Abstract:
:The low interference with growth expected in child for a cortisol analogue, deflazacort (DFZ), prompted us to verify if DFZ could affect growth less than prednisone (PDN). An interim analysis relative to 27 girls and 38 boys (out of 100 expected) aged 3-12 yrs, after a median period of 14 mo.s is reported. Children with connective tissues (CTD) and glomerular disorders (KD) were randomly allocated to DFZ or PDN. Anthropometric measurements and maturity ratings were performed. Mean daily doses of PDN (or DFZ equivalent), from 0.57 to 0.64 mg/kg (DFZ 0.92 to 0.94 mg/kg) to induce control and from 0.19 to 0.39 mg/kg (DFZ 0.34 to 0.36 mg/kg) to maintain disease under control were given in CTD and KD, respectively. The increase in bone age delay over time was significantly greater than for PDN (-4.0 mo/yr) than DFZ (-1.8 mo/yr) in the overall group. The increases in statural age delay and loss over time were significantly greater than for PDN (-5.9 and -5.9 mo/yr) than DFZ (-2.4 and -2.4 mo/yr), only in children with "taller" midparents. Although doses of DFZ 1.1-1.8 times those of PDN were given, growth retardation in PDN-treated children was nevertheless 2.3-2.5 times that in DFZ-ones.
journal_name
Calcif Tissue Intjournal_title
Calcified tissue internationalauthors
Aicardi G,Milani S,Imbimbo B,Vignolo M,Di Battista E,Gusmano R,Terragna A,Cordone G,Cottafava F,Coppo Rdoi
10.1007/BF02556381subject
Has Abstract,Author List Incompletepub_date
1991-04-01 00:00:00pages
283-7issue
4eissn
0171-967Xissn
1432-0827journal_volume
48pub_type
临床试验,杂志文章,随机对照试验abstract::Previous observational studies have identified various risk factors associated with the development of osteoporosis, including sex hormone-binding globulin (SHBG). The aim of this study was to determine the potential causal effects of circulating SHBG concentrations on bone mineral density (BMD). Two-sample Mendelian ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-020-00770-8
更新日期:2020-10-17 00:00:00
abstract::Enamel of intact human teeth laser irradiated in vitro under certain conditions is known to have less subsurface demineralization than unirradiated enamel on exposure to acid; consequently, the potential use of laser irradiance to reduce caries is apparent. The laser-induced physical and/or chemical changes that cause...
journal_title:Calcified tissue international
pub_type: 杂志文章,评审
doi:10.1007/BF02556711
更新日期:1986-04-01 00:00:00
abstract::In the past years, several epidemiological and clinical observations have underlined the importance of genetics in the pathogenesis of both female and male osteoporosis. It has been estimated that from 50 to 80% of the inter-individual variability in bone mass is genetically determined. In rare instances, osteoporosis...
journal_title:Calcified tissue international
pub_type: 杂志文章,评审
doi:10.1007/s00223-001-1049-3
更新日期:2001-10-01 00:00:00
abstract::We carried out a clinical trial of 1 alpha-hydroxycholecalciferol [1 alpha(OH)D3] at a dose of 1.0 microgram a day on 7 patients with psoriasis vulgaris. These patients had been treated by topical applications of corticosteroids before this study without improvement, and during the clinical trial, treatment of topical...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02555172
更新日期:1986-12-01 00:00:00
abstract::Bone mineral content (BMC) and bone mineral density (BMD) are common but imperfect surrogate measures of bone strength. The mechanical response tissue analyzer is a device that measures long bone bending stiffness (EI), which strongly predicts bone breaking strength. We hypothesized that isokinetic resistance training...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-009-9247-5
更新日期:2009-06-01 00:00:00
abstract::The peptide hormone calcitonin is a potent inhibitor of osteoclastic resorption, but it is unstable and poorly absorbed following oral administration. Conjugates of salmon calcitonin covalently linked to low-molecular-weight amphiphilic polymers show improved stability and absorption. The purpose of this study was to ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-002-1051-4
更新日期:2003-09-01 00:00:00
abstract::We had shown that aromatic amino acid (phenylalanine, tyrosine, and tryptophan) supplementation prevented bone loss in an aging C57BL/6 mice model. In vivo results from the markers of bone breakdown suggested an inhibition of osteoclastic activity or differentiation. To assess osteoclastic differentiation, we examined...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-014-9878-z
更新日期:2014-08-01 00:00:00
abstract::The crystallinity of bone mineral at different stages of maturation has been measured by quantitative X-ray diffraction methods. Crystallinity measurements were made on tibial mid-diaphyses from 17-day embryonic chicks, newly-formed periosteal bone from embryonic chicks, and density-fractionated bone from post-hatch c...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02405032
更新日期:1983-01-01 00:00:00
