Abstract:
:Parathyroid Hormone (PTH) stimulates calcium entry into bone cells in vitro, and this effect has been proposed to mediate the actions of PTH on bone. Using cells harvested from infant rat calvaria by collagenase digestion, we evaluated the sensitivity and specificity of this phenomenon. Calcium uptake was temperature dependent, and was increased by PTH over the concentration range 0.01 to 0.50 units/ml. A series of nonhormonal peptides obtained during the purification of a single batch of PTH was found to stimulate calcium uptake. In addition, isoproterenol, ACTH, calcitonin, and glucagon stimulated calcium uptake. In no case, however, was the degree of stimulation as great as that produced by biologically active PTH. Prostaglandins are also potent resorbers of bone, and a series of prostaglandins also stimulated calcium uptake into bone cells. These results are compatible with a calcium ionophore model of PTH and prostaglandin action on bone.
journal_name
Calcif Tissue Intjournal_title
Calcified tissue internationalauthors
Marcus R,Orner FBdoi
10.1007/BF02408543subject
Has Abstractpub_date
1980-01-01 00:00:00pages
207-11issue
3eissn
0171-967Xissn
1432-0827journal_volume
32pub_type
杂志文章abstract::The presence of lipids in urinary stones was determined by histochemical and biochemical methods. When crystals of calcium oxalate, made by mixing calcium chloride and potassium oxalate solutions and sections of human calcium oxalate urinary stones, were exposed to osmium vapors, there was no staining of the pure crys...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02556340
更新日期:1988-02-01 00:00:00
abstract::The purpose of the present study was to determine if the type of dietary fat can modify the fatty acid composition and arachidonic acid levels in the alveolar bone phospholipids. Three groups of rats were fed nutritionally adequate semipurified diets containing different lipids: 10% corn oil (control, group I, rich in...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF01351838
更新日期:1993-11-01 00:00:00
abstract::Bone labeling, histochemical, and fine structural studies were performed in order to clarify the effects of ipriflavone (IP) on rat bone tissue in vivo and in vitro. Labeling experiments showed a slight increase in bone formation during 3 days' administration. It was also noted that many osteoclasts detached from the ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02180245
更新日期:1992-01-01 00:00:00
abstract::The peptide hormone calcitonin is a potent inhibitor of osteoclastic resorption, but it is unstable and poorly absorbed following oral administration. Conjugates of salmon calcitonin covalently linked to low-molecular-weight amphiphilic polymers show improved stability and absorption. The purpose of this study was to ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-002-1051-4
更新日期:2003-09-01 00:00:00
abstract::Noncarious cervical lesions have a multifactorial etiology. Mechanical stress has been identified as one of the factors, but little evidence exists for its cause-effect relationship. This study was conducted at three different pH levels to observe the surface loss on dentin beams under tension and compression. Bovine ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-005-0271-9
更新日期:2006-12-01 00:00:00
abstract::Hip fracture may cause and/or complicate institutionalization. We undertook this study to define its overall prevalence among the residents of four nursing homes in Central Italy as well as its latency and impact on mobility when it occurred within institutions. We also performed a case control analysis with the aim o...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002230001212
更新日期:2001-06-01 00:00:00
abstract::The bone mineral density (BMD) of the spine was measured in the posteroanterior (PA) and lateral projections as well as the total body BMD in 447 black and white women. The lateral projection is comprised predominantly of cancellous bone whereas the total body BMD is predominantly cortical bone, and the PA spine is in...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900653
更新日期:1999-07-01 00:00:00
abstract::Quantitative ultrasound measurement (QUS) and bone mineral density (BMD) have each been shown to predict fracture risk in women. The present study examined whether a combination of QUS and BMD could improve the predictive accuracy of fracture risk. This is a population-based prospective study which involved 454 women ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-011-9556-3
更新日期:2012-02-01 00:00:00
abstract::Osteoporosis is a common disease among patients undergoing transplantation. Its prevalence and complications have been well described in solid organ recipients, especially kidney, liver, and heart. However, studies in bone marrow transplantation (BMT) are scarce. Among the mechanisms invoked in the pathogenesis of BMT...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900240
