Abstract：
:It has long been thought that collagen fibers within the bone matrix are deposited in an aligned pattern that channels mineral growth. If this model of bone structure is correct, both organic and inorganic phases of bone should have similar elastic anisotropy. Using an acoustic microscope, we measured longitudinal and transverse acoustic velocities of cortical specimens taken from 10 dog femurs before and after removal of either the mineral (using 10% EDTA) or collagen phases (using 7% sodium hypochlorite) and calculated longitudinal (CL) and transverse (CT) elastic coefficients. The anisotropy ratio (CL/CT) decreased significantly after demineralization (1.61 before versus 1.06 after, P < 0.0001, paired t-test). However, there was no significant change after decollagenization (1.51 before versus 1.48 after, P = 0.617, paired t-test). We conclude that the orientation of mineral crystals is the primary determinant of bone anisotropy, and the collagen matrix within osteonal bone has little directional orientation.
journal_name
Calcif Tissue Intjournal_title
Calcified tissue internationalauthors
Hasegawa K,Turner CH,Burr DBdoi
10.1007/BF00299319subject
Has Abstractpub_date
1994-11-01 00:00:00pages
381-6issue
5eissn
0171-967Xissn
1432-0827journal_volume
55pub_type
杂志文章abstract：:Bone tissue is a source of growth factors; among them, insulinlike growth factor I (IGF-I) is probably an important local regulator of bone formation. This study has been carried out in order to assess the effects of natural menopause on plasma concentrations of IGF-I in the first 6 years after the cessation of gonada...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF01352006
更新日期：1993-07-01 00:00:00
abstract：:To characterize osteopenic changes in ovariectomized (OVX) rats as a function of time, female Sprague Dawley rats (240 g body weight, 90 days old) were subjected to bilateral ovariectomy or sham surgery and killed at various times from 14-180 days postovariectomy. The proximal tibial metaphysis was processed undecalci...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02571317
更新日期：1988-09-01 00:00:00
abstract：:We separated osteoclasts from bone and observed the effect of several known and potential mediators of the control of bone resorption on their cytoplasmic motility. We already found that calcitonin (CT), a hormone that inhibits bone resorption, regularly causes complete inhibition of cytoplasmic motility, specific for...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02405095
更新日期：1983-07-01 00:00:00
abstract：:Proton pump inhibitors are taken by millions of patients for prevention and treatment of gastroesophageal diseases. Case-control studies have suggested that use of omeprazole is associated with an increased risk of hip fractures. The aim of this prospective study was to assess the risk of vertebral fractures in postme...
journal_title：Calcified tissue international
pub_type： 杂志文章,多中心研究
doi：10.1007/s00223-008-9188-4
更新日期：2009-01-01 00:00:00
abstract：:Mice deficient in the chloride channel ClC-7, which is likely involved in acidification of the resorption lacuna, display severe osteopetrosis. To fully characterize the osteopetrotic phenotype, the phenotypes of osteoclasts and osteoblasts were evaluated. ClC-7(-/-) mice and their corresponding wild-type littermates ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-008-9185-7
更新日期：2008-12-01 00:00:00
abstract：:The bone mineral status of 17 girls with Turner's syndrome was evaluated by single photon absorptiometry. Bone mineral content (BMC) was 25.4% below that predicted by normalization for age, sex, height, weight, and bone width. Only 25% of this demineralization could be attributed to delayed skeletal maturation. Bones ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02411296
更新日期：1982-01-01 00:00:00
abstract：:This randomized, double-blind study assessed the antifracture efficacy and safety of intermittent intravenous (IV) ibandronate versus oral daily risedronate in Japanese patients with primary osteoporosis. Ambulatory patients aged ≥60 years were randomized to receive 0.5 or 1 mg/month IV ibandronate plus oral daily pla...
