Abstract:
:The extractions of 85Sr2+, 18F-, sucrose-14C, EDTA-51Cr, and antipyrine-14C in bone were determined by the multiple indicator-dilution method. Fluoride and strontium extractions were 18 to 70% during a single transcapillary passage, and those of EDTA and sucrose were from 11 to 59%, whereas extraction of antipyrine was 87%. Injections of 85Sr2+ and 18F- made when perfusion was done alternately with blood and plasma resulted in similar fractional extractions. When flow and extraction were measured simultaneously, extraction was related inversely to flow.
journal_name
Calcif Tissue Intjournal_title
Calcified tissue internationalauthors
Lemon GJ,Davies DR,Hughes SP,Bassingthwaighte JB,Kelly PJdoi
10.1007/BF02407178subject
Has Abstractpub_date
1980-01-01 00:00:00pages
173-81issue
2eissn
0171-967Xissn
1432-0827journal_volume
31pub_type
杂志文章abstract::We studied the effect of raloxifene (RAL) on arthritis and bone mineral density (BMD) in rats with collagen-induced arthritis (CIA). Seven-month-old female Sprague-Dawley rats were divided into five groups: rats without CIA (CNT), CIA rats that underwent ovariectomy (OVX) and were treated with RAL (CIA + OVX + RAL), C...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-010-9432-6
更新日期:2011-02-01 00:00:00
abstract::Teriparatide (TPTD) is the most widely used anabolic agent in the treatment of patients with osteoporosis although its use is restricted in many countries. A recent randomised trial confirmed that TPTD was superior to risedronate at preventing vertebral fractures over a 2-year period. There is limited information on t...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-019-00563-8
更新日期:2019-08-01 00:00:00
abstract::The demonstration of histochemical characteristics in calcifying cartilage is fraught with methodological difficulties including the distinction of mineralized from unmineralized cartilage and the demonstration of cell detail in relatively hard tissue. This study uses the decalcified bone matrix-induced enchondral (en...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02555141
更新日期:1988-10-01 00:00:00
abstract::Whether the decrease of zinc content in the femoral-metaphyseal tissues of rats with skeletal unloading is involved in the alteration of bone metabolism was investigated. Skeletal unloading was designed using the model of hindlimb suspension in rats. Animals were fed for 4 days with the unloading. The metaphyseal zinc...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00310262
更新日期:1995-09-01 00:00:00
abstract::Formalin fixation of hard tissues alters the levels of some, but not all, of the parameters routinely measured by bone researchers. Although mineral parameters (ash weight, particle size (beta 1/2 002) and Ca/PO4 ratio) and lipid parameters (total lipid content and composition, extractability, and Ca-acidic phospholip...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02411262
更新日期:1982-07-01 00:00:00
abstract::The mechanism whereby liposomal entrapment enhances the hypocalcemic effect of calcitonin (CT) was evaluated in the rat. Phosphatidylcholine (PC) and PC plus cholesterol (PCC) preparations of large multilammelar vesicles (MLV) and small unilammelar vesicles (SUV) were used to entrap human calcitonin (hCT). The effect ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02555889
更新日期:1990-12-01 00:00:00
abstract::A comparative polarized light (PLM), scanning (SEM), and transmission (TEM) electron microscopy study was carried out on cross- and longitudinal sections of human lamellar bone in the tibiae of four male subjects aged 9, 23, 45, and 70 years. SEM analysis was also performed on rectangular-prismatic samples in order to...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF01673402
更新日期:1993-01-01 00:00:00
abstract::Bone tissue is a source of growth factors; among them, insulinlike growth factor I (IGF-I) is probably an important local regulator of bone formation. This study has been carried out in order to assess the effects of natural menopause on plasma concentrations of IGF-I in the first 6 years after the cessation of gonada...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF01352006
更新日期:1993-07-01 00:00:00
abstract::Doses of 8, 16 (low), 32, 48, 64 (medium), and 150 (high) mg/kg/day of cortisol were administered to groups of 8 growing rats each during 16 days, and their femurs were then submitted to 3-point bending tests at low strain rate. Low doses had no effect. Medium doses, previously shown to improve calcium (Ca) balance an...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00297297
更新日期:1992-01-01 00:00:00
abstract::This manuscript discusses mineral and bone disorders of chronic kidney disease (MBD-CKD) in pediatric patients with special emphasis on the underlying pathophysiology, the causes and clinical profile of growth retardation, the alterations in the growth plate, the strategies to optimize growth and the medical recommend...
