Abstract：
:Relapse after orthodontic tooth movement is a significant problem in orthodontics. The purpose of this study was to examine the efficacy of the osteoclast inhibitor osteoprotegerin-Fc (OPG-Fc) for inhibiting postorthodontic relapse. Rat maxillary molars were moved mesially and allowed to relapse for 24 days. Low-dose (1 mg/kg) or high-dose (5 mg/kg) OPG-Fc or saline was injected adjacent to the molars during relapse. Tooth movement, micro-CT, histologic bone quality, and serum OPG and TRAP-5b were measured. OPG-Fc injections significantly diminished postorthodontic relapse from 63% (0.78/1.20 mm) of total movement in vehicle control rats to 31% (0.31/1.00 mm) in low-dose and 24% (0.28/1.16 mm) in high-dose OPG-Fc groups 24 days after appliance removal. Normalization of bone and periodontal tissues occurred as early as 8 and 16 days in the high- and low-dose OPG-Fc-treated groups, respectively, while the vehicle-treated group showed only partial tissue recovery 24 days following tooth movement. After 24 days of relapse, there was complete recovery to pre-tooth-movement values for bone volume fraction (BVF) and tissue mineral density (TMD) in both the low- and high-dose OPG-Fc groups, while BVF recovered only partially and TMD did not recover in the vehicle control group. Greatly elevated serum OPG levels and reduced serum TRAP-5b levels in OPG-Fc-treated animals indicated systemic exposure to locally injected drug. The profound decrease in postorthodontic relapse by local OPG-Fc administration indicates that osteoclasts are critical to bone maturation following tooth movement and points to the potential pharmacologic use of OPG-Fc or other RANKL inhibitors for orthodontic retention.
journal_name
Calcif Tissue Intjournal_title
Calcified tissue internationalauthors
Hudson JB,Hatch N,Hayami T,Shin JM,Stolina M,Kostenuik PJ,Kapila Sdoi
10.1007/s00223-012-9579-4subject
Has Abstractpub_date
2012-04-01 00:00:00pages
330-42issue
4eissn
0171-967Xissn
1432-0827journal_volume
90pub_type
杂志文章abstract：:The purpose of this study was to use the concept of metastable equilibrium solubility (MES) to describe the anomalous solubility behavior of carbonated apatite (CAP) in the presence of solution strontium. A CAP sample (4.8 wt% CO(3), synthesized at 70 degrees C) was prepared by precipitation. Baseline MES distribution...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-002-0035-8
更新日期：2004-01-01 00:00:00
abstract：:The relationship between oral indicators and bone mineral density (BMD) has been studied by many investigators, with mixed and complex results. The purpose of the present cross-sectional study was to evaluate the associations of periodontal conditions and tooth loss with metacarpal BMD (m-BMD) in a community-based coh...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-004-0275-x
更新日期：2005-07-01 00:00:00
abstract：:Micro-computed tomography (microCT) has become a standard tool for the evaluation of bone morphology in preclinical studies. Unfortunately, the user-dependent definition of contour lines that separate trabecular from cortical bone is not only extremely time-consuming but may also represent a source of data bias and in...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-007-9063-8
更新日期：2007-10-01 00:00:00
abstract：:The calcium ion binding properties of a high molecular weight bovine phosphophoryn preparation have been studied at high ionic strength (0.5 M KCl as supporting electrolyte). Surprisingly, even under these conditions at which intermolecular ionic interactions are effectively screened, phosphophoryn was capable of bind...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02555712
更新日期：1987-02-01 00:00:00
abstract：:Thyroparathyroidectomized rats fed a diet containing 1.2% calcium, 0.55% phosphorus maintain normal serum levels of these ions. Treatment of such rats with parathyroid extract (PTE; 20 U/100 g twice daily; 10 days) has no statistically significant effect on rates of bone formation, matrix apposition, or osteoid matura...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02408051
更新日期：1979-11-01 00:00:00
abstract：:Cross-sectional and case-control studies are efficient and inexpensive approaches to the study of osteoporosis; their validity depends primarily on how the subjects are sampled. Retrospective studies of fractures may be biased if measurements change as a result of the fracture. Prospective cohort studies are less pron...
