Absence of correlation between BMP-4 polymorphism and postmenopausal osteoporosis in Italian women.

Abstract:

:Several studies have demonstrated that bone has the power of regeneration and repair. BMPs (bone morphogenetic proteins) are involved in the determination of osteoblast phenotype and bone turnover, therefore genes coding for these proteins, like BMP-4, could be considered potential candidate genes for osteoporosis. We investigated the association of BMP-4 gene polymorphism with osteoporosis in a cohort of 72 osteoporotic, postmenopausal women and 82 unrelated controls. We failed to detect any significant association between this genetic marker and the disease.

journal_name

Calcif Tissue Int

authors

Semprini S,Mango R,Brancati F,Dallapiccola B,Becherini L,Novelli G,De Lorenzo A,Brandi ML,Gennari L

doi

10.1007/s00223001103

subject

Has Abstract

pub_date

2000-07-01 00:00:00

pages

93-4

issue

1

eissn

0171-967X

issn

1432-0827

pii

10.1007/s00223001103

journal_volume

67

pub_type

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