Evaluation of partially demineralized osteoporotic cancellous bone matrix combined with human bone marrow stromal cells for tissue engineering: an in vitro and in vivo study.

abstract：:Targeted disruption of the c-src gene leads to a severe form of osteopetrosis in mice [2]. As the c-src gene is expressed in all tissues and cells tested, we have analyzed fibroblasts from three individuals with malignant, congenital osteopetrosis for the expression of c-src at the protein level. No differences could ...

journal_title：Calcified tissue international

authors： Meyerson G,Dahl N,Påhlman S

更新日期：1993-07-01 00:00:00

abstract：:The definition of osteoporosis was based for several years on bone mineral density values, which were used by most guidelines for defining treatment thresholds. The availability of tools for the estimation of fracture risk, such as FRAX™ or its adapted Italian version, DeFRA, is providing a way to grade osteoporosis s...

journal_title：Calcified tissue international

authors： Adami S,Bertoldo F,Gatti D,Minisola G,Rossini M,Sinigaglia L,Varenna M

更新日期：2013-09-01 00:00:00

abstract：:Irrespective of the method used for noninvasive bone mass determination, data comparison between different centers is a major problem as significant interunit variation may occur. We, therefore, have employed mobile densitometry units to reduce interunit variability in two large epidemiologic studies in Germany. Two c...

journal_title：Calcified tissue international

authors： Wapniarz M,Lehmann R,Randerath O,Baedeker S,John W,Klein K,Allolio B

更新日期：1994-03-01 00:00:00

abstract：:The primary objective of the present study was to evaluate the impact of physical activity and muscle strength on bone mineral density (BMD) of the tuberositas tibiae in adolescent boys. Two groups with different exercise levels were compared. The high activity group consisted of 20 subjects (age 15.9 +/- 0.3) from a ...

journal_title：Calcified tissue international

authors： Nordström P,Nordström G,Thorsen K,Lorentzon R

更新日期：1996-06-01 00:00:00

abstract：:We describe a tall-statured 14-year-old boy who illustrated the full phenotypic and radiographic features of Stickler syndrome type I. A bone biopsy showed evidence of reduced bone mass and bone turnover, such as reduced BV/TV (-43%), TbTh (-29%), and OS/BS (-48%), Ob.S/BS (-27%), and Oc/BS (-47%) compared to "age-mat...

journal_title：Calcified tissue international

authors： Al Kaissi A,Roschger P,Nawrot-Wawrzyniak K,Krebs A,Grill F,Klaushofer K

更新日期：2010-02-01 00:00:00

abstract：:Cortical bone can be modeled as a complex hierarchical composite interrelating both structure and material properties on four levels of structural organization: molecular, ultrastructural, microscopic, and macroscopic. In young animals, the microstructural systems are long parallel lamellar units, plexiform bone, whic...

journal_title：Calcified tissue international

authors： Katz JL,Yoon HS,Lipson S,Maharidge R,Meunier A,Christel P

更新日期：1984-01-01 00:00:00

abstract：:Osteoporosis is commonly associated with estrogen deficiency. However, the mechanisms by which the lack of this hormone causes bone loss are poorly understood. The bone structure of the oral cavity seems to be affected by estrogen deficiency, since a delayed healing process after tooth extraction has been observed aft...

journal_title：Calcified tissue international

authors： Zecchin KG,Pereira MC,Coletta RD,Graner E,Jorge J

更新日期：2005-02-01 00:00:00

abstract：:1,25(OH)2D3 was found to regulate its own receptor levels via an increase in corresponding mRNA levels in human osteoblast-like osteosarcoma cells (MG-63). In addition, exposure of the cells for 24h to dexamethasone, estradiol, retinoic acid, or triiodothyronine resulted in a dose-dependent accumulation of hVDR mRNA. ...

journal_title：Calcified tissue international

authors： Mäenpää P,Mahonen A,Pirskanen A

更新日期：1991-01-01 00:00:00

abstract：:Connective tissue diseases, including osteogenesis imperfecta (OI) and Ehlers-Danlos syndrome (EDS), exhibit a high degree of clinical and genetic heterogeneity. We report two sisters with blue sclerae, joint hypermobility and hearing loss. Whole-exome sequencing identified two compound heterozygous ZNF469 loss-of-fun...

journal_title：Calcified tissue international

authors： Rolvien T,Kornak U,Linke SJ,Amling M,Oheim R

更新日期：2020-09-01 00:00:00

abstract：:The P2X7 nucleotide receptor (P2X7R) is an ATP-gated ion channel expressed in bone cells. Homozygous null P2X7R (P2X7R(-/-)) mice have reduced bone formation, so we hypothesized that P2X7R(-/-) mice have impaired fracture healing compared to P2X7R(+/+) control mice. To test the hypothesis, adult P2X7R(-/-) mice and P2...