更新日期:1997-04-01 00:00:00
abstract::Ossification of the posterior longitudinal ligament of the spine (OPLL) is characterized by ectopic bone formation in the spinal ligaments. Mechanical stress, which acts on the posterior ligaments, is thought to be an important factor in the progression of OPLL. To clarify this mechanism, we investigated the effects o...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-002-0021-1
更新日期:2004-05-01 00:00:00
abstract::Diets with a high saturated fat content can produce deleterious effects on the absorption of dietary calcium and consequently an adverse effect on bone mineralization in growing animals. Hence dietary fat may have long-term consequences for skeletal health and skeletal pathologies such as osteoporosis. Whether a diet ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900492
更新日期:1998-07-01 00:00:00
abstract::The aim of this study was to investigate bone mineral density (BMD) and bone turnover in patients with primary knee osteoarthritis (KOA) and to compare them with generalized OA (GOA) and nonGOA patients. A total of 88 postmenopausal primary KOA patients were studied. OA was graded by using knee radiographs. BMD of the...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002230010068
更新日期:2000-05-01 00:00:00
abstract::The accuracy of a radiographic absorptiometry (RA) technique called digital image processing (DIP), discriminative ability of RA for osteoporotic fracture, and the relationship between RA and dual X-ray absorptiometry (DXA) of the spine and forearm were evaluated. We measured 16 cadaver hands, 32 healthy non-black pre...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900400
更新日期:1998-02-01 00:00:00
abstract::We studied the effect of raloxifene (RAL) on arthritis and bone mineral density (BMD) in rats with collagen-induced arthritis (CIA). Seven-month-old female Sprague-Dawley rats were divided into five groups: rats without CIA (CNT), CIA rats that underwent ovariectomy (OVX) and were treated with RAL (CIA + OVX + RAL), C...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-010-9432-6
更新日期:2011-02-01 00:00:00
abstract::The effects of a series of novel phosphonates on the kinetics of mineral development in an ionophore-primed 7:2:1 phosphatidylcholine (PC): dicetylphosphate (DCP): cholesterol (Chol) liposomal model system are reported. When present at 2.5 micromol/liter or 25 micromol/liter concentrations in the solution surrounding ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02509384
更新日期:1996-05-01 00:00:00
abstract::The five-year survival rate for primary bone cancers is ~ 70% while almost all cases of secondary metastatic bone cancer are terminal. Hypoxia, the deficiency of oxygen which occurs as the rate of tumour growth exceeds the supply of vascularisation, is a key promoter of tumour progression. Hypoxia-driven effects in th...
journal_title:Calcified tissue international
pub_type: 杂志文章,评审
doi:10.1007/s00223-017-0352-6
更新日期:2018-02-01 00:00:00
abstract::Bone is a dynamic tissue that is able to sense and adapt to mechanical stimuli by modulating its mass, geometry, and structure. Bone marrow stromal cells (BMSCs) are known to play an integral part in bone formation by providing an osteoprogenitor cell source capable of differentiating into mature osteoblasts in respon...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-003-0104-7
更新日期:2004-05-01 00:00:00
abstract::Amelogenins are the most abundant secreted proteins in developing dental enamel. These evolutionarily-conserved proteins have important roles in enamel mineral formation, as mutations within the amelogenin gene coding region lead to defects in enamel thickness or mineral structure. Because of extensive alternative spl...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-002-0036-7
更新日期:2003-11-01 00:00:00
abstract::Plasma osteocalcin (BGP), growth hormone (GH), and somatomedin C(SmC) were measured in 12 patients with acromegaly [7 clinically active (aA), 5 cured (cA)] and 9 control subjects (C). Basal plasma values for the three parameters were higher in aA than in C and in cA. No significant difference was found between cA and ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02555167
更新日期:1988-07-01 00:00:00
abstract::This article reviews the effects of restrictive eating disorders on bone health. The relationship between eating disorders and amenorrhea is discussed in detail. The pathologic impact of malnutrition on bone is explored by examining the results of studies using various available imaging techniques. The multiple hormon...
