Abstract：
:The main congenital conditions of hypophosphatemia expressed in adulthood include several forms of hereditary hypophosphatemic rickets and a congenital disorder of vitamin D metabolism characterized by osteomalacia and hypophosphatemia in adult patients. Hypophosphatemia in adults is defined as serum phosphate concentration < 0.80 mmol/L. The principal regulators of phosphate homeostasis, as is well known, are parathyroid hormone (PTH), activated vitamin D, and Fibroblast Growth Factor 23 (FGF23). Differential diagnosis of hypophosphatemia is based on the evaluation of mechanisms leading to this alteration, such as high PTH activity, inadequate phosphate absorption from the gut, or renal phosphate wasting, either due to primary tubular defects or high FGF23 levels. The most common inherited form associated to hypophosphatemia is X-linked hypophosphatemic rickets (XLH), caused by PHEX gene mutations with enhanced secretion of the FGF23. Until now, the management of hypophosphatemia in adulthood has been poorly investigated. It is widely debated whether adult patients benefit from the conventional treatments normally used for pediatric patients. The new treatment for XLH with burosumab, a recombinant human IgG1 monoclonal antibody that binds to FGF23, blocking its activity, may change the pharmacological management of adult subjects with hypophosphatemia associated to FGF23-dependent mechanisms.
journal_name
Calcif Tissue Intjournal_title
Calcified tissue internationalauthors
Marcucci G,Brandi MLdoi
10.1007/s00223-020-00695-2subject
Has Abstractpub_date
2021-01-01 00:00:00pages
91-103issue
1eissn
0171-967Xissn
1432-0827pii
10.1007/s00223-020-00695-2journal_volume
108pub_type
杂志文章,评审abstract：:Previous studies have indicated that children with inflammatory bowel disease (IBD) may not achieve optimal bone mass. We evaluated the skeletal characteristics in children and adolescents with IBD. This cross-sectional cohort study comprised 80 IBD patients (median age 14.9 years, range 5-20) with a median disease du...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-012-9617-2
更新日期：2012-08-01 00:00:00
abstract：:The severest long-term complications of orthopedic joint-prostheses are associated with loosening of the implant-bone interface, due to adverse reactions in bone and subsequent weakening of the connection between the two materials. Mechanical stresses, caused by joint loading, play a key role in the adaption of interf...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02406143
更新日期：1984-01-01 00:00:00
abstract：:It has been well established that bone morphogenetic protein-2 (BMP-2) can induce bone formation bothin vivo andin vitro, although high concentrations (up to milligrams) of BMP-2 have been required to achieve this effectin vivo. Further, clinical applications are usually limited to a single dose at the time of implant...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02678146
更新日期：2001-02-01 00:00:00
abstract：:Ectopic calcification of diseased tissues or around prosthetic implants can lead to serious disability. Therefore, calcification of implants of glutaraldehyde-cross-linked collagenous tissues and reconstituted collagen was compared with mineralization induced by demineralized bone matrix (DBM). Whereas implants of DBM...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02556366
更新日期：1988-05-01 00:00:00
abstract：:We carried out a clinical trial of 1 alpha-hydroxycholecalciferol [1 alpha(OH)D3] at a dose of 1.0 microgram a day on 7 patients with psoriasis vulgaris. These patients had been treated by topical applications of corticosteroids before this study without improvement, and during the clinical trial, treatment of topical...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02555172
更新日期：1986-12-01 00:00:00
abstract：:Sarcopenia is now clinically defined as a loss of muscle mass coupled with functional deterioration (either walking speed or distance or grip strength). Based on the FRAX studies suggesting that the questions without bone mineral density can be used to screen for osteoporosis, there is now a valid simple questionnaire...
journal_title：Calcified tissue international
pub_type： 杂志文章,评审
doi：10.1007/s00223-015-0022-5
更新日期：2016-04-01 00:00:00
abstract：:The European Forsteo Observational Study was designed to examine the effectiveness of teriparatide in postmenopausal women with osteoporosis treated for up to 18 months in normal clinical practice in eight European countries. The incidence of clinical vertebral and nonvertebral fragility fractures, back pain, and heal...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-009-9299-6
更新日期：2009-12-01 00:00:00
abstract：:The aim of this study was to follow the changes in bone mineral density (BMD) and biochemical markers of bone turnover in 10 children (7.5-17.5 years of age) with severe juvenile idiopathic arthritis (JIA), during a 3-year therapy with salmon calcitonin (100 IU/day 2 months on and 2 off for a year and 200 IU/day for 2...
