Effects of pleiotrophin (PTN) over-expression on mouse long bone development, fracture healing and bone repair.

abstract：:Targeted disruption of the c-src gene leads to a severe form of osteopetrosis in mice [2]. As the c-src gene is expressed in all tissues and cells tested, we have analyzed fibroblasts from three individuals with malignant, congenital osteopetrosis for the expression of c-src at the protein level. No differences could ...

journal_title：Calcified tissue international

authors： Meyerson G,Dahl N,Påhlman S

更新日期：1993-07-01 00:00:00

abstract：:The binding of prostaglandin E2 (PGE2) to bone cells was studied to provide direct evidence for the existence of specific receptors in bone. Bone cells were isolated by collagenase digestion of fetal and newborn rat calvaria. Isolated cells were incubated with 3H-PGE2 and collected on Millipore filters. Specific bindi...

journal_title：Calcified tissue international

authors： Dziak RM,Hurd D,Miyasaki KT,Brown M,Weinfeld N,Hausmann E

更新日期：1983-01-01 00:00:00

abstract：:Plasma membrane vesicles were prepared from chicken osteoclasts, and active calcium transport was demonstrated in a spectrofluorimetric assay using the fluorescent calcium concentration indicator, fura-2. Transport activity was inhibited by quercetin (10 microM), sodium vanadate (10 microM), and the anticalmodulin age...

journal_title：Calcified tissue international

authors： Bekker PJ,Gay CV

更新日期：1992-10-01 00:00:00

abstract：:A number of osteoporotic patients under bisphosphonate treatment present persistent fragility fractures and bone loss despite good compliance. The objective of this 18-month prospective study was to investigate the effect of teriparatide [rhPTH(1-34)] in 25 female osteoporotics who were inadequate responders to oral b...

journal_title：Calcified tissue international

authors： Jobke B,Muche B,Burghardt AJ,Semler J,Link TM,Majumdar S

更新日期：2011-08-01 00:00:00

abstract：:The purpose of this study was to examine the influence of exercise on the serum concentrations of intact parathyroid hormone (PTH). Serum PTH and plasma lactate were measured in 15 well-trained men, 9 long-distance runners and 6 fire-fighters, during two running exercises. Test one consisted of 40-minute treadmill run...

journal_title：Calcified tissue international

authors： Salvesen H,Johansson AG,Foxdal P,Wide L,Piehl-Aulin K,Ljunghall S

更新日期：1994-04-01 00:00:00

abstract：:A guidance on the assessment and treatment of postmenopausal women at risk from fractures due to osteoporosis was recently published in Osteoporosis International as a joint effort of the International Osteoporosis Foundation and European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (Ka...

journal_title：Calcified tissue international

authors： Kanis JA,Cooper C,Rizzoli R,Reginster JY,Scientific Advisory Board of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) and the Committees of Scientific Advisors and National Societies of the Inter

更新日期：2019-03-01 00:00:00

abstract：:The demonstration of histochemical characteristics in calcifying cartilage is fraught with methodological difficulties including the distinction of mineralized from unmineralized cartilage and the demonstration of cell detail in relatively hard tissue. This study uses the decalcified bone matrix-induced enchondral (en...

journal_title：Calcified tissue international

authors： Aaron RK,Jolly G,Ciombor DM,Barrach HJ

更新日期：1988-10-01 00:00:00

abstract：:Paget's disease of bone (PDB) is a chronic and focal bone disorder, characterized by increased osteoclast-mediated bone resorption and a subsequent compensatory increase in bone formation, resulting in a disorganized mosaic of woven and lamellar bone at one or more affected skeletal sites. As a result, bone pain, noti...

journal_title：Calcified tissue international

authors： Gennari L,Rendina D,Falchetti A,Merlotti D

更新日期：2019-05-01 00:00:00

abstract：:Bruck syndrome is a rare autosomal recessive form of osteogenesis imperfecta (OI), which is mainly characterized by joint contractures and recurrent fragility fractures. Mutations in FKBP10 and PLOD2 were identified as the underlying genetic defects of Bruck syndrome. Here we investigated the phenotypes and the pathog...

journal_title：Calcified tissue international

authors： Lv F,Xu X,Song Y,Li L,Asan,Wang J,Yang H,Wang O,Jiang Y,Xia W,Xing X,Li M

更新日期：2018-03-01 00:00:00

abstract：:Racial differences in bone mineral density (BMD) appear to account in part for racial differences in the incidence of osteoporosis and fractures. We previously reported that the greater BMD in adult blacks compared with whites is associated with a higher serum 17 beta-estradiol and greater secretion of growth hormone ...

