The role of skeletal blood flow in determining the uptake of 99mTc-methylene diphosphonate.

abstract：:Aluminum ions (Al) and chromium (III) ions (Cr), as they exist in aqueous solution at neutral pH, adsorb onto calcium hydroxyapatite crystals (HAP) and severely inhibit their dissolution process, when present in concentrations less than 1 microM. Iron (III) ions (Fe), at concentrations up to 10 microM, have no effect ...

journal_title：Calcified tissue international

authors： Christoffersen MR,Thyregod HC,Christoffersen J

更新日期：1987-07-01 00:00:00

abstract：:Osteoarthritis (OA), the most prevalent chronic joint disease, increases in prevalence with age, and affects majority of individuals over the age of 65 and is a leading musculoskeletal cause of impaired mobility in the elderly. Because the precise molecular mechanisms which are involved in the degradation of cartilage...

journal_title：Calcified tissue international

authors： Xia B,Di Chen,Zhang J,Hu S,Jin H,Tong P

更新日期：2014-12-01 00:00:00

abstract：:Unfixed, undecalcified sections from closed fractures of rat metatarsals have been studied by quantitative cytochemistry from the first week after fracture to late in the fracture-healing process. Alkaline phosphatase activity appeared to be related to calcification. Glucose 6-phosphate dehydrogenase activity was asso...

journal_title：Calcified tissue international

authors： Dunham J,Catterall A,Bitensky L,Chayen J

更新日期：1983-01-01 00:00:00

abstract：:We compared the cytotoxic effects of alendronate (ALN) and incadronate (YM175) on isolated rabbit osteoclasts in vitro and on rats in vivo. In the in vitro experiment, each bisphosphonate was added to the culture of isolated osteoclasts at the final concentration of 3 x 10(-5), 3 x 10(-4), or 3 x 10(-3) M, and the amo...

journal_title：Calcified tissue international

authors： Ito M,Chokki M,Ogino Y,Satomi Y,Azuma Y,Ohta T,Kiyoki M

更新日期：1998-08-01 00:00:00

abstract：:The purpose of this study was to examine the influence of exercise on the serum concentrations of intact parathyroid hormone (PTH). Serum PTH and plasma lactate were measured in 15 well-trained men, 9 long-distance runners and 6 fire-fighters, during two running exercises. Test one consisted of 40-minute treadmill run...

journal_title：Calcified tissue international

authors： Salvesen H,Johansson AG,Foxdal P,Wide L,Piehl-Aulin K,Ljunghall S

更新日期：1994-04-01 00:00:00

abstract：:Low-grade inflammation negatively affects bone. Resveratrol is a natural compound proven to possess both anti-inflammatory and bone protective properties. However, it is uncertain if the bone effects are mediated though anti-inflammatory effects. Firstly, we investigated if resveratrol affects proliferation and differ...

journal_title：Calcified tissue international

authors： Ornstrup MJ,Harsløf T,Sørensen L,Stenkjær L,Langdahl BL,Pedersen SB

更新日期：2016-08-01 00:00:00

abstract：:A positional cloning effort in French Canadian families with Paget's disease of bone (PDB) resulted in the identification of a mutation in the sequestosome1 (SQSTM1) gene in a subset of both familial and sporadic PDB cases. This was confirmed in samples of mainly United Kingdom (UK) origin. In this study, we performed...

journal_title：Calcified tissue international

authors： Beyens G,Van Hul E,Van Driessche K,Fransen E,Devogelaer JP,Vanhoenacker F,Van Offel J,Verbruggen L,De Clerck L,Westhovens R,Van Hul W

更新日期：2004-08-01 00:00:00

abstract：:Hyperthyroidism and thyroid hormone substitutive therapy with serum iT3 in the normal range of values are known to lead to increased bone remodeling and loss of bone mass. We looked for a relationship between serum iT3 and bone metabolic or bone mass parameters in 402 euthyroid women aged 44-60. In a group of 93 preme...

journal_title：Calcified tissue international

authors： Schoutens A,Laurent E,Markowicz E,Lisart J,De Maertelaer V

更新日期：1991-08-01 00:00:00

abstract：:In order to study in detail the processes leading to the resorption and ankylosis of teeth after trauma, the effects of cold application on the periodontal tissues were studied in the mouse. Liquid nitrogen was applied locally to the outer surface of the lower jaw which resulted in a freezing of the incisor and its su...

journal_title：Calcified tissue international

authors： Wesselink PR,Beertsen W,Everts V

更新日期：1986-07-01 00:00:00

abstract：:The effect of teriparatide treatment on microdamage accumulation has yet to be examined in animal studies. The purpose of this study was to investigate the effect of once-weekly teriparatide treatment on bone microdamage accumulation and the relationship between microdamage parameters and bone mass, architecture, turn...

