Abstract:
:The primary objective of the present study was to evaluate the impact of physical activity and muscle strength on bone mineral density (BMD) of the tuberositas tibiae in adolescent boys. Two groups with different exercise levels were compared. The high activity group consisted of 20 subjects (age 15.9 +/- 0.3) from a junior ice hockey team. The reference group consisted of 24 volunteers (age 15.9 +/- 0.3) not training for more than 3 hours per week. The groups were matched for age, weight, and pubertal stage. BMDs (g/cm2) of the tuberositas tibiae and proximal tibia were measured using dual energy X-ray absorptiometry. Quadriceps strength was significantly higher in the high activity group (P < 0.01). Univariate correlations were measured between tuberositas tibiae BMD and pubertal stage, weight, height, BMI, fat mass, lean body mass, quadriceps strength, and hamstrings strength in the high activity group and the reference group, respectively. Quadriceps strength was estimated to be the best significant predictor of BMD of the tuberositas tibiae in the reference group. A multivariate analysis confirmed this result. In the high activity group, there was no significant predictor of BMD of the tuberositas tibiae. There was no significant difference in BMD at this site when comparing the two groups. However, five of the boys in the high activity group had a former history of Mb Osgood-Schlatter with a significantly lower BMD of the tuberositas tibiae than the rest of the boys in that group. After exclusion of these boys, the remaining 15 boys were matched against 20 boys from the reference group using the previous criteria. These 15 boys then showed a significantly higher BMD of the tuberositas tibiae (P < 0.05) but not of the proximal tibia than the 20 boys in the reference group. In conclusion, this study demonstrates site-specific increments of tuberositas tibiae BMD in adolescent ice hockey players unless they are affected by the negative effects on BMD by Mb Osgood-Schlatter. These increments seem primarily to be associated with forceful muscle contractions related to high quadriceps strength and not greater weight-bearing loading. Muscle strength seems to positively affect BMD of the tuberositas tibiae in adolescents, but only up to a certain level, above which additional muscle strength has no effect.
journal_name
Calcif Tissue Intjournal_title
Calcified tissue internationalauthors
Nordström P,Nordström G,Thorsen K,Lorentzon Rdoi
10.1007/BF02509438subject
Has Abstractpub_date
1996-06-01 00:00:00pages
402-8issue
6eissn
0171-967Xissn
1432-0827journal_volume
58pub_type
杂志文章abstract::The small proteoglycan decorin had been localized previously at the d-band in the gap zone of collagen fibrils in nonmineralizing tissues. In bone matrix this zone is proteoglycan free and is at least in some species the place where mineralization along collagen fibrils starts. To study the metabolism of the small pro...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900279
更新日期:1997-06-01 00:00:00
abstract::Vitamin D supplementation is recommended for women with osteoporosis. In the FOCUS-D trial comparing the combination tablet alendronate plus vitamin D3 5,600 IU (ALN/D) with standard care (SC) prescribed by patients' personal physicians, ALN/D was more effective in improving serum 25(OH)D and bone turnover markers by ...
journal_title:Calcified tissue international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00223-013-9763-1
更新日期:2014-02-01 00:00:00
abstract::ELISAs for measuring the urinary excretion of collagen crosslinks and related peptides appear to show marked differences in sensitivity to anti-resorptive therapy. This presumably reflects variations in specificity of the anylate being detected in these assays, and the way in which they respond to treatment. To clarif...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900148
更新日期:1996-11-01 00:00:00
abstract::Orthopaedic wear debris induces release of bone-resorbing factors from macrophages and fibroblasts. However, the extent to which elemental metallic particles induce bone cells to express factors contributing to implant loosening remains unclear. This study showed that exposure of MG-63 osteoblast-like cells to titaniu...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223001125
更新日期:2000-08-01 00:00:00
abstract::We compared indices of three-dimensional microstructure of iliac trabecular bone between 26 patients with vertebral compression fractures due to postmenopausal osteoporosis and 24 control subjects without vertebral fracture, who were matched for age, sex, race, menopausal status, and several densitometric and histolog...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02554913
更新日期:1985-12-01 00:00:00
abstract::The effects of a series of novel phosphonates on the kinetics of mineral development in an ionophore-primed 7:2:1 phosphatidylcholine (PC): dicetylphosphate (DCP): cholesterol (Chol) liposomal model system are reported. When present at 2.5 micromol/liter or 25 micromol/liter concentrations in the solution surrounding ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02509384
更新日期:1996-05-01 00:00:00
abstract::It is our hypothesis that interstitial fluid flow plays a role in the bone remodeling response to mechanical loading. The fluid flow-induced expression of three proteins (collagen, osteopontin, and alkaline phosphatase) involved in bone remodeling was investigated. Rat calvarial osteoblasts subjected to pulsatile flui...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900185
更新日期:1997-01-01 00:00:00
abstract::There is considerable interest in determining whether hypergravity can be used as a countermeasure for microgravity-induced bone loss. This study was conducted on 20 immature male rats in order to investigate possible elastic adaptations of cortical bone in rapidly growing rats exposed to chronic hypergravity. Ten rat...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900111
更新日期:1996-09-01 00:00:00
abstract::Methotrexate (MTX) is one of the most commonly prescribed drugs for autoimmune rheumatic diseases. As there is no consensus on its negative effects on bone, the purpose of this investigation was to determine the clinical spectrum of patients with stress fractures due to long-term MTX treatment (i.e., MTX osteopathy). ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-020-00765-5
更新日期:2021-02-01 00:00:00
abstract::Sarcopenia and osteoporosis are two sides of the same coin. They represent different aspects of the same age-related process of musculoskeletal atrophy and together culminate in falls, fractures, deconditioning, and increased mortality in older individuals. However, the current therapeutic approach to the prevention o...
