Insulin enhances the growth of cartilage in organ and tissue cultures of mouse neonatal mandibular condyle.

Abstract:

:Condylar cartilages were cultured in the form of organ cultures on top of collagen sponges in medium containing 2% fetal calf serum and were treated with 3.5-350 nM insulin for 6 days. Doses of 175 nM of insulin caused a marked increase (+96%) in DNA synthesis and in proteoglycan production (+74%), features that manifested themselves structurally by a 60% increase in overall size of the cultured explants. Using a tissue culture system comprised of cartilage progenitor cells, insulin was found to enhance the differentiation of the progenitor cells so that by 6 days in culture an appreciable nodule of differentiated chondrocytes developed. The latter was surrounded by perichondrial cells whereas the extracellular matrix within the newly formed, insulin-induced, nodule reacted positively for cartilage-specific antigens (type II collagen and bone sialoprotein). It is suggested that insulin induces a direct stimulatory effect on progenitor cell proliferation, cartilage differentiation, and extracellular matrix deposition.

journal_name

Calcif Tissue Int

authors

Maor G,Silbermann M,von der Mark K,Heingard D,Laron Z

doi

10.1007/BF00296654

subject

Has Abstract

pub_date

1993-04-01 00:00:00

pages

291-9

issue

4

eissn

0171-967X

issn

1432-0827

journal_volume

52

pub_type

杂志文章
  • Intact serum parathyroid hormone levels increase during running exercise in well-trained men.

    abstract::The purpose of this study was to examine the influence of exercise on the serum concentrations of intact parathyroid hormone (PTH). Serum PTH and plasma lactate were measured in 15 well-trained men, 9 long-distance runners and 6 fire-fighters, during two running exercises. Test one consisted of 40-minute treadmill run...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/BF00295947

    authors: Salvesen H,Johansson AG,Foxdal P,Wide L,Piehl-Aulin K,Ljunghall S

    更新日期:1994-04-01 00:00:00

  • The effect of bone cell stimulatory factors can be measured with thymidine incorporation only under specific conditions.

    abstract::This study examines the efficacy of using radiolabeled thymidine as a measure of bone cell DNA synthesis. The effect of a bone-active peptide on cell proliferation is assessed under different labeling conditions and it is shown that the apparent stimulation in DNA synthesis is due to an increase in participating cells...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/BF02553298

    authors: Puzas JE,Brand JS

    更新日期:1986-08-01 00:00:00

  • The matrix of endochondral bone differs from the matrix of intramembranous bone.

    abstract::Osseous tissue develops via two distinctly different processes: endochondral (EC) ossification and intramembranous (IM) ossification. The present study tests the hypothesis that each type of osseous tissue contains unique inducing factors for the promotion of cartilage and bone development. Previous work suggests that...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/BF02556258

    authors: Scott CK,Hightower JA

    更新日期:1991-11-01 00:00:00

  • Involvement of insulin-like growth factor I in development of ossification of the posterior longitudinal ligament of the spine.

    abstract::In order to investigate the pathogenesis of ossification of the posterior longitudinal ligament (OPLL) of the spine, we examined the distribution of insulin-like growth factor I (IGF-I) in the posterior longitudinal ligaments of OPLL patients, and analyzed the effects of IGF-I on the cultured spinal ligament cells. Fo...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/s002239900410

    authors: Goto K,Yamazaki M,Tagawa M,Goto S,Kon T,Moriya H,Fujimura S

    更新日期:1998-02-01 00:00:00

  • Histomorphometric evaluation of the recovering effect of human parathyroid hormone (1-34) on bone structure and turnover in streptozotocin-induced diabetic rats.

    abstract::The purpose of this study was to determine whether human parathyroid hormone (h-PTH) enhances trabecular bone mass and connectivities that were reduced by streptozotocin (STZ)-induced diabetes in rats. Seven-month-old female Wistar rats were injected with STZ or its vehicle intraperitoneally. All vehicle-injected norm...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/pl00005838

    authors: Tsuchida T,Sato K,Miyakoshi N,Abe T,Kudo T,Tamura Y,Kasukawa Y,Suzuki K

    更新日期:2000-03-01 00:00:00

  • Spine and femur densitometry at the menopause: are both sites necessary in the assessment of the risk of osteoporosis?

    abstract::The aim of our study was to compare the results provided by the measurement of vertebral and femoral bone mineral density (BMD) for assessing the individual risk of osteoporosis as defined by either low BMD and/or rapid bone loss. Vertebral and femoral BMD were measured twice at a mean interval of 21 months in 85 norm...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/BF00310196

    authors: Pouilles JM,Tremollieres F,Ribot C

    更新日期:1993-05-01 00:00:00

  • Effect of physical activity during teenage years, based on type of sport and duration of exercise, on bone mineral density of young, premenopausal Japanese women.