journal_title：Calcified tissue international

authors： Wright NM,Papadea N,Veldhuis JD,Bell NH

更新日期：2002-03-01 00:00:00

abstract：:Men and women (n = 518) receiving moderate-to-high doses of corticosteroids were enrolled in two studies with similar protocols and randomly assigned to receive either placebo or risedronate (2.5 or 5 mg) for 1 year. All patients received daily calcium supplementation (500-1000 mg), and most also received supplemental...

journal_title：Calcified tissue international

authors： Wallach S,Cohen S,Reid DM,Hughes RA,Hosking DJ,Laan RF,Doherty SM,Maricic M,Rosen C,Brown J,Barton I,Chines AA

更新日期：2000-10-01 00:00:00

abstract：:Mandibular first molars from 17-day-old mouse embryos were cultivated in vitro for 10 days using a new organ culture method. This method consisted of using a small glass dish and an agar chamber to slowly float the molars to the gas-medium interface where they were maintained by the surface tension of the medium. The ...

journal_title：Calcified tissue international

authors： Sakakura Y

更新日期：1986-10-01 00:00:00

abstract：:The aim of this study was to investigate the relation between birth weight and calcaneal bone stiffness in a large sample of Belgian, healthy, preadolescent children. Participants were 827 children (3.6-11.2 years, 51.6 % boys) from the Belgian cohort of the IDEFICS study. Birth weight was obtained using a parental qu...

journal_title：Calcified tissue international

authors： Van den Bussche K,Michels N,Gracia-Marco L,Herrmann D,Eiben G,De Henauw S,Sioen I

更新日期：2012-10-01 00:00:00

abstract：:Disturbances in mineral and bone metabolism are common in patients with chronic kidney disease (CKD), especially those undergoing dialysis. Renal osteodystrophy, which describes an alteration of bone morphology, is an important component of this systemic disorder and may explain the elevated risk of fracture which adv...

journal_title：Calcified tissue international

authors： Komaba H,Ketteler M,Cunningham J,Fukagawa M

更新日期：2021-01-02 00:00:00

abstract：:Ossification of the posterior longitudinal ligament of the spine (OPLL) is characterized by ectopic bone formation in the spinal ligaments. Mechanical stress, which acts on the posterior ligaments, is thought to be an important factor in the progression of OPLL. To clarify this mechanism, we investigated the effects o...

journal_title：Calcified tissue international

authors： Iwasaki K,Furukawa KI,Tanno M,Kusumi T,Ueyama K,Tanaka M,Kudo H,Toh S,Harata S,Motomura S

更新日期：2004-05-01 00:00:00

abstract：:Hyperthyroidism and thyroid hormone substitutive therapy with serum iT3 in the normal range of values are known to lead to increased bone remodeling and loss of bone mass. We looked for a relationship between serum iT3 and bone metabolic or bone mass parameters in 402 euthyroid women aged 44-60. In a group of 93 preme...

journal_title：Calcified tissue international

authors： Schoutens A,Laurent E,Markowicz E,Lisart J,De Maertelaer V

更新日期：1991-08-01 00:00:00

abstract：:The acute-phase response (APR) is frequently observed in patients treated with intravenous (iv) zoledronate (ZOL). We investigated whether a short course of rosuvastatin (ROSU) could attenuate the ZOL--induced APR through blocking the mevalonate pathway at a proximal level. Twenty-eight osteoporotic postmenopausal wom...

journal_title：Calcified tissue international

authors： Makras P,Anastasilakis AD,Polyzos SA,Bisbinas I,Sakellariou GT,Papapoulos SE

更新日期：2011-05-01 00:00:00

abstract：:The effect of long-chain n-3 polyunsaturated fatty acid (PUFA) on bone measurements was evaluated in gonad-intact middle-aged male rats. Seven rats were killed on day 0 of dietary intervention to determine bone parameters at baseline. Experimental rats (7/group) were fed one of the following lipid treatments (g/kg die...

journal_title：Calcified tissue international

authors： Shen CL,Yeh JK,Rasty J,Chyu MC,Dunn DM,Li Y,Watkins BA

更新日期：2007-04-01 00:00:00

abstract：:In order to investigate the pathogenesis of ossification of the posterior longitudinal ligament (OPLL) of the spine, we examined the distribution of insulin-like growth factor I (IGF-I) in the posterior longitudinal ligaments of OPLL patients, and analyzed the effects of IGF-I on the cultured spinal ligament cells. Fo...

journal_title：Calcified tissue international

authors： Goto K,Yamazaki M,Tagawa M,Goto S,Kon T,Moriya H,Fujimura S

更新日期：1998-02-01 00:00:00

abstract：:The developing mandibular condylar growth center consists of a number of histologically distinct cell types. There is an increase in cell volume that takes place from the condylar surface layer through the center of ossification, resulting in a disorganized, irregular cellular pattern. Consequently, the isolation and ...

