Abstract:
:The purpose of this study was to ascertain whether biochemical markers of bone turnover predict bone loss. The survey was carried out in Taiji, Wakayama Prefecture, Japan. From a list of inhabitants aged 40-79 years, 400 participants (50 men and 50 women in each of four age groups) were selected randomly. Bone mineral density (BMD) was measured, and blood and urine samples of all participants were examined to obtain values for eight biochemical markers: alkaline phosphatase (ALP), bone Gla protein (BGP), type I procollagen (carboxyterminal peptide of type I procollagen; PICP), cross-linked carboxyterminal telopeptide region of type I collagen (ICTP), and urinary excretion of calcium (Ca), phosphate (P), pyridinoline (Pyr), and deoxypyridinoline (D-Pyr). Each marker was evaluated as a predictor of the rate of bone change in lumbar spine and femoral neck BMD over a 3-year period. The value of Pyr was significantly related to the change of lumbar spine BMD in men (P = 0.009), and that of BGP was found to be significant in women (P = 0.045). By contrast, none of the bone markers significantly correlated with bone loss at the femoral neck. The coefficient of determination at the lumbar spine was 5% and 7% at the femoral neck only. We conclude that biochemical markers of bone turnover cannot predict bone loss rates in middle-aged or elderly Japanese men and women over a 3-year period with sufficient accuracy for use in clinical decision making.
journal_name
Calcif Tissue Intjournal_title
Calcified tissue internationalauthors
Yoshimura N,Hashimoto T,Sakata K,Morioka S,Kasamatsu T,Cooper Cdoi
10.1007/s002239900682subject
Has Abstractpub_date
1999-09-01 00:00:00pages
198-202issue
3eissn
0171-967Xissn
1432-0827pii
CT23-98journal_volume
65pub_type
杂志文章abstract::We separated osteoclasts from bone and observed the effect of several known and potential mediators of the control of bone resorption on their cytoplasmic motility. We already found that calcitonin (CT), a hormone that inhibits bone resorption, regularly causes complete inhibition of cytoplasmic motility, specific for...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02405095
更新日期:1983-07-01 00:00:00
abstract::The histologic heterogeneity of osteoporosis relative to normal controls has attracted great interest. There has been controversy as to whether patients with high turnover osteoporosis may convert to a normal or low turnover form, and vice versa. We have studied 44 patients over 12 years by dynamic histomorphometry an...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00675620
更新日期:1993-01-01 00:00:00
abstract::We studied the influence of age, gender, latitude, season, diet and ethnicity on plasma 25-hydroxyvitamin D 25 OHD, PTH, 1,25-dihydroxyvitamin D, vitamin D-binding protein, bone-specific alkaline phosphatase, and osteocalcin levels in 46 Greenlanders living in Nuuk (64 degrees N) on a traditional fare (group A), 45 Gr...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-003-0110-9
更新日期:2004-03-01 00:00:00
abstract::Vitamin D supplementation is recommended for women with osteoporosis. In the FOCUS-D trial comparing the combination tablet alendronate plus vitamin D3 5,600 IU (ALN/D) with standard care (SC) prescribed by patients' personal physicians, ALN/D was more effective in improving serum 25(OH)D and bone turnover markers by ...
