Melatonin Suppresses Estrogen Deficiency-Induced Osteoporosis and Promotes Osteoblastogenesis by Inactivating the NLRP3 Inflammasome.

abstract：:The native human parathyroid hormone, hPTH-(1-84), and certain carboxyl truncated analogs such as hPTH-(1-34) and even smaller fragments such as hPTH-(1-31)NH2, [Leu27]cyclo(Glu22-Lys26)hPTH-(1-31)NH2, and hPTH-(1-30)NH2 stimulate femoral trabecular and cortical bone growth in ovariectomized (OVX) rats. Here we show t...

journal_title：Calcified tissue international

authors： Whitfield JF,Morley P,Fraher L,Hodsman AB,Holdsworth DW,Watson PH,Willick GE,Barbier JR,Gulam M,Isaacs RJ,MacLean S,Ross V

更新日期：2000-04-01 00:00:00

abstract：:The interaction between estrogens and androgens, with their protective effects in bone, and parathyroid hormone (PTH), a calcitropic peptide hormone, is complex but may be better understood with murine models. The purpose of this study was to characterize skeletal phenotypes of mice deficient in estrogen receptor alph...

journal_title：Calcified tissue international

authors： Tözüm TF,Oppenlander ME,Koh-Paige AJ,Robins DM,McCauley LK

更新日期：2004-07-01 00:00:00

abstract：:Icariin, the main constituent of Herba Epimedii, appears to be a promising alternative to classic drugs used to treat osteoporosis. However, the detailed molecular mechanisms of its action and the role of icariin in the cross-talk between osteoblasts and adipocytes remain unclear. The present study was designed to inv...

journal_title：Calcified tissue international

authors： Zhang D,Fong C,Jia Z,Cui L,Yao X,Yang M

更新日期：2016-08-01 00:00:00

abstract：:The influence of the macroscale material properties of bone on its mechanical competence has been extensively investigated, but less is known about possible contributions from bone's nanoscale material properties. These nanoscale properties, particularly the collagen network and the size and shape of hydroxyapatite mi...

journal_title：Calcified tissue international

authors： Acerbo AS,Kwaczala AT,Yang L,Judex S,Miller LM

更新日期：2014-11-01 00:00:00

abstract：:Thyroparathyroidectomized rats fed a diet containing 1.2% calcium, 0.55% phosphorus maintain normal serum levels of these ions. Treatment of such rats with parathyroid extract (PTE; 20 U/100 g twice daily; 10 days) has no statistically significant effect on rates of bone formation, matrix apposition, or osteoid matura...

journal_title：Calcified tissue international

authors： Rader JI,Howard GA,Feist E,Turner RT,Baylink DJ

更新日期：1979-11-01 00:00:00

abstract：:This study sought to develop a noninvasive, reliable, clinically relevant, and easy-to-implement mouse model that can be used for investigation of the pathophysiology of PTOA and for preclinical testing of new therapies of PTOA. Accordingly, we have established a closed intraarticular tibial plateau compression loadin...

journal_title：Calcified tissue international

authors： Stiffel V,Rundle CH,Sheng MH,Das S,Lau KW

更新日期：2020-02-01 00:00:00

abstract：:Risk factors for increased mortality in hip fracture patients include older age, male sex, fracture type, bone mineral density, and pre-existing co-morbidities. The role of biochemical and other anthropometric parameters on hip fracture mortality remains unclear. The aim of this study was to identify the risk factors ...

journal_title：Calcified tissue international

authors： Gulin T,Kruljac I,Kirigin L,Merc M,Pavić M,Trcin MT,Bokulić A,Megla ŽB,Kaštelan D

更新日期：2016-01-01 00:00:00

abstract：:Pleiotrophin (PTN) was found to have potent effects on regulation of osteoblast recruitment, proliferation and differentiation. The present study examined the long-term effects of targeted PTN over-expression on bone development and repair in a transgenic mouse model. Femurs and tibiae from the PTN transgenic mice and...

journal_title：Calcified tissue international

authors： Li G,Bunn JR,Mushipe MT,He Q,Chen X

更新日期：2005-04-01 00:00:00

abstract：:The purpose of this study was to examine the influence of exercise on the serum concentrations of intact parathyroid hormone (PTH). Serum PTH and plasma lactate were measured in 15 well-trained men, 9 long-distance runners and 6 fire-fighters, during two running exercises. Test one consisted of 40-minute treadmill run...

journal_title：Calcified tissue international

authors： Salvesen H,Johansson AG,Foxdal P,Wide L,Piehl-Aulin K,Ljunghall S

更新日期：1994-04-01 00:00:00

abstract：:Humanin (HN), a mitochondrial derived peptide, plays cyto-protective role under various stress. In this study, we aimed to investigate the effects of HNGF6A, an analogue of HN, on osteoblast apoptosis and differentiation and the underlying mechanisms. Cell proliferation of murine osteoblastic cell line MC3TC-E1 was ex...