journal_title:Calcified tissue international
pub_type: 杂志文章,评审
doi:10.1007/s00223-020-00787-z
更新日期:2021-01-16 00:00:00
abstract::It is our hypothesis that interstitial fluid flow plays a role in the bone remodeling response to mechanical loading. The fluid flow-induced expression of three proteins (collagen, osteopontin, and alkaline phosphatase) involved in bone remodeling was investigated. Rat calvarial osteoblasts subjected to pulsatile flui...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900185
更新日期:1997-01-01 00:00:00
abstract::Sustained exposure to high levels of parathyroid hormone (PTH), as observed in hyperparathyroidism, is catabolic to bone. The increase in the RANKL/OPG ratio in response to continuous PTH, resulting in increased osteoclastogenesis, is well established. However, the effects of prolonged PTH exposure on key regulators o...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-016-0176-9
更新日期:2016-11-01 00:00:00
abstract::The purpose of this study was to determine the efficacy of using bone mineral measurements of the calcaneus to evaluate osteoporosis. Dual energy X-ray absorptiometry (DXA) of the calcaneus was compared with posteroanterior lumbar absorptiometry (DXA) and vertebral quantitative computed tomography (QCT) measurements i...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00298738
更新日期:1995-01-01 00:00:00
abstract::It has long been thought that collagen fibers within the bone matrix are deposited in an aligned pattern that channels mineral growth. If this model of bone structure is correct, both organic and inorganic phases of bone should have similar elastic anisotropy. Using an acoustic microscope, we measured longitudinal and...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00299319
更新日期:1994-11-01 00:00:00
abstract::Aluminum ions (Al) and chromium (III) ions (Cr), as they exist in aqueous solution at neutral pH, adsorb onto calcium hydroxyapatite crystals (HAP) and severely inhibit their dissolution process, when present in concentrations less than 1 microM. Iron (III) ions (Fe), at concentrations up to 10 microM, have no effect ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02555127
更新日期:1987-07-01 00:00:00
abstract::There is still controversy over the impact of diabetes control and duration on bone mass and growth parameters in children and adolescents with insulin-dependent diabetes mellitus (IDDM). The aim of this study was to assess bone mineral density (BMD) at axial and appendicular sites, in children with noncomplicated IDD...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900390
更新日期:1998-01-01 00:00:00
abstract::A 69-year-old man became hypocalcemic under medical observation. The hypocalcemia occurred in the presence of circulating immunoreactive parathyroid hormone (PTH). Common causes of secondary hyperparathyroidism were excluded, as was PTH resistance using PTH infusions. The immunoreactive PTH was examined in detail. PTH...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00298499
更新日期:1992-08-01 00:00:00
abstract::Non-steroidal anti-inflammatory drugs (NSAID) have been recommended to prevent of heterotopic ossification (HO) after total hip arthroplasty (THA), but debates are still ongoing. The present Bayesian network meta-analysis of randomized clinical trials (RCTs) compared all available pathways of NSAID treatment as prophy...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-020-00763-7
更新日期:2021-02-01 00:00:00
abstract::This study aimed to evaluate the association between objectively measured habitual physical activity and calcaneal and forearm bone mineral density (BMD, g/cm(2)), one mechanically more loaded and one less loaded skeletal region, in children aged 6-8 years. BMD was measured in 297 boys and 265 girls by peripheral dual...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-006-0137-9
更新日期:2007-01-01 00:00:00
abstract::Compressive strength index (CSI) of the femoral neck is a parameter that integrates the information of bone mineral density (BMD), femoral neck width (FNW), and body weight. CSI is considered to have the potential to improve the performance of assessment for hip fracture risk. However, studies on CSI have been rare. I...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-010-9406-8
更新日期:2010-10-01 00:00:00
abstract::Sarcopenia and osteoporosis are two sides of the same coin. They represent different aspects of the same age-related process of musculoskeletal atrophy and together culminate in falls, fractures, deconditioning, and increased mortality in older individuals. However, the current therapeutic approach to the prevention o...
