当前位置： SCI文献检索 > CALCIFIED TISSUE INTERNATIONAL期刊下所有文献 > No effect of rosuvastatin in the zoledronate-induced acute-phase response.

No effect of rosuvastatin in the zoledronate-induced acute-phase response.

Abstract：

:The acute-phase response (APR) is frequently observed in patients treated with intravenous (iv) zoledronate (ZOL). We investigated whether a short course of rosuvastatin (ROSU) could attenuate the ZOL--induced APR through blocking the mevalonate pathway at a proximal level. Twenty-eight osteoporotic postmenopausal women with no prior bisphosphonate use (mean age 65.3 ± 1.9 years) were subjected to ZOL iv infusion. Patients were randomly assigned into either a ROSU+ group (n = 12), which received ROSU 10 mg/day starting 5 days before the infusion of ZOL for a total period of 11 days, or a ROSU- group (n = 16), which did not receive ROSU. The visual analog pain scale (VAS) for musculoskeletal symptoms and body temperature was used to define clinically APR. In addition, white blood cell (WBC) count, leukocytic subpopulations, and C-reactive protein (CRP) were obtained before and 48 h following the infusion. Seven (58.3%) patients in the ROSU+ group and 13 (81.3%) in the ROSU- group experienced APR (P = not significant). No difference was found in fever and VAS measurements. CRP and granulocytes increased significantly in both groups; WBC count increased, while lymphocytes and eosinophils decreased significantly only in the ROSU- group. In a post hoc analysis of only patients with an APR, all laboratory parameters exhibited a similar significant change solely within the ROSU- group. In conclusion, our data suggest that a short course of ROS at this dose cannot prevent the ZOL-induced APR among osteoporotic women. Milder changes in acute-phase laboratory parameters in ROSU+ patients suggest that studies with higher doses may be warranted.

journal_name

Calcif Tissue Int

journal_title

Calcified tissue international

authors

Makras P,Anastasilakis AD,Polyzos SA,Bisbinas I,Sakellariou GT,Papapoulos SE

doi

10.1007/s00223-011-9468-2

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

402-8

issue

5

eissn

0171-967X

issn

1432-0827

journal_volume

88

pub_type

杂志文章,随机对照试验

相关文献

CALCIFIED TISSUE INTERNATIONAL文献大全
  • Malignant osteopetrosis: c-src kinase is not reduced in fibroblasts.

    abstract：:Targeted disruption of the c-src gene leads to a severe form of osteopetrosis in mice [2]. As the c-src gene is expressed in all tissues and cells tested, we have analyzed fibroblasts from three individuals with malignant, congenital osteopetrosis for the expression of c-src at the protein level. No differences could ...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/BF01352018

    authors： Meyerson G,Dahl N,Påhlman S

    更新日期：1993-07-01 00:00:00

  • A critical review of bone mass and the risk of fractures in osteoporosis.

    abstract：:The usefulness of various bone mineral measurement techniques is a subject of current controversy. In order to explore whether disparate conclusions may have arisen from differences in analytic methodology, data from published reports of bone mass and nonviolent fractures have been reanalyzed in terms of fracture risk...

    journal_title：Calcified tissue international

    pub_type： 杂志文章,meta分析

    doi：10.1007/BF02555036

    authors： Ross PD,Davis JW,Vogel JM,Wasnich RD

    更新日期：1990-03-01 00:00:00

  • A new culture method assuring the three-dimensional development of the mouse embryonic molar tooth in vitro.

    abstract：:Mandibular first molars from 17-day-old mouse embryos were cultivated in vitro for 10 days using a new organ culture method. This method consisted of using a small glass dish and an agar chamber to slowly float the molars to the gas-medium interface where they were maintained by the surface tension of the medium. The ...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/BF02555218

    authors： Sakakura Y

    更新日期：1986-10-01 00:00:00

  • Purification and immunochemistry of a soluble matrix protein of the chicken eggshell (ovocleidin 17).

