In vitro synthesis of type I collagen: quantification of carboxyterminal propeptide of procollagen type I versus tritiated proline incorporation.

abstract：:We investigated the effects of conjugated estrogens as an add-back replacement drug, incadronate sodium as a bisphosphonate, and alfacalcidol as a vitamin D(3) analog on femoral bone mineral density (BMD) and bone mineral content (BMC) in female rats chronically treated with the gonadotropin-releasing hormone (GnRH) a...

journal_title：Calcified tissue international

authors： Sakamoto S,Sassa S,Mitamura T,Kudo H,Suzuki S,Yoshimura S,Zhou Y,Kikuchi T,Shinoda H

更新日期：1999-08-01 00:00:00

abstract：:This study examined bone density among postmenopausal Buddhist nuns and female religious followers of Buddhism in southern Taiwan and related the measurements to subjects characteristics including age, body mass, physical activity, nutrient intake, and vegetarian practice. A total of 258 postmenopausal Taiwanese veget...

journal_title：Calcified tissue international

authors： Chiu JF,Lan SJ,Yang CY,Wang PW,Yao WJ,Su LH,Hsieh CC

更新日期：1997-03-01 00:00:00

abstract：:Crouzon syndrome is a debilitating congenital disorder involving abnormal craniofacial skeletal development caused by mutations in fibroblast growth factor receptor-2 (FGFR2). Phenotypic expression in humans exhibits an autosomal dominant pattern that commonly involves premature fusion of the coronal suture (craniosyn...

journal_title：Calcified tissue international

authors： Liu J,Nam HK,Wang E,Hatch NE

更新日期：2013-05-01 00:00:00

abstract：:At 4 and 24 hours after injection of (35S)sulfate, there were 22-67% fewer silver grains on conventionally fixed sections than on sections fixed by cryotechniques. Differences were smaller when (3H) glucosamine was chosen as precursor. The number of silver grains increased between 4 and 24 hours in predentine and in a...

journal_title：Calcified tissue international

authors： Goldberg M,Escaig F

更新日期：1985-09-01 00:00:00

abstract：:We examined the osteogenesis process in transforming growth factor beta 1 (TGF-beta 1)-treated neonatal and adult rats, aiming to investigate the age difference in the effect of TGF-beta 1 on mesenchymal cell differentiation. Recombinant human (rh) TGF-beta 1 (20 and 200 ng) was injected onto the outer periostea of th...

journal_title：Calcified tissue international

authors： Taniguchi Y,Tanaka T,Gotoh K,Satoh R,Inazu M

更新日期：1993-08-01 00:00:00

abstract：:We studied the effect of raloxifene (RAL) on arthritis and bone mineral density (BMD) in rats with collagen-induced arthritis (CIA). Seven-month-old female Sprague-Dawley rats were divided into five groups: rats without CIA (CNT), CIA rats that underwent ovariectomy (OVX) and were treated with RAL (CIA + OVX + RAL), C...

journal_title：Calcified tissue international

authors： Hayashi I,Hagino H,Okano T,Enokida M,Teshima R

更新日期：2011-02-01 00:00:00

abstract：:Raman spectroscopy and imaging are known to be valuable tools for the analysis of bone, the determination of protein secondary structure, and the study of the composition of crystalline materials. We have utilized all of these attributes to examine how mechanical loading and the resulting deformation affects bone ultr...

journal_title：Calcified tissue international

authors： Carden A,Rajachar RM,Morris MD,Kohn DH

更新日期：2003-02-01 00:00:00

abstract：:Micro-computed tomography (microCT) has become a standard tool for the evaluation of bone morphology in preclinical studies. Unfortunately, the user-dependent definition of contour lines that separate trabecular from cortical bone is not only extremely time-consuming but may also represent a source of data bias and in...

journal_title：Calcified tissue international

authors： Lublinsky S,Ozcivici E,Judex S

更新日期：2007-10-01 00:00:00

abstract：:The crystallinity of bone mineral at different stages of maturation has been measured by quantitative X-ray diffraction methods. Crystallinity measurements were made on tibial mid-diaphyses from 17-day embryonic chicks, newly-formed periosteal bone from embryonic chicks, and density-fractionated bone from post-hatch c...

journal_title：Calcified tissue international

authors： Bonar LC,Roufosse AH,Sabine WK,Grynpas MD,Glimcher MJ

更新日期：1983-01-01 00:00:00

abstract：:In this cross-sectional study, 91 healthy premenopausal women aged 20-39 years were investigated to determine the effect of physical activities during their teenage years on their current bone mineral densities (BMD). We measured whole-body BMD (WBMD), lumbar BMD (LBMD), and radial BMD (RBMD) with dual energy X-ray ab...