journal_title：Calcified tissue international

authors： Zhu X,Zhao Z,Zeng C,Chen B,Huang H,Chen Y,Zhou Q,Yang L,Lv J,Zhang J,Pan D,Shen J,Duque G,Cai D

更新日期：2020-05-01 00:00:00

abstract：:Measurements of broadband ultrasonic attenuation (BUA) represent an established means of skeletal status assessment in osteoporosis. Today, the skeletal site that is the most widely used clinically is the calcaneus (heel bone). However, we hypothesized that fracture risk predictions could be improved if ultrasound mea...

journal_title：Calcified tissue international

authors： Padilla F,Akrout L,Kolta S,Latremouille C,Roux C,Laugier P

更新日期：2004-11-01 00:00:00

abstract：:Measurement of areal bone mineral density (aBMD) in intravertebral subregions may increase the diagnostic sensitivity of dual-energy X-ray absorptiometry (DXA)-derived parameters for vertebral fragility. This study investigated whether DXA-derived bone parameters in vertebral subregions were better predictors of verte...

journal_title：Calcified tissue international

authors： Briggs AM,Perilli E,Codrington J,Reynolds KJ,Parkinson IH,Wark JD

更新日期：2014-08-01 00:00:00

abstract：:The dentin-enamel junction (DEJ) plays an important role in preventing crack propagation from enamel into dentin. This function stems from its complex structure and materials properties that are different from either dentin or enamel. The molecular structural differences in both mineral and organic matrix across the D...

journal_title：Calcified tissue international

authors： Xu C,Yao X,Walker MP,Wang Y

更新日期：2009-03-01 00:00:00

abstract：:To investigate the possible role of calmodulin in the calcium sensitivity of parathyroid adenylate cyclase (AC), the effect of the calmodulin inhibitor trifluoperazine hydrochloride (TFP) on the calcium sensitivity of forskolin-stimulated AC activity was investigated in membranes prepared from normal porcine parathyro...

journal_title：Calcified tissue international

authors： Oldham SB,Lipson LG

更新日期：1986-05-01 00:00:00

abstract：:We compared the cytotoxic effects of alendronate (ALN) and incadronate (YM175) on isolated rabbit osteoclasts in vitro and on rats in vivo. In the in vitro experiment, each bisphosphonate was added to the culture of isolated osteoclasts at the final concentration of 3 x 10(-5), 3 x 10(-4), or 3 x 10(-3) M, and the amo...

journal_title：Calcified tissue international

authors： Ito M,Chokki M,Ogino Y,Satomi Y,Azuma Y,Ohta T,Kiyoki M

更新日期：1998-08-01 00:00:00

abstract：:The crystallinity of bone mineral at different stages of maturation has been measured by quantitative X-ray diffraction methods. Crystallinity measurements were made on tibial mid-diaphyses from 17-day embryonic chicks, newly-formed periosteal bone from embryonic chicks, and density-fractionated bone from post-hatch c...

journal_title：Calcified tissue international

authors： Bonar LC,Roufosse AH,Sabine WK,Grynpas MD,Glimcher MJ

更新日期：1983-01-01 00:00:00

abstract：:The protein components of biomineralized structures (matrix proteins) are believed to modulate crystal nucleation and growth, and thereby influence the shape and strength of the final structure. The chicken eggshell contains a complex array of distinct matrix proteins. The most abundant of these was purified to homoge...

journal_title：Calcified tissue international

authors： Hincke MT,Tsang CP,Courtney M,Hill V,Narbaitz R

更新日期：1995-06-01 00:00:00

abstract：:We have previously shown that cyclosporin A (CsA) produces high bone remodeling with resorption exceeding formation and loss of bone volume in the rat. This may have important clinical implications where CsA is widely used in organ transplantation. 1,25 dihydroxyvitamin D3 (1,25(OH)2D3) is a bone mineralizing hormone ...

journal_title：Calcified tissue international

authors： Epstein S,Schlosberg M,Fallon M,Thomas S,Movsowitz C,Ismail F

更新日期：1990-09-01 00:00:00

abstract：:Allogenous demineralized bone matrix (DBM) represents a potential scaffold for bone tissue engineering due to its close relation in structure and function with autologous bone, but its supply is often restricted by donor availability. Thus, an expanded source of human bone is needed. The aim of this study was to evalu...

journal_title：Calcified tissue international

authors： Liu G,Sun J,Li Y,Zhou H,Cui L,Liu W,Cao Y

更新日期：2008-09-01 00:00:00

abstract：:The accuracy of a radiographic absorptiometry (RA) technique called digital image processing (DIP), discriminative ability of RA for osteoporotic fracture, and the relationship between RA and dual X-ray absorptiometry (DXA) of the spine and forearm were evaluated. We measured 16 cadaver hands, 32 healthy non-black pre...

