Abstract:
:We measured serum concentrations of bone Gla-protein (osteocalcin, BGP) and carboxyterminal propeptide of type I procollagen (PICP) in 14 patients with active acromegaly. Blood was collected at 0800 for measurement of bone Gla-protein (BGP), carboxyterminal propeptide of type I procollagen (PICP), and insulin-like growth factor I (IGF-I); growth hormone (GH) was then determined at 15-minute intervals for 3 hours and the integrated mean was calculated. The same protocol was repeated at regular intervals during treatment with the long-acting somatostatin analog, octreotide, 150-450 micrograms/day for 6-33 months (median 15). In a case-control analysis, serum BGP concentrations recorded in the acromegalic patients were significantly elevated (14.2 +/- 4.2 micrograms/liter versus 8.0 +/- 3.3 micrograms/liter, P < 0.001). Octreotide treatment induced a roughly parallel reduction in serum GH, IGF-I, and BGP. We found a significant positive correlation between BGP levels recorded before and during therapy and the logarithm of corresponding mean GH levels (r = 0.67, P < 0.001). Also IGF-I concentrations were positively correlated with BGP (r = 0.66, P < 0.001). On the other hand, PICP levels recorded in the acromegalics did not differ from control subjects (146 +/- 46 micrograms/liter versus 127 +/- 44 micrograms/liter, NS) and no correlation was found between either GH and PICP or IGF-I and PICP. To conclude, the present data are compatible with the view that GH and IGF-I play an important role in the control of BGP but not PICP production. It could be that BGP and PICP are submitted to different hormonal modulation.
journal_name
Calcif Tissue Intjournal_title
Calcified tissue internationalauthors
Terzolo M,Piovesan A,Osella G,Pia A,Reimondo G,Pozzi C,Raucci C,Torta M,Paccotti P,Angeli Adoi
10.1007/BF00298716subject
Has Abstractpub_date
1993-03-01 00:00:00pages
188-91issue
3eissn
0171-967Xissn
1432-0827journal_volume
52pub_type
杂志文章abstract::Syndesmophyte occurrence and axial bone loss were investigated in the heterozygous Tg187 tumor necrosis factor (TNF) transgenic mouse model (Tg-huTNF) of arthritis. Female and male Tg-huTNF mice were compared to wild-type mice (WT) at 2, 4, 6, 8, and 10 weeks. Syndesmophytes, intervertebral disc space, osteoclasts, os...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-017-0237-8
更新日期:2017-06-01 00:00:00
abstract::To compare the ability of the bone mineral density (BMD) at the distal forearm, collagen I alpha 1 (COLIA1) polymorphism, and ultrasound stiffness to identify individuals with increased risk of wrist fracture, we studied 183 postmenopausal Czech women with a wrist fracture and 178 postmenopausal controls, ages 45-70 y...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-004-0134-9
更新日期:2005-02-01 00:00:00
abstract::Human osteoblasts were obtained by migration and proliferation of cells from embryonic membranous bone on glass fragments. Light and electron microscopy analyses revealed a typical osteoblast-like appearance with high protein synthesis activity. The cells showed high alkaline phosphatase activity that was associated w...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00316880
更新日期:1992-11-01 00:00:00
abstract::Until 2006 the only mutations known to cause osteogenesis imperfecta (OI) were in the two genes coding for type I collagen chains. These dominant mutations affecting the expression or primary sequence of collagen α1(I) and α2(I) chains account for over 90% of OI cases. Since then a growing list of mutant genes causing...
journal_title:Calcified tissue international
pub_type: 杂志文章,评审
doi:10.1007/s00223-013-9723-9
更新日期:2013-10-01 00:00:00
abstract::Alkaptonuria (AKU) is characterised by increased circulating homogentisic acid and deposition of ochronotic pigment in collagen-rich connective tissues (ochronosis), stiffening the tissue. This process over many years leads to a painful and severe osteoarthropathy, particularly affecting the cartilage of the spine and...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-020-00764-6
更新日期:2021-02-01 00:00:00
abstract::Bone tissue is a source of growth factors; among them, insulinlike growth factor I (IGF-I) is probably an important local regulator of bone formation. This study has been carried out in order to assess the effects of natural menopause on plasma concentrations of IGF-I in the first 6 years after the cessation of gonada...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF01352006
更新日期:1993-07-01 00:00:00
abstract::Ipriflavone (i.p.) positively affects bone density in postmenopausal osteoporosis, primarily by inhibiting bone resorption. Using in vitro models of human osteoblast differentiation, we have observed that i.p. and some of its metabolites stimulate the expression of bone sialoprotein, decorin, and type I collagen, and ...