journal_title：Calcified tissue international
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00223-013-9734-6
更新日期：2013-08-01 00:00:00
abstract：:Diets with a high saturated fat content can produce deleterious effects on the absorption of dietary calcium and consequently an adverse effect on bone mineralization in growing animals. Hence dietary fat may have long-term consequences for skeletal health and skeletal pathologies such as osteoporosis. Whether a diet ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900492
更新日期：1998-07-01 00:00:00
abstract：:There is considerable interest in determining whether hypergravity can be used as a countermeasure for microgravity-induced bone loss. This study was conducted on 20 immature male rats in order to investigate possible elastic adaptations of cortical bone in rapidly growing rats exposed to chronic hypergravity. Ten rat...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900111
更新日期：1996-09-01 00:00:00
abstract：:Histomorphometric evaluation of bone formation in an intravital tetracycline-labeled skeleton of a suddenly deceased osteoporotic woman is presented. The 24 skeletal sites investigated displayed substantial regional variations which, for two out of four cortical bone dynamics and all trabecular bone dynamics, were sig...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02556619
更新日期：1987-04-01 00:00:00
abstract：:Considerable advances in oncology over recent decades have led to improved survival, while raising concerns about long-term consequences of anticancer treatments. In patients with breast or prostate malignancies, bone health is a major issue due to the high risk of bone metastases and the frequent prolonged use of hor...
journal_title：Calcified tissue international
pub_type： 杂志文章,评审
doi：10.1007/s00223-017-0369-x
更新日期：2018-02-01 00:00:00
abstract：:We have previously shown that cyclosporin A (CsA) produces high bone remodeling with resorption exceeding formation and loss of bone volume in the rat. This may have important clinical implications where CsA is widely used in organ transplantation. 1,25 dihydroxyvitamin D3 (1,25(OH)2D3) is a bone mineralizing hormone ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02555980
更新日期：1990-09-01 00:00:00
abstract：:Currently used diagnostic measures for sarcopenia are based on the evaluation of appendicular skeletal muscle mass (ASMM) divided by height-squared (ASMMI). This study aimed to investigate the associations between different operational definitions of appendicular muscle mass and BMD at different skeletal sites in agin...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-014-9902-3
更新日期：2014-10-01 00:00:00
abstract：:The effect of long-chain n-3 polyunsaturated fatty acid (PUFA) on bone measurements was evaluated in gonad-intact middle-aged male rats. Seven rats were killed on day 0 of dietary intervention to determine bone parameters at baseline. Experimental rats (7/group) were fed one of the following lipid treatments (g/kg die...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-007-9010-8
更新日期：2007-04-01 00:00:00
abstract：:Normative bone mineral density (BMD) and bone mineral content (BMC) values for the total body (TB), proximal femur (PF), and antero-posterior lumbar spine (LS) were obtained from a large cross-sectional sample of children and adolescents who were 8-17 years of age. There were 977 scans for the TB, 892 for the PF, and ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900138
更新日期：1996-11-01 00:00:00
abstract：:The purpose of this study was to determine whether total serum calcium, parathyroid gland structure, and/or levels of parathyroid hormone, 1,25 and 24,25 DHCC, are altered in pigs with dental and skeletal fluorosis. Eight experimental animals receiving 2 mg F-/kg b.w. per day from age 8-14 months were compared with ei...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02556714
更新日期：1986-04-01 00:00:00
abstract：:Our knowledge of the developmental changes in the concentration of serum and bone osteocalcin (OC) is limited. To investigate the interrelationship between skeletal and circulatory OC during acquisition of peak bone density in mice, we examined the temporal changes in the concentration of serum and bone OC from 3 to 1...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-001-1106-y
更新日期：2002-11-01 00:00:00
abstract：:Macroporous biphasic calcium phosphate (MBCP) blocks were implanted into rabbit trabecular bone and muscle, recovered 18 weeks later, and then observed and analyzed by transmission electron microscopy (TEM), electron diffraction, and electron microprobes. The results showed that (1) apatitic microcrystals appeared by ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/pl00005825
更新日期：1999-05-01 00:00:00
abstract：:The method of heat-denaturation and trypsin digestion was used to dissect bone biochemically into mineral-protected and mineral-unprotected pools of collagenous matrix. It was found that varying the particle size of the bone powder had a profound effect on the results. Using mature bovine cortical bone, the observed p...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02553750
更新日期：1988-04-01 00:00:00
abstract：:Identifying persons with a high risk of osteoporotic fractures remains a challenge. DXA uptake in women with elevated risk of osteoporosis seems to be depending on distance to scanning facilities. This study aimed to investigate the ability of a small portable scanner in identifying women with reduced bone mineral den...