journal_title：Calcified tissue international
pub_type： 杂志文章,评审
doi：10.1007/BF02555081
更新日期：1991-01-01 00:00:00
abstract：:A strategy based on high pressure liquid chromatography (HPLC) techniques for the isolation or a principal amelogenin molecule from a single human dentition is described. A partial sequence (33 residues) for this 24 kDa amelogenin is presented and related to earlier studies of human 5 kDa tyrosine-rich amelogenin poly...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02555993
更新日期：1990-08-01 00:00:00
abstract：:Using a histochemical method for demonstrating acid phosphatase activity, we have studied osteoclasts residing at two different bone sites in rat incisor alveolar bone, one at the endosteum and the other at the tooth socket, and compared the response of these osteoclasts to systemic changes. After 12 days of calcium (...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02405315
更新日期：1984-03-01 00:00:00
abstract：:Insulin is a potent stimulator of collagen synthesis and other osteoblastic cell functions. In various insulin-sensitive tissues, stimulation of glucose transport and glycolytic metabolism are hallmarks of insulin action and may play a role in insulin regulation of cellular function. However, the effects of insulin on...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02556657
更新日期：1989-07-01 00:00:00
abstract：:Doses of 8, 16 (low), 32, 48, 64 (medium), and 150 (high) mg/kg/day of cortisol were administered to groups of 8 growing rats each during 16 days, and their femurs were then submitted to 3-point bending tests at low strain rate. Low doses had no effect. Medium doses, previously shown to improve calcium (Ca) balance an...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF00297297
更新日期：1992-01-01 00:00:00
abstract：:Postmenopausal osteoporosis induced by estrogen deficiency causes inadequate new bone formation and affects millions of women worldwide. Melatonin can improve bone mineral density at the femoral neck in postmenopausal women with osteopenia. This study aimed to investigate the mechanism of melatonin in estrogen deficie...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-018-0428-y
更新日期：2018-10-01 00:00:00
abstract：:In order to determine whether the bacterial bone resorbing agents lipopolysaccharide (LPS) and muramyl dipeptide (MDP) interact with osteoblasts, their effect on the synthesis of collagenase and tissue inhibitor or metalloproteinases (TIMP) from monolayer cultures of mouse osteoblast-like cells was investigated. All c...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02556318
更新日期：1989-05-01 00:00:00
abstract：:Bone involvement is one of the most disabling aspects of type I Gaucher disease and its pathophysiology is still not well understood. As an invasive procedure, bone biopsies are not appropriate in a large population study. The development of sensitive bone resorption and formation tests have allowed the authors to stu...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-001-2072-0
更新日期：2003-03-01 00:00:00
abstract：:High resolution transmission electron microscopy (Hr TEM) studies on biological and synthetic calcium phosphate have provided information on the dissolution process at the crystal level. The purpose of this study was to investigate the dissolution of ceramic hydroxyapatite (HA) after implantation using Hr TEM. Recover...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02561408
更新日期：1989-08-01 00:00:00
abstract：:This report describes a method using direct photon absorptiometry (DPA) for determination in vivo of the bone mineral content to bone width ratio (BMC/W) in the rat femur. A significant correlation was noted between measurements by DPA and whole femur dry weight and ash weight. Measurements were reproducible within re...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02409496
更新日期：1981-01-01 00:00:00
abstract：:The perilacunar areas of low mineral density in microradiographs from cortical bone of patients with hypophosphatemic (vitamin D-resistant) rickets are not evenly distributed throughout the bone tissue. Their frequency and distribution were determined in bone from 9 patients with this disease. It was found that the le...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02441169
更新日期：1979-04-17 00:00:00
abstract：:Even though indirect evidence indicates that PTH exerts an anabolic effect on dentinogenesis, the existence of PTH receptors and any second-messenger response in odontoblasts have not been demonstrated. The aim of this study was to investigate whether rat incisor odontoblasts express PTH receptors, and to identify whi...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900426
更新日期：1998-03-01 00:00:00
abstract：:The purpose of this study was to determine whether total serum calcium, parathyroid gland structure, and/or levels of parathyroid hormone, 1,25 and 24,25 DHCC, are altered in pigs with dental and skeletal fluorosis. Eight experimental animals receiving 2 mg F-/kg b.w. per day from age 8-14 months were compared with ei...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02556714
