当前位置： SCI文献检索 > CALCIFIED TISSUE INTERNATIONAL期刊下所有文献 > Changes in proline synthetic and degradative enzymes during matrix-induced cartilage and bone formation.

Changes in proline synthetic and degradative enzymes during matrix-induced cartilage and bone formation.

Abstract：

:Proline biosynthetic and degradative enzymes are unevenly distributed in differentiated mammalian tissues. Activities of the synthetic enzymes are relatively high in collagenous tissues, whereas activities of the degradative enzymes are high in noncollagenous tissues. In order to further characterize tissue-specific proline biosynthesis and degradation, we have determined proline enzyme activities during cartilage and bone formation induced by demineralized bone matrix. We can thus follow temporal changes in enzyme activity in a single tissue as different cell types develop. Ornithine aminotransferase and pyrroline-5-carboxylate reductase have peaks of activity which correlate with maximal type II collagen synthesis by chondrocytes. Both enzymes also are active during bone formation. In contrast, proline oxidase and pyrroline-5-carboxylate dehydrogenase are present at low levels and do not change as new cell types appear. Arginase activity peaks during the first 3 days and then rapidly decreases by the time cartilage and bone formation begin. These observations further substantiate the importance of proline biosynthesis in collagenous tissues. The close correlation between ornithine aminotransferase activity and type II collagen synthesis suggests that the pathway from ornithine to proline may be especially important during formation of type II collagen.

journal_name

Calcif Tissue Int

journal_title

Calcified tissue international

authors

Smith RJ,Reddi AH,Phang JM

doi

10.1007/BF02441197

subject

Has Abstract

pub_date

1979-07-03 00:00:00

pages

275-9

issue

3

eissn

0171-967X

issn

1432-0827

journal_volume

27

pub_type

杂志文章

相关文献

CALCIFIED TISSUE INTERNATIONAL文献大全
  • Effect of metal ions on calcifying growth plate cartilage chondrocytes.

    abstract：:The effects of the trace metals zinc (Zn), manganese (Mn), and cadmium (Cd) on the metabolism of growth plate chondrocytes was examined using a mineralizing culture system. Supplementation of serum-free primary cultures of growth plate chondrocytes with 10-100 mu m Zn resulted in an increase in cell protein and greatl...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s002239900442

    authors： Litchfield TM,Ishikawa Y,Wu LN,Wuthier RE,Sauer GR

    更新日期：1998-04-01 00:00:00

  • Osteoblasts Regulate Angiogenesis in Response to Mechanical Unloading.

    abstract：:During mechanical unloading, endothelial cells reduce osteogenesis and increase bone resorption. Here we describe the feedback response of endothelial cells to unloaded osteoblasts. Primary endothelial cells, ex vivo mouse aortic rings and chicken egg yolk membranes were incubated with conditioned medium from mouse pr...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s00223-018-0496-z

    authors： Veeriah V,Paone R,Chatterjee S,Teti A,Capulli M

    更新日期：2019-03-01 00:00:00

  • Impact of detraining on bone loss in former collegiate female gymnasts.

    abstract：:Undesirable changes in health-related parameters are thought to occur in retiring female athletes, but this has not been examined in longitudinal studies. The purpose of this study was to examine longitudinal changes in bone mineral density (BMD), body composition, and dietary intake in gymnasts and controls. Nonathle...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s00223-004-0228-4

    authors： Kudlac J,Nichols DL,Sanborn CF,DiMarco NM

    更新日期：2004-12-01 00:00:00

  • Treatment of Paget's disease of bone with a combination of intranasal salmon calcitonin and oral calcium and thiazide.

    abstract：:The purpose of this study was to establish the smallest dose of nasally administered salmon calcitonin (SCT) which, if given in conjunction with a previously published calcium/thiazide treatment, would be as effective as parenteral SCT in the treatment of Paget's disease of bone. Forty patients suffering from symptoma...