journal_title：Calcified tissue international
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00223-015-0084-4
更新日期：2016-03-01 00:00:00
abstract：:The mineral in bone is located primarily within the collagen fibril, and during mineralization the fibril is formed first and then water within the fibril is replaced with mineral. Our goal is to understand the mechanism of fibril mineralization, and as a first step we recently determined the size exclusion characteri...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-007-9085-2
更新日期：2008-02-01 00:00:00
abstract：:Connective tissue diseases, including osteogenesis imperfecta (OI) and Ehlers-Danlos syndrome (EDS), exhibit a high degree of clinical and genetic heterogeneity. We report two sisters with blue sclerae, joint hypermobility and hearing loss. Whole-exome sequencing identified two compound heterozygous ZNF469 loss-of-fun...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-020-00721-3
更新日期：2020-09-01 00:00:00
abstract：:Teriparatide (TPTD) is known to increase the cortical thickness and porosity. The purpose of the present study was to determine whether switching from TPTD to ibandronate (IBN) would be useful for improving cortical bone parameters as assessed using high-resolution quantitative computed tomography (HR-QCT) analyses in...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-016-0180-0
更新日期：2016-11-01 00:00:00
abstract：:Osteoporosis is a common age-related disease with a strong genetic influence. COLIA1 is one of the most extensively studied candidate genes and has consistently been associated with BMD and fracture. We examined the effects of the polymorphisms -1997G>T, -1663indelT, and +1245G>T and their haplotypes on vertebral frac...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-008-9199-1
更新日期：2009-02-01 00:00:00
abstract：:Matrix extracellular phosphoglycoprotein (MEPE) is an inhibitor of mineralization in situ and in cell cultures where altered expression is associated with oncogenic osteomalacia and hypophosphatemic rickets. The purpose of this study was to determine whether the intact protein or the peptide(s) originating from this p...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-009-9313-z
更新日期：2010-01-01 00:00:00
abstract：:The diphosphonates dichloromethanediphosphonate (Cl2MDP) and to a minor degree 1-hydroxyethane-1,1-diphosphonate (EDHP) increased the glycogen content in cultured cartilage cells of rabbit ear. This effect was not due to different concentrations of glucose in the medium. ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02408621
更新日期：1980-01-01 00:00:00
abstract：:We compared indices of three-dimensional microstructure of iliac trabecular bone between 26 patients with vertebral compression fractures due to postmenopausal osteoporosis and 24 control subjects without vertebral fracture, who were matched for age, sex, race, menopausal status, and several densitometric and histolog...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02554913
更新日期：1985-12-01 00:00:00
abstract：:High serum levels of IGFBP-1 are related both to low body mass index (BMI) and to low insulin-like growth factor 1 (IGF-I), which both in turn are related to low bone mineral density (BMD) and to increased fracture risk. However, we have found no previous prospective studies on IGFBP-1 and fracture risk. Despite its n...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-016-0152-4
更新日期：2016-10-01 00:00:00
abstract：:Several studies have shown an association between circulating leptin concentration and bone mineral density. but most studies are cross-sectional in design and report findings in women only. We per-formed a population-based longitudinal study relating baseline plasma leptin concentration to bone mass at the lumbar spi...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-002-0017-x
更新日期：2004-05-01 00:00:00
abstract：:The effect of teriparatide treatment on microdamage accumulation has yet to be examined in animal studies. The purpose of this study was to investigate the effect of once-weekly teriparatide treatment on bone microdamage accumulation and the relationship between microdamage parameters and bone mass, architecture, turn...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-018-0500-7
更新日期：2019-04-01 00:00:00
