Abstract：
:We studied the epidemiology of osteoporotic fractures of the proximal femur (cervical and trochanteric fractures) in residents of Barcelona, aged 45 years or over, for a 1-year period. Fractures resulting from metastases were not included. During the period of observation, a total of 1,358 patients with hip fractures were treated at acute-care hospitals in Barcelona. Of those, 1,163 were researched. For each case, age, sex, and home address were registered. The incidence of hip fractures per 100,000 inhabitants aged 45 years or over was 115.6 in men and 252.2 in women. Age was the most influencing factor in the occurrence of hip fractures. Women presented fractures of the proximal femur more frequently than men. The epidemiological curve was similar to that reported in other western countries, although the crude rate was lower than that found in northern countries. We conclude that osteoporotic fractures of the proximal femur are common processes in the Mediterranean area, and reflect the impact of osteoporosis in our environment; however, the lower incidence compared with northern geographical areas may probably reflect the influence of climatic, ethnic, or other factors.
journal_name
Calcif Tissue Intjournal_title
Calcified tissue internationalauthors
Diez A,Puig J,Martinez MT,Diez JL,Aubia J,Vivancos Jdoi
10.1007/BF02555965subject
Has Abstractpub_date
1989-06-01 00:00:00pages
382-6issue
6eissn
0171-967Xissn
1432-0827journal_volume
44pub_type
杂志文章abstract：:Glycogen storage disease type 1a (Von Gierke's disease) is one of the more common glycogen storage diseases (GSD). GSD 1a patients can have severe idiopathic osteopenia, often beginning at a young age. Since calcium tracer studies offer a sensitive probe of the bone microenvironment and of calcium deposition, kinetics...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF00369209
更新日期：1996-12-01 00:00:00
abstract：:Raman spectroscopy has been used to demonstrate, for the first time, that calcium mineralization in the core of the major lateral teeth of the chiton Acanthopleura echinata takes place as an ordered process, with crystalline carbonated apatite being the first mineral deposited. Deposition begins at the top of the toot...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002230001156
更新日期：2000-11-01 00:00:00
abstract：:Mononuclear phagocytes have been implicated as important cellular elements in the process of bone resorption. We have postulated that the recruitment and migration of mononuclear phagocytes to bone occurs via a mechanism(s) in which bone-derived chemotactic factors (BDCF) are released from foci undergoing resorption. ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02557681
更新日期：1985-01-01 00:00:00
abstract：:Psoriatic arthritis (PsA) is an inflammatory rheumatic disorder that occurs in patients with psoriasis and predominantly affects musculoskeletal structures, skin, and nails. The etiology of PsA is not well understood but evidence supports an interplay of genetic, immunologic, and environmental factors which promote pa...
journal_title：Calcified tissue international
pub_type： 杂志文章,评审
doi：10.1007/s00223-017-0380-2
更新日期：2018-05-01 00:00:00
abstract：:A number of osteoporotic patients under bisphosphonate treatment present persistent fragility fractures and bone loss despite good compliance. The objective of this 18-month prospective study was to investigate the effect of teriparatide [rhPTH(1-34)] in 25 female osteoporotics who were inadequate responders to oral b...
