Abstract：
:The effects of a series of novel phosphonates on the kinetics of mineral development in an ionophore-primed 7:2:1 phosphatidylcholine (PC): dicetylphosphate (DCP): cholesterol (Chol) liposomal model system are reported. When present at 2.5 micromol/liter or 25 micromol/liter concentrations in the solution surrounding the liposomes, the investigated phosphonates did not significantly delay the initial formation of hydroxyapatite-like calcium phosphate salts (HAP) within the liposomes or the penetration of HAP crystals through the enclosing membranes. However, the phosphonates variably retarded the subsequent growth and proliferation of the HAP crystals once they became directly exposed to the phosphonate-containing solution. The effectiveness of phosphonates in inhibiting extraliposomal precipitation strongly depended on their structure. The inhibitory action on active surface growth sites of released intraliposomal crystals was found to be the most effective if the phosphonate molecule contained two phosphonic groups linked to the same C atom. At a phosphonate concentration of 25 micromol/liter, the following general order of effectiveness was established: geminal bisphosphonate >/= geminal tetrakisphosphonate > bisacylphosphonates > monoacylphosphonate > bisalkylphosphonate. Within the bisacylphosphonate family, the highest inhibitory action was observed when four or five -CH2- groups separated the ketophosphonic groups.
journal_name
Calcif Tissue Intjournal_title
Calcified tissue internationalauthors
Skrtic D,Eidelman N,Golomb G,Breuer E,Eanes EDdoi
10.1007/BF02509384subject
Has Abstractpub_date
1996-05-01 00:00:00pages
347-54issue
5eissn
0171-967Xissn
1432-0827journal_volume
58pub_type
杂志文章abstract：:Administration of active vitamin D sterols to treat secondary hyperparathyroidism in patients with chronic kidney disease receiving dialysis has been associated with elevated serum calcium and phosphorus levels, which may lead to increased risk of vascular calcification. However, calcimimetics, by binding to the parat...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-006-0126-z
更新日期：2006-12-01 00:00:00
abstract：:Synovial fluid basic calcium phosphate (BCP) crystals are associated with severe destructive arthropathy. BCP crystals induce the secretion of matrix-degrading enzymes such as collagenase. No prophylactic or therapeutic agents are recognized to ameliorate the cartilage damage associated with BCP deposits in joints. As...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF00571332
更新日期：1993-06-01 00:00:00
abstract：:Sarcopenia and osteoporosis are two sides of the same coin. They represent different aspects of the same age-related process of musculoskeletal atrophy and together culminate in falls, fractures, deconditioning, and increased mortality in older individuals. However, the current therapeutic approach to the prevention o...
journal_title：Calcified tissue international
pub_type： 杂志文章,评审
doi：10.1007/s00223-015-9956-x
更新日期：2015-03-01 00:00:00
abstract：:Arterial calcification leading to increased arterial stiffness, a powerful risk factor for cardiovascular disease, may underlie the association of osteoporosis with cardiovascular disease in postmenopausal women. Osteoprotegerin (OPG), an indirect inhibitor of osteoclastogenesis, may be involved in arterial calcificat...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-008-9153-2
更新日期：2008-08-01 00:00:00
abstract：:Bone mineral content (BMC) and bone mineral density (BMD) are common but imperfect surrogate measures of bone strength. The mechanical response tissue analyzer is a device that measures long bone bending stiffness (EI), which strongly predicts bone breaking strength. We hypothesized that isokinetic resistance training...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-009-9247-5
更新日期：2009-06-01 00:00:00
abstract：:Plasma membrane vesicles were prepared from chicken osteoclasts, and active calcium transport was demonstrated in a spectrofluorimetric assay using the fluorescent calcium concentration indicator, fura-2. Transport activity was inhibited by quercetin (10 microM), sodium vanadate (10 microM), and the anticalmodulin age...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF00334493
更新日期：1992-10-01 00:00:00
abstract：:A 56 year-old man with a 2-year history of transitional-cell carcinoma of the urinary bladder presented with back pain and diffuse radiological osteosclerosis. Laboratory studies revealed borderline-low ionized serum calcium, and markedly elevated serum alkaline phosphatase (ALP) activity and serum osteocalcin. Serum ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900560
更新日期：1998-12-01 00:00:00
abstract：:Whole enamel scrapings from unerupted teeth of embryonic calves have been separated into fractions of varying density by stepwise centrifugation in bromoform-toluene mixtures of increasing specific gravity. Partition of enamel in this manner yields individual fractions of increasing mineral phase age and maturation. W...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02405006
更新日期：1983-01-01 00:00:00
abstract：:A strategy based on high pressure liquid chromatography (HPLC) techniques for the isolation or a principal amelogenin molecule from a single human dentition is described. A partial sequence (33 residues) for this 24 kDa amelogenin is presented and related to earlier studies of human 5 kDa tyrosine-rich amelogenin poly...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02555993
更新日期：1990-08-01 00:00:00
abstract：:We studied the epidemiology of osteoporotic fractures of the proximal femur (cervical and trochanteric fractures) in residents of Barcelona, aged 45 years or over, for a 1-year period. Fractures resulting from metastases were not included. During the period of observation, a total of 1,358 patients with hip fractures ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02555965
更新日期：1989-06-01 00:00:00
abstract：:Fracture healing is a natural process that recapitulates embryonic skeletal development. In the early phase after fracture, reactive oxygen species (ROS) are produced under inflammatory and ischemic conditions due to vessel injury and soft tissue damage, leading to cell death. Usually, such damage during the course of...