journal_title:Calcified tissue international
pub_type: 杂志文章,评审
doi:10.1007/s00223-015-9956-x
更新日期:2015-03-01 00:00:00
abstract::Osteoporosis is characterized by low bone mass and a deterioration of bone architecture and likely is influenced by genetic factors. The ovariectomized (OVX) mouse is well suited for osteoporosis research, as shown to date by cross-sectional studies. Here, we investigate longitudinal changes by in vivo micro-computed ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-008-9150-5
更新日期:2008-07-01 00:00:00
abstract::In the past years, several epidemiological and clinical observations have underlined the importance of genetics in the pathogenesis of both female and male osteoporosis. It has been estimated that from 50 to 80% of the inter-individual variability in bone mass is genetically determined. In rare instances, osteoporosis...
journal_title:Calcified tissue international
pub_type: 杂志文章,评审
doi:10.1007/s00223-001-1049-3
更新日期:2001-10-01 00:00:00
abstract::Aging bone shows a progressive decline in mass and strength. Previous studies have suggested that bone marrow stem cells are reduced with aging and that this could be responsible, in part, for age-associated bone deficits. We measured the number of osteoprogenitor cells present in the bone marrow from adult and aged r...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00296343
更新日期:1995-02-01 00:00:00
abstract::Bone involvement, mainly osteoporosis but also osteosclerosis, is frequent in patients with indolent systemic mastocytosis (ISM). The recent characterization of the canonical Wnt/β-catenin pathway in the regulation of bone remodeling provided important insights for our understanding of the pathophysiology of a number ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-015-9969-5
更新日期:2015-05-01 00:00:00
abstract::The purpose of the present study was to determine if the type of dietary fat can modify the fatty acid composition and arachidonic acid levels in the alveolar bone phospholipids. Three groups of rats were fed nutritionally adequate semipurified diets containing different lipids: 10% corn oil (control, group I, rich in...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF01351838
更新日期:1993-11-01 00:00:00
abstract::Increased bone loss has been noted in lymphoma patients; however, the incidence of hip fracture is not known. The aim of our study was to explore the risk for hip fracture in patients with lymphoma compared with the entire Swedish population. The risk of hip fracture was determined in a retrospective population cohort...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-020-00674-7
更新日期:2020-06-01 00:00:00
abstract::To investigate the effect of low doses of intranasal salmon calcitonin on plasma cyclic AMP (cAMP) and serum ionized calcium, 40 healthy postmenopausal women were randomized to receive a single dose of either placebo or 50, 100, or 200 IU of salmon calcitonin as a nasal spray. Blood samples were collected throughout a...