journal_title:Calcified tissue international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00223-013-9763-1
更新日期:2014-02-01 00:00:00
abstract::KH1060 is a new 20-epi-vitamin D3 analog, which has exerted a considerable immunosuppressive potency in vitro. We have tested in vivo the effect of KH1060 on the suppression of renal allograft rejection in the rat. Allogenic kidney transplantation from DA donor rats to Lewis recipient rats treated intraperitoneally wi...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00296066
更新日期:1994-02-01 00:00:00
abstract::Two rheumatic syndromes associated with deposition of calcium phosphate crystals in soft tissues of the shoulder have prompted us to study the cellular mechanisms of calcium phosphate crystal solubilization. Synthetic 45Ca labeled calcium phosphate crystal aggregates were solubilized by cultured human fibroblasts or m...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02405384
更新日期:1984-12-01 00:00:00
abstract::Changes in the acidity of osteoclasts were evaluated by direct measurement of the fluorescent intensity of osteoclasts exposed to acridine orange, a fluorescent weak base which becomes concentrated in acid-containing subcellular compartments. Parathyroid hormone (PTH) produced dose-dependent increases in fluorescent i...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02554924
更新日期:1985-12-01 00:00:00
abstract::Using a histochemical method for demonstrating acid phosphatase activity, we have studied osteoclasts residing at two different bone sites in rat incisor alveolar bone, one at the endosteum and the other at the tooth socket, and compared the response of these osteoclasts to systemic changes. After 12 days of calcium (...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02405315
更新日期:1984-03-01 00:00:00
abstract::Proteoglycans are recognized to inhibit calcium pyrophosphate dihydrate (CPPD) crystal formation but the mechanisms are not known. To study the role of carboxylate (-CO2-) ligands, the possible inhibitor effects of sodium acetate, sodium D-glucuronate, disodium malate, and trisodium citrate were studied using solution...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02555838
更新日期:1988-01-01 00:00:00
abstract::The calcium ion binding properties of a high molecular weight bovine phosphophoryn preparation have been studied at high ionic strength (0.5 M KCl as supporting electrolyte). Surprisingly, even under these conditions at which intermolecular ionic interactions are effectively screened, phosphophoryn was capable of bind...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02555712
更新日期:1987-02-01 00:00:00
abstract::To assess whether vertebral fractures are associated with osteopenia in chronic alcoholic patients, a transversal study was carried out in 76 chronic alcoholic males and 62 age-matched healthy males. Lumbar bone mineral density (BMD) by dual photon absorptiometry and spinal chest X-ray films were done in all patients....
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00298430
更新日期:1995-08-01 00:00:00
abstract::Cost-effective intervention thresholds (ITs) based on FRAX(®) were determined for Portugal. Assuming a willingness to pay (WTP) of €32,000 per quality-adjusted life years (QALYs), treatment with generic alendronate is cost effective for men and women aged 50 years or more, with 10-year probabilities for major osteopor...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-016-0132-8
更新日期:2016-08-01 00:00:00
abstract::Bone involvement is one of the most disabling aspects of type I Gaucher disease and its pathophysiology is still not well understood. As an invasive procedure, bone biopsies are not appropriate in a large population study. The development of sensitive bone resorption and formation tests have allowed the authors to stu...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-001-2072-0
更新日期:2003-03-01 00:00:00
abstract::Roux-en-Y gastric bypass surgery (RYGB) is an effective treatment of morbid obesity, with positive effects on obesity-related complications. The treatment is associated with bone loss, which in turn might increase fracture risk. The aim of this study was to evaluate changes in bone mineral density (BMD) and bone archi...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-015-0091-5
更新日期:2016-03-01 00:00:00
abstract::Osseous tissue develops via two distinctly different processes: endochondral (EC) ossification and intramembranous (IM) ossification. The present study tests the hypothesis that each type of osseous tissue contains unique inducing factors for the promotion of cartilage and bone development. Previous work suggests that...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02556258
更新日期:1991-11-01 00:00:00
abstract::Parathyroid hormone (PTH), hPTH-(1-84), and its hPTH-(1-34), hPTH-(1-31)NH2, and hPTH-(1-30)NH2 fragments reduced the tail artery pressure in anesthetized female Sprague-Dawley rats by 42.4-67.1% within about 1 minute after injection into a femoral vein, but reduced the pressure by only 8.5-36.2% 2-19 minutes after su...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900233
更新日期:1997-03-01 00:00:00
abstract::Bone mineralization density distribution (BMDD) is an important determinant of bone mechanical properties. The most available skeletal site for access to the BMDD is the iliac crest. Compared to cancellous bone much less information on BMDD is available for cortical bone. Hence, we analyzed complete transiliac crest b...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-014-9901-4
更新日期:2014-10-01 00:00:00
abstract::Anemia is commonly associated with osteoporosis and sarcopenia in older persons. However, there is a common subset of patients identified as osteosarcopenic at a higher risk of adverse outcomes. Whether these patients are also at a higher risk of anemia remains unknown. In this study, we aimed to compare hemoglobin (H...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-020-00706-2
更新日期:2020-08-01 00:00:00
abstract::Prior exposure to PTH markedly decreased the responsiveness of isolated, cultured bone cells to the stimulatory effect of the hormone on cyclic AMP formation. This process of desensitization developed within 30 min, persisted during prolonged incubation of the cells in PTH-free medium, and could not be attributed to e...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02408528
更新日期:1980-01-01 00:00:00
abstract::Psoriatic arthritis (PsA) is an inflammatory rheumatic disorder that occurs in patients with psoriasis and predominantly affects musculoskeletal structures, skin, and nails. The etiology of PsA is not well understood but evidence supports an interplay of genetic, immunologic, and environmental factors which promote pa...