journal_title：Calcified tissue international
pub_type： 临床试验,杂志文章
doi：10.1007/s00223-011-9500-6
更新日期：2011-08-01 00:00:00
abstract：:Recent evidence of the occurrence of brushite in newly formed bone mineral prompted a study of the solubility properties of brushite:apatite mixtures under physiological conditions and the influence on them of pH, lactate, pyruvate, and, particularly, noncollagenous bone proteins (NCBPs). Brushite alone was surprising...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02411226
更新日期：1982-03-01 00:00:00
abstract：:In order to assess similarities and differences in women that suffer surgical versus natural menopause, a series of bone, clinical, and biochemical parameters was assayed in a clinical sample of 35 women with surgical menopause and 112 women with natural menopause. Biochemical parameters included hormones [parathyroid...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-003-0054-0
更新日期：2004-02-01 00:00:00
abstract：:The method of heat-denaturation and trypsin digestion was used to dissect bone biochemically into mineral-protected and mineral-unprotected pools of collagenous matrix. It was found that varying the particle size of the bone powder had a profound effect on the results. Using mature bovine cortical bone, the observed p...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02553750
更新日期：1988-04-01 00:00:00
abstract：:The aim of our study was to compare the results provided by the measurement of vertebral and femoral bone mineral density (BMD) for assessing the individual risk of osteoporosis as defined by either low BMD and/or rapid bone loss. Vertebral and femoral BMD were measured twice at a mean interval of 21 months in 85 norm...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF00310196
更新日期：1993-05-01 00:00:00
abstract：:Studies of the effect of parathyroidectomy (PTX) on bone turnover in patients with the combination of primary hyperparathyroidism (PHPT) and Paget's disease (PD) are largely limited to case reports. The etiology of the combination is disputed. We report 30 patients and their biochemical (n = 17) and histomorphometric ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900728
更新日期：1999-12-01 00:00:00
abstract：:Pregnancy and lactation-associated osteoporosis (PAO) is a rare condition with little known pathophysiology. Most cases are diagnosed in the third trimester of pregnancy or in the first weeks postpartum, particularly in first pregnancies. Vertebral fractures are most commonly observed and characterised by prolonged se...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-015-0028-z
更新日期：2015-10-01 00:00:00
abstract：:GNAS is one of the most complex gene loci in the human genome and encodes multiple gene products including Gsα, XLαs, NESP55, A/B, and AS transcripts. XLαs, the extra-large G protein ɑ-subunit, is paternally expressed. XLɑs and Gsɑ share the common 2-13 exons with different promoters and first exons. Therefore, XLɑs c...
journal_title：Calcified tissue international
pub_type： 杂志文章,评审
doi：10.1007/s00223-020-00714-2
更新日期：2020-09-01 00:00:00
abstract：:In order to determine whether the bacterial bone resorbing agents lipopolysaccharide (LPS) and muramyl dipeptide (MDP) interact with osteoblasts, their effect on the synthesis of collagenase and tissue inhibitor or metalloproteinases (TIMP) from monolayer cultures of mouse osteoblast-like cells was investigated. All c...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02556318
更新日期：1989-05-01 00:00:00
abstract：:Mature dental enamel is the most mineralized of all mammalian tissues and considered to be free of collagen. Hydroxylysylpyridinoline (HP) and lysylpyridinoline (LP) are two nonreducible cross-links of mature collagen. Hydroxyproline (Hyp) is an amino acid that is believed to be indicative of the presence of collagen....
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-004-0122-0
更新日期：2005-02-01 00:00:00
abstract：:Measurements of broadband ultrasonic attenuation (BUA) represent an established means of skeletal status assessment in osteoporosis. Today, the skeletal site that is the most widely used clinically is the calcaneus (heel bone). However, we hypothesized that fracture risk predictions could be improved if ultrasound mea...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-004-0216-8
更新日期：2004-11-01 00:00:00
abstract：:Bone involvement, mainly osteoporosis but also osteosclerosis, is frequent in patients with indolent systemic mastocytosis (ISM). The recent characterization of the canonical Wnt/β-catenin pathway in the regulation of bone remodeling provided important insights for our understanding of the pathophysiology of a number ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-015-9969-5
更新日期：2015-05-01 00:00:00
abstract：:There is increasing interest in identifying new pathways and candidate genes that confer susceptibility to osteoporosis. There is evidence that adipogenesis and osteogenesis may be related, including a common bone marrow progenitor cell for both adipocytes and osteoblasts. Perilipin 1 (PLIN1) and Perilipin 4 (PLIN4) a...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-011-9552-7
更新日期：2012-02-01 00:00:00
abstract：:We compared the cytotoxic effects of alendronate (ALN) and incadronate (YM175) on isolated rabbit osteoclasts in vitro and on rats in vivo. In the in vitro experiment, each bisphosphonate was added to the culture of isolated osteoclasts at the final concentration of 3 x 10(-5), 3 x 10(-4), or 3 x 10(-3) M, and the amo...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900505
更新日期：1998-08-01 00:00:00
abstract：:The European Forsteo Observational Study was designed to examine the effectiveness of teriparatide in postmenopausal women with osteoporosis treated for up to 18 months in normal clinical practice in eight European countries. The incidence of clinical vertebral and nonvertebral fragility fractures, back pain, and heal...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-009-9299-6
更新日期：2009-12-01 00:00:00
abstract：:In 11 postmenopausal women with histologically proven osteoporosis and normal lactose tolerance, a direct correlation between calcium absorption and intestinal lactase activity was observed. The results suggest that varying degrees of relative deficiencies in intestinal lactase might contribute to the graded decrease ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02557688
更新日期：1985-01-01 00:00:00
abstract：:Paget's disease of bone (PDB) is a chronic and focal bone disorder, characterized by increased osteoclast-mediated bone resorption and a subsequent compensatory increase in bone formation, resulting in a disorganized mosaic of woven and lamellar bone at one or more affected skeletal sites. As a result, bone pain, noti...