journal_title：Calcified tissue international

authors： Yoshitake S,Mashiba T,Saito M,Fujihara R,Iwata K,Takao-Kawabata R,Yamamoto T

更新日期：2019-04-01 00:00:00

abstract：:The metacarpal bone mineral density (BMD) and metacarpal index (MCI) of the second metacarpal bone were measured by computed X-ray densitometry (CXD) (Teijin Ltd., Tokyo), which we have established with the development of microdensitometry of radiographs. In this study, we evaluated the basic attributes of this CXD me...

journal_title：Calcified tissue international

authors： Matsumoto C,Kushida K,Yamazaki K,Imose K,Inoue T

更新日期：1994-11-01 00:00:00

abstract：:The small leucine-rich bone proteoglycans, biglycan and decorin, can be purified by chromatography on hydroxyapatite columns, demonstrating their potential affinities for bone apatite. To determine their effects on in vitro apatite formation and growth, a mixture of the chondroitin-sulfate (CS) bone proteoglycans, or ...

journal_title：Calcified tissue international

authors： Boskey AL,Spevak L,Doty SB,Rosenberg L

更新日期：1997-10-01 00:00:00

abstract：:Five years ago we reported results from a cross-sectional study of the effect of nutritional factors on calcium-regulating hormones and bone loss in perimenopausal women. We found an inverse correlation between serum 25-hydroxyvitamin D (25OHD) and immunoreactive parathyroid hormone (PTH), and we postulated that over ...

journal_title：Calcified tissue international

authors： Lukert B,Higgins J,Stoskopf M

更新日期：1992-09-01 00:00:00

abstract：:Ultrasound measurements of the calcaneus are related to incidence of osteoporotic fracture. Such measurements are generally made at fixed coordinates relative to a footplate. This study compares measurements at an anatomically located region of interest (ROIanat) and at fixed coordinates (ROIfixed), with bone mineral ...

journal_title：Calcified tissue international

authors： Brooke-Wavell K,Jones PR,Pye DW

更新日期：1995-07-01 00:00:00

abstract：:In order to investigate the pathogenesis of ossification of the posterior longitudinal ligament (OPLL) of the spine, we examined the distribution of insulin-like growth factor I (IGF-I) in the posterior longitudinal ligaments of OPLL patients, and analyzed the effects of IGF-I on the cultured spinal ligament cells. Fo...

journal_title：Calcified tissue international

authors： Goto K,Yamazaki M,Tagawa M,Goto S,Kon T,Moriya H,Fujimura S

更新日期：1998-02-01 00:00:00

abstract：:Until 2006 the only mutations known to cause osteogenesis imperfecta (OI) were in the two genes coding for type I collagen chains. These dominant mutations affecting the expression or primary sequence of collagen α1(I) and α2(I) chains account for over 90% of OI cases. Since then a growing list of mutant genes causing...

journal_title：Calcified tissue international

authors： Eyre DR,Weis MA

更新日期：2013-10-01 00:00:00

abstract：:Inorganic phosphate (P(i)) can regulate the level of skeletal alkaline phosphatase (ALP) activity in human osteoblast-like cells, but not by means of changes in transcription or release from the cell surface. The current studies were intended to determine whether (1) P(i) affected the inactivation of ALP activity in h...

journal_title：Calcified tissue international

authors： Farley JR

更新日期：1995-11-01 00:00:00

abstract：:The feasibility of two noninvasive methods [dual photon absorptiometry (DPA) and dual energy X-ray absorptiometry (DXA)] for prediction in vivo of local variations of trabecular bone strength within the proximal tibia was evaluated in 14 cadaveric knees. Trabecular bone strength was measured using an osteopenetrometer...

journal_title：Calcified tissue international

authors： Petersen MM,Jensen NC,Gehrchen PM,Nielsen PK,Nielsen PT

更新日期：1996-10-01 00:00:00

abstract：:Extracellular ATP, and to a lesser extent adenosine, an ATP metabolite, stimulated cell proliferation in osteoblast-like cells (MC3T3-E1). ATP increased cytosolic Ca2+ due to Ca2+ mobilization from intracellular storage in the same concentration range of the nucleotide as that effective for DNA synthesis, suggesting t...

journal_title：Calcified tissue international

authors： Shimegi S

更新日期：1996-02-01 00:00:00

abstract：:This study sought to develop a noninvasive, reliable, clinically relevant, and easy-to-implement mouse model that can be used for investigation of the pathophysiology of PTOA and for preclinical testing of new therapies of PTOA. Accordingly, we have established a closed intraarticular tibial plateau compression loadin...