journal_title：Calcified tissue international

authors： Landesberg R,Proctor RL,Rosier RN,Puzas JE

更新日期：1995-01-01 00:00:00

abstract：:The increased uptake of bone-seeking radionuclides following a fracture has been stated to be due to an increase in bone blood flow, resulting in an increase in capillary surface area available for exchange. This paper examines the relationship between the maximum instantaneous extraction of 99mTc-MDP and blood flow i...

journal_title：Calcified tissue international

authors： McCarthy ID,Hughes SP

更新日期：1983-07-01 00:00:00

abstract：:This study revealed the distinguished changes of preferential orientation of collagen and apatite and Young's modulus in two different types of osteoporotic bones compared with the normal bone. Little is known about the bone material properties of osteoporotic bones; therefore, we aimed to assess material properties i...

journal_title：Calcified tissue international

authors： Ozasa R,Ishimoto T,Miyabe S,Hashimoto J,Hirao M,Yoshikawa H,Nakano T

更新日期：2019-04-01 00:00:00

abstract：:Monoclonal antibody against bovine serum alpha 2HS glycoprotein was raised in mice and the localization of this glycoprotein in bovine and human teeth was examined by immunohistochemical techniques on undemineralized ground sections after surface etching with dilute HCl. Positive reactions were found in both bovine an...

journal_title：Calcified tissue international

authors： Takagi Y,Shimokawa H,Suzuki M,Nagai H,Sasaki S

更新日期：1990-07-01 00:00:00

abstract：:Vitamin K promotes the formation of gamma-carboxylated glutamate (GLA) in several protein species. GLA residues have a high affinity for the Ca ion. In the present study, we tested the hypothesis that experimental vitamin K deficiency in rats could induce changes in Ca metabolism. Vitamin K depletion, which was associ...

journal_title：Calcified tissue international

authors： Robert D,Jorgetti V,Lacour B,Leclerq M,Cournot-Witmer G,Ulmann A,Drüeke T

更新日期：1985-03-01 00:00:00

abstract：:Non-steroidal anti-inflammatory drugs (NSAID) have been recommended to prevent of heterotopic ossification (HO) after total hip arthroplasty (THA), but debates are still ongoing. The present Bayesian network meta-analysis of randomized clinical trials (RCTs) compared all available pathways of NSAID treatment as prophy...

journal_title：Calcified tissue international

authors： Migliorini F,Trivellas A,Eschweiler J,Driessen A,Tingart M,Maffulli N

更新日期：2021-02-01 00:00:00

abstract：:Conventional transmission electron microscopy requires an effective dehydration of the tissue specimens under investigation. This dehydration, for which ethanol most often is used, may influence the solubility of the slightly soluble calcium phosphates. To study the behavior of calcium phosphates in ethanol, stable ne...

journal_title：Calcified tissue international

authors： Larsen MJ,Thorsen A,Jensen SJ

更新日期：1985-03-01 00:00:00

abstract：:Vitamin D supplementation is recommended for women with osteoporosis. In the FOCUS-D trial comparing the combination tablet alendronate plus vitamin D3 5,600 IU (ALN/D) with standard care (SC) prescribed by patients' personal physicians, ALN/D was more effective in improving serum 25(OH)D and bone turnover markers by ...

journal_title：Calcified tissue international

authors： Roux C,Binkley N,Boonen S,Kiel DP,Ralston SH,Reginster JY,Pong A,Rosenberg E,Santora A,FOCUS-D Investigators.

更新日期：2014-02-01 00:00:00

abstract：:Pregnancy and lactation-associated osteoporosis (PAO) is a rare condition with little known pathophysiology. Most cases are diagnosed in the third trimester of pregnancy or in the first weeks postpartum, particularly in first pregnancies. Vertebral fractures are most commonly observed and characterised by prolonged se...

journal_title：Calcified tissue international

authors： Grizzo FM,da Silva Martins J,Pinheiro MM,Jorgetti V,Carvalho MD,Pelloso SM

更新日期：2015-10-01 00:00:00

abstract：:Hip fracture may cause and/or complicate institutionalization. We undertook this study to define its overall prevalence among the residents of four nursing homes in Central Italy as well as its latency and impact on mobility when it occurred within institutions. We also performed a case control analysis with the aim o...

journal_title：Calcified tissue international

authors： Maggio D,Ubaldi E,Simonelli G,Cenci S,Pedone C,Cherubini A

更新日期：2001-06-01 00:00:00

abstract：:The effects of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) (2.3 x 10(-12) - 1.4 x 10(-6) [M]) on alkaline phosphatase, collagen, and cell proliferation were examined in primary cultured hypertrophic chondrocytes prepared from the distal epiphyseal growth plate of the tibias of 12-day chick embryos. 1,25(OH)2D3 showed time-...

journal_title：Calcified tissue international

authors： Inao S,Conrad HE

更新日期：1992-05-01 00:00:00