journal_title:Calcified tissue international
pub_type: 杂志文章,评审
doi:10.1007/s002239900378
更新日期:1997-01-01 00:00:00
abstract::Osteoclasts are large, multinucleated, terminally differentiated cells formed by the fusion of mononuclear hemopoietic precursors. Their function is the resorption of bone, which is an essential part of the growth, modeling and remodeling of the skeleton. Though some osteoclast differentiation factors have recently be...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-002-2098-y
更新日期:2003-10-01 00:00:00
abstract::The dentin-enamel junction (DEJ) plays an important role in preventing crack propagation from enamel into dentin. This function stems from its complex structure and materials properties that are different from either dentin or enamel. The molecular structural differences in both mineral and organic matrix across the D...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-008-9212-8
更新日期:2009-03-01 00:00:00
abstract::Condylar cartilages were cultured in the form of organ cultures on top of collagen sponges in medium containing 2% fetal calf serum and were treated with 3.5-350 nM insulin for 6 days. Doses of 175 nM of insulin caused a marked increase (+96%) in DNA synthesis and in proteoglycan production (+74%), features that manif...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00296654
更新日期:1993-04-01 00:00:00
abstract::The method of heat-denaturation and trypsin digestion was used to dissect bone biochemically into mineral-protected and mineral-unprotected pools of collagenous matrix. It was found that varying the particle size of the bone powder had a profound effect on the results. Using mature bovine cortical bone, the observed p...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02553750
更新日期:1988-04-01 00:00:00
abstract::Roux-en-Y gastric bypass surgery (RYGB) is an effective treatment of morbid obesity, with positive effects on obesity-related complications. The treatment is associated with bone loss, which in turn might increase fracture risk. The aim of this study was to evaluate changes in bone mineral density (BMD) and bone archi...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-015-0091-5
更新日期:2016-03-01 00:00:00
abstract::The aim of this work was a preliminary assessment of the feasibility of using in vivo measurements of mechanical properties of bones to detect mineral loss and further to relate them to the tendency of the bone to fracture in the case of loss of minerals, such as in osteoporosis. Previous studies of bone strength in v...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00298727
更新日期:1993-03-01 00:00:00
abstract::This study examined bone density among postmenopausal Buddhist nuns and female religious followers of Buddhism in southern Taiwan and related the measurements to subjects characteristics including age, body mass, physical activity, nutrient intake, and vegetarian practice. A total of 258 postmenopausal Taiwanese veget...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/pl00005812
更新日期:1997-03-01 00:00:00
abstract::The existence of nutritional deficiency rickets among infants in sunny Riyadh was confirmed radiologically. Most of the rachitic infants were breast-fed, some received unsupplemented infant feeding formulae, and all live in an environment that is devoid of sunlight. Their mean age at the time of onset was 10.5 months....
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02405328
更新日期:1984-05-01 00:00:00
abstract::Regular exercise and physical activity (PA) are known to be protective factors for maintaining bone mineral density (BMD) and preventing osteoporotic fracture. We investigated the associations between leisure-time PA and BMD in 2,903 premenopausal and 2,267 postmenopausal women in Korea. BMDs of the lumbar spine and f...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-012-9624-3
更新日期:2012-09-01 00:00:00
abstract::Adiponectin, a protein classically known to be secreted by adipocytes, is also secreted by bone-forming cells. Results of previous studies have been contradictory as to whether serum adiponectin and bone mineral density (BMD) are associated. The aim of this study was to investigate a possible association between serum...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-010-9376-x
更新日期:2010-07-01 00:00:00
abstract::Osteoarthritis (OA) is a chronic, debilitating disease affecting millions of people worldwide. Management of OA involves pharmacological and non-pharmacological approaches. Conventional pharmacological treatments have limited efficacy and are associated with a number of side-effects, restricting the number of patients...
journal_title:Calcified tissue international
pub_type: 杂志文章,评审
doi:10.1007/s00223-020-00672-9
更新日期:2020-02-13 00:00:00
abstract::Osteoarthritis (OA), the most prevalent chronic joint disease, increases in prevalence with age, and affects majority of individuals over the age of 65 and is a leading musculoskeletal cause of impaired mobility in the elderly. Because the precise molecular mechanisms which are involved in the degradation of cartilage...