journal_title:Calcified tissue international
pub_type: 杂志文章,评审
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更新日期:2018-05-01 00:00:00
abstract::Quantitative ultrasound (US) measurements have been shown to be a new technique assessing bone status. This study aimed to assess a new US instrument, the DBM Sonic 1200(R) (IGEA) which permits the measurement of the speed of sound in the proximal phalanges (SOSp) of the hand. The results obtained were compared with D...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900574
更新日期:1999-01-01 00:00:00
abstract::The effect of zinc on in vitro deoxyribonucleic acid (DNA) synthesis activity in the femoral-diaphyseal and metaphyseal tissues of newborn rats was investigated to determine a role of zinc in bone growth. In vitro DNA synthesis was assayed in a reaction mixture containing the 100 g centrifugation supernatant, which in...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-001-2010-1
更新日期:2001-09-01 00:00:00
abstract::ELISAs for measuring the urinary excretion of collagen crosslinks and related peptides appear to show marked differences in sensitivity to anti-resorptive therapy. This presumably reflects variations in specificity of the anylate being detected in these assays, and the way in which they respond to treatment. To clarif...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900148
更新日期:1996-11-01 00:00:00
abstract::The aim of our study was to compare the results provided by the measurement of vertebral and femoral bone mineral density (BMD) for assessing the individual risk of osteoporosis as defined by either low BMD and/or rapid bone loss. Vertebral and femoral BMD were measured twice at a mean interval of 21 months in 85 norm...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00310196
更新日期:1993-05-01 00:00:00
abstract::We examined differences in patients' survival after hip fracture (HF) and risk for subsequent HF among patients treated with oral and intravenous bisphosphonates (oBPs, iBPs), denosumab (DMAB), and patients without therapy. We used data from all patients in Austria aged ≥ 50 who sustained a HF between 2012 and 2017 an...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-019-00611-3
更新日期:2019-12-01 00:00:00
abstract::The primary aim of the project was to determine the combined effect of whole-body electromyostimulation (WB-EMS) and protein supplements on local and overall muscle/fat distribution in older man with sarcopenic obesity (SO). Community-dwelling (cdw) men ≥ 70 years with SO were randomly allocated to a WB-EMS and protei...
journal_title:Calcified tissue international
pub_type: 杂志文章,随机对照试验
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更新日期:2018-09-01 00:00:00
abstract::The mineral of cortical bones has been studied in newborn, growing, and adult rats and in the calf and cow, using X-ray diffraction and infrared spectroscopy during the thermal decomposition of bones and by microassay of carbonate. The mineral of all the bone samples, regardless of species or age, was found to be a ca...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02563793
更新日期:1987-09-01 00:00:00
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journal_title:Calcified tissue international
pub_type: 杂志文章
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更新日期:2018-09-01 00:00:00
abstract::Using data from the Peking Vertebral Fracture Study, we conducted a longitudinal cohort study to investigate the association between type 2 diabetes mellitus (T2DM) and the risk of incident fractures, especially of vertebral fractures (VFs), and we also examined the modifying effect of body mass index (BMI) on this as...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-019-00598-x
更新日期:2019-11-01 00:00:00
abstract::Bone involvement, mainly osteoporosis but also osteosclerosis, is frequent in patients with indolent systemic mastocytosis (ISM). The recent characterization of the canonical Wnt/β-catenin pathway in the regulation of bone remodeling provided important insights for our understanding of the pathophysiology of a number ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-015-9969-5
更新日期:2015-05-01 00:00:00