Abstract：
:Measurements of broadband ultrasonic attenuation (BUA) represent an established means of skeletal status assessment in osteoporosis. Today, the skeletal site that is the most widely used clinically is the calcaneus (heel bone). However, we hypothesized that fracture risk predictions could be improved if ultrasound measurements were performed directly at the main site of fracture, e.g., the proximal femur. The goal of this paper is to demonstrate in vitro the feasibility of quantitative ultra sound (QUS) imaging at the upper part of fee femur, and to investigate the relationships of BUA to bone mineral density (BMD). Forty-four excise human femurs were measured in transmission with a pair of focused 0.5-MHz central frequency transducers. Two-dimensional scans were performed, and the radio frequency (rf) signals were recorded at each measurement point. A data acceptance criterion for region of interest (ROI) selection was established based on the linearity of the frequency-dependent attenuation. Five measurements with repositioning were performed on each sample to determine the reproducibility. Dual energy x-ray absorptiometry (DXA) scans have been performed on the samples for BMD measurements: Three ROIs were selected in the specimens: greater, trochanter intertrochanteric, and femoral neck regions. Coefficient of variations were in the range 1.6% to 2.5%. The determination coefficients (r(2)) between BUA and BMD in site-matched ROIs were 0.81, 0.78, and 0.73, respectively, for the greater trochanteric, intertrochanteric, and femoral neck regions. Our results are consistent with data previously shown at the calcaneus and demonstrate the feasibility of QUS measurements at the femur in vitro, with reasonable reproducibility.
journal_name
Calcif Tissue Intjournal_title
Calcified tissue internationalauthors
Padilla F,Akrout L,Kolta S,Latremouille C,Roux C,Laugier Pdoi
10.1007/s00223-004-0216-8subject
Has Abstractpub_date
2004-11-01 00:00:00pages
421-30issue
5eissn
0171-967Xissn
1432-0827journal_volume
75pub_type
杂志文章abstract：:Quantitative ultrasound measurement (QUS) and bone mineral density (BMD) have each been shown to predict fracture risk in women. The present study examined whether a combination of QUS and BMD could improve the predictive accuracy of fracture risk. This is a population-based prospective study which involved 454 women ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-011-9556-3
更新日期：2012-02-01 00:00:00
abstract：:The acute-phase response (APR) is frequently observed in patients treated with intravenous (iv) zoledronate (ZOL). We investigated whether a short course of rosuvastatin (ROSU) could attenuate the ZOL--induced APR through blocking the mevalonate pathway at a proximal level. Twenty-eight osteoporotic postmenopausal wom...
journal_title：Calcified tissue international
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00223-011-9468-2
更新日期：2011-05-01 00:00:00
abstract：:There is increasing evidence that 1,25 dihydroxyvitamin D3 acts directly to differentiate and activate cells of mononuclear phagocyte lineage (MNP). However, it seems possible that in bone marrow this hormone may modulate the differentiation of MNP via the factor elaborated by the stromal cells or the macrophages. We ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02556592
更新日期：1986-01-01 00:00:00
abstract：:The calcium ion binding properties of a high molecular weight bovine phosphophoryn preparation have been studied at high ionic strength (0.5 M KCl as supporting electrolyte). Surprisingly, even under these conditions at which intermolecular ionic interactions are effectively screened, phosphophoryn was capable of bind...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02555712
更新日期：1987-02-01 00:00:00
abstract：:High resolution transmission electron microscopy (Hr TEM) studies on biological and synthetic calcium phosphate have provided information on the dissolution process at the crystal level. The purpose of this study was to investigate the dissolution of ceramic hydroxyapatite (HA) after implantation using Hr TEM. Recover...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02561408
更新日期：1989-08-01 00:00:00
abstract：:Results of previous studies suggest that children and adolescents with osteogenesis imperfecta (OI) type IV have muscle force deficits. However, muscle function remains to be objectively quantified in this population. This study aimed to assess upper and lower extremity muscle function in patients with OI type IV. It ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-017-0287-y