journal_title：Calcified tissue international

authors： Hara S,Yanagi H,Amagai H,Endoh K,Tsuchiya S,Tomura S

更新日期：2001-01-01 00:00:00

abstract：:The effect of the configuration of porous cylindrical hydroxyapatite (HA) scaffold and laminin preparation of the scaffold on bone formation was estimated. HA scaffolds with a hollow center of 2 or 4 mm in diameter and those without a hollow center were used. The scaffolds were immersed in laminin solution or in cultu...

journal_title：Calcified tissue international

authors： Yoshikawa M,Tsuji N,Shimomura Y,Hayashi H,Ohgushi H

更新日期：2008-08-01 00:00:00

abstract：:We have recently reported that risedronate preserves normal bone formation and decreases bone remodeling in women with postmenopausal osteoporosis after 3 years of treatment. We report now the results of a 2-year extension study. The primary objective of this study was to determine the effect of 5 years of risedronate...

journal_title：Calcified tissue international

authors： Ste-Marie LG,Sod E,Johnson T,Chines A

更新日期：2004-12-01 00:00:00

abstract：:Although radiogenic free radicals are widely used as molecular probes in biological calcified tissues, their nature and their location remain controversial. In the present study we have synthesized and irradiated apatites in which 13CO3(2-) ions substitute hydroxyl or phosphate ions in hydroxyapatite. The 13C-coupling...

journal_title：Calcified tissue international

authors： Geoffroy M,Tochon-Danguy HJ

更新日期：1982-01-01 00:00:00

abstract：:Treatment of large bone defects (LBDs) is technically demanding. Tissue engineering is an option. A bioactive graft may be produced by combining tissue scaffolds and healing promotive factors in order to accelerate bone repair. We investigated the role of Simvastatin (Sim)-embedded porous Gelapin (Gel) scaffold on exp...

journal_title：Calcified tissue international

authors： Moshiri A,Shahrezaee M,Shekarchi B,Oryan A,Azma K

更新日期：2015-06-01 00:00:00

abstract：:This study sought to confirm that osteoblasts of C3H/HeJ (C3H) mice, which have higher differentiation status and bone-forming ability compared to C57BL/6J (B6) osteoblasts, also have a lower apoptosis level and to test whether the higher differentiation status and bone-forming ability of C3H osteoblasts were related ...

journal_title：Calcified tissue international

authors： Sheng MH,Lau KH,Mohan S,Baylink DJ,Wergedal JE

更新日期：2006-05-01 00:00:00

abstract：:The mechanism whereby liposomal entrapment enhances the hypocalcemic effect of calcitonin (CT) was evaluated in the rat. Phosphatidylcholine (PC) and PC plus cholesterol (PCC) preparations of large multilammelar vesicles (MLV) and small unilammelar vesicles (SUV) were used to entrap human calcitonin (hCT). The effect ...

journal_title：Calcified tissue international

authors： Fukunaga M,Miller MM,Deftos LJ

更新日期：1990-12-01 00:00:00

abstract：:Quantitative computed tomography (QCT) was compared to dual X-ray absorptiometry (DXA) measured in the lumbar spine of 508 European women defined as normal without fracture (NoF), or osteoporotic (OP), with either vertebral fracture (VF), or peripheral fracture (PF). The correlations between QCT and DXA BMD measuremen...

journal_title：Calcified tissue international

authors： Bergot C,Laval-Jeantet AM,Hutchinson K,Dautraix I,Caulin F,Genant HK

更新日期：2001-02-01 00:00:00

abstract：:The usefulness of various bone mineral measurement techniques is a subject of current controversy. In order to explore whether disparate conclusions may have arisen from differences in analytic methodology, data from published reports of bone mass and nonviolent fractures have been reanalyzed in terms of fracture risk...

journal_title：Calcified tissue international

authors： Ross PD,Davis JW,Vogel JM,Wasnich RD

更新日期：1990-03-01 00:00:00

abstract：:Regular physical activity (PA) is associated with reduced risk of the development and progression of musculoskeletal, metabolic and vascular disease. However, PA declines with age and this can contribute to multiple adverse outcomes. The aims of this study were to describe the relationship between accelerometer-determ...

journal_title：Calcified tissue international

authors： Westbury LD,Dodds RM,Syddall HE,Baczynska AM,Shaw SC,Dennison EM,Roberts HC,Sayer AA,Cooper C,Patel HP

更新日期：2018-09-01 00:00:00

abstract：:Osteoarthritis (OA) is a chronic, debilitating disease affecting millions of people worldwide. Management of OA involves pharmacological and non-pharmacological approaches. Conventional pharmacological treatments have limited efficacy and are associated with a number of side-effects, restricting the number of patients...

journal_title：Calcified tissue international

authors： Ghouri A,Conaghan PG

更新日期：2020-02-13 00:00:00

abstract：:The goal of this study was to find out if bone can recover after long-term administration of bisphosphonate. Disodium pamidronate (APD) was given orally by gavage to mature beagle dogs at doses of 0, 2.5, 12.5, and 25 mg/kg/day for 1 year (0.1% concentration) and the animals were allowed to recover for another year. A...