journal_title：Calcified tissue international
pub_type： 临床试验,杂志文章
doi：10.1007/s00223-001-0008-3
更新日期：2001-07-01 00:00:00
abstract：:Undesired bone loss around implants is considered to occur mainly because of a stress-shielding phenomenon. Bone surrounding the total knee arthroplasty (TKA) adjusts its mineral density and structure to meet new mechanical demands. Immobilization, in combination with local operative trauma to the bone and soft tissue...
journal_title：Calcified tissue international
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00223-002-1022-9
更新日期：2002-12-01 00:00:00
abstract：:KH1060 is a new 20-epi-vitamin D3 analog, which has exerted a considerable immunosuppressive potency in vitro. We have tested in vivo the effect of KH1060 on the suppression of renal allograft rejection in the rat. Allogenic kidney transplantation from DA donor rats to Lewis recipient rats treated intraperitoneally wi...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF00296066
更新日期：1994-02-01 00:00:00
abstract：:Peritubular dentin (PTD) is a relatively dense mineralized tissue surrounding tooth dentin tubules, whose composition and mode of formation are still unclear. Fourier transform infrared microspectroscopic studies of the organic and mineral components of the highly developed horse PTD indicate that the peritubular matr...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-001-2108-5
更新日期：2002-08-01 00:00:00
abstract：:ATP is as effective as inorganic pyrophosphate in retarding the rate of dissolution of calcium hydroxyapatite at pH 7, ADP is less effective, and AMP is without effect. The inhibition is due to the adsorption of ATP and ADP units on the crystal surface. ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02405386
更新日期：1984-12-01 00:00:00
abstract：:Formalin fixation of hard tissues alters the levels of some, but not all, of the parameters routinely measured by bone researchers. Although mineral parameters (ash weight, particle size (beta 1/2 002) and Ca/PO4 ratio) and lipid parameters (total lipid content and composition, extractability, and Ca-acidic phospholip...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02411262
更新日期：1982-07-01 00:00:00
abstract：:The crystallinity of bone mineral at different stages of maturation has been measured by quantitative X-ray diffraction methods. Crystallinity measurements were made on tibial mid-diaphyses from 17-day embryonic chicks, newly-formed periosteal bone from embryonic chicks, and density-fractionated bone from post-hatch c...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02405032
更新日期：1983-01-01 00:00:00
abstract：:Osteoblast differentiation is predominantly regulated by the WNT/β-catenin signaling (canonical WNT pathway), which, together with bone morphogenetic proteins, acts as the master regulator of osteogenesis. The recent characterization of the canonical WNT pathway in the regulation of bone modeling and remodeling provid...
