Once-Weekly Teriparatide Treatment Prevents Microdamage Accumulation in the Lumbar Vertebral Trabecular Bone of Ovariectomized Cynomolgus Monkeys.

abstract：:Primary cilia are responsible for sensing mechanical loading in osteocytes. However, the underlying working mechanism of cilia remains elusive. An osteocyte model is necessary to reveal the role of cilia. Furthermore, the osteocyte model should be with upregulated or downregulated primary cilium expression. Herein, we...

journal_title：Calcified tissue international

authors： Ding D,Yang X,Luan HQ,Wu XT,He C,Sun LW,Fan YB

更新日期：2020-12-01 00:00:00

abstract：:Radioimmunoassay of the carboxyterminal propeptide of human type I procollagen has been recently introduced to measure in vitro synthesis of type I collagen by osteoblasts and fibroblasts. However, it has not been assessed whether the equivalent results are obtained with this new assay and with tritiated proline incor...

journal_title：Calcified tissue international

authors： Nacher M,Serrano S,Mariñoso ML,García MC,Bosch J,Díez A,Lloreta J,Aubia J

更新日期：1999-03-01 00:00:00

abstract：:ATP is as effective as inorganic pyrophosphate in retarding the rate of dissolution of calcium hydroxyapatite at pH 7, ADP is less effective, and AMP is without effect. The inhibition is due to the adsorption of ATP and ADP units on the crystal surface. ...

journal_title：Calcified tissue international

authors： Christoffersen MR,Christoffersen J

更新日期：1984-12-01 00:00:00

abstract：:Synovial fluid basic calcium phosphate (BCP) crystals are associated with severe destructive arthropathy. BCP crystals induce the secretion of matrix-degrading enzymes such as collagenase. No prophylactic or therapeutic agents are recognized to ameliorate the cartilage damage associated with BCP deposits in joints. As...

journal_title：Calcified tissue international

authors： McCarthy GM,Mitchell PG,Cheung HS

更新日期：1993-06-01 00:00:00

abstract：:In humans, gastric surgery results in in osteopenia via mechanisms that are insufficiently understood; surgery-induced changes in the hormonal axes involving the stomach, thyroid, and the parathyroids may play a role. To study this in more detail, we evaluated calcium (Ca), magnesium (Mg), and phosphorus (P) metabolis...

journal_title：Calcified tissue international

authors： Rümenapf G,Schwille PO,Erben RG,Schreiber M,Bergé B,Fries W,Schmiedl A,Koroma S,Hohenberger W

更新日期：1998-11-01 00:00:00

abstract：:A resolution-enhanced Fourier Transform Infrared (FTIR) Spectroscopic study of the CO3(2-) ion in pig enamel of increasing age and maturity has demonstrated the existence of four different, main carbonate locations. The major CO3(2-) site arises as a result of the substitution of CO3(2-) ions in the positions occupied...

journal_title：Calcified tissue international

authors： Rey C,Renugopalakrishnan V,Shimizu M,Collins B,Glimcher MJ

更新日期：1991-10-01 00:00:00

abstract：:Cartilage oligomeric matrix protein (COMP) is a macromolecule of yet unknown function with restricted distribution among tissues. In the present study, the ultrastructural localization of COMP in porcine immature joint cartilage and growth plate cartilage was semiquantitatively delineated. Tissues were fixed in a mixt...

journal_title：Calcified tissue international

authors： Ekman S,Reinholt FP,Hultenby K,Heinegârd D

更新日期：1997-06-01 00:00:00

abstract：:Methotrexate (MTX) is one of the most commonly prescribed drugs for autoimmune rheumatic diseases. As there is no consensus on its negative effects on bone, the purpose of this investigation was to determine the clinical spectrum of patients with stress fractures due to long-term MTX treatment (i.e., MTX osteopathy). ...

journal_title：Calcified tissue international

authors： Rolvien T,Jandl NM,Stürznickel J,Beil FT,Kötter I,Oheim R,Lohse AW,Barvencik F,Amling M

更新日期：2021-02-01 00:00:00

abstract：:Tumor cells with high skeletal homing affinity express numerous cell surface receptors that bind ligands produced in bone. Upon arrival, these cells survive in the host environment, encompassed in close proximity to bone marrow cells. Interactions between tumor cells and cells of the host microenvironment are essentia...

journal_title：Calcified tissue international

authors： Kovacic N,Croucher PI,McDonald MM

更新日期：2014-01-01 00:00:00

abstract：:The effect of long-chain n-3 polyunsaturated fatty acid (PUFA) on bone measurements was evaluated in gonad-intact middle-aged male rats. Seven rats were killed on day 0 of dietary intervention to determine bone parameters at baseline. Experimental rats (7/group) were fed one of the following lipid treatments (g/kg die...

