Bone mineralization and metabolism of 3H-25-hydroxyvitamin D3 in thyroparathyroidectomized rats treated with parathyroid extract.

Abstract:

:Thyroparathyroidectomized rats fed a diet containing 1.2% calcium, 0.55% phosphorus maintain normal serum levels of these ions. Treatment of such rats with parathyroid extract (PTE; 20 U/100 g twice daily; 10 days) has no statistically significant effect on rates of bone formation, matrix apposition, or osteoid maturation. Significant decreases in osteoid width and mineralizing front width, as well as a 60% increase in the rate of initial mineralization were observed in the PTE-treated group. Conversion of 3H-25-hydroxyvitamin D3 to 3H-1,25-dihydroxyvitamin D3 was 4-fold higher in the PTE-treated group than in the untreated animals. Increased formation of 1,25-dihydroxyvitamin D3 in response to treatment with PTE may play a major role in correcting the mineralizing defect resulting from thyroparathyroidectomy.

journal_name

Calcif Tissue Int

authors

Rader JI,Howard GA,Feist E,Turner RT,Baylink DJ

doi

10.1007/BF02408051

subject

Has Abstract

pub_date

1979-11-01 00:00:00

pages

21-6

issue

1

eissn

0171-967X

issn

1432-0827

journal_volume

29

pub_type

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