journal_title:Calcified tissue international
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02555817
更新日期:1990-01-01 00:00:00
abstract::KH1060 is a new 20-epi-vitamin D3 analog, which has exerted a considerable immunosuppressive potency in vitro. We have tested in vivo the effect of KH1060 on the suppression of renal allograft rejection in the rat. Allogenic kidney transplantation from DA donor rats to Lewis recipient rats treated intraperitoneally wi...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00296066
更新日期:1994-02-01 00:00:00
abstract::We studied the influence of age, gender, latitude, season, diet and ethnicity on plasma 25-hydroxyvitamin D 25 OHD, PTH, 1,25-dihydroxyvitamin D, vitamin D-binding protein, bone-specific alkaline phosphatase, and osteocalcin levels in 46 Greenlanders living in Nuuk (64 degrees N) on a traditional fare (group A), 45 Gr...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-003-0110-9
更新日期:2004-03-01 00:00:00
abstract::Effects of a single dose of 200 IU of nasal salmon calcitonin (SCT) on calcium metabolism and biochemical markers of bone turnover were investigated in 12 healthy male volunteers in a randomized, placebo-controlled, cross-over design. The nasal spray was given in the morning, and subsequently blood and urine samples w...
journal_title:Calcified tissue international
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF01320907
更新日期:1993-10-01 00:00:00
abstract::Bone involvement is one of the most disabling aspects of type I Gaucher disease and its pathophysiology is still not well understood. As an invasive procedure, bone biopsies are not appropriate in a large population study. The development of sensitive bone resorption and formation tests have allowed the authors to stu...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-001-2072-0
更新日期:2003-03-01 00:00:00
abstract::Until 2006 the only mutations known to cause osteogenesis imperfecta (OI) were in the two genes coding for type I collagen chains. These dominant mutations affecting the expression or primary sequence of collagen α1(I) and α2(I) chains account for over 90% of OI cases. Since then a growing list of mutant genes causing...
journal_title:Calcified tissue international
pub_type: 杂志文章,评审
doi:10.1007/s00223-013-9723-9
更新日期:2013-10-01 00:00:00
abstract::Atomic force microscopy (AFM) was used to obtain three-dimensional images of isolated mineralites extracted from young postnatal bovine bone. The mean mineralite size is 9 nm x 6 nm x 2.0 nm, significantly shorter and thicker than the mineralites of mature bovine bone measured by the same technique. Mineralites of the...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-002-1077-7
更新日期:2003-05-01 00:00:00
abstract::Compressive strength index (CSI) of the femoral neck is a parameter that integrates the information of bone mineral density (BMD), femoral neck width (FNW), and body weight. CSI is considered to have the potential to improve the performance of assessment for hip fracture risk. However, studies on CSI have been rare. I...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-010-9406-8
更新日期:2010-10-01 00:00:00
abstract::The ability of 1,25(OH)2D3 and of 24,25(OH)2D3 to prevent or to heal rickets in chicks was evaluated by studies of plasma biochemistry, growth plate histology, bone morphometry and microradiography, and bone mineralization. 1,25(OH)2D3 at a dose of 100 ng/day produced fewest abnormalities compared with vitamin D3-trea...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02405303
更新日期:1984-01-01 00:00:00
abstract::In the rat, prolonged administration of the luteinizing, hormone-releasing hormone agonist buserelin (25 micrograms/kg body wt/day s.c.) lowers blood estradiol, raises bone resorption, and induces osteopenia. The present study was undertaken to determine whether withdrawal of buserelin normalizes blood estradiol, slow...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02555819
更新日期:1990-01-01 00:00:00
abstract::Extracellular ATP, and to a lesser extent adenosine, an ATP metabolite, stimulated cell proliferation in osteoblast-like cells (MC3T3-E1). ATP increased cytosolic Ca2+ due to Ca2+ mobilization from intracellular storage in the same concentration range of the nucleotide as that effective for DNA synthesis, suggesting t...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02529732
更新日期:1996-02-01 00:00:00
abstract::In order to study in detail the processes leading to the resorption and ankylosis of teeth after trauma, the effects of cold application on the periodontal tissues were studied in the mouse. Liquid nitrogen was applied locally to the outer surface of the lower jaw which resulted in a freezing of the incisor and its su...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02555735
更新日期:1986-07-01 00:00:00
abstract::Ribbon-like crystals, from developing enamel of human fetuses, were studied by high resolution electron microscopy. These crystals were classically described as the first organized mineral formed during amelogenesis. They were characterized by a mean width-to-thickness ratio (W.T-1) of 9.5, and 40% were bent. On latti...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00334485
更新日期:1992-10-01 00:00:00
abstract::We studied the most complete skeletons found in an excavation from the 14th and 15th century in central Stockholm. One hundred eighty-seven were from men and 156 from women: 241 individuals were estimated to be between 20 and 39 and 102 between 40 and 59 years old at death. We examined the bones radiographically and b...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00301601
更新日期:1995-05-01 00:00:00