    journal_title：Calcified tissue international

    pub_type： 临床试验,杂志文章

    doi：10.1007/BF02556111

    authors： Evans RA,Somers NM,Dunstan CR,Hills E,Evans M

    更新日期：1991-09-01 00:00:00

  • Phosphorus-31 in vivo magnetic resonance spectroscopy of bone fails to diagnose osteoporosis.

    abstract：:The values of in vivo T1 relaxation time (T1) of phosphorus atoms of wrist bone have been measured by phosphorus-31 magnetic resonance spectroscopy (MRS) in 65 menopausal women separated into three groups: (1) age-matched women without any paraclinical or clinical osteoporosis; (2) patients with paraclinical osteoporo...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/BF00298583

    authors： Confort-Gouny S,Mattéi JP,Vion-Dury J,Roux H,Bisset JP,Cozzone PJ

    更新日期：1995-06-01 00:00:00

  • Ovariectomy reduces the gelatinolytic activity and expression of matrix metalloproteinases and collagen in rat molar extraction wounds.

    abstract：:Osteoporosis is commonly associated with estrogen deficiency. However, the mechanisms by which the lack of this hormone causes bone loss are poorly understood. The bone structure of the oral cavity seems to be affected by estrogen deficiency, since a delayed healing process after tooth extraction has been observed aft...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s00223-004-0013-4

    authors： Zecchin KG,Pereira MC,Coletta RD,Graner E,Jorge J

    更新日期：2005-02-01 00:00:00

  • Vitamin K1 supplementation retards bone loss in postmenopausal women between 50 and 60 years of age.

    abstract：:Although several observational studies have demonstrated an association between vitamin K status and bone mineral density (BMD) in postmenopausal women, no placebo-controlled intervention trials of the effect of vitamin K1 supplementation on bone loss have been reported thus far. In the trial presented here we have in...

    journal_title：Calcified tissue international

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/s00223-002-2084-4

    authors： Braam LA,Knapen MH,Geusens P,Brouns F,Hamulyák K,Gerichhausen MJ,Vermeer C

    更新日期：2003-07-01 00:00:00

  • Bone turnover and the response to alendronate treatment in postmenopausal osteoporosis.

    abstract：:This study investigated whether bone turnover influences the response to alendronate in women with postmenopausal osteoporosis. One hundred postmenopausal osteoporotic women were randomized to receive either alendronate (10 mg/day) plus calcium (1000 mg/day) (n = 50) or calcium alone (n = 50). Vertebral and radial bon...

    journal_title：Calcified tissue international

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/s002239900713

    authors： Gonnelli S,Cepollaro C,Pondrelli C,Martini S,Montagnani A,Monaco R,Gennari C

    更新日期：1999-11-01 00:00:00

  • The risk of Colles' fracture is associated with the collagen I alpha1 Sp1 polymorphism and ultrasound transmission velocity in the calcaneus only in heavier postmenopausal women.

    abstract：:To compare the ability of the bone mineral density (BMD) at the distal forearm, collagen I alpha 1 (COLIA1) polymorphism, and ultrasound stiffness to identify individuals with increased risk of wrist fracture, we studied 183 postmenopausal Czech women with a wrist fracture and 178 postmenopausal controls, ages 45-70 y...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s00223-004-0134-9

    authors： Weichetova M,Stepan JJ,Haas T,Michalska D

    更新日期：2005-02-01 00:00:00

  • The effects of bisphosphonates on the resorption cycle of isolated osteoclasts.

    abstract：:Binding sites for wheat germ agglutinin (WGA)-lectin have been shown to become revealed in the demineralized resorption lacunae that osteoclasts excavate on bone substrate. Peroxidase-conjugated WGA-lectin, which binds to bone matrix glycoconjugates and proteoglycans, was used in pit formation assays to assess the act...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/BF00299317

    authors： Selander K,Lehenkari P,Väänänen HK

    更新日期：1994-11-01 00:00:00

  • Immobilized DPP and other proteins modify OCP formation.