journal_title：Calcified tissue international

authors： Li J,Meyer R,Duncan RL,Turner CH

更新日期：2009-05-01 00:00:00

abstract：:Atomic force microscopy (AFM) was used to obtain three-dimensional images of isolated mineralites extracted from young postnatal bovine bone. The mean mineralite size is 9 nm x 6 nm x 2.0 nm, significantly shorter and thicker than the mineralites of mature bovine bone measured by the same technique. Mineralites of the...

journal_title：Calcified tissue international

authors： Tong W,Glimcher MJ,Katz JL,Kuhn L,Eppell SJ

更新日期：2003-05-01 00:00:00

abstract：:The CYP3A7 enzyme metabolizes some steroid hormones, including dehydroepiandrosterone sulfate (DHEAS). The age-related decline of serum DHEAS levels is believed to contribute to osteoporosis. Previously, the CYP3A7*1C polymorphism has been shown to cause a persistent high CYP3A7 enzyme activity, resulting in lower lev...

journal_title：Calcified tissue international

authors： Bácsi K,Kósa JP,Borgulya G,Balla B,Lazáry A,Nagy Z,Horváth C,Speer G,Lakatos P

更新日期：2007-03-01 00:00:00

abstract：:We measured serum concentrations of bone Gla-protein (osteocalcin, BGP) and carboxyterminal propeptide of type I procollagen (PICP) in 14 patients with active acromegaly. Blood was collected at 0800 for measurement of bone Gla-protein (BGP), carboxyterminal propeptide of type I procollagen (PICP), and insulin-like gro...

journal_title：Calcified tissue international

authors： Terzolo M,Piovesan A,Osella G,Pia A,Reimondo G,Pozzi C,Raucci C,Torta M,Paccotti P,Angeli A

更新日期：1993-03-01 00:00:00

abstract：:The purpose of this research was to address the following question: How is the solubility of fluoride-pretreated carbonated apatite (CAP) in aqueous acidic media related to the equilibrium solution fluoride and/or the CAP adsorbed fluoride levels? A CAP sample prepared by a precipitation method at 70 degrees C contain...

journal_title：Calcified tissue international

authors： Barry AB,Zhuang H,Baig AA,Higuchi WI

更新日期：2003-03-01 00:00:00

abstract：:It has recently been demonstrated that calcium ionophore A23187 mimics certain of the effects of parathyroid hormone (PTH) on bone in vitro, including stimulation of 45Ca release and cAMP formation. To further examine the relative effects of these two agents on bone cell metabolism, we compared the effects of syntheti...

journal_title：Calcified tissue international

authors： DeBartolo TF,Pegg LE,Shasserre C,Hahn TJ

更新日期：1982-09-01 00:00:00

abstract：:In order to study in detail the processes leading to the resorption and ankylosis of teeth after trauma, the effects of cold application on the periodontal tissues were studied in the mouse. Liquid nitrogen was applied locally to the outer surface of the lower jaw which resulted in a freezing of the incisor and its su...

journal_title：Calcified tissue international

authors： Wesselink PR,Beertsen W,Everts V

更新日期：1986-07-01 00:00:00

abstract：:The binding of prostaglandin E2 (PGE2) to bone cells was studied to provide direct evidence for the existence of specific receptors in bone. Bone cells were isolated by collagenase digestion of fetal and newborn rat calvaria. Isolated cells were incubated with 3H-PGE2 and collected on Millipore filters. Specific bindi...

journal_title：Calcified tissue international

authors： Dziak RM,Hurd D,Miyasaki KT,Brown M,Weinfeld N,Hausmann E

更新日期：1983-01-01 00:00:00

abstract：:Lumbar spine bone mass and density were measured with Dual photon absorptiometry (DPA) in 60 patients with crush fractures and 60 age-matched normal women. Short-term reproducibility of bone mineral density (BMD) was 1.3% in normal women and 2.5% in osteoporotic women; long-term reproducibility in normal women was 2.2...

journal_title：Calcified tissue international

authors： Pouilles JM,Tremollieres F,Louvet JP,Fournie B,Morlock G,Ribot C

更新日期：1988-12-01 00:00:00

abstract：:Polymorphisms in the region of the gene for the vitamin D receptor (VDR) (chromosome 12q12-14) have been associated with differences in bone mineral density (BMD) in some studies but not in others. Because linkage analysis assesses allele sharing identical-by-descent among relatives instead of the association of a par...

journal_title：Calcified tissue international

authors： Zee RY,Myers RH,Hannan MT,Wilson PW,Ordovas JM,Schaefer EJ,Lindpaintner K,Kiel DP

更新日期：2000-12-01 00:00:00

abstract：:To compare the ability of the bone mineral density (BMD) at the distal forearm, collagen I alpha 1 (COLIA1) polymorphism, and ultrasound stiffness to identify individuals with increased risk of wrist fracture, we studied 183 postmenopausal Czech women with a wrist fracture and 178 postmenopausal controls, ages 45-70 y...