journal_title:Calcified tissue international
pub_type: 杂志文章,评审
doi:10.1007/s00223-015-9956-x
更新日期:2015-03-01 00:00:00
abstract::Vascular calcification (VC), which is associated with high cardiovascular morbidity and mortality in patients with chronic kidney disease, is promoted by the osteoblastic differentiation of vascular smooth muscle cells (VSMCs). The present study explored the functional roles and molecular mechanisms of the long noncod...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-020-00696-1
更新日期:2020-07-01 00:00:00
abstract::The protein components of biomineralized structures (matrix proteins) are believed to modulate crystal nucleation and growth, and thereby influence the shape and strength of the final structure. The chicken eggshell contains a complex array of distinct matrix proteins. The most abundant of these was purified to homoge...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00298593
更新日期:1995-06-01 00:00:00
abstract::A guidance on the assessment and treatment of postmenopausal women at risk from fractures due to osteoporosis was recently published in Osteoporosis International as a joint effort of the International Osteoporosis Foundation and European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (Ka...
journal_title:Calcified tissue international
pub_type: 杂志文章,评审
doi:10.1007/s00223-018-00512-x
更新日期:2019-03-01 00:00:00
abstract::Osteoporosis is a bone disease leading to an increased fracture risk. It is considered a complex multifactorial genetic disorder with interaction of environmental and genetic factors. As a candidate gene for osteoporosis, we studied vitamin D binding protein (DBP, or group-specific component, Gc), which binds to and t...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-009-9251-9
更新日期:2009-08-01 00:00:00
abstract::Cost-effective intervention thresholds (ITs) based on FRAX(®) were determined for Portugal. Assuming a willingness to pay (WTP) of €32,000 per quality-adjusted life years (QALYs), treatment with generic alendronate is cost effective for men and women aged 50 years or more, with 10-year probabilities for major osteopor...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-016-0132-8
更新日期:2016-08-01 00:00:00
abstract::Parathyroid hormone (PTH), hPTH-(1-84), and its hPTH-(1-34), hPTH-(1-31)NH2, and hPTH-(1-30)NH2 fragments reduced the tail artery pressure in anesthetized female Sprague-Dawley rats by 42.4-67.1% within about 1 minute after injection into a femoral vein, but reduced the pressure by only 8.5-36.2% 2-19 minutes after su...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900233
更新日期:1997-03-01 00:00:00
abstract::To define the quantitative aspects of ossification of human fetal spine, we performed a high resolution densitometric study by lateral and postero-anterior scanning of five fetal spines (18-36 weeks of conceptual age) and one spine of a 4-month-old infant. The data were plotted against developmental age for each spine...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00299001
更新日期:1995-07-01 00:00:00
abstract::Crouzon syndrome is a debilitating congenital disorder involving abnormal craniofacial skeletal development caused by mutations in fibroblast growth factor receptor-2 (FGFR2). Phenotypic expression in humans exhibits an autosomal dominant pattern that commonly involves premature fusion of the coronal suture (craniosyn...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-013-9701-2
更新日期:2013-05-01 00:00:00
abstract::Vitamin D supplementation is recommended for women with osteoporosis. In the FOCUS-D trial comparing the combination tablet alendronate plus vitamin D3 5,600 IU (ALN/D) with standard care (SC) prescribed by patients' personal physicians, ALN/D was more effective in improving serum 25(OH)D and bone turnover markers by ...
journal_title:Calcified tissue international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00223-013-9763-1
更新日期:2014-02-01 00:00:00