    abstract：:Osteonectin, gamma-carboxyglutamic acid-containing (Gla) protein, and dentin phosphoprotein were covalently attached to sepharose beads and inoculated in solutions at two different degrees of supersaturation with respect to both octacalcium phosphate (OCP) and hydroxyapatite. In both solutions, the inhibitory activity...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/BF00308323

    authors： Doi Y,Horiguchi T,Kim SH,Moriwaki Y,Wakamatsu N,Adachi M,Shigeta H,Sasaki S,Shimokawa H

    更新日期：1993-02-01 00:00:00

  • Presence of lipids in urinary stones: results of preliminary studies.

    abstract：:The presence of lipids in urinary stones was determined by histochemical and biochemical methods. When crystals of calcium oxalate, made by mixing calcium chloride and potassium oxalate solutions and sections of human calcium oxalate urinary stones, were exposed to osmium vapors, there was no staining of the pure crys...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/BF02556340

    authors： Khan SR,Shevock PN,Hackett RL

    更新日期：1988-02-01 00:00:00

  • Early growth response gene 1 regulates bone properties in mice.

    abstract：:Transcriptional regulation of the postnatal skeleton is incompletely understood. Here, we determined the consequence of loss of early growth response gene 1 (EGR-1) on bone properties. Analyses were performed on both the microscopic and molecular levels utilizing micro-computed tomography (micro-CT) and Fourier transf...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s00223-011-9486-0

    authors： Reumann MK,Strachna O,Lukashova L,Verdelis K,Donnelly E,Boskey AL,Mayer-Kuckuk P

    更新日期：2011-07-01 00:00:00

  • Molecular structure at the bone-implant interface: a vibrational spectroscopic characterization.

    abstract：:Test implant plates surgically retrieved from distal femurs of dogs were studied by Raman spectroscopy in order to characterize the bone-implant interface. The implant surface consisted of phosphate mineral, plasma sprayed on a titanium substrate. On the basis of its spectroscopic signature, the phosphate mineral of b...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/BF02556157

    authors： Walters MA,Blumenthal NC,Leung Y,Wang Y,Ricci JL,Spivak JM

    更新日期：1991-05-01 00:00:00

  • 1,25-dihydroxyvitamin D3 and the regulation of macrophage function.

    abstract：:Vitamin D3 deficient (D-) mice show a depressed inflammatory response and both inflammatory peritoneal macrophages and bone marrow polymorphonuclear leukocytes of D- mice exhibit a decreased spontaneous migration under agarose. The impaired phagocytic response of peritoneal macrophages from D- mice can be corrected by...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/BF02409507

    authors： Bar-Shavit Z,Noff D,Edelstein S,Meyer M,Shibolet S,Goldman R

    更新日期：1981-01-01 00:00:00

  • The magnitude and rate of bone loss in ovariectomized mice differs among inbred strains as determined by longitudinal in vivo micro-computed tomography.

    abstract：:Osteoporosis is characterized by low bone mass and a deterioration of bone architecture and likely is influenced by genetic factors. The ovariectomized (OVX) mouse is well suited for osteoporosis research, as shown to date by cross-sectional studies. Here, we investigate longitudinal changes by in vivo micro-computed ...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s00223-008-9150-5

    authors： Klinck J,Boyd SK

    更新日期：2008-07-01 00:00:00

  • No effect of rosuvastatin in the zoledronate-induced acute-phase response.

    abstract：:The acute-phase response (APR) is frequently observed in patients treated with intravenous (iv) zoledronate (ZOL). We investigated whether a short course of rosuvastatin (ROSU) could attenuate the ZOL--induced APR through blocking the mevalonate pathway at a proximal level. Twenty-eight osteoporotic postmenopausal wom...

    journal_title：Calcified tissue international

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00223-011-9468-2

    authors： Makras P,Anastasilakis AD,Polyzos SA,Bisbinas I,Sakellariou GT,Papapoulos SE