更新日期：2017-10-01 00:00:00
abstract：:The wedges of the mid-diaphyseal osteotomies carried out to correct the femoral and/or tibial native deformity in type III osteogenesis imperfecta (OI III) were used to study the remodeling patterns and lamellar organization at the level of the major deformity. Histology and scanning electron microscopy (SEM) morpholo...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-013-9771-1
更新日期：2013-11-01 00:00:00
abstract：:Discarded tissues, like human amniotic membranes and adipose tissue, were investigated for the application of Decellularized Human Amniotic Membrane (DAM) as a viable scaffold for transplantation of Adipose-derived stromal cells (ASCs) in bone regeneration of non-healing calvarial defects in rats. Amniotic membrane wa...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-020-00793-1
更新日期：2021-01-09 00:00:00
abstract：:Calcium and phosphate were allowed to diffuse into gelatin and Type I collagen gels which were then cut into slices and analyzed for ion concentrations. Solutions of calcium and phosphate were then prepared, with ion concentrations equivalent to the highest levels in the slices, and mixed together, whereupon a rapid a...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02556459
更新日期：1991-06-01 00:00:00
abstract：:The ability of 1,25(OH)2D3 and of 24,25(OH)2D3 to prevent or to heal rickets in chicks was evaluated by studies of plasma biochemistry, growth plate histology, bone morphometry and microradiography, and bone mineralization. 1,25(OH)2D3 at a dose of 100 ng/day produced fewest abnormalities compared with vitamin D3-trea...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02405303
更新日期：1984-01-01 00:00:00
abstract：:We investigated the effects of conjugated estrogens as an add-back replacement drug, incadronate sodium as a bisphosphonate, and alfacalcidol as a vitamin D(3) analog on femoral bone mineral density (BMD) and bone mineral content (BMC) in female rats chronically treated with the gonadotropin-releasing hormone (GnRH) a...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900675
更新日期：1999-08-01 00:00:00
abstract：:The definition of osteoporosis was based for several years on bone mineral density values, which were used by most guidelines for defining treatment thresholds. The availability of tools for the estimation of fracture risk, such as FRAX™ or its adapted Italian version, DeFRA, is providing a way to grade osteoporosis s...
journal_title：Calcified tissue international
pub_type： 社论
doi：10.1007/s00223-013-9748-0
更新日期：2013-09-01 00:00:00
abstract：:We studied the effect of raloxifene (RAL) on arthritis and bone mineral density (BMD) in rats with collagen-induced arthritis (CIA). Seven-month-old female Sprague-Dawley rats were divided into five groups: rats without CIA (CNT), CIA rats that underwent ovariectomy (OVX) and were treated with RAL (CIA + OVX + RAL), C...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-010-9432-6
更新日期：2011-02-01 00:00:00
abstract：:The DMS Lexxos is the first cone-beam dual X-ray absorptiometry (DXA) system capable of performing bone mineral density (BMD) measurements of the spine and hip. By using a two-dimensional (2-D) detector array rather than the linear array used with conventional fan-beam DXA systems, image acquisition time on Lexxos is ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-004-0080-6
更新日期：2005-02-01 00:00:00
abstract：:The diphosphonates dichloromethanediphosphonate (Cl2MDP) and to a minor degree 1-hydroxyethane-1,1-diphosphonate (EDHP) increased the glycogen content in cultured cartilage cells of rabbit ear. This effect was not due to different concentrations of glucose in the medium. ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02408621
更新日期：1980-01-01 00:00:00
abstract：:Magnetic resonance imaging (MRI) is commonly used in the assessment of the musculoskeletal system and associated pathology. The ability of MRI to measure the signals from water and lipid protons enables quantitative measurements of bone porosity. The goal of this investigation was to demonstrate that the density and c...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002230050015
更新日期：2000-01-01 00:00:00
abstract：:Disturbances in mineral and bone metabolism are common in patients with chronic kidney disease (CKD), especially those undergoing dialysis. Renal osteodystrophy, which describes an alteration of bone morphology, is an important component of this systemic disorder and may explain the elevated risk of fracture which adv...