    abstract::In this cross-sectional study, 91 healthy premenopausal women aged 20-39 years were investigated to determine the effect of physical activities during their teenage years on their current bone mineral densities (BMD). We measured whole-body BMD (WBMD), lumbar BMD (LBMD), and radial BMD (RBMD) with dual energy X-ray ab...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/BF02684999

    authors: Hara S,Yanagi H,Amagai H,Endoh K,Tsuchiya S,Tomura S

    更新日期:2001-01-01 00:00:00

  • Old and New Drugs for the Management of Bone Disorders in CKD.

    abstract::Disturbances in mineral and bone metabolism are common in patients with chronic kidney disease (CKD), especially those undergoing dialysis. Renal osteodystrophy, which describes an alteration of bone morphology, is an important component of this systemic disorder and may explain the elevated risk of fracture which adv...

    journal_title:Calcified tissue international

    pub_type: 杂志文章,评审

    doi:10.1007/s00223-020-00788-y

    authors: Komaba H,Ketteler M,Cunningham J,Fukagawa M

    更新日期:2021-01-02 00:00:00

  • Spinal bone mineral after 5 weeks of bed rest.

    abstract::Patients put at bedrest for medical reasons lose 1-2% of spinal bone mineral per week. Losses of this magnitude during even short-term space flights of a few months would pose a serious limitation and require countermeasures. The spinal bone mineral (L2-L4) was determined in 6 healthy males (precision = 2%) before and...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/BF02555226

    authors: LeBlanc A,Schneider V,Krebs J,Evans H,Jhingran S,Johnson P

    更新日期:1987-11-01 00:00:00

  • Age-related changes in serum undercarboxylated osteocalcin and its relationships with bone density, bone quality, and hip fracture.

    abstract::The effect of the degree of carboxylation of osteocalcin (OC) on the properties of bone is unclear. The aim of this study was to relate serum concentrations of total OC (tOC) and undercarboxylated OC (ucOC), measured with a two-site immunoassay, to bone mineral density (BMD) at the femoral neck and ultrasonic transmit...

    journal_title:Calcified tissue international

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/s002239900432

    authors: Liu G,Peacock M

    更新日期:1998-04-01 00:00:00

  • Stimulation of carbonic anhydrase in osteoclasts by parathyroid hormone.

    abstract::Changes in the acidity of osteoclasts were evaluated by direct measurement of the fluorescent intensity of osteoclasts exposed to acridine orange, a fluorescent weak base which becomes concentrated in acid-containing subcellular compartments. Parathyroid hormone (PTH) produced dose-dependent increases in fluorescent i...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/BF02554924

    authors: Anderson RE,Jee WS,Woodbury DM

    更新日期:1985-12-01 00:00:00

  • Molybdenum-induced changes in the epiphyseal growth plate.

    abstract::Molybdenum (Mo), at high concentrations, induces changes in the epiphyseal growth plate through its effects on copper (Cu) metabolism but it is unclear whether or not Mo can induce changes independent of its effects on copper status. To this end, the effect of Mo on longitudinal bone growth was examined in rats. Dieta...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/BF01321835

    authors: Parry NM,Phillippo M,Reid MD,McGaw BA,Flint DJ,Loveridge N

    更新日期:1993-09-01 00:00:00

  • Local stresses and bone adaption around orthopedic implants.

    abstract::The severest long-term complications of orthopedic joint-prostheses are associated with loosening of the implant-bone interface, due to adverse reactions in bone and subsequent weakening of the connection between the two materials. Mechanical stresses, caused by joint loading, play a key role in the adaption of interf...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/BF02406143

    authors: Huiskes R,Nunamaker D

    更新日期:1984-01-01 00:00:00

  • Magnetic resonance imaging measurements of bone density and cross-sectional geometry.

    abstract::Magnetic resonance imaging (MRI) is commonly used in the assessment of the musculoskeletal system and associated pathology. The ability of MRI to measure the signals from water and lipid protons enables quantitative measurements of bone porosity. The goal of this investigation was to demonstrate that the density and c...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/s002230050015

    authors: Hong J,Hipp JA,Mulkern RV,Jaramillo D,Snyder BD

    更新日期:2000-01-01 00:00:00

  • NSAIDs for Prophylaxis for Heterotopic Ossification After Total Hip Arthroplasty: A Bayesian Network Meta-analysis.