    abstract：:The protein components of biomineralized structures (matrix proteins) are believed to modulate crystal nucleation and growth, and thereby influence the shape and strength of the final structure. The chicken eggshell contains a complex array of distinct matrix proteins. The most abundant of these was purified to homoge...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/BF00298593

    authors： Hincke MT,Tsang CP,Courtney M,Hill V,Narbaitz R

    更新日期：1995-06-01 00:00:00

  • Unanticipated changes in steady-state mRNA levels for glyceraldehyde-3-phosphate dehydrogenase in rat tibiae.

    abstract：:Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) mRNA levels are commonly used as an internal control to normalize gene expression data based on the belief that this gene is constitutively expressed. However, GAPDH mRNA levels increased by more than 2.5-fold in tibiae of hindlimb unloaded female rats compared to L32 m...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s00223-002-1098-2

    authors： Maran A,Hefferan TE,Zhang M,Turner RT

    更新日期：2004-02-01 00:00:00

  • Comparison of parathyroid hormone and calcium ionophore A23187 effects on bone resorption and nucleic acid synthesis in cultured fetal rat bone.

    abstract：:It has recently been demonstrated that calcium ionophore A23187 mimics certain of the effects of parathyroid hormone (PTH) on bone in vitro, including stimulation of 45Ca release and cAMP formation. To further examine the relative effects of these two agents on bone cell metabolism, we compared the effects of syntheti...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/BF02411291

    authors： DeBartolo TF,Pegg LE,Shasserre C,Hahn TJ

    更新日期：1982-09-01 00:00:00

  • Discriminatory ability of quantitative ultrasound measurements is similar to dual-energy X-ray absorptiometry in a Brazilian women population with osteoporotic fracture.

    abstract：:The discriminating ability and relevance of clinical risk factors, quantitative ultrasound (QUS) variables, X-ray-based bone mineral density (BMD) and hip axis length (HAL) measurements to evaluate the risk of osteoporotic fracture in elderly Brazilian women were examined in this study. QUS at the calcaneus (Achilles ...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s00223-002-1096-4

    authors： Pinheiro MM,Castro CH,Frisoli A Jr,Szejnfeld VL

    更新日期：2003-12-01 00:00:00

  • Impact of Conventional Medical Therapy on Bone Mineral Density and Bone Turnover in Adult Patients with X-Linked Hypophosphatemia: A 6-Year Prospective Cohort Study.

    abstract：:X-linked hypophosphatemia (XLH) is a rare, inheritable disorder manifesting as rickets in children and osteomalacia in adults. While conventional medical treatment with oral phosphate and alfacalcidol is recommended in childhood, it is undecided whether adults should continue therapy. The aim of this 6-year prospectiv...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s00223-017-0363-3

    authors： Shanbhogue VV,Hansen S,Jørgensen NR,Beck-Nielsen SS

    更新日期：2018-03-01 00:00:00

  • Induction of interleukin-6 release in human osteoblast-like cells exposed to titanium particles in vitro.

    abstract：:Orthopaedic wear debris induces release of bone-resorbing factors from macrophages and fibroblasts. However, the extent to which elemental metallic particles induce bone cells to express factors contributing to implant loosening remains unclear. This study showed that exposure of MG-63 osteoblast-like cells to titaniu...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s00223001125

    authors： Shida J,Trindade MC,Goodman SB,Schurman DJ,Smith RL

    更新日期：2000-08-01 00:00:00

  • Treatment with zoledronic acid ameliorates negative geometric changes in the proximal femur following acute spinal cord injury.

    abstract：:Acute spinal cord injury is associated with rapid bone loss and an increased risk of fracture. In this double-blind, randomized, placebo-controlled trial, 17 patients were followed for 1 year after administration of either 4 or 5 mg of zoledronic acid or placebo. Bone mineral density (BMD) and structural analyses of t...

    journal_title：Calcified tissue international

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00223-007-9012-6

    authors： Shapiro J,Smith B,Beck T,Ballard P,Dapthary M,BrintzenhofeSzoc K,Caminis J

    更新日期：2007-05-01 00:00:00

  • Recovery from pamidronate (APD): a two-year study in the dog.

