Abstract:
:Raf-1, the product of proto-oncogene c-raf-1, has key roles in the signal transduction pathways within the cell. The molecular mechanisms of tooth development in the mouse embryo are not known in detail. We examined the expression of Raf-1 during subsequent tooth development by immunohistochemical analysis. In mouse embryos at days 12.5 post-coitum (p.c.), Raf-1 was expressed in the dental invaginating epithelium. At p.c. 13.5 (bud stage), Raf-1 was also expressed in the epithelial cells of the enamel organ, but not in the mesenchyme of the dental papilla. We added anti-proliferating cell nuclear antigen (PCNA) antibody as a marker for proliferating cells at early stages of tooth development. At p.c. 12.5 and p.c. 13.5, the staining patterns were very similar to that for Raf-1. At p.c. 15.5 (cap stage), Raf-1 could not be detected. At p.c. 17.5 (bell stage), Raf-1 was expressed in both the odontoblastic and subodontoblastic cells of the dental papilla. However, Raf-1 was not found in the epithelial cells of the enamel organ. We also added anti-type I collagen antibody as a marker for odontoblasts differentiation. The staining pattern for type I collagen antibody as a marker for odontoblasts differentiation. The staining pattern for type I collagen in odontoblasts was almost the same as for Raf-1. The results suggest that Raf-1 may play some roles in both cell proliferation and differentiation at different stages of tooth germ development.
journal_name
Calcif Tissue Intjournal_title
Calcified tissue internationalauthors
Sunohara M,Tanzawa H,Kaneko Y,Fuse A,Sato Kdoi
10.1007/BF02509547subject
Has Abstractpub_date
1996-01-01 00:00:00pages
60-4issue
1eissn
0171-967Xissn
1432-0827journal_volume
58pub_type
杂志文章abstract::Proteoglycans are recognized to inhibit calcium pyrophosphate dihydrate (CPPD) crystal formation but the mechanisms are not known. To study the role of carboxylate (-CO2-) ligands, the possible inhibitor effects of sodium acetate, sodium D-glucuronate, disodium malate, and trisodium citrate were studied using solution...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02555838
更新日期:1988-01-01 00:00:00
abstract::Serum immunoreactive osteocalcin (irOC) consists of two fractions that differ from each other by their affinity for hydroxyapatite. The high and low affinity fractions are referred to as irOCbound and irOCfree, respectively. To evaluate whether these fractions are determinants for different characteristics of bone or ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900543
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abstract::The recent advancement of high resolution magnetic resonance imaging has opened up new avenues for the determination of structural characteristics of the trabecular network, which may significantly improve the diagnosis of osteoporosis. An analysis of the calcaneus in healthy women has shown similar age-related change...
journal_title:Calcified tissue international
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abstract::Glycogen storage disease type 1a (Von Gierke's disease) is one of the more common glycogen storage diseases (GSD). GSD 1a patients can have severe idiopathic osteopenia, often beginning at a young age. Since calcium tracer studies offer a sensitive probe of the bone microenvironment and of calcium deposition, kinetics...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00369209
更新日期:1996-12-01 00:00:00
abstract::The wedges of the mid-diaphyseal osteotomies carried out to correct the femoral and/or tibial native deformity in type III osteogenesis imperfecta (OI III) were used to study the remodeling patterns and lamellar organization at the level of the major deformity. Histology and scanning electron microscopy (SEM) morpholo...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-013-9771-1
更新日期:2013-11-01 00:00:00
abstract::The aim of this study was to investigate the relation between birth weight and calcaneal bone stiffness in a large sample of Belgian, healthy, preadolescent children. Participants were 827 children (3.6-11.2 years, 51.6 % boys) from the Belgian cohort of the IDEFICS study. Birth weight was obtained using a parental qu...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-012-9636-z
更新日期:2012-10-01 00:00:00
abstract::We studied the acute phase response, including specific cytokine production, [interleukin-1 (IL-1), interleukin-6 (IL-6), tumor necrosis factor alpha(TNF alpha)] following a single dose of Aredia (disodium pamidronate) in patients with increased bone turnover and, in vitro, the role played by specific cytokines in the...
