Abstract:
:Ultrasound measurements of the calcaneus are related to incidence of osteoporotic fracture. Such measurements are generally made at fixed coordinates relative to a footplate. This study compares measurements at an anatomically located region of interest (ROIanat) and at fixed coordinates (ROIfixed), with bone mineral density measurements, in 84 postmenopausal women. Bone mineral density (BMD) was assessed using dual energy X-ray absorptiometry at both ROIs as well as at lumbar spine and femoral neck. Broadband ultrasound attenuation and velocity of sound were measured using a CUBA system at ROIanat and ROIfixed. Additionally, broadband ultrasound attenuation at ROIfixed was measured using a Walker Sonix instrument. Mean bone mineral density, broadband ultrasound attenuation and velocity of sound did not differ significantly between ROIfixed and ROIanat, although broadband ultrasound attenuation by Walker Sonix (81.4 +/- 14.6 dBMHz-1) was significantly (P < 0.001) greater than that by CUBA (63.7 +/- 14.2 dBMHz-1). The relationship between broadband ultrasound attenuation and BMD differed significantly between the 2 ROIs and the correlation of this relationship was significantly greater at ROIfixed than at ROIanat(r = 0.74 versus 0.46, P < 0.01). The differing relationship may reflect structural variation at different regions. ROI selection may thus be a possible confounding factor in ultrasound measurement.
journal_name
Calcif Tissue Intjournal_title
Calcified tissue internationalauthors
Brooke-Wavell K,Jones PR,Pye DWdoi
10.1007/BF00298991subject
Has Abstractpub_date
1995-07-01 00:00:00pages
20-4issue
1eissn
0171-967Xissn
1432-0827journal_volume
57pub_type
杂志文章abstract::Normal rat bone maturation has been studied using biochemical methods and hydrazine separation of matrix and mineral for X-ray diffraction. In the bone, the amount of mineral increases between 4 and 22 weeks of age, while in the matrix, the ratio of noncollagenous protein to collagen progressively decreases. In minera...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02407162
更新日期:1980-01-01 00:00:00
abstract::The goal of this study was to find out if bone can recover after long-term administration of bisphosphonate. Disodium pamidronate (APD) was given orally by gavage to mature beagle dogs at doses of 0, 2.5, 12.5, and 25 mg/kg/day for 1 year (0.1% concentration) and the animals were allowed to recover for another year. A...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00310408
更新日期:1994-10-01 00:00:00
abstract::Experimental analysis with paired femurs provides the opportunity to study within-person differences in fracture type and associated structural side differences. We hypothesized that different fracture types in the hips of a subject are associated with structural asymmetry. Bone mineral density (BMD) and structural me...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-010-9388-6
更新日期:2010-09-01 00:00:00
abstract::The feasibility of two noninvasive methods [dual photon absorptiometry (DPA) and dual energy X-ray absorptiometry (DXA)] for prediction in vivo of local variations of trabecular bone strength within the proximal tibia was evaluated in 14 cadaveric knees. Trabecular bone strength was measured using an osteopenetrometer...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900131
更新日期:1996-10-01 00:00:00
abstract::There is increasing evidence that 1,25 dihydroxyvitamin D3 acts directly to differentiate and activate cells of mononuclear phagocyte lineage (MNP). However, it seems possible that in bone marrow this hormone may modulate the differentiation of MNP via the factor elaborated by the stromal cells or the macrophages. We ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02556592
更新日期:1986-01-01 00:00:00
abstract::Extracellular ATP, and to a lesser extent adenosine, an ATP metabolite, stimulated cell proliferation in osteoblast-like cells (MC3T3-E1). ATP increased cytosolic Ca2+ due to Ca2+ mobilization from intracellular storage in the same concentration range of the nucleotide as that effective for DNA synthesis, suggesting t...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02529732
更新日期:1996-02-01 00:00:00
abstract::In several studies on patients with rheumatoid arthritis, an association of bone loss with a persistently high disease activity has been found. The aim of our study was to investigate the relation between disease activity and serum levels of vitamin D metabolites, parathyroid hormone (PTH), and parameters of bone turn...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900416
更新日期:1998-03-01 00:00:00
abstract::Osteoporosis is a common disease among patients undergoing transplantation. Its prevalence and complications have been well described in solid organ recipients, especially kidney, liver, and heart. However, studies in bone marrow transplantation (BMT) are scarce. Among the mechanisms invoked in the pathogenesis of BMT...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900240
更新日期:1997-04-01 00:00:00
abstract::1,25 Dihydroxyvitamin D3 (1,25(OH)2D3) (2.0 micrograms) was given intramuscularly to 6 healthy adult males. Twenty-four circadian patterns of blood-ionized calcium (Ca2+), serum phosphate (Pi), and total calcium (CaT) were assessed pre- and posthormone administration. Correlations of mean mineral rhythms with normativ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02553700
更新日期:1985-07-01 00:00:00
abstract::Several studies have demonstrated that bone has the power of regeneration and repair. BMPs (bone morphogenetic proteins) are involved in the determination of osteoblast phenotype and bone turnover, therefore genes coding for these proteins, like BMP-4, could be considered potential candidate genes for osteoporosis. We...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223001103
更新日期:2000-07-01 00:00:00
abstract::Various studies have investigated the serum sclerostin and bone morphogenetic protein-2 (BMP-2) levels in patients with ankylosing spondylitis (AS), but the results were inconsistent. The aim of this meta-analysis was to synthetically assess the associations of serum levels of sclerostin and BMP-2 with AS. Multiple el...