    abstract：:The goal of this study was to find out if bone can recover after long-term administration of bisphosphonate. Disodium pamidronate (APD) was given orally by gavage to mature beagle dogs at doses of 0, 2.5, 12.5, and 25 mg/kg/day for 1 year (0.1% concentration) and the animals were allowed to recover for another year. A...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/BF00310408

    authors： Grynpas MD,Kasra M,Dumitriu M,Nespeca R,Very JM,Mertz BP

    更新日期：1994-10-01 00:00:00

  • PTHR1 polymorphisms influence BMD variation through effects on the growing skeleton.

    abstract：:We investigated whether polymorphisms in PTHR1 are associated with bone mineral density (BMD), to determine whether the association of this gene with BMD was due to effects on attainment of peak bone mass or effects on subsequent bone loss. The PTHR1 gene, including its 14 exons, their exon-intron boundaries, and 1,50...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s00223-007-9072-7

    authors： Vilariño-Güell C,Miles LJ,Duncan EL,Ralston SH,Compston JE,Cooper C,Langdahl BL,Maclelland A,Pols HA,Reid DM,Uitterlinden AG,Steer CD,Tobias JH,Wass JA,Brown MA

    更新日期：2007-10-01 00:00:00

  • Effect of raloxifene on arthritis and bone mineral density in rats with collagen-induced arthritis.

    abstract：:We studied the effect of raloxifene (RAL) on arthritis and bone mineral density (BMD) in rats with collagen-induced arthritis (CIA). Seven-month-old female Sprague-Dawley rats were divided into five groups: rats without CIA (CNT), CIA rats that underwent ovariectomy (OVX) and were treated with RAL (CIA + OVX + RAL), C...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s00223-010-9432-6

    authors： Hayashi I,Hagino H,Okano T,Enokida M,Teshima R

    更新日期：2011-02-01 00:00:00

  • Association of Plasma SDF-1 with Bone Mineral Density, Body Composition, and Hip Fractures in Older Adults: The Cardiovascular Health Study.

    abstract：:Aging is associated with an increase in circulating inflammatory factors. One, the cytokine stromal cell-derived factor 1 (SDF-1 or CXCL12), is critical to stem cell mobilization, migration, and homing as well as to bone marrow stem cell (BMSC), osteoblast, and osteoclast function. SDF-1 has pleiotropic roles in bone ...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s00223-017-0245-8

    authors： Carbone LD,Bůžková P,Fink HA,Robbins JA,Bethel M,Hamrick MW,Hill WD

    更新日期：2017-06-01 00:00:00

  • The Orientation of Nanoscale Apatite Platelets in Relation to Osteoblastic-Osteocyte Lacunae on Trabecular Bone Surface.

    abstract：:The orientation of nanoscale mineral platelets was quantitatively evaluated in relation to the shape of lacunae associated with partially embedded osteocytes (osteoblastic-osteocytes) on the surface of deproteinised trabecular bone of adult sheep. By scanning electron microscopy and image analysis, the mean orientatio...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s00223-015-0072-8

    authors： Shah FA,Zanghellini E,Matic A,Thomsen P,Palmquist A

    更新日期：2016-02-01 00:00:00

  • Bone mineral density and bone turnover in patients with knee osteoarthritis compared with generalized osteoarthritis.

    abstract：:The aim of this study was to investigate bone mineral density (BMD) and bone turnover in patients with primary knee osteoarthritis (KOA) and to compare them with generalized OA (GOA) and nonGOA patients. A total of 88 postmenopausal primary KOA patients were studied. OA was graded by using knee radiographs. BMD of the...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s002230010068

    authors： Naitou K,Kushida K,Takahashi M,Ohishi T,Inoue T

    更新日期：2000-05-01 00:00:00

  • A comparison of spinal quantitative computed tomography with dual energy X-ray absorptiometry in European women with vertebral and nonvertebral fractures.