journal_title：Calcified tissue international
pub_type： 杂志文章,评审
doi：10.1007/s00223-013-9749-z
更新日期：2013-08-01 00:00:00
abstract：:Hip fracture may cause and/or complicate institutionalization. We undertook this study to define its overall prevalence among the residents of four nursing homes in Central Italy as well as its latency and impact on mobility when it occurred within institutions. We also performed a case control analysis with the aim o...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002230001212
更新日期：2001-06-01 00:00:00
abstract：:To compare the ability of the bone mineral density (BMD) at the distal forearm, collagen I alpha 1 (COLIA1) polymorphism, and ultrasound stiffness to identify individuals with increased risk of wrist fracture, we studied 183 postmenopausal Czech women with a wrist fracture and 178 postmenopausal controls, ages 45-70 y...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-004-0134-9
更新日期：2005-02-01 00:00:00
abstract：:The aim of this study was to investigate bone mineral density (BMD) and bone turnover in patients with primary knee osteoarthritis (KOA) and to compare them with generalized OA (GOA) and nonGOA patients. A total of 88 postmenopausal primary KOA patients were studied. OA was graded by using knee radiographs. BMD of the...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002230010068
更新日期：2000-05-01 00:00:00
abstract：:The aim of this study was to test whether the nitric oxide (NO) donor sodium nitroprusside (SNP) has an effect on mineralization in ATDC5 cells. Mineralization in ATDC5 cell culture was induced by addition of beta-glycerophosphate or inorganic phosphate, visualized by staining precipitated calcium with an alizarin red...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-005-1233-y
更新日期：2006-03-01 00:00:00
abstract：:The aim of this study was to investigate the relation between birth weight and calcaneal bone stiffness in a large sample of Belgian, healthy, preadolescent children. Participants were 827 children (3.6-11.2 years, 51.6 % boys) from the Belgian cohort of the IDEFICS study. Birth weight was obtained using a parental qu...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-012-9636-z
更新日期：2012-10-01 00:00:00
abstract：:High resolution transmission electron microscopy (Hr TEM) studies on biological and synthetic calcium phosphate have provided information on the dissolution process at the crystal level. The purpose of this study was to investigate the dissolution of ceramic hydroxyapatite (HA) after implantation using Hr TEM. Recover...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02561408
更新日期：1989-08-01 00:00:00
abstract：:Parathyroid Hormone (PTH) stimulates calcium entry into bone cells in vitro, and this effect has been proposed to mediate the actions of PTH on bone. Using cells harvested from infant rat calvaria by collagenase digestion, we evaluated the sensitivity and specificity of this phenomenon. Calcium uptake was temperature ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02408543
更新日期：1980-01-01 00:00:00
abstract：:Racial differences in bone mineral density (BMD) appear to account in part for racial differences in the incidence of osteoporosis and fractures. We previously reported that the greater BMD in adult blacks compared with whites is associated with a higher serum 17 beta-estradiol and greater secretion of growth hormone ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-001-1068-0
更新日期：2002-03-01 00:00:00
abstract：:To determine the relationships among nutrients intake, bone mass, and bone turnover in women we have investigated these issues in a population-based, cross-sectional, observational study in one county in central Sweden. A total of 175 women aged 28-74 at entry to the study were included. Dietary assessment was made by...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF00298425
更新日期：1995-08-01 00:00:00
abstract：:Atomic force microscopy (AFM) was used to obtain three-dimensional images of isolated mineralites extracted from young postnatal bovine bone. The mean mineralite size is 9 nm x 6 nm x 2.0 nm, significantly shorter and thicker than the mineralites of mature bovine bone measured by the same technique. Mineralites of the...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-002-1077-7
更新日期：2003-05-01 00:00:00
abstract：:The purpose of this study was to examine the effects of green tea extract (GTE) intake on bone structural and physiological properties, such as bone mass, trabecular bone microarchitecture, cortical bone geometry, and bone mechanical strength, in growing rats. Four-week-old male Wistar rats were divided into the follo...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-017-0358-0
更新日期：2018-03-01 00:00:00
abstract：:The goals of internal fixation are an accurate reduction and stable fixation in the presence of adequate bony vascularity. This can be achieved by a variety of means including plate fixation. A certain amount of periosteal stripping is necessary for proper open reduction of a fracture and for proper plate application....
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900080
更新日期：1996-07-01 00:00:00
abstract：:Cost-effective intervention thresholds (ITs) based on FRAX(®) were determined for Portugal. Assuming a willingness to pay (WTP) of €32,000 per quality-adjusted life years (QALYs), treatment with generic alendronate is cost effective for men and women aged 50 years or more, with 10-year probabilities for major osteopor...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-016-0132-8
更新日期：2016-08-01 00:00:00
abstract：:Raman spectroscopy and imaging are known to be valuable tools for the analysis of bone, the determination of protein secondary structure, and the study of the composition of crystalline materials. We have utilized all of these attributes to examine how mechanical loading and the resulting deformation affects bone ultr...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-002-1039-0
更新日期：2003-02-01 00:00:00
abstract：:Calcium deficiency is a major etiological determinant of rickets in Nigerian children and is accompanied by undermineralization of the developing bone matrix which is composed largely of type I collagen. We have assessed types I and III collagen metabolism by measuring the circulating concentrations of teh N- and C-te...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900301
更新日期：1997-08-01 00:00:00