journal_title:Calcified tissue international
pub_type: 杂志文章,评审
doi:10.1007/s00223-016-0164-0
更新日期:2017-05-01 00:00:00
abstract::Insulin is a potent stimulator of collagen synthesis and other osteoblastic cell functions. In various insulin-sensitive tissues, stimulation of glucose transport and glycolytic metabolism are hallmarks of insulin action and may play a role in insulin regulation of cellular function. However, the effects of insulin on...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02556657
更新日期:1989-07-01 00:00:00
abstract::The purpose of this study was to determine whether total serum calcium, parathyroid gland structure, and/or levels of parathyroid hormone, 1,25 and 24,25 DHCC, are altered in pigs with dental and skeletal fluorosis. Eight experimental animals receiving 2 mg F-/kg b.w. per day from age 8-14 months were compared with ei...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02556714
更新日期:1986-04-01 00:00:00
abstract::To assess the reductions in bone mass, strength, and turnover in adjuvant-induced arthritic rats and to examine the effect of a new benzamide compound, DU-6712, on these parameters, a 28-day dosing experiment was performed using 8-week-old female Lewis rats. Arthritis was induced by injecting the adjuvant into the hin...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900472
更新日期:1998-06-01 00:00:00
abstract::Discarded tissues, like human amniotic membranes and adipose tissue, were investigated for the application of Decellularized Human Amniotic Membrane (DAM) as a viable scaffold for transplantation of Adipose-derived stromal cells (ASCs) in bone regeneration of non-healing calvarial defects in rats. Amniotic membrane wa...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-020-00793-1
更新日期:2021-01-09 00:00:00
abstract::Bone collagen undergoes a series of enzymatic and nonenzymatic posttranslational modifications with maturation. The aim of this study was to analyze the collagenolytic efficiency of cathepsin K in relation to the extent of bone collagen age. Bone collagen posttranslational maturation was induced in vitro by preincubat...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-012-9604-7
更新日期:2012-07-01 00:00:00
abstract::Binding sites for wheat germ agglutinin (WGA)-lectin have been shown to become revealed in the demineralized resorption lacunae that osteoclasts excavate on bone substrate. Peroxidase-conjugated WGA-lectin, which binds to bone matrix glycoconjugates and proteoglycans, was used in pit formation assays to assess the act...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00299317
更新日期:1994-11-01 00:00:00
abstract::Serum immunoreactive osteocalcin (irOC) consists of two fractions that differ from each other by their affinity for hydroxyapatite. The high and low affinity fractions are referred to as irOCbound and irOCfree, respectively. To evaluate whether these fractions are determinants for different characteristics of bone or ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900543
更新日期:1998-11-01 00:00:00
abstract::Skeletal tissues contain, apart from cells of the osteogenic and chondrogenic lineage, cells of hemopoietic origin, e.g., macrophages, osteoclasts, and their precursors. In the present study we examined the sensitivity for extracellular ATP4- of the above-mentioned cell types in freshly isolated, bone-derived cell pop...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00297190
更新日期:1994-08-01 00:00:00
abstract::Twenty-five female Caucasians, aged 19-57 years, with the hypermobility syndrome had bone density measurements using established noninvasive techniques such as dual X-ray absorptiometry (DXA), single photon absorptiometry (SPA), heel ultrasound (US), and peripheral computed tomography (pQCT) acquisitions of the radius...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223001093
更新日期:2000-07-01 00:00:00
abstract::The extracellular protein matrix of developing enamel includes a major class of proteins, the amelogenins, which are believed to be concerned in regulating enamel biomineralization. Previous studies have shown the amelogenins of the extracellular matrix to be a complex of proline-rich hydrophobic proteins which, it is...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02556044
更新日期:1989-10-01 00:00:00