journal_title:Calcified tissue international
pub_type: 杂志文章,评审
doi:10.1007/s00223-014-9917-9
更新日期:2014-12-01 00:00:00
abstract::The CYP3A7 enzyme metabolizes some steroid hormones, including dehydroepiandrosterone sulfate (DHEAS). The age-related decline of serum DHEAS levels is believed to contribute to osteoporosis. Previously, the CYP3A7*1C polymorphism has been shown to cause a persistent high CYP3A7 enzyme activity, resulting in lower lev...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-006-0227-8
更新日期:2007-03-01 00:00:00
abstract::Thyroparathyroidectomized rats fed a diet containing 1.2% calcium, 0.55% phosphorus maintain normal serum levels of these ions. Treatment of such rats with parathyroid extract (PTE; 20 U/100 g twice daily; 10 days) has no statistically significant effect on rates of bone formation, matrix apposition, or osteoid matura...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02408051
更新日期:1979-11-01 00:00:00
abstract::A case-control study was undertaken to understand the etiopathology of the bone deformities among young children in a fluoride-affected village of the Bihar State. Two villages were selected: one village with high fluoride in drinking water (7.9 +/- 4.15 ppm), and the other village with normal levels of fluoride (0.6 ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-005-0233-2
更新日期:2005-06-01 00:00:00
abstract::Regular tennis play is associated with impressive asymmetries in bone strength in favor of the racquet arm, particularly in the humerus. However, the relative effects of service and ground strokes are not known. Serendipitously, we encountered a 46-year-old regular tennis player who has played service and ground strok...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-015-9995-3
更新日期:2015-08-01 00:00:00
abstract::Osteoporosis is a common disease among patients undergoing transplantation. Its prevalence and complications have been well described in solid organ recipients, especially kidney, liver, and heart. However, studies in bone marrow transplantation (BMT) are scarce. Among the mechanisms invoked in the pathogenesis of BMT...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900240
更新日期:1997-04-01 00:00:00
abstract::Osteoporosis is characterized by low bone mass and a deterioration of bone architecture and likely is influenced by genetic factors. The ovariectomized (OVX) mouse is well suited for osteoporosis research, as shown to date by cross-sectional studies. Here, we investigate longitudinal changes by in vivo micro-computed ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-008-9150-5
更新日期:2008-07-01 00:00:00
abstract::A morphological and electron microscopic study of bone from patients with osteogenesis imperfecta (OI) has been performed. Bone from OI patients from various anatomical sites has been compared with that from normal, age-, site-, and sex-matched controls. The morphology of OI bone appeared variable among patients and s...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02526881
更新日期:1996-03-01 00:00:00
abstract::The ultimate hope of researchers and patients is a pathway to development of treatments for osteoarthritis to modify the disease process in addition to the symptoms. However, development of disease modifying drugs requires objective endpoints such as measures of joint structure, joint tissue homeostasis and/or joint s...
journal_title:Calcified tissue international
pub_type: 杂志文章,评审
doi:10.1007/s00223-020-00701-7
更新日期:2020-05-04 00:00:00
abstract::The effect of zinc on in vitro deoxyribonucleic acid (DNA) synthesis activity in the femoral-diaphyseal and metaphyseal tissues of newborn rats was investigated to determine a role of zinc in bone growth. In vitro DNA synthesis was assayed in a reaction mixture containing the 100 g centrifugation supernatant, which in...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-001-2010-1
更新日期:2001-09-01 00:00:00
abstract::The aim of this study was to investigate the effect of transplanted chondrocytes on endochondral bone formation in cartilage repair tissue. In the knee joint of miniature pigs, cartilage lesions were treated by microfracturing and were then either left empty, covered with a collagen membrane, or treated by matrix-asso...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-009-9288-9
更新日期:2009-11-01 00:00:00
abstract::The purpose of the present work was to investigate the appearance of ossification centers in human femur by Dual-energy X-ray Absorptiometry (DXA), comparing densitometric data with morphogenetic events. Posteroanterior scans were performed on 31 dried femora (from 11.5 weeks of conceptual age to 1 year of postnatal l...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/pl00005841
更新日期:2000-04-01 00:00:00