journal_title：Calcified tissue international

authors： Grynpas MD,Kasra M,Dumitriu M,Nespeca R,Very JM,Mertz BP

更新日期：1994-10-01 00:00:00

abstract：:Bone loss during advancing age in women and men is partly the result of sex steroid deficiency. As the contribution of circulating sex steroids and sex hormone-binding globulin (SHBG) to bone loss remains uncertain, we sought to determine whether levels of sex steroids or SHBG predict change in bone mineral density (B...

journal_title：Calcified tissue international

authors： Bjørnerem A,Emaus N,Berntsen GK,Joakimsen RM,Fønnebø V,Wilsgaard T,Oian P,Seeman E,Straume B

更新日期：2007-08-01 00:00:00

abstract：:Racial differences in bone mineral density (BMD) appear to account in part for racial differences in the incidence of osteoporosis and fractures. We previously reported that the greater BMD in adult blacks compared with whites is associated with a higher serum 17 beta-estradiol and greater secretion of growth hormone ...

journal_title：Calcified tissue international

authors： Wright NM,Papadea N,Veldhuis JD,Bell NH

更新日期：2002-03-01 00:00:00

abstract：:The native human parathyroid hormone, hPTH-(1-84), and certain carboxyl truncated analogs such as hPTH-(1-34) and even smaller fragments such as hPTH-(1-31)NH2, [Leu27]cyclo(Glu22-Lys26)hPTH-(1-31)NH2, and hPTH-(1-30)NH2 stimulate femoral trabecular and cortical bone growth in ovariectomized (OVX) rats. Here we show t...

journal_title：Calcified tissue international

authors： Whitfield JF,Morley P,Fraher L,Hodsman AB,Holdsworth DW,Watson PH,Willick GE,Barbier JR,Gulam M,Isaacs RJ,MacLean S,Ross V

更新日期：2000-04-01 00:00:00

abstract：:It is our hypothesis that interstitial fluid flow plays a role in the bone remodeling response to mechanical loading. The fluid flow-induced expression of three proteins (collagen, osteopontin, and alkaline phosphatase) involved in bone remodeling was investigated. Rat calvarial osteoblasts subjected to pulsatile flui...

journal_title：Calcified tissue international

authors： Hillsley MV,Frangos JA

更新日期：1997-01-01 00:00:00

abstract：:Bone mineralization density distribution (BMDD) is an important determinant of bone mechanical properties. The most available skeletal site for access to the BMDD is the iliac crest. Compared to cancellous bone much less information on BMDD is available for cortical bone. Hence, we analyzed complete transiliac crest b...

journal_title：Calcified tissue international

authors： Misof BM,Dempster DW,Zhou H,Roschger P,Fratzl-Zelman N,Fratzl P,Silverberg SJ,Shane E,Cohen A,Stein E,Nickolas TL,Recker RR,Lappe J,Bilezikian JP,Klaushofer K

更新日期：2014-10-01 00:00:00

abstract：:The current study is based on our earlier investigation carried out in 1999, where bone mineral density (BMD) of 35 neurofibromatosis type 1 (NF1) patients was measured and osteoporosis was shown to be common in NF1. The findings have been confirmed by a number of later publications. The purpose of the current longitu...

journal_title：Calcified tissue international

authors： Heervä E,Leinonen P,Kuorilehto T,Peltonen S,Pöyhönen M,Väänänen K,Peltonen J

更新日期：2013-01-01 00:00:00

abstract：:Tumor tissue from a patient with squamous cell carcinoma of the lung and hypercalcemia has been serially implanted into athymic mice. Tumor-bearing mice develop cachexia, hypercalcemia without bone metastases, hypophosphatemia, increased urinary cyclic adenosine monophosphate (cAMP) to creatinine ratio, and undetectab...

journal_title：Calcified tissue international

authors： Abramson EC,Kukla LJ,Shevrin DH,Lad TE,McGuire WP,Kukreja SC

更新日期：1984-09-01 00:00:00

abstract：:Cost-effective intervention thresholds (ITs) based on FRAX(®) were determined for Portugal. Assuming a willingness to pay (WTP) of €32,000 per quality-adjusted life years (QALYs), treatment with generic alendronate is cost effective for men and women aged 50 years or more, with 10-year probabilities for major osteopor...

journal_title：Calcified tissue international

authors： Marques A,Lourenço Ó,Ortsäter G,Borgström F,Kanis JA,da Silva JA

更新日期：2016-08-01 00:00:00

abstract：:It is generally accepted that bone formation is depressed during corticosteroid treatment, but the effects of glucocorticoids on bone resorption are less well characterized. We have investigated the effects of short-term treatment with high-dose oral glucocorticoids on biochemical markers of bone turnover in 20 consec...

journal_title：Calcified tissue international

authors： Bornefalk E,Dahlén I,Michaëlsson K,Ljunggren,Ljunghall S

更新日期：1998-07-01 00:00:00