journal_title：Calcified tissue international
pub_type： 杂志文章,评审
doi：10.1007/s00223-019-00576-3
更新日期：2019-10-01 00:00:00
abstract：:Parathyroid hormone (PTH), hPTH-(1-84), and its hPTH-(1-34), hPTH-(1-31)NH2, and hPTH-(1-30)NH2 fragments reduced the tail artery pressure in anesthetized female Sprague-Dawley rats by 42.4-67.1% within about 1 minute after injection into a femoral vein, but reduced the pressure by only 8.5-36.2% 2-19 minutes after su...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900233
更新日期：1997-03-01 00:00:00
abstract：:The goals of internal fixation are an accurate reduction and stable fixation in the presence of adequate bony vascularity. This can be achieved by a variety of means including plate fixation. A certain amount of periosteal stripping is necessary for proper open reduction of a fracture and for proper plate application....
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900080
更新日期：1996-07-01 00:00:00
abstract：:Our objective was to assess the effects of HIV infection and antiretroviral therapy on trabecular and cortical microarchitecture in postmenopausal minority women. A subgroup of 106 (46 HIV-infected, 60 uninfected) postmenopausal Hispanic and African American women from an established cohort had areal bone mineral dens...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-013-9716-8
更新日期：2013-06-01 00:00:00
abstract：:Relapse after orthodontic tooth movement is a significant problem in orthodontics. The purpose of this study was to examine the efficacy of the osteoclast inhibitor osteoprotegerin-Fc (OPG-Fc) for inhibiting postorthodontic relapse. Rat maxillary molars were moved mesially and allowed to relapse for 24 days. Low-dose ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-012-9579-4
更新日期：2012-04-01 00:00:00
abstract：:The objective of this study was to compare the bone mineral density (BMD) of men with Down syndrome (DS) to otherwise mentally retarded (MR) men and to investigate whether leg muscle strength of these patients is related to BMD. Two groups with MR (with and without DS) participated in the study, having met the followi...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002230010035
更新日期：2000-03-01 00:00:00
abstract：:This report describes a method using direct photon absorptiometry (DPA) for determination in vivo of the bone mineral content to bone width ratio (BMC/W) in the rat femur. A significant correlation was noted between measurements by DPA and whole femur dry weight and ash weight. Measurements were reproducible within re...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02409496
更新日期：1981-01-01 00:00:00
abstract：:The extractions of 85Sr2+, 18F-, sucrose-14C, EDTA-51Cr, and antipyrine-14C in bone were determined by the multiple indicator-dilution method. Fluoride and strontium extractions were 18 to 70% during a single transcapillary passage, and those of EDTA and sucrose were from 11 to 59%, whereas extraction of antipyrine wa...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02407178
更新日期：1980-01-01 00:00:00
abstract：:Gallium nitrate (GaN) reduces cancer-related hypercalcemia and inhibits bone resorption in vitro. This study investigated the effects of chronic GaN administration on bone, kidney, and parathyroid gland activity of growing rats. Experimental animals received GaN (1.75 mg elemental gallium i.p. QOD X 8, Ga+), and contr...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02555260
更新日期：1987-05-01 00:00:00
abstract：:The effect of SrCl(2) treatment on bone nanostructure in a rat ovariectomy model was studied using scanning small-angle X-ray scattering (sSAXS). Twelve 6-month-old female Wistar rats were used. Six animals were ovariectomized (+ovx) and six were left intact after sham surgery (-ovx). Six animals, three +ovx and three...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-010-9341-8
更新日期：2010-04-01 00:00:00
abstract：:The aim of this study was to follow the changes in bone mineral density (BMD) and biochemical markers of bone turnover in 10 children (7.5-17.5 years of age) with severe juvenile idiopathic arthritis (JIA), during a 3-year therapy with salmon calcitonin (100 IU/day 2 months on and 2 off for a year and 200 IU/day for 2...