    abstract：:Quantitative computed tomography (QCT) was compared to dual X-ray absorptiometry (DXA) measured in the lumbar spine of 508 European women defined as normal without fracture (NoF), or osteoporotic (OP), with either vertebral fracture (VF), or peripheral fracture (PF). The correlations between QCT and DXA BMD measuremen...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/BF02678144

    authors： Bergot C,Laval-Jeantet AM,Hutchinson K,Dautraix I,Caulin F,Genant HK

    更新日期：2001-02-01 00:00:00

  • Bone marker alterations in patients with type 1 Gaucher disease.

    abstract：:Bone involvement is one of the most disabling aspects of type I Gaucher disease and its pathophysiology is still not well understood. As an invasive procedure, bone biopsies are not appropriate in a large population study. The development of sensitive bone resorption and formation tests have allowed the authors to stu...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s00223-001-2072-0

    authors： Ciana G,Martini C,Leopaldi A,Tamaro G,Katouzian F,Ronfani L,Bembi B

    更新日期：2003-03-01 00:00:00

  • Long-term treatment with eldecalcitol (1α, 25-dihydroxy-2β- (3-hydroxypropyloxy) vitamin D3) suppresses bone turnover and leads to prevention of bone loss and bone fragility in ovariectomized rats.

    abstract：:The purpose of this study is to estimate the efficacy of eldecalcitol (1α, 25-Dihydroxy-2β- (3-hydroxypropyloxy) vitamin D3; ELD) on bone metabolism after long-term administration. Six-month-old Wistar-Imamichi rats were ovariectomized (OVX) and administered ELD orally at doses of 7.5, 15, or 30 ng/kg daily. Bone mine...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s00223-014-9937-5

    authors： Takeda S,Smith SY,Tamura T,Saito H,Takahashi F,Samadfam R,Haile S,Doyle N,Endo K

    更新日期：2015-01-01 00:00:00

  • Spinal bone mineral after 5 weeks of bed rest.

    abstract：:Patients put at bedrest for medical reasons lose 1-2% of spinal bone mineral per week. Losses of this magnitude during even short-term space flights of a few months would pose a serious limitation and require countermeasures. The spinal bone mineral (L2-L4) was determined in 6 healthy males (precision = 2%) before and...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/BF02555226

    authors： LeBlanc A,Schneider V,Krebs J,Evans H,Jhingran S,Johnson P

    更新日期：1987-11-01 00:00:00

  • Material damping for monitoring of density and strength of bones.

    abstract：:The aim of this work was a preliminary assessment of the feasibility of using in vivo measurements of mechanical properties of bones to detect mineral loss and further to relate them to the tendency of the bone to fracture in the case of loss of minerals, such as in osteoporosis. Previous studies of bone strength in v...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/BF00298727

    authors： Dimarogonas AD,Abbasi-Jahromi SH,Avioli LV

    更新日期：1993-03-01 00:00:00

  • Efficacy of periodontal disease and tooth loss to screen for low bone mineral density in Japanese women.

    abstract：:The relationship between oral indicators and bone mineral density (BMD) has been studied by many investigators, with mixed and complex results. The purpose of the present cross-sectional study was to evaluate the associations of periodontal conditions and tooth loss with metacarpal BMD (m-BMD) in a community-based coh...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s00223-004-0275-x

    authors： Inagaki K,Kurosu Y,Yoshinari N,Noguchi T,Krall EA,Garcia RI

    更新日期：2005-07-01 00:00:00

  • Diurnal rhythm in serum osteocalcin: relation with sleep, growth hormone, and PTH(1-84).

    abstract：:We examined the role of sleep, growth hormone (GH), and parathyroid hormone [PTH(1-84)] as regulators of the diurnal rhythm of the osteoblastic bone marker, serum osteocalcin (OC). Nine normal subjects were followed with hourly blood sampling during one 24-hour period with normal sleep pattern, and one 24-hour period ...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/BF02555845

    authors： Nielsen HK,Brixen K,Kassem M,Christensen SE,Mosekilde L

    更新日期：1991-12-01 00:00:00

  • Ultrasonic velocity as a predictor of strength in bovine cancellous bone.