journal_title：Calcified tissue international
pub_type： 杂志文章,评审
doi：10.1007/s00223-019-00522-3
更新日期：2019-05-01 00:00:00
abstract：:Although hypogonadism is a risk factor for bone loss and fractures, the different etiopathophysiology and hormonal profile of classical and obesity-induced hypogonadism may lead to differences in musculoskeletal profile. This is a cross-sectional study of hypogonadal men between 40 and 74 years old. Our outcomes inclu...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-017-0316-x
更新日期：2017-12-01 00:00:00
abstract：:The effect of teriparatide treatment on microdamage accumulation has yet to be examined in animal studies. The purpose of this study was to investigate the effect of once-weekly teriparatide treatment on bone microdamage accumulation and the relationship between microdamage parameters and bone mass, architecture, turn...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-018-0500-7
更新日期：2019-04-01 00:00:00
abstract：:This manuscript discusses mineral and bone disorders of chronic kidney disease (MBD-CKD) in pediatric patients with special emphasis on the underlying pathophysiology, the causes and clinical profile of growth retardation, the alterations in the growth plate, the strategies to optimize growth and the medical recommend...
journal_title：Calcified tissue international
pub_type： 杂志文章,评审
doi：10.1007/s00223-020-00787-z
更新日期：2021-01-16 00:00:00
abstract：:Postmenopausal osteoporosis induced by estrogen deficiency causes inadequate new bone formation and affects millions of women worldwide. Melatonin can improve bone mineral density at the femoral neck in postmenopausal women with osteopenia. This study aimed to investigate the mechanism of melatonin in estrogen deficie...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-018-0428-y
更新日期：2018-10-01 00:00:00
abstract：:Bone mineral content (BMC) and bone mineral density (BMD) are common but imperfect surrogate measures of bone strength. The mechanical response tissue analyzer is a device that measures long bone bending stiffness (EI), which strongly predicts bone breaking strength. We hypothesized that isokinetic resistance training...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-009-9247-5
更新日期：2009-06-01 00:00:00
abstract：:Gallium nitrate (GaN) reduces cancer-related hypercalcemia and inhibits bone resorption in vitro. This study investigated the effects of chronic GaN administration on bone, kidney, and parathyroid gland activity of growing rats. Experimental animals received GaN (1.75 mg elemental gallium i.p. QOD X 8, Ga+), and contr...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02555260
更新日期：1987-05-01 00:00:00
abstract：:Molybdenum (Mo), at high concentrations, induces changes in the epiphyseal growth plate through its effects on copper (Cu) metabolism but it is unclear whether or not Mo can induce changes independent of its effects on copper status. To this end, the effect of Mo on longitudinal bone growth was examined in rats. Dieta...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF01321835
更新日期：1993-09-01 00:00:00
abstract：:Previous observational studies have identified various risk factors associated with the development of osteoporosis, including sex hormone-binding globulin (SHBG). The aim of this study was to determine the potential causal effects of circulating SHBG concentrations on bone mineral density (BMD). Two-sample Mendelian ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-020-00770-8
更新日期：2020-10-17 00:00:00
abstract：:Glucocorticoid-induced osteoporosis has been reported to be caused by enhanced bone resorption and suppressed bone formation. To clarify whether administration of vitamin K, which enhances bone formation, prevents prednisolone-induced loss of bone mineral density (BMD), a randomized, prospective, controlled study was ...
journal_title：Calcified tissue international
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/pl00005832
更新日期：2000-02-01 00:00:00
