,Vailas AC,Vanderby R Jr

    更新日期：1996-09-01 00:00:00

  • Ethanol-induced formation of solid calcium phosphates.

    abstract：:Conventional transmission electron microscopy requires an effective dehydration of the tissue specimens under investigation. This dehydration, for which ethanol most often is used, may influence the solubility of the slightly soluble calcium phosphates. To study the behavior of calcium phosphates in ethanol, stable ne...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/BF02554840

    authors： Larsen MJ,Thorsen A,Jensen SJ

    更新日期：1985-03-01 00:00:00

  • Impact of Conventional Medical Therapy on Bone Mineral Density and Bone Turnover in Adult Patients with X-Linked Hypophosphatemia: A 6-Year Prospective Cohort Study.

    abstract：:X-linked hypophosphatemia (XLH) is a rare, inheritable disorder manifesting as rickets in children and osteomalacia in adults. While conventional medical treatment with oral phosphate and alfacalcidol is recommended in childhood, it is undecided whether adults should continue therapy. The aim of this 6-year prospectiv...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s00223-017-0363-3

    authors： Shanbhogue VV,Hansen S,Jørgensen NR,Beck-Nielsen SS

    更新日期：2018-03-01 00:00:00

  • Alkaline phosphatase in osteoblasts is down-regulated by pulsatile fluid flow.

    abstract：:It is our hypothesis that interstitial fluid flow plays a role in the bone remodeling response to mechanical loading. The fluid flow-induced expression of three proteins (collagen, osteopontin, and alkaline phosphatase) involved in bone remodeling was investigated. Rat calvarial osteoblasts subjected to pulsatile flui...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s002239900185

    authors： Hillsley MV,Frangos JA

    更新日期：1997-01-01 00:00:00

  • Signaling between tumor cells and the host bone marrow microenvironment.

    abstract：:Tumor cells with high skeletal homing affinity express numerous cell surface receptors that bind ligands produced in bone. Upon arrival, these cells survive in the host environment, encompassed in close proximity to bone marrow cells. Interactions between tumor cells and cells of the host microenvironment are essentia...

    journal_title：Calcified tissue international

    pub_type： 杂志文章,评审

    doi：10.1007/s00223-013-9794-7

    authors： Kovacic N,Croucher PI,McDonald MM

    更新日期：2014-01-01 00:00:00

  • Histochemical and fine structural study of bone of ipriflavone-treated rats.

    abstract：:Bone labeling, histochemical, and fine structural studies were performed in order to clarify the effects of ipriflavone (IP) on rat bone tissue in vivo and in vitro. Labeling experiments showed a slight increase in bone formation during 3 days' administration. It was also noted that many osteoclasts detached from the ...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/BF02180245

    authors： Ozawa H,Nakamura H,Irie K,Irie M

    更新日期：1992-01-01 00:00:00

  • Serum levels of bone Gla protein (osteocalcin, BGP) and carboxyterminal propeptide of type I procollagen (PICP) in acromegaly: effects of long-term octreotide treatment.

    abstract：:We measured serum concentrations of bone Gla-protein (osteocalcin, BGP) and carboxyterminal propeptide of type I procollagen (PICP) in 14 patients with active acromegaly. Blood was collected at 0800 for measurement of bone Gla-protein (BGP), carboxyterminal propeptide of type I procollagen (PICP), and insulin-like gro...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/BF00298716

    authors： Terzolo M,Piovesan A,Osella G,Pia A,Reimondo G,Pozzi C,Raucci C,Torta M,Paccotti P,Angeli A

    更新日期：1993-03-01 00:00:00

  • The relation between trabecular bone strength and bone mineral density assessed by dual photon and dual energy X-ray absorptiometry in the proximal tibia.

    abstract：:The feasibility of two noninvasive methods [dual photon absorptiometry (DPA) and dual energy X-ray absorptiometry (DXA)] for prediction in vivo of local variations of trabecular bone strength within the proximal tibia was evaluated in 14 cadaveric knees. Trabecular bone strength was measured using an osteopenetrometer...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s002239900131

    authors： Petersen MM,Jensen NC,Gehrchen PM,Nielsen PK,Nielsen PT

    更新日期：1996-10-01 00:00:00

  • The role of three-dimensional trabecular microstructure in the pathogenesis of vertebral compression fractures.

    abstract：:We compared indices of three-dimensional microstructure of iliac trabecular bone between 26 patients with vertebral compression fractures due to postmenopausal osteoporosis and 24 control subjects without vertebral fracture, who were matched for age, sex, race, menopausal status, and several densitometric and histolog...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/BF02554913

    authors： Kleerekoper M,Villanueva AR,Stanciu J,Rao DS,Parfitt AM

    更新日期：1985-12-01 00:00:00

  • Fourier-transform infrared spectroscopic study of Ca2+-binding to osteocalcin.