journal_title：Calcified tissue international

authors： Stiffel V,Rundle CH,Sheng MH,Das S,Lau KW

更新日期：2020-02-01 00:00:00

abstract：:To study the mechanism of action of thyroid hormones on bone, we examined the effects of immunosuppressive and nonimmunosuppressive cyclosporins, as well as of transforming growth factor beta 1 (TGF beta 1), 17 beta-estradiol (E2), and dihydroxytestosterone (DHT) on thyroxine (T4)- and triiodothyronine (T3)-stimulated...

journal_title：Calcified tissue international

authors： Lakatos P,Stern PH

更新日期：1992-02-01 00:00:00

abstract：:Roux-en-Y gastric bypass surgery (RYGB) is an effective treatment of morbid obesity, with positive effects on obesity-related complications. The treatment is associated with bone loss, which in turn might increase fracture risk. The aim of this study was to evaluate changes in bone mineral density (BMD) and bone archi...

journal_title：Calcified tissue international

authors： Frederiksen KD,Hanson S,Hansen S,Brixen K,Gram J,Jørgensen NR,Støving RK

更新日期：2016-03-01 00:00:00

abstract：:This report describes a method using direct photon absorptiometry (DPA) for determination in vivo of the bone mineral content to bone width ratio (BMC/W) in the rat femur. A significant correlation was noted between measurements by DPA and whole femur dry weight and ash weight. Measurements were reproducible within re...

journal_title：Calcified tissue international

authors： Sanchez TV,Myers RC,Bond JT,Mayor GH

更新日期：1981-01-01 00:00:00

abstract：:The absorption kinetics of intranasal salmon calcitonin were assessed in 4 normal subjects and 9 patients with Klinefelter's syndrome. After administration, absorption occurred within 5 minutes. There was a highly significant correlation between the amount administered and the amount absorbed (r = -0.83, P less than 0...

journal_title：Calcified tissue international

authors： Pun KK,Chan LW,Lau P,Ho PW,Wang C

更新日期：1990-02-01 00:00:00

abstract：:This randomized, double-blind study assessed the antifracture efficacy and safety of intermittent intravenous (IV) ibandronate versus oral daily risedronate in Japanese patients with primary osteoporosis. Ambulatory patients aged ≥60 years were randomized to receive 0.5 or 1 mg/month IV ibandronate plus oral daily pla...

journal_title：Calcified tissue international

authors： Nakamura T,Nakano T,Ito M,Hagino H,Hashimoto J,Tobinai M,Mizunuma H,MOVER Study Group.

更新日期：2013-08-01 00:00:00

abstract：:Duffy antigen receptor for chemokines (DARC) binds to a number of pro-inflammatory chemokines, and since chemokines are known to regulate trafficking of osteoclast (OC) precursors, we predicted that DARC would regulate OC recruitment to sites of inflammation by modulating chemokine activity. To test this hypothesis, w...

journal_title：Calcified tissue international

authors： Alemi F,Elgendy M,Edderkaoui B

更新日期：2016-11-01 00:00:00

abstract：:Bone involvement, mainly osteoporosis but also osteosclerosis, is frequent in patients with indolent systemic mastocytosis (ISM). The recent characterization of the canonical Wnt/β-catenin pathway in the regulation of bone remodeling provided important insights for our understanding of the pathophysiology of a number ...

journal_title：Calcified tissue international

authors： Rossini M,Viapiana O,Zanotti R,Tripi G,Perbellini O,Idolazzi L,Bonifacio M,Adami S,Gatti D

更新日期：2015-05-01 00:00:00

abstract：:To define the quantitative aspects of ossification of human fetal spine, we performed a high resolution densitometric study by lateral and postero-anterior scanning of five fetal spines (18-36 weeks of conceptual age) and one spine of a 4-month-old infant. The data were plotted against developmental age for each spine...

journal_title：Calcified tissue international

authors： Panattoni GL,Sciolla A,Isaia GC

更新日期：1995-07-01 00:00:00

abstract：:Twenty boys were followed during their puberty for about 2 years with examinations every third month. At each examination we determined serum concentrations of 25OHD3, 1,25(OH)2D3, 24,25(OH)2D3, 25.26(OH)2D3, alkaline phosphatase (AP) and testosterone together with bone mineral content (BMC) at the distal forearm. Hig...

journal_title：Calcified tissue international

authors： Krabbe S,Christiansen C,Hummer L

更新日期：1986-03-01 00:00:00

abstract：:Osteocalcin, the gamma-carboxyglutamic acid-containing protein, which is the most abundant noncollagenous protein of bone and dentin, is considered to play roles in bone formation and remodeling. It is unclear how the gamma-carboxyglutamic acid side-chains in osteocalcin coordinate to Ca2+, since the X-ray structure o...

journal_title：Calcified tissue international

authors： Mizuguchi M,Fujisawa R,Nara M,Nitta K,Kawano K

更新日期：2001-12-01 00:00:00