journal_title：Calcified tissue international
pub_type： 临床试验,杂志文章
doi：10.1007/s00223-001-0008-3
更新日期：2001-07-01 00:00:00
abstract：:This study sought to confirm that osteoblasts of C3H/HeJ (C3H) mice, which have higher differentiation status and bone-forming ability compared to C57BL/6J (B6) osteoblasts, also have a lower apoptosis level and to test whether the higher differentiation status and bone-forming ability of C3H osteoblasts were related ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-005-0303-5
更新日期：2006-05-01 00:00:00
abstract：:The diphosphonates dichloromethanediphosphonate (Cl2MDP) and to a minor degree 1-hydroxyethane-1,1-diphosphonate (EDHP) increased the glycogen content in cultured cartilage cells of rabbit ear. This effect was not due to different concentrations of glucose in the medium. ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02408621
更新日期：1980-01-01 00:00:00
abstract：:The small proteoglycan decorin had been localized previously at the d-band in the gap zone of collagen fibrils in nonmineralizing tissues. In bone matrix this zone is proteoglycan free and is at least in some species the place where mineralization along collagen fibrils starts. To study the metabolism of the small pro...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900279
更新日期：1997-06-01 00:00:00
abstract：:Biochemical markers applicable to the ovariectomized rat model can provide important tools for studying the bone remodeling process in this animal model of postmenopausal osteoporosis. We describe the development and application of two biochemical markers, a C-telopeptide (of type-I collagen) enzyme-linked immunosorbe...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002230010088
更新日期：2000-06-01 00:00:00
abstract：:Osseous tissue develops via two distinctly different processes: endochondral (EC) ossification and intramembranous (IM) ossification. The present study tests the hypothesis that each type of osseous tissue contains unique inducing factors for the promotion of cartilage and bone development. Previous work suggests that...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02556258
更新日期：1991-11-01 00:00:00
abstract：:The relationship between bisphosphonate-induced bone mineral density (BMD) gains and antifracture efficacy remains to be fully elucidated. Data from two antifracture studies were analyzed. Postmenopausal osteoporotic women received oral (2.5 mg daily, 20 mg intermittent) or intravenous (0.5 mg, 1 mg quarterly) ibandro...
journal_title：Calcified tissue international
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00223-010-9403-y
更新日期：2010-10-01 00:00:00
abstract：:High impact loading is known to prevent some of the age-related bone loss but its effects on the density distribution of cortical bone are relatively unknown. This study examined the effects of age and habitual sprinting on tibial and fibular mid-shaft bone traits (structural, cortical radial and polar bone mineral de...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-014-9881-4
更新日期：2014-08-01 00:00:00
abstract：:The aim of this study was to test whether the nitric oxide (NO) donor sodium nitroprusside (SNP) has an effect on mineralization in ATDC5 cells. Mineralization in ATDC5 cell culture was induced by addition of beta-glycerophosphate or inorganic phosphate, visualized by staining precipitated calcium with an alizarin red...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-005-1233-y
更新日期：2006-03-01 00:00:00
abstract：:N-acetyl-beta-D-glucosaminidase (NAG) is a lysosomal enzyme predominantly located in renal proximal tubules. In idiopathic hypoparathyroidism (IHP), 100 Units of human PTH (1-34) increased urinary excretion of NAG from 0.029 +/- 0.027 to 0.173 +/- 0.035 U/lGF (p less than 0.05) in two patients before treatment and fro...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02556010
更新日期：1989-12-01 00:00:00
