Abstract：
:Bone involvement is one of the most disabling aspects of type I Gaucher disease and its pathophysiology is still not well understood. As an invasive procedure, bone biopsies are not appropriate in a large population study. The development of sensitive bone resorption and formation tests have allowed the authors to study bone metabolism in a noninvasive manner in a group of type 1 Gaucher patients. Ten type I Gaucher adult patients with mild-to-severe bone disease were evaluated. Bone mineral density and markers of bone formation (total alkaline phosphatase and isoenzymes, carboxyterminal propeptide of type I procollagen, osteocalcin) and resorption (carboxyterminal telopeptide of type I collagen, urinary hydroxyproline, free-deoxypyridinoline and calcium) were measured in patients and in a control group, matched for sex and age. In Gaucher patients, carboxyterminal propeptide of type I procollagen (PICP), a bone formation index, was significantly lower compared with normal subjects (mean 101.17 ng/ml vs 140.75 ng/ml, P = 0.038), and analysis of bone resorption indexes showed a significant increase (mean 4.24 ng/ml vs 2.87 ng/ml, P = 0.012) of serum carboxyterminal telopeptide of type I collagen (ICTP). No significant differences were observed in osteocalcin, alkaline phosphatase, and urinary hydroxyproline. Bone mineral density revealed osteopenia in six patients, with a mean Z-score of ?1.04. It was not possible to show a relationship between sex, splenectomy status, age, weight, spleen, and liver volume and bone density, expressed as a Z-score nor a correlation between Z score and severity of skeletal disease. Results have shown a predominance of the resorption phase in the bone metabolism of Gaucher patients. These markers could be useful in monitoring the effect of enzyme replacement therapy on Gaucher disease skeletal involvement.
journal_name
Calcif Tissue Intjournal_title
Calcified tissue internationalauthors
Ciana G,Martini C,Leopaldi A,Tamaro G,Katouzian F,Ronfani L,Bembi Bdoi
10.1007/s00223-001-2072-0subject
Has Abstractpub_date
2003-03-01 00:00:00pages
185-9issue
3eissn
0171-967Xissn
1432-0827journal_volume
72pub_type
杂志文章abstract：:The effects of the trace metals zinc (Zn), manganese (Mn), and cadmium (Cd) on the metabolism of growth plate chondrocytes was examined using a mineralizing culture system. Supplementation of serum-free primary cultures of growth plate chondrocytes with 10-100 mu m Zn resulted in an increase in cell protein and greatl...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900442
更新日期：1998-04-01 00:00:00
abstract：:The effects of 5, 10, and 20% dietary xylitol supplementations on the resorption of bone were studied. The resorption was measured by the urinary excretion of [3H] radioactivity from [3H]tetracycline-prelabeled rats. The 10 and 20% oral xylitol administrations caused a significant decrease in the excretion of [3H] as ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF00298616
更新日期：1995-03-01 00:00:00
abstract：:The developing mandibular condylar growth center consists of a number of histologically distinct cell types. There is an increase in cell volume that takes place from the condylar surface layer through the center of ossification, resulting in a disorganized, irregular cellular pattern. Consequently, the isolation and ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF00298747
更新日期：1995-01-01 00:00:00
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journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02565132
更新日期：1991-08-01 00:00:00
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journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02441197
更新日期：1979-07-03 00:00:00
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journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900366
更新日期：1997-12-01 00:00:00
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journal_title：Calcified tissue international
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/pl00005832
更新日期：2000-02-01 00:00:00
abstract：:The bone mineral density (BMD) of the radius and spine was determined by photo absorptiometry in a large number of controls (radius: n = 111; spine: n = 85; age range: 50-79 years) and osteoporotic women (radius: n = 98; spine n = 140; age range: 50-79 years) with at least one "atraumatic" vertebral compression fractu...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02554998
更新日期：1990-04-01 00:00:00
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journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-008-9182-x
更新日期：2008-12-01 00:00:00
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journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF00296343
更新日期：1995-02-01 00:00:00
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journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-015-0074-6
更新日期：2016-02-01 00:00:00
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journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-013-9701-2
更新日期：2013-05-01 00:00:00
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journal_title：Calcified tissue international
pub_type： 杂志文章,评审
doi：10.1007/s00223-015-9956-x
更新日期：2015-03-01 00:00:00
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journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002230050015
更新日期：2000-01-01 00:00:00
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journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-002-0021-1
更新日期：2004-05-01 00:00:00
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journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-008-9159-9
更新日期：2008-09-01 00:00:00
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journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02555167
更新日期：1988-07-01 00:00:00
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journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002230050006
更新日期：2000-01-01 00:00:00
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journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-001-1131-x
更新日期：2003-01-01 00:00:00
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journal_title：Calcified tissue international
pub_type： 杂志文章
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journal_title：Calcified tissue international
pub_type： 杂志文章
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journal_title：Calcified tissue international
pub_type： 杂志文章
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journal_title：Calcified tissue international
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期：2000-10-01 00:00:00
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journal_title：Calcified tissue international
pub_type： 杂志文章
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journal_title：Calcified tissue international
pub_type： 杂志文章
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更新日期：2005-02-01 00:00:00
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journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02556157
更新日期：1991-05-01 00:00:00
abstract：:The primary objective of the present study was to evaluate the impact of physical activity and muscle strength on bone mineral density (BMD) of the tuberositas tibiae in adolescent boys. Two groups with different exercise levels were compared. The high activity group consisted of 20 subjects (age 15.9 +/- 0.3) from a ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02509438
更新日期：1996-06-01 00:00:00
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journal_title：Calcified tissue international
pub_type： 杂志文章
doi：
更新日期：1982-01-01 00:00:00
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journal_title：Calcified tissue international
pub_type： 杂志文章
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更新日期：2020-03-01 00:00:00
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journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF01321835
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