Abstract：
:Sarcopenia and osteoporosis are two sides of the same coin. They represent different aspects of the same age-related process of musculoskeletal atrophy and together culminate in falls, fractures, deconditioning, and increased mortality in older individuals. However, the current therapeutic approach to the prevention of minimal trauma fracture is unilateral and focuses solely on bone. In theory, an integrated approach that recognizes the interaction between muscle and bone could break the vicious cycle of their combined involution and more effectively minimize falls/fractures. In this review, signaling pathways and cross-talk mechanisms that integrate bone/muscle, and the emergence of novel therapies that exploit these pathways to target osteoporosis/sarcopenia will be discussed. In broad terms, these agents act on nuclear receptors (e.g., VDR, AR) or transmembrane receptors (e.g., activins, GH/IGF-1) expressed in muscle and bone, and seek to alter biologic responses to musculoskeletal aging, loading, and injury. Challenges in the development of these dual bone-muscle therapies, early clinical trials examining their safety/efficacy, and novel targets that hold promise in the reversal of musculoskeletal aging will be discussed.
journal_name
Calcif Tissue Intjournal_title
Calcified tissue internationalauthors
Girgis CMdoi
10.1007/s00223-015-9956-xsubject
Has Abstractpub_date
2015-03-01 00:00:00pages
243-55issue
3eissn
0171-967Xissn
1432-0827journal_volume
96pub_type
杂志文章,评审abstract：:Previous studies have indicated that children with inflammatory bowel disease (IBD) may not achieve optimal bone mass. We evaluated the skeletal characteristics in children and adolescents with IBD. This cross-sectional cohort study comprised 80 IBD patients (median age 14.9 years, range 5-20) with a median disease du...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-012-9617-2
更新日期：2012-08-01 00:00:00
abstract：:Observational studies examining associations of smoking and alcohol consumption with bone mineral density (BMD) have generated inconsistent results and suffer from several methodological limitations. We aim to evaluate whether there are causal associations between smoking, alcohol consumption, and BMD using a Mendelia...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-018-0452-y
更新日期：2018-11-01 00:00:00
abstract：:Orthopaedic wear debris induces release of bone-resorbing factors from macrophages and fibroblasts. However, the extent to which elemental metallic particles induce bone cells to express factors contributing to implant loosening remains unclear. This study showed that exposure of MG-63 osteoblast-like cells to titaniu...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223001125
更新日期：2000-08-01 00:00:00
abstract：:In this cross-sectional study, 91 healthy premenopausal women aged 20-39 years were investigated to determine the effect of physical activities during their teenage years on their current bone mineral densities (BMD). We measured whole-body BMD (WBMD), lumbar BMD (LBMD), and radial BMD (RBMD) with dual energy X-ray ab...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02684999
更新日期：2001-01-01 00:00:00
abstract：:Genome-wide association studies (GWAS) have demonstrated that genetic variation at the MADS box transcription enhancer factor 2, polypeptide C (MEF2C) locus is robustly associated with bone mineral density, primarily at the femoral neck. MEF2C is a transcription factor known to operate via the Wnt signaling pathway. O...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-013-9824-5
更新日期：2014-04-01 00:00:00
abstract：:Differences in trabecular and cortical bone loss have been demonstrated clinically, but differences in bone loss at different skeletal sites remain unclear. We examined regional variations in bone loss histomorphometrically in two strains of mice in which osteopenia progresses spontaneously: tiptoe-walking Yoshimura (...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900455
更新日期：1998-05-01 00:00:00
abstract：:Long-term use of hydrochlorothiazide (HCTZ), a common diuretic agent for hypertension, has been associated with increased bone density and reduced hip fracture rates in patients. In this study, we sought to examine whether HCTZ has an anabolic effect on the proliferation of human osteoblasts (derived from either verte...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF00369219
更新日期：1996-12-01 00:00:00
abstract：:Undesirable changes in health-related parameters are thought to occur in retiring female athletes, but this has not been examined in longitudinal studies. The purpose of this study was to examine longitudinal changes in bone mineral density (BMD), body composition, and dietary intake in gymnasts and controls. Nonathle...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-004-0228-4