journal_title：Calcified tissue international

authors： Shen CL,Yeh JK,Rasty J,Chyu MC,Dunn DM,Li Y,Watkins BA

更新日期：2007-04-01 00:00:00

abstract：:Men and women (n = 518) receiving moderate-to-high doses of corticosteroids were enrolled in two studies with similar protocols and randomly assigned to receive either placebo or risedronate (2.5 or 5 mg) for 1 year. All patients received daily calcium supplementation (500-1000 mg), and most also received supplemental...

journal_title：Calcified tissue international

authors： Wallach S,Cohen S,Reid DM,Hughes RA,Hosking DJ,Laan RF,Doherty SM,Maricic M,Rosen C,Brown J,Barton I,Chines AA

更新日期：2000-10-01 00:00:00

abstract：:Pyrolyzed scales, fin spines, and bone from the ray-finned bony fish Polypterus (Actinopterygii) showed two mineral phases on X-ray diffraction: hydroxyapatite (HA), Ca5(PO4)3OH, and whitlockite, Ca3(PO4)2. The ratio of HA/whitlockite varied with the structure (scale, spine, bone) within each individual fish. The rela...

journal_title：Calcified tissue international

authors： Meinke DK,Skinner HC,Thomson KS

更新日期：1979-08-24 00:00:00

abstract：:Vit-D-Dependent calcium binding protein and parvalbumin have both been detected in ameloblasts and calcified cartilage by immunohistochemical techniques. These two Ca2+ binding proteins may play a crucial role in the local accumulation of Ca2+ ions during the process of mineralization. The mechanisms underlying the de...

journal_title：Calcified tissue international

authors： Celio MR,Norman AW,Heizmann CW

更新日期：1984-01-01 00:00:00

abstract：:The binding of prostaglandin E2 (PGE2) to bone cells was studied to provide direct evidence for the existence of specific receptors in bone. Bone cells were isolated by collagenase digestion of fetal and newborn rat calvaria. Isolated cells were incubated with 3H-PGE2 and collected on Millipore filters. Specific bindi...

journal_title：Calcified tissue international

authors： Dziak RM,Hurd D,Miyasaki KT,Brown M,Weinfeld N,Hausmann E

更新日期：1983-01-01 00:00:00

abstract：:It has been well established that bone morphogenetic protein-2 (BMP-2) can induce bone formation bothin vivo andin vitro, although high concentrations (up to milligrams) of BMP-2 have been required to achieve this effectin vivo. Further, clinical applications are usually limited to a single dose at the time of implant...

journal_title：Calcified tissue international

authors： Cheng SL,Lou J,Wright NM,Lai CF,Avioli LV,Riew KD

更新日期：2001-02-01 00:00:00

abstract：:In order to investigate the pathogenesis of ossification of the posterior longitudinal ligament (OPLL) of the spine, we examined the distribution of insulin-like growth factor I (IGF-I) in the posterior longitudinal ligaments of OPLL patients, and analyzed the effects of IGF-I on the cultured spinal ligament cells. Fo...

journal_title：Calcified tissue international

authors： Goto K,Yamazaki M,Tagawa M,Goto S,Kon T,Moriya H,Fujimura S

更新日期：1998-02-01 00:00:00

abstract：:Osteoporosis is characterized by low bone mass and a deterioration of bone architecture and likely is influenced by genetic factors. The ovariectomized (OVX) mouse is well suited for osteoporosis research, as shown to date by cross-sectional studies. Here, we investigate longitudinal changes by in vivo micro-computed ...

journal_title：Calcified tissue international

authors： Klinck J,Boyd SK

更新日期：2008-07-01 00:00:00

abstract：:High impact loading is known to prevent some of the age-related bone loss but its effects on the density distribution of cortical bone are relatively unknown. This study examined the effects of age and habitual sprinting on tibial and fibular mid-shaft bone traits (structural, cortical radial and polar bone mineral de...

journal_title：Calcified tissue international

authors： Rantalainen T,Duckham RL,Suominen H,Heinonen A,Alén M,Korhonen MT

更新日期：2014-08-01 00:00:00

abstract：:Plasma osteocalcin (BGP), growth hormone (GH), and somatomedin C(SmC) were measured in 12 patients with acromegaly [7 clinically active (aA), 5 cured (cA)] and 9 control subjects (C). Basal plasma values for the three parameters were higher in aA than in C and in cA. No significant difference was found between cA and ...

journal_title：Calcified tissue international

authors： de la Piedra C,Larrañaga J,Castro N,Horcajada C,Rapado A,Herrera Pombo JL,Carbó E

更新日期：1988-07-01 00:00:00

abstract：:Bone turnover markers (BTMs) are widely used for the management of osteoporosis, and the premenopausal reference range is the target value for the treatment of postmenopausal osteoporosis with antiresorbing agents. Three serum BTMs (serum C-telopeptide of type I collagen [CTX], osteocalcin [OC], and N-terminal propept...

journal_title：Calcified tissue international

authors： Adami S,Bianchi G,Brandi ML,Giannini S,Ortolani S,DiMunno O,Frediani B,Rossini M,BONTURNO study group.