    更新日期：2011-05-01 00:00:00

  • A ChIP-seq-defined genome-wide map of MEF2C binding reveals inflammatory pathways associated with its role in bone density determination.

    abstract：:Genome-wide association studies (GWAS) have demonstrated that genetic variation at the MADS box transcription enhancer factor 2, polypeptide C (MEF2C) locus is robustly associated with bone mineral density, primarily at the femoral neck. MEF2C is a transcription factor known to operate via the Wnt signaling pathway. O...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s00223-013-9824-5

    authors： Johnson ME,Deliard S,Zhu F,Xia Q,Wells AD,Hankenson KD,Grant SF

    更新日期：2014-04-01 00:00:00

  • Cost-Effectiveness of Intervention Thresholds for the Treatment of Osteoporosis Based on FRAX(®) in Portugal.

    abstract：:Cost-effective intervention thresholds (ITs) based on FRAX(®) were determined for Portugal. Assuming a willingness to pay (WTP) of €32,000 per quality-adjusted life years (QALYs), treatment with generic alendronate is cost effective for men and women aged 50 years or more, with 10-year probabilities for major osteopor...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s00223-016-0132-8

    authors： Marques A,Lourenço Ó,Ortsäter G,Borgström F,Kanis JA,da Silva JA

    更新日期：2016-08-01 00:00:00

  • Fluoride absorption: the influence of gastric acidity.

    abstract：:The influence of gastric acidity on the absorption of intragastrically administered fluoride was investigated in rats. Intact animals were pretreated with atropine or cimetidine to reduce gastric acid secretion or were given fluoride in NaHCO3 to reduce the acidity of the gastric contents. Compared with pentagastrin-t...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/BF02405334

    authors： Whitford GM,Pashley DH

    更新日期：1984-05-01 00:00:00

  • Effects of pleiotrophin (PTN) over-expression on mouse long bone development, fracture healing and bone repair.

    abstract：:Pleiotrophin (PTN) was found to have potent effects on regulation of osteoblast recruitment, proliferation and differentiation. The present study examined the long-term effects of targeted PTN over-expression on bone development and repair in a transgenic mouse model. Femurs and tibiae from the PTN transgenic mice and...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s00223-004-0145-6

    authors： Li G,Bunn JR,Mushipe MT,He Q,Chen X

    更新日期：2005-04-01 00:00:00

  • Discriminatory ability of quantitative ultrasound measurements is similar to dual-energy X-ray absorptiometry in a Brazilian women population with osteoporotic fracture.

    abstract：:The discriminating ability and relevance of clinical risk factors, quantitative ultrasound (QUS) variables, X-ray-based bone mineral density (BMD) and hip axis length (HAL) measurements to evaluate the risk of osteoporotic fracture in elderly Brazilian women were examined in this study. QUS at the calcaneus (Achilles ...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s00223-002-1096-4

    authors： Pinheiro MM,Castro CH,Frisoli A Jr,Szejnfeld VL

    更新日期：2003-12-01 00:00:00

  • The relationship between proton pump inhibitor adherence and fracture risk in the elderly.

    abstract：:Studies suggest that long-term use of proton pump inhibitors (PPIs) may be associated with an increased risk of fracture. However, the role of medication adherence in this association is not fully understood. A retrospective cohort study was conducted to examine the relationship between PPI use/adherence and fracture ...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s00223-014-9855-6

    authors： Ding J,Heller DA,Ahern FM,Brown TV

    更新日期：2014-06-01 00:00:00

  • Distribution of fluoride concentration in the rat's bone.

    abstract：:The present study was undertaken to determine the fluoride distribution profile in the rat femur. Male Wistar rats were divided into four groups and given water containing 0, 25, 50, and 100 ppm of fluoride, respectively, for 10 weeks. The fluoride distribution from the periosteum to the endosteum was determined in ea...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/BF02555045

    authors： Narita N,Kato K,Nakagaki H,Ohno N,Kameyama Y,Weatherell JA

    更新日期：1990-03-01 00:00:00

  • HNGF6A Inhibits Oxidative Stress-Induced MC3T3-E1 Cell Apoptosis and Osteoblast Phenotype Inhibition by Targeting Circ_0001843/miR-214 Pathway.