journal_title:Calcified tissue international
pub_type: 杂志文章,meta分析
doi:10.1007/s00223-019-00542-z
更新日期:2019-07-01 00:00:00
abstract::We compared the effects of four vitamin D metabolites, 1 alpha,25 dihydroxy vitamin D3 (1 alpha,25(OH)2D3), 1 alpha hydroxy vitamin D3 (1 alpha OH D3), 25 hydroxy vitamin D3 (25 OH D3), and 24R,25 dihydroxy vitamin D (24R,25(OH)sD3) on resorption and collagen synthesis in fetal rat bone maintained in organ culture. Re...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02408532
更新日期:1980-01-01 00:00:00
abstract::Conventional glucocorticoids exert a negative influence on calcium balance, and long-term treatment with these agents leads to osteopenia. Deflazacort is an oxazoline derivative of prednisolone with documented calcium-sparing properties when compared to prednisone on a weight basis. The purpose of the present study wa...
journal_title:Calcified tissue international
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02556669
更新日期:1987-12-01 00:00:00
abstract::Toxicological studies have demonstrated that intermittent PTH1-34 treatment is associated with an increased incidence of osteosarcoma in Fischer 344 rats. Comet and micronucleus (MN) tests, standard methods to evaluate genotoxic potential of drugs, were used to detect DNA and chromosome breaks, respectively, after PTH...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-010-9396-6
更新日期:2010-11-01 00:00:00
abstract::Aging and sex hormones related changes lead to inflammatory and oxidant conditions, which are involved in the pathogenesis of osteoporosis. Recent studies have suggested that polyphenols may exert a protective effect in such conditions. We assessed the effect of phloridzin (Phlo), a flavonoid exclusively found in appl...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-005-0060-5
更新日期:2005-11-01 00:00:00
abstract::Synovial fluid basic calcium phosphate (BCP) crystals are associated with severe destructive arthropathy. BCP crystals induce the secretion of matrix-degrading enzymes such as collagenase. No prophylactic or therapeutic agents are recognized to ameliorate the cartilage damage associated with BCP deposits in joints. As...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00571332
更新日期:1993-06-01 00:00:00
abstract::This article reviews the effects of restrictive eating disorders on bone health. The relationship between eating disorders and amenorrhea is discussed in detail. The pathologic impact of malnutrition on bone is explored by examining the results of studies using various available imaging techniques. The multiple hormon...