更新日期：2008-05-01 00:00:00

abstract：:The influence of the macroscale material properties of bone on its mechanical competence has been extensively investigated, but less is known about possible contributions from bone's nanoscale material properties. These nanoscale properties, particularly the collagen network and the size and shape of hydroxyapatite mi...

journal_title：Calcified tissue international

authors： Acerbo AS,Kwaczala AT,Yang L,Judex S,Miller LM

更新日期：2014-11-01 00:00:00

abstract：:The development of prophylaxes and treatments of bone diseases that can effectively increase the strength of bone as a structure necessitates a better understanding of the time course by which chemical properties define the stiffness of the material during primary and secondary mineralization. It was hypothesized that...

journal_title：Calcified tissue international

authors： Busa B,Miller LM,Rubin CT,Qin YX,Judex S

更新日期：2005-12-01 00:00:00

abstract：:We studied the influence of age, gender, latitude, season, diet and ethnicity on plasma 25-hydroxyvitamin D 25 OHD, PTH, 1,25-dihydroxyvitamin D, vitamin D-binding protein, bone-specific alkaline phosphatase, and osteocalcin levels in 46 Greenlanders living in Nuuk (64 degrees N) on a traditional fare (group A), 45 Gr...

journal_title：Calcified tissue international

authors： Rejnmark L,Jørgensen ME,Pedersen MB,Hansen JC,Heickendorff L,Lauridsen AL,Mulvad G,Siggaard C,Skjoldborg H,Sørensen TB,Pedersen EB,Mosekilde L

更新日期：2004-03-01 00:00:00

abstract：:Mandibular first molars from 17-day-old mouse embryos were cultivated in vitro for 10 days using a new organ culture method. This method consisted of using a small glass dish and an agar chamber to slowly float the molars to the gas-medium interface where they were maintained by the surface tension of the medium. The ...

journal_title：Calcified tissue international

authors： Sakakura Y

更新日期：1986-10-01 00:00:00

abstract：:We studied the most complete skeletons found in an excavation from the 14th and 15th century in central Stockholm. One hundred eighty-seven were from men and 156 from women: 241 individuals were estimated to be between 20 and 39 and 102 between 40 and 59 years old at death. We examined the bones radiographically and b...

journal_title：Calcified tissue international

authors： Ekenman I,Eriksson SA,Lindgren JU

更新日期：1995-05-01 00:00:00

abstract：:Twenty boys were followed during their puberty for about 2 years with examinations every third month. At each examination we determined serum concentrations of 25OHD3, 1,25(OH)2D3, 24,25(OH)2D3, 25.26(OH)2D3, alkaline phosphatase (AP) and testosterone together with bone mineral content (BMC) at the distal forearm. Hig...

journal_title：Calcified tissue international

authors： Krabbe S,Christiansen C,Hummer L

更新日期：1986-03-01 00:00:00

abstract：:We have previously shown that cyclosporin A (CsA) produces high bone remodeling with resorption exceeding formation and loss of bone volume in the rat. This may have important clinical implications where CsA is widely used in organ transplantation. 1,25 dihydroxyvitamin D3 (1,25(OH)2D3) is a bone mineralizing hormone ...

journal_title：Calcified tissue international

authors： Epstein S,Schlosberg M,Fallon M,Thomas S,Movsowitz C,Ismail F

更新日期：1990-09-01 00:00:00

abstract：:We compared indices of three-dimensional microstructure of iliac trabecular bone between 26 patients with vertebral compression fractures due to postmenopausal osteoporosis and 24 control subjects without vertebral fracture, who were matched for age, sex, race, menopausal status, and several densitometric and histolog...

journal_title：Calcified tissue international

authors： Kleerekoper M,Villanueva AR,Stanciu J,Rao DS,Parfitt AM

更新日期：1985-12-01 00:00:00

abstract：:Parathyroid Hormone (PTH) stimulates calcium entry into bone cells in vitro, and this effect has been proposed to mediate the actions of PTH on bone. Using cells harvested from infant rat calvaria by collagenase digestion, we evaluated the sensitivity and specificity of this phenomenon. Calcium uptake was temperature ...

journal_title：Calcified tissue international

authors： Marcus R,Orner FB

更新日期：1980-01-01 00:00:00

abstract：:High PTH levels increase bone turnover and decrease bone mineral density (BMD). Low plasma 25-hydroxyvitamin D (25OHD) levels cause secondary hyperparathyroidism, but the relative contribution of low 25OHD and high PTH levels on risk of fracture is largely unknown. Within the cohort of women (n = 2,016) included in th...

journal_title：Calcified tissue international

authors： Rejnmark L,Vestergaard P,Brot C,Mosekilde L

更新日期：2011-03-01 00:00:00