    abstract：:Humanin (HN), a mitochondrial derived peptide, plays cyto-protective role under various stress. In this study, we aimed to investigate the effects of HNGF6A, an analogue of HN, on osteoblast apoptosis and differentiation and the underlying mechanisms. Cell proliferation of murine osteoblastic cell line MC3TC-E1 was ex...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s00223-020-00660-z

    authors： Zhu X,Zhao Z,Zeng C,Chen B,Huang H,Chen Y,Zhou Q,Yang L,Lv J,Zhang J,Pan D,Shen J,Duque G,Cai D

    更新日期：2020-05-01 00:00:00

  • The transduction of mechanical force into biochemical events in bone cells may involve activation of phospholipase A2.

    abstract：:Mechanical forces applied to cultured bone cells induce the production of cAMP via stimulation of the formation of prostaglandin E2 (PGE2) and its release into the medium, resulting in stimulation of adenylate cyclase. In this paper we show that either the antibiotic gentamycin (100 micrograms/ml) or antiphospholipid ...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/BF02553753

    authors： Binderman I,Zor U,Kaye AM,Shimshoni Z,Harell A,Sömjen D

    更新日期：1988-04-01 00:00:00

  • Recovery from pamidronate (APD): a two-year study in the dog.

    abstract：:The goal of this study was to find out if bone can recover after long-term administration of bisphosphonate. Disodium pamidronate (APD) was given orally by gavage to mature beagle dogs at doses of 0, 2.5, 12.5, and 25 mg/kg/day for 1 year (0.1% concentration) and the animals were allowed to recover for another year. A...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/BF00310408

    authors： Grynpas MD,Kasra M,Dumitriu M,Nespeca R,Very JM,Mertz BP

    更新日期：1994-10-01 00:00:00

  • Absorption of intranasal salmon calcitonin in normal subjects and hypogonadic men.

    abstract：:The absorption kinetics of intranasal salmon calcitonin were assessed in 4 normal subjects and 9 patients with Klinefelter's syndrome. After administration, absorption occurred within 5 minutes. There was a highly significant correlation between the amount administered and the amount absorbed (r = -0.83, P less than 0...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/BF02556097

    authors： Pun KK,Chan LW,Lau P,Ho PW,Wang C

    更新日期：1990-02-01 00:00:00

  • Osteoarthritis: Current Molecular Biomarkers and the Way Forward.

    abstract：:The ultimate hope of researchers and patients is a pathway to development of treatments for osteoarthritis to modify the disease process in addition to the symptoms. However, development of disease modifying drugs requires objective endpoints such as measures of joint structure, joint tissue homeostasis and/or joint s...

    journal_title：Calcified tissue international

    pub_type： 杂志文章,评审

    doi：10.1007/s00223-020-00701-7

    authors： Kraus VB,Karsdal MA

    更新日期：2020-05-04 00:00:00

  • Prevention of bone loss by phloridzin, an apple polyphenol, in ovariectomized rats under inflammation conditions.

    abstract：:Aging and sex hormones related changes lead to inflammatory and oxidant conditions, which are involved in the pathogenesis of osteoporosis. Recent studies have suggested that polyphenols may exert a protective effect in such conditions. We assessed the effect of phloridzin (Phlo), a flavonoid exclusively found in appl...

    journal_title：Calcified tissue international

    pub_type： 杂志文章

    doi：10.1007/s00223-005-0060-5

    authors： Puel C,Quintin A,Mathey J,Obled C,Davicco MJ,Lebecque P,Kati-Coulibaly S,Horcajada MN,Coxam V

    更新日期：2005-11-01 00:00:00