journal_title:Calcified tissue international
pub_type: 杂志文章,评审
doi:10.1007/s00223-016-0164-0
更新日期:2017-05-01 00:00:00
abstract::This study aimed to investigate the effects of recombinant human bone morphogenetic protein (rhBMP-7) on human cancellous bone grafts (BGs) while differentiating between anabolic and catabolic events. Human BGs alone or supplemented with rhBMP-7 were harvested 14 weeks after subcutaneous implantation into NOD/Scid mic...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-019-00574-5
更新日期:2019-09-01 00:00:00
abstract::The bone mineral density (BMD) of the spine was measured in the posteroanterior (PA) and lateral projections as well as the total body BMD in 447 black and white women. The lateral projection is comprised predominantly of cancellous bone whereas the total body BMD is predominantly cortical bone, and the PA spine is in...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900653
更新日期:1999-07-01 00:00:00
abstract::The tumor-suppressor p53 is a transcription factor that regulates a number of genes in the process of cell-cycle inhibition, apoptosis, and DNA damage. Recent studies have revealed a crucial role for p53 in bone remodeling. In our previous studies we have shown that p53 is an important regulator of osteoblast differen...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-011-9533-x
更新日期:2011-11-01 00:00:00
abstract::Osteoclasts are large, multinucleated, terminally differentiated cells formed by the fusion of mononuclear hemopoietic precursors. Their function is the resorption of bone, which is an essential part of the growth, modeling and remodeling of the skeleton. Though some osteoclast differentiation factors have recently be...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-002-2098-y
更新日期:2003-10-01 00:00:00
abstract::Mandibular first molars of 17-day-old mouse embryos were cultured in vitro to examine the histological effects of various concentrations of parathyroid hormone (PTH) on odontogenesis of the molars. PTH did not affect the cytodifferentiation of mesenchymal cells into preodontoblasts but inhibited that of preodontoblast...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02555728
更新日期:1987-01-01 00:00:00
abstract::We studied the relationship between serum calcium (Ca) and parathyroid hormone (PTH) in patients with idiopathic hypoparathyroidism (IHP) to investigate the diversity of the degree of parathyroid insufficiency and a regulation of PTH secretion by Ca in IHP. Serum intact PTH concentrations ranged from < 1.0 to 10.3 pg/...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:
更新日期:1993-12-01 00:00:00
abstract::We studied the epidemiology of osteoporotic fractures of the proximal femur (cervical and trochanteric fractures) in residents of Barcelona, aged 45 years or over, for a 1-year period. Fractures resulting from metastases were not included. During the period of observation, a total of 1,358 patients with hip fractures ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02555965
更新日期:1989-06-01 00:00:00
abstract::The evidence now strongly supports a central role for oestrogen in the maintenance of the normal female skeleton. Loss of endogenous oestrogen leads to a period of accelerated bone loss which can be prevented with appropriate oestrogen replacement. The route of administration is not important provided adequate dosages...
journal_title:Calcified tissue international
pub_type: 杂志文章,评审
doi:10.1007/BF02555090
更新日期:1991-01-01 00:00:00
abstract::The small proteoglycan decorin had been localized previously at the d-band in the gap zone of collagen fibrils in nonmineralizing tissues. In bone matrix this zone is proteoglycan free and is at least in some species the place where mineralization along collagen fibrils starts. To study the metabolism of the small pro...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900279
更新日期:1997-06-01 00:00:00
abstract::Vitamin K promotes the formation of gamma-carboxylated glutamate (GLA) in several protein species. GLA residues have a high affinity for the Ca ion. In the present study, we tested the hypothesis that experimental vitamin K deficiency in rats could induce changes in Ca metabolism. Vitamin K depletion, which was associ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02554833
更新日期:1985-03-01 00:00:00
abstract::The P2X7 nucleotide receptor (P2X7R) is an ATP-gated ion channel expressed in bone cells. Homozygous null P2X7R (P2X7R(-/-)) mice have reduced bone formation, so we hypothesized that P2X7R(-/-) mice have impaired fracture healing compared to P2X7R(+/+) control mice. To test the hypothesis, adult P2X7R(-/-) mice and P2...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-009-9237-7
更新日期:2009-05-01 00:00:00
abstract::Condylar cartilages were cultured in the form of organ cultures on top of collagen sponges in medium containing 2% fetal calf serum and were treated with 3.5-350 nM insulin for 6 days. Doses of 175 nM of insulin caused a marked increase (+96%) in DNA synthesis and in proteoglycan production (+74%), features that manif...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00296654
更新日期:1993-04-01 00:00:00
abstract::Calcium deficiency is a major etiological determinant of rickets in Nigerian children and is accompanied by undermineralization of the developing bone matrix which is composed largely of type I collagen. We have assessed types I and III collagen metabolism by measuring the circulating concentrations of teh N- and C-te...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900301
更新日期:1997-08-01 00:00:00