更新日期：1986-04-01 00:00:00
abstract：:Quantitative computed tomography (QCT) was compared to dual X-ray absorptiometry (DXA) measured in the lumbar spine of 508 European women defined as normal without fracture (NoF), or osteoporotic (OP), with either vertebral fracture (VF), or peripheral fracture (PF). The correlations between QCT and DXA BMD measuremen...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02678144
更新日期：2001-02-01 00:00:00
abstract：:Energy-dispersive X-ray microanalysis was used to determine calcium/phosphorous (Ca/P) ratios in undecalcified teeth, and the sulfur (S) content of dentin of decalcified teeth from normal patients and patients with familial hypophosphatemia, in an attempt to determine the effect of phosphorus deficiency. The results s...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02555886
更新日期：1990-12-01 00:00:00
abstract：:We compared the effects of four vitamin D metabolites, 1 alpha,25 dihydroxy vitamin D3 (1 alpha,25(OH)2D3), 1 alpha hydroxy vitamin D3 (1 alpha OH D3), 25 hydroxy vitamin D3 (25 OH D3), and 24R,25 dihydroxy vitamin D (24R,25(OH)sD3) on resorption and collagen synthesis in fetal rat bone maintained in organ culture. Re...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02408532
更新日期：1980-01-01 00:00:00
abstract：:Human osteoblasts were obtained by migration and proliferation of cells from embryonic membranous bone on glass fragments. Light and electron microscopy analyses revealed a typical osteoblast-like appearance with high protein synthesis activity. The cells showed high alkaline phosphatase activity that was associated w...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF00316880
更新日期：1992-11-01 00:00:00
abstract：:Crouzon syndrome is a debilitating congenital disorder involving abnormal craniofacial skeletal development caused by mutations in fibroblast growth factor receptor-2 (FGFR2). Phenotypic expression in humans exhibits an autosomal dominant pattern that commonly involves premature fusion of the coronal suture (craniosyn...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-013-9701-2
更新日期：2013-05-01 00:00:00
abstract：:We have used in situ hybridization to examine expression of collagen type I, II, and X mRNA and osteonectin mRNA in the chick epiphysis. Tissue samples from the proximal tibial growth cartilage were fixed in modified Carnoy's solution, dehydrated in ethanol, and embedded in paraffin. Longitudinal and transverse sectio...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02556062
更新日期：1989-09-01 00:00:00
abstract：:The small proteoglycan decorin had been localized previously at the d-band in the gap zone of collagen fibrils in nonmineralizing tissues. In bone matrix this zone is proteoglycan free and is at least in some species the place where mineralization along collagen fibrils starts. To study the metabolism of the small pro...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900279
更新日期：1997-06-01 00:00:00
abstract：:Although radiogenic free radicals are widely used as molecular probes in biological calcified tissues, their nature and their location remain controversial. In the present study we have synthesized and irradiated apatites in which 13CO3(2-) ions substitute hydroxyl or phosphate ions in hydroxyapatite. The 13C-coupling...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：
更新日期：1982-01-01 00:00:00
abstract：:Osteoarthritis (OA) is a chronic, debilitating disease affecting millions of people worldwide. Management of OA involves pharmacological and non-pharmacological approaches. Conventional pharmacological treatments have limited efficacy and are associated with a number of side-effects, restricting the number of patients...
journal_title：Calcified tissue international
pub_type： 杂志文章,评审
doi：10.1007/s00223-020-00672-9
更新日期：2020-02-13 00:00:00
abstract：:An organ culture system has been developed whereby mechanical stress can be applied to cranial sutures under controlled experimental conditions. The application of a continuous tensile mechanical stress (30 g) to cranial sutures from newborn rabbits (1--2 days) was accompanied by a significant increase in the incorpor...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02441232
更新日期：1979-10-31 00:00:00
abstract：:Radiation therapy (RT) is an established treatment modality for malignant neoplasms. RT induces tissue damage that may lead to osteoradionecrosis in more severe cases. Suitable animal models to study RT-induced changes in membranous craniofacial bone are currently not available. The aim of this study was therefore to ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-009-9217-y
更新日期：2009-05-01 00:00:00
abstract：:Sarcopenia and osteoporosis are two sides of the same coin. They represent different aspects of the same age-related process of musculoskeletal atrophy and together culminate in falls, fractures, deconditioning, and increased mortality in older individuals. However, the current therapeutic approach to the prevention o...
journal_title：Calcified tissue international
pub_type： 杂志文章,评审
doi：10.1007/s00223-015-9956-x
更新日期：2015-03-01 00:00:00