journal_title：Calcified tissue international

authors： Hagiwara S,Engelke K,Takada M,Yang SO,Grampp S,Dhillon MS,Genant HK

更新日期：1998-02-01 00:00:00

abstract：:Formalin fixation of hard tissues alters the levels of some, but not all, of the parameters routinely measured by bone researchers. Although mineral parameters (ash weight, particle size (beta 1/2 002) and Ca/PO4 ratio) and lipid parameters (total lipid content and composition, extractability, and Ca-acidic phospholip...

journal_title：Calcified tissue international

authors： Boskey AL,Cohen ML,Bullough PG

更新日期：1982-07-01 00:00:00

abstract：:The existence of nutritional deficiency rickets among infants in sunny Riyadh was confirmed radiologically. Most of the rachitic infants were breast-fed, some received unsupplemented infant feeding formulae, and all live in an environment that is devoid of sunlight. Their mean age at the time of onset was 10.5 months....

journal_title：Calcified tissue international

authors： Elidrissy AT,Sedrani SH,Lawson DE

更新日期：1984-05-01 00:00:00

abstract：:Unfixed, undecalcified sections from closed fractures of rat metatarsals have been studied by quantitative cytochemistry from the first week after fracture to late in the fracture-healing process. Alkaline phosphatase activity appeared to be related to calcification. Glucose 6-phosphate dehydrogenase activity was asso...

journal_title：Calcified tissue international

authors： Dunham J,Catterall A,Bitensky L,Chayen J

更新日期：1983-01-01 00:00:00

abstract：:Cross-sectional and case-control studies are efficient and inexpensive approaches to the study of osteoporosis; their validity depends primarily on how the subjects are sampled. Retrospective studies of fractures may be biased if measurements change as a result of the fracture. Prospective cohort studies are less pron...

journal_title：Calcified tissue international

authors： Cummings SR

更新日期：1991-01-01 00:00:00

abstract：:The CYP3A7 enzyme metabolizes some steroid hormones, including dehydroepiandrosterone sulfate (DHEAS). The age-related decline of serum DHEAS levels is believed to contribute to osteoporosis. Previously, the CYP3A7*1C polymorphism has been shown to cause a persistent high CYP3A7 enzyme activity, resulting in lower lev...

journal_title：Calcified tissue international

authors： Bácsi K,Kósa JP,Borgulya G,Balla B,Lazáry A,Nagy Z,Horváth C,Speer G,Lakatos P

更新日期：2007-03-01 00:00:00

abstract：:Alkaline phosphatase is detected in both soluble and particulate fractions of rat bone. The concentration of alkaline phosphatase in the particulate fraction of rat skull cap bone and femur is high during the peak period of calcification of these bones suggesting the possibility of using it as a marker for the rate of...

journal_title：Calcified tissue international

authors： Murthy GP,Rajalakshmi R,Ramakrishnan CV

更新日期：1986-09-01 00:00:00

abstract：:Teriparatide (TPTD) is known to increase the cortical thickness and porosity. The purpose of the present study was to determine whether switching from TPTD to ibandronate (IBN) would be useful for improving cortical bone parameters as assessed using high-resolution quantitative computed tomography (HR-QCT) analyses in...

journal_title：Calcified tissue international

authors： Iwamoto J,Seki A,Nango N

更新日期：2016-11-01 00:00:00

abstract：:Serum immunoreactive osteocalcin (irOC) consists of two fractions that differ from each other by their affinity for hydroxyapatite. The high and low affinity fractions are referred to as irOCbound and irOCfree, respectively. To evaluate whether these fractions are determinants for different characteristics of bone or ...

journal_title：Calcified tissue international

authors： Knapen MH,Nieuwenhuijzen Kruseman AC,Wouters RS,Vermeer C

更新日期：1998-11-01 00:00:00

abstract：:The feasibility of two noninvasive methods [dual photon absorptiometry (DPA) and dual energy X-ray absorptiometry (DXA)] for prediction in vivo of local variations of trabecular bone strength within the proximal tibia was evaluated in 14 cadaveric knees. Trabecular bone strength was measured using an osteopenetrometer...

journal_title：Calcified tissue international

authors： Petersen MM,Jensen NC,Gehrchen PM,Nielsen PK,Nielsen PT

更新日期：1996-10-01 00:00:00

abstract：:Long-term use of hydrochlorothiazide (HCTZ), a common diuretic agent for hypertension, has been associated with increased bone density and reduced hip fracture rates in patients. In this study, we sought to examine whether HCTZ has an anabolic effect on the proliferation of human osteoblasts (derived from either verte...

journal_title：Calcified tissue international

authors： Lau KH,Song XD,Ochi M,Wergedal JE

更新日期：1996-12-01 00:00:00