更新日期：2004-12-01 00:00:00
abstract：:The effect of magnesium (Mg) supplementation on bone metabolism has been studied in the normal young mouse. Weanling male mice were given Mg-supplemented drinking water (5 mM or 32 mM Mg) for 4 weeks. Mineral and skeletal changes were assessed by biochemical methods and by histomorphometric analysis of endosteal bone ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02405119
更新日期：1983-09-01 00:00:00
abstract：:KH1060 is a new 20-epi-vitamin D3 analog, which has exerted a considerable immunosuppressive potency in vitro. We have tested in vivo the effect of KH1060 on the suppression of renal allograft rejection in the rat. Allogenic kidney transplantation from DA donor rats to Lewis recipient rats treated intraperitoneally wi...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF00296066
更新日期：1994-02-01 00:00:00
abstract：:We describe a tall-statured 14-year-old boy who illustrated the full phenotypic and radiographic features of Stickler syndrome type I. A bone biopsy showed evidence of reduced bone mass and bone turnover, such as reduced BV/TV (-43%), TbTh (-29%), and OS/BS (-48%), Ob.S/BS (-27%), and Oc/BS (-47%) compared to "age-mat...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-009-9324-9
更新日期：2010-02-01 00:00:00
abstract：:Skeletal tissues contain, apart from cells of the osteogenic and chondrogenic lineage, cells of hemopoietic origin, e.g., macrophages, osteoclasts, and their precursors. In the present study we examined the sensitivity for extracellular ATP4- of the above-mentioned cell types in freshly isolated, bone-derived cell pop...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF00297190
更新日期：1994-08-01 00:00:00
abstract：:The aim of this study was to follow the changes in bone mineral density (BMD) and biochemical markers of bone turnover in 10 children (7.5-17.5 years of age) with severe juvenile idiopathic arthritis (JIA), during a 3-year therapy with salmon calcitonin (100 IU/day 2 months on and 2 off for a year and 200 IU/day for 2...
journal_title：Calcified tissue international
pub_type： 临床试验,杂志文章
doi：10.1007/s00223-001-0008-3
更新日期：2001-07-01 00:00:00
abstract：:Calcaneus bone mineral density (BMD) of 738 Japanese women (605 healthy and 133 with osteoporosis) was measured using single X-ray absorptiometry (SXA). A reference range of calcaneus BMD values for healthy Japanese women was established and the usefulness of this method for screening and diagnosis of osteoporosis was...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900665
更新日期：1999-08-01 00:00:00
abstract：:We studied the acute phase response, including specific cytokine production, [interleukin-1 (IL-1), interleukin-6 (IL-6), tumor necrosis factor alpha(TNF alpha)] following a single dose of Aredia (disodium pamidronate) in patients with increased bone turnover and, in vitro, the role played by specific cytokines in the...
journal_title：Calcified tissue international
pub_type： 临床试验,杂志文章
doi：10.1007/s002239900353
更新日期：1997-11-01 00:00:00
abstract：:Mandibular first molars from 17-day-old mouse embryos were cultivated in vitro for 10 days using a new organ culture method. This method consisted of using a small glass dish and an agar chamber to slowly float the molars to the gas-medium interface where they were maintained by the surface tension of the medium. The ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02555218
更新日期：1986-10-01 00:00:00
abstract：:The aim of this study was to test whether the nitric oxide (NO) donor sodium nitroprusside (SNP) has an effect on mineralization in ATDC5 cells. Mineralization in ATDC5 cell culture was induced by addition of beta-glycerophosphate or inorganic phosphate, visualized by staining precipitated calcium with an alizarin red...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-005-1233-y
更新日期：2006-03-01 00:00:00
abstract：:Roux-en-Y gastric bypass surgery (RYGB) is an effective treatment of morbid obesity, with positive effects on obesity-related complications. The treatment is associated with bone loss, which in turn might increase fracture risk. The aim of this study was to evaluate changes in bone mineral density (BMD) and bone archi...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-015-0091-5
更新日期：2016-03-01 00:00:00
abstract：:We hypothesized that reactive oxygen species play an important role in avascular/ischemic osteonecrosis. When isolated chick osteocytes were cultured with hydrogen peroxide, annexin V binding, which is the earliest marker of apoptosis, increased in a dose-dependent fashion. Hydrogen peroxide also induced the activatio...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-001-1110-2
更新日期：2002-09-01 00:00:00
abstract：:