journal_title：Calcified tissue international
pub_type： 杂志文章,评审
doi：10.1007/s00223-020-00788-y
更新日期：2021-01-02 00:00:00
abstract：:The severest long-term complications of orthopedic joint-prostheses are associated with loosening of the implant-bone interface, due to adverse reactions in bone and subsequent weakening of the connection between the two materials. Mechanical stresses, caused by joint loading, play a key role in the adaption of interf...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02406143
更新日期：1984-01-01 00:00:00
abstract：:The bone anabolic effect of parathyroid hormone (PTH) therapy is blunted when used in patients who were previously on bisphosphonate treatment. Osteocytes may play a role in the bisphosphonate silencing effect on PTH therapy since bisphosphonates have been shown to reach the lacunocanalicular system. In vivo osteocyte...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-013-9720-z
更新日期：2013-06-01 00:00:00
abstract：:The mechanism whereby liposomal entrapment enhances the hypocalcemic effect of calcitonin (CT) was evaluated in the rat. Phosphatidylcholine (PC) and PC plus cholesterol (PCC) preparations of large multilammelar vesicles (MLV) and small unilammelar vesicles (SUV) were used to entrap human calcitonin (hCT). The effect ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02555889
更新日期：1990-12-01 00:00:00
abstract：:In general, physical exercise appears to have favorable effects on the skeleton. However, a few recent reports have described negative effects, including reduced bone density (BMD) and high bone turnover in runners. The aim of our study was to compare endurance runners to controls with respect to BMD at different site...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900366
更新日期：1997-12-01 00:00:00
abstract：:Several rare inherited disorders have been described that show phenotypic overlap with Paget's disease of bone (PDB) and in which PDB is a component of a multisystem disorder affecting muscle and the central nervous system. These conditions are the subject of this review article. Insertion mutations within exon 1 of t...
journal_title：Calcified tissue international
pub_type： 杂志文章,评审
doi：10.1007/s00223-019-00520-5
更新日期：2019-05-01 00:00:00
abstract：:Bone formation in a variety of contexts depends on angiogenesis; however, there are few reports of the vascular response to osteogenic skeletal loading. We used the rat forelimb compression model to characterize vascular changes after fatigue loading. The right forelimbs of 72 adult rats were loaded cyclically in vivo...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-007-9031-3
更新日期：2007-06-01 00:00:00
abstract：:Calcium-acidic phospholipid-phosphate complexes (Ca-PL-PO4) cause hydroxyapatite (HA) deposition in vitro. The acidic phospholipids--phosphatidylserine (PS), phosphatidylinositol (PI), phosphatidylglycerol (PG), and diphosphatidylglycerol (DPG)--all form Ca-PL-PO4 complexes: Nonacidic phospholipids--sphingomyelin (SPL...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：
更新日期：1982-01-01 00:00:00
abstract：:The present study reports on the separation of fluid from soft, "cheeselike" enamel of porcine permanent teeth in the secretory stage, and the determination of its chemical composition. The enamel tissues were dissected from mandibles of 5 to 6-month-old piglets and pooled under mineral oil in centrifuge tubes, and th...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02555250
更新日期：1987-08-01 00:00:00
abstract：:The mineral of cortical bones has been studied in newborn, growing, and adult rats and in the calf and cow, using X-ray diffraction and infrared spectroscopy during the thermal decomposition of bones and by microassay of carbonate. The mineral of all the bone samples, regardless of species or age, was found to be a ca...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02563793
更新日期：1987-09-01 00:00:00
abstract：:Osteoporosis is a bone disease leading to an increased fracture risk. It is considered a complex multifactorial genetic disorder with interaction of environmental and genetic factors. As a candidate gene for osteoporosis, we studied vitamin D binding protein (DBP, or group-specific component, Gc), which binds to and t...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-009-9251-9
更新日期：2009-08-01 00:00:00
abstract：:The presence of lipids in urinary stones was determined by histochemical and biochemical methods. When crystals of calcium oxalate, made by mixing calcium chloride and potassium oxalate solutions and sections of human calcium oxalate urinary stones, were exposed to osmium vapors, there was no staining of the pure crys...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02556340
更新日期：1988-02-01 00:00:00
abstract：:Carboxy-terminal pyridinoline cross-linked telopeptide of type I collagen (ICTP) in serum has recently been proposed as a new biochemical marker of bone resorption. In the present study we compared serum ICTP with radiopharmaceutical and histomorphometric measurements of bone turnover in postmenopausal women with mild...
journal_title：Calcified tissue international
pub_type： 临床试验,杂志文章
doi：10.1007/BF00316286
更新日期：1994-01-01 00:00:00
abstract：:The effect of long-chain n-3 polyunsaturated fatty acid (PUFA) on bone measurements was evaluated in gonad-intact middle-aged male rats. Seven rats were killed on day 0 of dietary intervention to determine bone parameters at baseline. Experimental rats (7/group) were fed one of the following lipid treatments (g/kg die...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-007-9010-8
更新日期：2007-04-01 00:00:00