    abstract::Non-steroidal anti-inflammatory drugs (NSAID) have been recommended to prevent of heterotopic ossification (HO) after total hip arthroplasty (THA), but debates are still ongoing. The present Bayesian network meta-analysis of randomized clinical trials (RCTs) compared all available pathways of NSAID treatment as prophy...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/s00223-020-00763-7

    authors: Migliorini F,Trivellas A,Eschweiler J,Driessen A,Tingart M,Maffulli N

    更新日期:2021-02-01 00:00:00

  • Effect of 1 alpha-hydroxycholecalciferol on psoriasis vulgaris: a pilot study.

    abstract::We carried out a clinical trial of 1 alpha-hydroxycholecalciferol [1 alpha(OH)D3] at a dose of 1.0 microgram a day on 7 patients with psoriasis vulgaris. These patients had been treated by topical applications of corticosteroids before this study without improvement, and during the clinical trial, treatment of topical...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/BF02555172

    authors: Takamoto S,Onishi T,Morimoto S,Imanaka S,Yukawa S,Kozuka T,Kitano Y,Seino Y,Kumahara Y

    更新日期:1986-12-01 00:00:00

  • Ultrastructural study of apatite precipitation in implanted calcium phosphate ceramic: influence of the implantation site.

    abstract::Macroporous biphasic calcium phosphate (MBCP) blocks were implanted into rabbit trabecular bone and muscle, recovered 18 weeks later, and then observed and analyzed by transmission electron microscopy (TEM), electron diffraction, and electron microprobes. The results showed that (1) apatitic microcrystals appeared by ...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/pl00005825

    authors: Rohanizadeh R,Trécant-Viana M,Daculsi G

    更新日期:1999-05-01 00:00:00

  • Longitudinal Change in Peripheral Quantitative Computed Tomography Assessment in Older Adults: The Hertfordshire Cohort Study.

    abstract::There are few longitudinal data on change in bone structure and muscle mass, strength and function in later life. We report these, and consider bone-muscle interrelationships in older men and women. We studied 188 men and 166 women from the Hertfordshire Cohort Study, who underwent peripheral quantitative computed tom...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/s00223-018-0442-0

    authors: Patel A,Edwards MH,Jameson KA,Ward KA,Fuggle N,Cooper C,Dennison EM

    更新日期:2018-11-01 00:00:00

  • Three-dimensional cortical bone microstructure in a rat model of hypoxia-induced growth retardation.

    abstract::Little is known about hypoxia-induced modification of the canal network in the cortical bone despite its involvement in intracortical vascularity and bone blood supply. In this study, we examined the effect of chronic hypoxia on the canal network in postnatal bone. Tibiae were harvested from 4- and 8-week-old rats (hy...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/s00223-010-9415-7

    authors: Matsumoto T,Ando N,Tomii T,Uesugi K

    更新日期:2011-01-01 00:00:00

  • Effects of Combined Whole-Body Electromyostimulation and Protein Supplementation on Local and Overall Muscle/Fat Distribution in Older Men with Sarcopenic Obesity: The Randomized Controlled Franconia Sarcopenic Obesity (FranSO) Study.

    abstract::The primary aim of the project was to determine the combined effect of whole-body electromyostimulation (WB-EMS) and protein supplements on local and overall muscle/fat distribution in older man with sarcopenic obesity (SO). Community-dwelling (cdw) men ≥ 70 years with SO were randomly allocated to a WB-EMS and protei...

    journal_title:Calcified tissue international

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00223-018-0424-2

    authors: Kemmler W,Grimm A,Bebenek M,Kohl M,von Stengel S

    更新日期:2018-09-01 00:00:00

  • Gut Microbiota, Immune System, and Bone.

    abstract::The gut microbiota (GM) is the whole of commensal, symbiotic, and pathogenic microorganisms living in our intestine. The GM-host interactions contribute to the maturation of the host immune system, modulating its systemic response. It is well documented that GM can interact with non-enteral cells such as immune cells,...

    journal_title:Calcified tissue international

    pub_type: 杂志文章,评审

    doi:10.1007/s00223-017-0331-y

    authors: D'Amelio P,Sassi F

    更新日期:2018-04-01 00:00:00

  • Developing antler, a model for endocrine regulation of bone growth. Concentration gradient of T3, T4, and alkaline phosphatase in the antler, jugular, and the saphenous veins.

    abstract::Thyroxine (T4), triiodothyronine (T3), and alkaline phosphatase (AP) were assayed monthly in white-tailed deer plasma obtained from the antler (A), jugular (J), and the saphenous (S) veins during the period of antler growth and the period of mineralization. The concentrations of T3, T4, and AP in the J and S were not ...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/BF02555129

    authors: Bubenik GA,Sempere AJ,Hamr J

    更新日期:1987-07-01 00:00:00

  • Bone turnover markers and PTH levels in surgical versus natural menopause.