    abstract：:Osteocalcin, the gamma-carboxyglutamic acid-containing protein, which is the most abundant noncollagenous protein of bone and dentin, is considered to play roles in bone formation and remodeling. It is unclear how the gamma-carboxyglutamic acid side-chains in osteocalcin coordinate to Ca2+, since the X-ray structure o...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s002230010042

    authors： Mizuguchi M,Fujisawa R,Nara M,Nitta K,Kawano K

    更新日期：2001-12-01 00:00:00

  • Quantitative trait locus on chromosome 1q influences bone loss in young Mexican American adults.

    abstract：:Bone loss occurs as early as the third decade and its cumulative effect throughout adulthood may impact risk for osteoporosis in later life, however, the genes and environmental factors influencing early bone loss are largely unknown. We investigated the role of genes in the change in bone mineral density (BMD) in par...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s00223-008-9197-3

    authors： Shaffer JR,Kammerer CM,Bruder JM,Cole SA,Dyer TD,Almasy L,Maccluer JW,Blangero J,Bauer RL,Mitchell BD

    更新日期：2009-02-01 00:00:00

  • Rapid establishment of chemical and mechanical properties during lamellar bone formation.

    abstract：:The development of prophylaxes and treatments of bone diseases that can effectively increase the strength of bone as a structure necessitates a better understanding of the time course by which chemical properties define the stiffness of the material during primary and secondary mineralization. It was hypothesized that...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s00223-005-0148-y

    authors： Busa B,Miller LM,Rubin CT,Qin YX,Judex S

    更新日期：2005-12-01 00:00:00

  • Biochemical markers of bone turnover and bone loss at the lumbar spine and femoral neck: the Taiji study.

    abstract：:The purpose of this study was to ascertain whether biochemical markers of bone turnover predict bone loss. The survey was carried out in Taiji, Wakayama Prefecture, Japan. From a list of inhabitants aged 40-79 years, 400 participants (50 men and 50 women in each of four age groups) were selected randomly. Bone mineral...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s002239900682

    authors： Yoshimura N,Hashimoto T,Sakata K,Morioka S,Kasamatsu T,Cooper C

    更新日期：1999-09-01 00:00:00

  • Purification and immunochemistry of a soluble matrix protein of the chicken eggshell (ovocleidin 17).

    abstract：:The protein components of biomineralized structures (matrix proteins) are believed to modulate crystal nucleation and growth, and thereby influence the shape and strength of the final structure. The chicken eggshell contains a complex array of distinct matrix proteins. The most abundant of these was purified to homoge...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/BF00298593

    authors： Hincke MT,Tsang CP,Courtney M,Hill V,Narbaitz R

    更新日期：1995-06-01 00:00:00

  • In vitro synthesis of type I collagen: quantification of carboxyterminal propeptide of procollagen type I versus tritiated proline incorporation.

    abstract：:Radioimmunoassay of the carboxyterminal propeptide of human type I procollagen has been recently introduced to measure in vitro synthesis of type I collagen by osteoblasts and fibroblasts. However, it has not been assessed whether the equivalent results are obtained with this new assay and with tritiated proline incor...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s002239900607

    authors： Nacher M,Serrano S,Mariñoso ML,García MC,Bosch J,Díez A,Lloreta J,Aubia J

    更新日期：1999-03-01 00:00:00

  • Gene expression for extracellular matrix proteins in shockwave-induced osteogenesis in rats.

    abstract：:To clarify the mechanisms underlying shockwave-induced osteogenesis, we applied shockwave to rat femoral shafts from the ventral side. We assessed bone mineral content (BMC) and bone mineral density (BMD), and analyzed the spatial and temporal gene expression for pro-alpha1 (I) collagen (COL1A1), pro-alpha1 (II) colla...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s00223-003-0043-3

    authors： Takahashi K,Yamazaki M,Saisu T,Nakajima A,Shimizu S,Mitsuhashi S,Moriya H

    更新日期：2004-02-01 00:00:00

  • Bone mineral density and bone turnover in patients with knee osteoarthritis compared with generalized osteoarthritis.

    abstract：:The aim of this study was to investigate bone mineral density (BMD) and bone turnover in patients with primary knee osteoarthritis (KOA) and to compare them with generalized OA (GOA) and nonGOA patients. A total of 88 postmenopausal primary KOA patients were studied. OA was graded by using knee radiographs. BMD of the...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s002230010068

    authors： Naitou K,Kushida K,Takahashi M,Ohishi T,Inoue T

    更新日期：2000-05-01 00:00:00

  • Effects of risedronate treatment on bone density and vertebral fracture in patients on corticosteroid therapy.

    abstract：:Men and women (n = 518) receiving moderate-to-high doses of corticosteroids were enrolled in two studies with similar protocols and randomly assigned to receive either placebo or risedronate (2.5 or 5 mg) for 1 year. All patients received daily calcium supplementation (500-1000 mg), and most also received supplemental...

    journal_title：Calcified tissue international

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1007/s002230001146

    authors： Wallach S,Cohen S,Reid DM,Hughes RA,Hosking DJ,Laan RF,Doherty SM,Maricic M,Rosen C,Brown J,Barton I,Chines AA

    更新日期：2000-10-01 00:00:00