abstract::The current study is based on our earlier investigation carried out in 1999, where bone mineral density (BMD) of 35 neurofibromatosis type 1 (NF1) patients was measured and osteoporosis was shown to be common in NF1. The findings have been confirmed by a number of later publications. The purpose of the current longitu...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-012-9661-y
更新日期:2013-01-01 00:00:00
abstract::Ectopic calcification of diseased tissues or around prosthetic implants can lead to serious disability. Therefore, calcification of implants of glutaraldehyde-cross-linked collagenous tissues and reconstituted collagen was compared with mineralization induced by demineralized bone matrix (DBM). Whereas implants of DBM...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02556366
更新日期:1988-05-01 00:00:00
abstract::ELISAs for measuring the urinary excretion of collagen crosslinks and related peptides appear to show marked differences in sensitivity to anti-resorptive therapy. This presumably reflects variations in specificity of the anylate being detected in these assays, and the way in which they respond to treatment. To clarif...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900148
更新日期:1996-11-01 00:00:00
abstract::We conducted a case-control study on fracture risk associated with the use of orally administered prednisolone/prednisone, budesonide, methylprednisolone, and hydrocortisone to assess if the various preparations were associated with different fracture patterns. Cases were all subjects with any fracture sustained durin...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-008-9124-7
更新日期:2008-04-01 00:00:00
abstract::The feasibility of two noninvasive methods [dual photon absorptiometry (DPA) and dual energy X-ray absorptiometry (DXA)] for prediction in vivo of local variations of trabecular bone strength within the proximal tibia was evaluated in 14 cadaveric knees. Trabecular bone strength was measured using an osteopenetrometer...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900131
更新日期:1996-10-01 00:00:00
abstract::The recent advancement of high resolution magnetic resonance imaging has opened up new avenues for the determination of structural characteristics of the trabecular network, which may significantly improve the diagnosis of osteoporosis. An analysis of the calcaneus in healthy women has shown similar age-related change...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002230001168
更新日期:2001-03-01 00:00:00
abstract::Amelogenins are the most abundant secreted proteins in developing dental enamel. These evolutionarily-conserved proteins have important roles in enamel mineral formation, as mutations within the amelogenin gene coding region lead to defects in enamel thickness or mineral structure. Because of extensive alternative spl...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-002-0036-7
更新日期:2003-11-01 00:00:00
abstract::Sarcopenia is now clinically defined as a loss of muscle mass coupled with functional deterioration (either walking speed or distance or grip strength). Based on the FRAX studies suggesting that the questions without bone mineral density can be used to screen for osteoporosis, there is now a valid simple questionnaire...
journal_title:Calcified tissue international
pub_type: 杂志文章,评审
doi:10.1007/s00223-015-0022-5
更新日期:2016-04-01 00:00:00
abstract::Osteoarthritis (OA) is a chronic, debilitating disease affecting millions of people worldwide. Management of OA involves pharmacological and non-pharmacological approaches. Conventional pharmacological treatments have limited efficacy and are associated with a number of side-effects, restricting the number of patients...
journal_title:Calcified tissue international
pub_type: 杂志文章,评审
doi:10.1007/s00223-020-00672-9
更新日期:2020-02-13 00:00:00
abstract::Anemia is commonly associated with osteoporosis and sarcopenia in older persons. However, there is a common subset of patients identified as osteosarcopenic at a higher risk of adverse outcomes. Whether these patients are also at a higher risk of anemia remains unknown. In this study, we aimed to compare hemoglobin (H...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-020-00706-2
更新日期:2020-08-01 00:00:00
abstract::The dentin-enamel junction (DEJ) plays an important role in preventing crack propagation from enamel into dentin. This function stems from its complex structure and materials properties that are different from either dentin or enamel. The molecular structural differences in both mineral and organic matrix across the D...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-008-9212-8
更新日期:2009-03-01 00:00:00
abstract::Cross-sectional and case-control studies are efficient and inexpensive approaches to the study of osteoporosis; their validity depends primarily on how the subjects are sampled. Retrospective studies of fractures may be biased if measurements change as a result of the fracture. Prospective cohort studies are less pron...