    abstract：:Ultrasonic methods measure properties intrinsic to bone's structure that are not necessarily dependent on bone mass. Therefore, ultrasound may prove to be a useful tool for diagnosing bone fragility and osteoporosis. The goal of this study was to determine the relationship between apparent velocity of ultrasound (AVU)...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/BF02565132

    authors： Turner CH,Eich M

    更新日期：1991-08-01 00:00:00

  • Short-term effect of vitamin K administration on prednisolone-induced loss of bone mineral density in patients with chronic glomerulonephritis.

    abstract：:Glucocorticoid-induced osteoporosis has been reported to be caused by enhanced bone resorption and suppressed bone formation. To clarify whether administration of vitamin K, which enhances bone formation, prevents prednisolone-induced loss of bone mineral density (BMD), a randomized, prospective, controlled study was ...

    journal_title：Calcified tissue international

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/pl00005832

    authors： Yonemura K,Kimura M,Miyaji T,Hishida A

    更新日期：2000-02-01 00:00:00

  • Prevention of osteopenia induced with a gonadotropin-releasing hormone agonist in rats.

    abstract：:We investigated the effects of conjugated estrogens as an add-back replacement drug, incadronate sodium as a bisphosphonate, and alfacalcidol as a vitamin D(3) analog on femoral bone mineral density (BMD) and bone mineral content (BMC) in female rats chronically treated with the gonadotropin-releasing hormone (GnRH) a...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s002239900675

    authors： Sakamoto S,Sassa S,Mitamura T,Kudo H,Suzuki S,Yoshimura S,Zhou Y,Kikuchi T,Shinoda H

    更新日期：1999-08-01 00:00:00

  • Fuzzy logic structure analysis of trabecular bone of the calcaneus to estimate proximal femur fracture load and discriminate subjects with and without vertebral fractures using high-resolution magnetic resonance imaging at 1.5 T and 3 T.

    abstract：:Newly developed fuzzy logic-derived structural parameters were used to characterize trabecular bone architecture in high-resolution magnetic resonance imaging (HR-MRI) of human cadaver calcaneus specimens. These parameters were compared to standard histomorphological structural measures and analyzed concerning perform...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s00223-007-9058-5

    authors： Patel PV,Eckstein F,Carballido-Gamio J,Phan C,Matsuura M,Lochmüller EM,Majumdar S,Link TM

    更新日期：2007-10-01 00:00:00

  • Developmental expression of genes in chick growth cartilage detected by in situ hybridization.

    abstract：:We have used in situ hybridization to examine expression of collagen type I, II, and X mRNA and osteonectin mRNA in the chick epiphysis. Tissue samples from the proximal tibial growth cartilage were fixed in modified Carnoy's solution, dehydrated in ethanol, and embedded in paraffin. Longitudinal and transverse sectio...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/BF02556062

    authors： Oshima O,Leboy PS,McDonald SA,Tuan RS,Shapiro IM

    更新日期：1989-09-01 00:00:00

  • Melatonin Suppresses Estrogen Deficiency-Induced Osteoporosis and Promotes Osteoblastogenesis by Inactivating the NLRP3 Inflammasome.

    abstract：:Postmenopausal osteoporosis induced by estrogen deficiency causes inadequate new bone formation and affects millions of women worldwide. Melatonin can improve bone mineral density at the femoral neck in postmenopausal women with osteopenia. This study aimed to investigate the mechanism of melatonin in estrogen deficie...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s00223-018-0428-y

    authors： Xu L,Zhang L,Wang Z,Li C,Li S,Li L,Fan Q,Zheng L

    更新日期：2018-10-01 00:00:00

  • Regional variations in histomorphometric bone dynamics from the skeleton of an osteoporotic woman.

    abstract：:Histomorphometric evaluation of bone formation in an intravital tetracycline-labeled skeleton of a suddenly deceased osteoporotic woman is presented. The 24 skeletal sites investigated displayed substantial regional variations which, for two out of four cortical bone dynamics and all trabecular bone dynamics, were sig...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/BF02556619

    authors： Pødenphant J,Engel U

    更新日期：1987-04-01 00:00:00