    abstract::In order to assess similarities and differences in women that suffer surgical versus natural menopause, a series of bone, clinical, and biochemical parameters was assayed in a clinical sample of 35 women with surgical menopause and 112 women with natural menopause. Biochemical parameters included hormones [parathyroid...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/s00223-003-0054-0

    authors: García-Pérez MA,Moreno-Mercer J,Tarín JJ,Cano A

    更新日期:2004-02-01 00:00:00

  • Local bone mineral density, muscle strength, and exercise in adolescent boys: a comparative study of two groups with different muscle strength and exercise levels.

    abstract::The primary objective of the present study was to evaluate the impact of physical activity and muscle strength on bone mineral density (BMD) of the tuberositas tibiae in adolescent boys. Two groups with different exercise levels were compared. The high activity group consisted of 20 subjects (age 15.9 +/- 0.3) from a ...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/BF02509438

    authors: Nordström P,Nordström G,Thorsen K,Lorentzon R

    更新日期:1996-06-01 00:00:00

  • Pregnancy and Lactation-Associated Osteoporosis: Bone Histomorphometric Analysis and Response to Treatment with Zoledronic Acid.

    abstract::Pregnancy and lactation-associated osteoporosis (PAO) is a rare condition with little known pathophysiology. Most cases are diagnosed in the third trimester of pregnancy or in the first weeks postpartum, particularly in first pregnancies. Vertebral fractures are most commonly observed and characterised by prolonged se...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/s00223-015-0028-z

    authors: Grizzo FM,da Silva Martins J,Pinheiro MM,Jorgetti V,Carvalho MD,Pelloso SM

    更新日期:2015-10-01 00:00:00

  • A Polymorphism in a gene encoding Perilipin 4 is associated with height but not with bone measures in individuals from the Framingham Osteoporosis Study.

    abstract::There is increasing interest in identifying new pathways and candidate genes that confer susceptibility to osteoporosis. There is evidence that adipogenesis and osteogenesis may be related, including a common bone marrow progenitor cell for both adipocytes and osteoblasts. Perilipin 1 (PLIN1) and Perilipin 4 (PLIN4) a...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/s00223-011-9552-7

    authors: Cusano NE,Kiel DP,Demissie S,Karasik D,Adrienne Cupples L,Corella D,Gao Q,Richardson K,Yiannakouris N,Ordovas JM

    更新日期:2012-02-01 00:00:00

  • Is There Causal Relationship of Smoking and Alcohol Consumption with Bone Mineral Density? A Mendelian Randomization Study.

    abstract::Observational studies examining associations of smoking and alcohol consumption with bone mineral density (BMD) have generated inconsistent results and suffer from several methodological limitations. We aim to evaluate whether there are causal associations between smoking, alcohol consumption, and BMD using a Mendelia...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/s00223-018-0452-y

    authors: Guo R,Wu L,Fu Q

    更新日期:2018-11-01 00:00:00

  • Effects of Collagen Crosslinking on Bone Material Properties in Health and Disease.

    abstract::Data have accumulated to show that various types of collagen crosslinking are implicated in the health of individuals, as well as in a number of disease states, such as osteoporosis, diabetes mellitus, chronic kidney disease, inflammatory bowel disease, or in conditions of mild hyperhomocysteinemia, or when glucocorti...

    journal_title:Calcified tissue international

    pub_type: 杂志文章,评审

    doi:10.1007/s00223-015-9985-5

    authors: Saito M,Marumo K

    更新日期:2015-09-01 00:00:00

  • Clinical usefulness of serum tartrate-resistant acid phosphatase in Paget's disease of bone: correlation with other biochemical markers of bone remodelling.

    abstract::Tartrate resistant acid phosphatase (TRAP) has been proposed as a new biochemical marker for bone resorption. We have compared this new marker, TRAP, with the classical biochemical markers of bone remodelling, serum alkaline phosphatase (sAP), serum osteocalcin (sBGP), and with the urinary hydroxyproline/creatinine ra...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/BF02555896

    authors: Torres R,de la Piedra C,Rapado A

    更新日期:1991-07-01 00:00:00

  • Increase in vertebral fracture risk in postmenopausal women using omeprazole.

    abstract::Proton pump inhibitors are taken by millions of patients for prevention and treatment of gastroesophageal diseases. Case-control studies have suggested that use of omeprazole is associated with an increased risk of hip fractures. The aim of this prospective study was to assess the risk of vertebral fractures in postme...

    journal_title:Calcified tissue international

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00223-008-9188-4

    authors: Roux C,Briot K,Gossec L,Kolta S,Blenk T,Felsenberg D,Reid DM,Eastell R,Glüer CC

    更新日期:2009-01-01 00:00:00