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Effects of high-fat diet on mature bone mineral content, structure, and mechanical properties.

Abstract：

:Diets with a high saturated fat content can produce deleterious effects on the absorption of dietary calcium and consequently an adverse effect on bone mineralization in growing animals. Hence dietary fat may have long-term consequences for skeletal health and skeletal pathologies such as osteoporosis. Whether a diet high in saturated fat has similar negative effects on adult bone, however, remains unresolved. Thus, we investigated effects of a high-fat diet on mature bone structure and mechanics. Adult (40-week-old) roosters were maintained for 20 weeks on either a diet high in saturated fat (HF) or a low-fat (LF) diet. Cortical bone samples (tarsometatarsus) were tested mechanically in three-point bending, and cancellous bone cores from the femoral condyles and tibial plateau (four sites per knee) were tested mechanically in compression. Cortical bone cross-sectional areal data were also compared among the groups, and bone mineral content (BMC) was determined (by ashing) for both cortical bone and cancellous bone samples. There were no significant high-fat diet effects on mature cortical bone mechanical properties, geometric structure, or mineral content. Diet, however, did affect cancellous bone composition. For example, LF cancellous BMC was significantly greater than HF. Mechanical properties of the cancellous bone showed similar trends such that LF cancellous bone strength was consistently greater than HF. The potential for adverse effects of a HF diet on intestinal calcium absorption in the mature animal may be more apparent in cancellous bone, with its faster rate of turnover, than in cortical bone. Changes in cancellous bone structure and mechanical properties, related to dietary saturated fats, may have implications for understanding the role of nutrition in skeletal health and prevention of pathological bone loss (osteoporosis).

journal_name

Calcif Tissue Int

journal_title

Calcified tissue international

authors

Wohl GR,Loehrke L,Watkins BA,Zernicke RF

doi

10.1007/s002239900492

subject

Has Abstract

pub_date

1998-07-01 00:00:00

pages

74-9

issue

eissn

0171-967X

issn

1432-0827

journal_volume

pub_type

杂志文章

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Effects of high-fat diet on mature bone mineral content, structure, and mechanical properties.