journal_title：Calcified tissue international

authors： Weichetova M,Stepan JJ,Haas T,Michalska D

更新日期：2005-02-01 00:00:00

abstract：:A 69-year-old man became hypocalcemic under medical observation. The hypocalcemia occurred in the presence of circulating immunoreactive parathyroid hormone (PTH). Common causes of secondary hyperparathyroidism were excluded, as was PTH resistance using PTH infusions. The immunoreactive PTH was examined in detail. PTH...

journal_title：Calcified tissue international

authors： McElduff A,Lackmann M,Wilkinson M

更新日期：1992-08-01 00:00:00

abstract：:Pleiotrophin (PTN) was found to have potent effects on regulation of osteoblast recruitment, proliferation and differentiation. The present study examined the long-term effects of targeted PTN over-expression on bone development and repair in a transgenic mouse model. Femurs and tibiae from the PTN transgenic mice and...

journal_title：Calcified tissue international

authors： Li G,Bunn JR,Mushipe MT,He Q,Chen X

更新日期：2005-04-01 00:00:00

abstract：:The effects of 5, 10, and 20% dietary xylitol supplementations on the resorption of bone were studied. The resorption was measured by the urinary excretion of [3H] radioactivity from [3H]tetracycline-prelabeled rats. The 10 and 20% oral xylitol administrations caused a significant decrease in the excretion of [3H] as ...

journal_title：Calcified tissue international

authors： Mattila P,Svanberg M,Knuuttila M

更新日期：1995-03-01 00:00:00

abstract：:Anemia is commonly associated with osteoporosis and sarcopenia in older persons. However, there is a common subset of patients identified as osteosarcopenic at a higher risk of adverse outcomes. Whether these patients are also at a higher risk of anemia remains unknown. In this study, we aimed to compare hemoglobin (H...

journal_title：Calcified tissue international

authors： Bani Hassan E,Vogrin S,Hernandez Viña I,Boersma D,Suriyaarachchi P,Duque G

更新日期：2020-08-01 00:00:00

abstract：:The aim of our study was to compare the results provided by the measurement of vertebral and femoral bone mineral density (BMD) for assessing the individual risk of osteoporosis as defined by either low BMD and/or rapid bone loss. Vertebral and femoral BMD were measured twice at a mean interval of 21 months in 85 norm...

journal_title：Calcified tissue international

authors： Pouilles JM,Tremollieres F,Ribot C

更新日期：1993-05-01 00:00:00

abstract：:In vitro models of osteogenesis are essential for investigating bone biology and the effects of pharmaceutical, chemical, and physical cues on bone formation. Osteogenesis takes place in a complex three-dimensional (3D) environment with cells from both mesenchymal and hematopoietic origins. Existing in vitro models of...

journal_title：Calcified tissue international

authors： Gurkan UA,Kishore V,Condon KW,Bellido TM,Akkus O

更新日期：2011-05-01 00:00:00

abstract：:The low interference with growth expected in child for a cortisol analogue, deflazacort (DFZ), prompted us to verify if DFZ could affect growth less than prednisone (PDN). An interim analysis relative to 27 girls and 38 boys (out of 100 expected) aged 3-12 yrs, after a median period of 14 mo.s is reported. Children wi...

journal_title：Calcified tissue international

authors： Aicardi G,Milani S,Imbimbo B,Vignolo M,Di Battista E,Gusmano R,Terragna A,Cordone G,Cottafava F,Coppo R

更新日期：1991-04-01 00:00:00

abstract：:To evaluate the associations of sarcopenia and previous falls with 2-year major osteoporotic fractures (MOFs) in community-dwelling older adults. Four thousand Chinese men and women ≥ 65 years recruited from Hong Kong communities were prospectively followed up. Measures of muscle mass, grip strength, gait speed and fa...

journal_title：Calcified tissue international

authors： Su Y,Lam FMH,Leung J,Cheung WH,Ho SC,Kwok T

更新日期：2020-08-01 00:00:00

abstract：:Psoriatic arthritis (PsA) is an inflammatory rheumatic disorder that occurs in patients with psoriasis and predominantly affects musculoskeletal structures, skin, and nails. The etiology of PsA is not well understood but evidence supports an interplay of genetic, immunologic, and environmental factors which promote pa...

journal_title：Calcified tissue international

authors： Paine A,Ritchlin C

更新日期：2018-05-01 00:00:00

abstract：:Enhanced osteoclast formation and function is a fundamental cause of alterations to bone structure and plays an important role in several diseases impairing bone quality. Recent work revealed that TRP calcium channels 3 and 6 might play a special role in this context. By analyzing the bone phenotype of TRPC6-deficient...

journal_title：Calcified tissue international

authors： Klein S,Mentrup B,Timmen M,Sherwood J,Lindemann O,Fobker M,Kronenberg D,Pap T,Raschke MJ,Stange R

更新日期：2020-06-01 00:00:00