journal_title:Calcified tissue international
pub_type: 杂志文章,评审
doi:10.1007/BF02555081
更新日期:1991-01-01 00:00:00
abstract::Prostaglandin E2 and leukotriene B4 are metabolites of arachidonic acid with well-characterized effects on osteoblastic cells. Prostaglandin E2 has been shown to be a potent bone-resorbing agent and to stimulate as well as inhibit osteoblastic cell proliferation. Leukotriene B4 has also been demonstrated to stimulate ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00301636
更新日期:1992-04-01 00:00:00
abstract::Mandibular first molars of 17-day-old mouse embryos were cultured in vitro to examine the histological effects of various concentrations of parathyroid hormone (PTH) on odontogenesis of the molars. PTH did not affect the cytodifferentiation of mesenchymal cells into preodontoblasts but inhibited that of preodontoblast...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02555728
更新日期:1987-01-01 00:00:00
abstract::The developing mandibular condylar growth center consists of a number of histologically distinct cell types. There is an increase in cell volume that takes place from the condylar surface layer through the center of ossification, resulting in a disorganized, irregular cellular pattern. Consequently, the isolation and ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00298747
更新日期:1995-01-01 00:00:00
abstract::Enhanced osteoclast formation and function is a fundamental cause of alterations to bone structure and plays an important role in several diseases impairing bone quality. Recent work revealed that TRP calcium channels 3 and 6 might play a special role in this context. By analyzing the bone phenotype of TRPC6-deficient...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-020-00673-8
更新日期:2020-06-01 00:00:00
abstract::Glucocorticoid-induced osteoporosis has been reported to be caused by enhanced bone resorption and suppressed bone formation. To clarify whether administration of vitamin K, which enhances bone formation, prevents prednisolone-induced loss of bone mineral density (BMD), a randomized, prospective, controlled study was ...
journal_title:Calcified tissue international
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/pl00005832
更新日期:2000-02-01 00:00:00
abstract::Aging is associated with an increase in circulating inflammatory factors. One, the cytokine stromal cell-derived factor 1 (SDF-1 or CXCL12), is critical to stem cell mobilization, migration, and homing as well as to bone marrow stem cell (BMSC), osteoblast, and osteoclast function. SDF-1 has pleiotropic roles in bone ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-017-0245-8
更新日期:2017-06-01 00:00:00
abstract::Considerable advances in oncology over recent decades have led to improved survival, while raising concerns about long-term consequences of anticancer treatments. In patients with breast or prostate malignancies, bone health is a major issue due to the high risk of bone metastases and the frequent prolonged use of hor...
journal_title:Calcified tissue international
pub_type: 杂志文章,评审
doi:10.1007/s00223-017-0369-x
更新日期:2018-02-01 00:00:00
abstract::In 11 postmenopausal women with histologically proven osteoporosis and normal lactose tolerance, a direct correlation between calcium absorption and intestinal lactase activity was observed. The results suggest that varying degrees of relative deficiencies in intestinal lactase might contribute to the graded decrease ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02557688
更新日期:1985-01-01 00:00:00
abstract::Five years ago we reported results from a cross-sectional study of the effect of nutritional factors on calcium-regulating hormones and bone loss in perimenopausal women. We found an inverse correlation between serum 25-hydroxyvitamin D (25OHD) and immunoreactive parathyroid hormone (PTH), and we postulated that over ...
journal_title:Calcified tissue international
pub_type: 临床试验,杂志文章
doi:10.1007/BF00334543
更新日期:1992-09-01 00:00:00
abstract::Postmenopausal osteoporosis induced by estrogen deficiency causes inadequate new bone formation and affects millions of women worldwide. Melatonin can improve bone mineral density at the femoral neck in postmenopausal women with osteopenia. This study aimed to investigate the mechanism of melatonin in estrogen deficie...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-018-0428-y
更新日期:2018-10-01 00:00:00