Effect of 1 alpha-hydroxycholecalciferol on psoriasis vulgaris: a pilot study.

Abstract:

:We carried out a clinical trial of 1 alpha-hydroxycholecalciferol [1 alpha(OH)D3] at a dose of 1.0 microgram a day on 7 patients with psoriasis vulgaris. These patients had been treated by topical applications of corticosteroids before this study without improvement, and during the clinical trial, treatment of topical corticosteroids was continued on 6 of the 7 patients. Four of 7 patients showed complete remission and marked improvement and 2 additional patients showed minimal improvement of their skin lesions during and after the treatment with 1 alpha(OH)D3. No adverse reactions were noted during the treatment period. The mechanism of the phenomenon we observed has yet to be elucidated. Controlled trials of large numbers of patients with psoriasis vulgaris treated with 1 alpha(OH)D3 are under way.

journal_name

Calcif Tissue Int

authors

Takamoto S,Onishi T,Morimoto S,Imanaka S,Yukawa S,Kozuka T,Kitano Y,Seino Y,Kumahara Y

doi

10.1007/BF02555172

subject

Has Abstract

pub_date

1986-12-01 00:00:00

pages

360-4

issue

6

eissn

0171-967X

issn

1432-0827

journal_volume

39

pub_type

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