journal_title:Calcified tissue international
pub_type: 临床试验,杂志文章
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更新日期:1997-11-01 00:00:00
abstract::The purpose of this study was to examine the effects of green tea extract (GTE) intake on bone structural and physiological properties, such as bone mass, trabecular bone microarchitecture, cortical bone geometry, and bone mechanical strength, in growing rats. Four-week-old male Wistar rats were divided into the follo...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-017-0358-0
更新日期:2018-03-01 00:00:00
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journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02555127
更新日期:1987-07-01 00:00:00
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journal_title:Calcified tissue international
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00223-011-9468-2
更新日期:2011-05-01 00:00:00
abstract::Aging is associated with an increase in circulating inflammatory factors. One, the cytokine stromal cell-derived factor 1 (SDF-1 or CXCL12), is critical to stem cell mobilization, migration, and homing as well as to bone marrow stem cell (BMSC), osteoblast, and osteoclast function. SDF-1 has pleiotropic roles in bone ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-017-0245-8
更新日期:2017-06-01 00:00:00
abstract::Changes in the acidity of osteoclasts were evaluated by direct measurement of the fluorescent intensity of osteoclasts exposed to acridine orange, a fluorescent weak base which becomes concentrated in acid-containing subcellular compartments. Parathyroid hormone (PTH) produced dose-dependent increases in fluorescent i...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02554924
更新日期:1985-12-01 00:00:00
abstract::Proton pump inhibitors are taken by millions of patients for prevention and treatment of gastroesophageal diseases. Case-control studies have suggested that use of omeprazole is associated with an increased risk of hip fractures. The aim of this prospective study was to assess the risk of vertebral fractures in postme...
journal_title:Calcified tissue international
pub_type: 杂志文章,多中心研究
doi:10.1007/s00223-008-9188-4
更新日期:2009-01-01 00:00:00
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journal_title:Calcified tissue international
pub_type: 杂志文章,评审
doi:10.1007/s00223-020-00672-9
更新日期:2020-02-13 00:00:00
abstract::Residents of a long-stay geriatric ward at the University Hospital Basel were included in a study to investigate the effects of hypovitaminosis D and immobility. All 91 women (mean age 82.5 years) and 92 men (mean age 78.7 years) were enrolled in the study. Measurements included bone resorption, as measured by urinary...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900638
更新日期:1999-06-01 00:00:00
abstract::Monoclonal antibody against bovine serum alpha 2HS glycoprotein was raised in mice and the localization of this glycoprotein in bovine and human teeth was examined by immunohistochemical techniques on undemineralized ground sections after surface etching with dilute HCl. Positive reactions were found in both bovine an...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02555864
更新日期:1990-07-01 00:00:00
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journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02565132
更新日期:1991-08-01 00:00:00
abstract::In the past decade there have been numerous publications reporting a significant and direct relationship between handgrip strength and bone mineral density (BMD) of the proximal femur in older adults. The present report challenges the appropriateness of the methods, and thus the conclusions used in these studies. Spec...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900621
更新日期:1999-04-01 00:00:00
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journal_title:Calcified tissue international
pub_type: 杂志文章,评审
doi:10.1007/s00223-019-00522-3
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journal_title:Calcified tissue international
pub_type: 杂志文章
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更新日期:1984-01-01 00:00:00
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journal_title:Calcified tissue international
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journal_title:Calcified tissue international
pub_type: 杂志文章
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更新日期:1984-01-01 00:00:00
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journal_title:Calcified tissue international
pub_type: 杂志文章
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更新日期:2003-09-01 00:00:00
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journal_title:Calcified tissue international
pub_type: 杂志文章
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更新日期:1992-08-01 00:00:00
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journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02555886
更新日期:1990-12-01 00:00:00
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journal_title:Calcified tissue international
pub_type: 杂志文章,随机对照试验
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更新日期:2013-08-01 00:00:00
abstract::Previous studies have indicated that children with inflammatory bowel disease (IBD) may not achieve optimal bone mass. We evaluated the skeletal characteristics in children and adolescents with IBD. This cross-sectional cohort study comprised 80 IBD patients (median age 14.9 years, range 5-20) with a median disease du...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-012-9617-2
更新日期:2012-08-01 00:00:00
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journal_title:Calcified tissue international
pub_type: 杂志文章
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更新日期:2004-05-01 00:00:00
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journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/pl00005825
更新日期:1999-05-01 00:00:00
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journal_title:Calcified tissue international
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1007/s002239900512
更新日期:1998-09-01 00:00:00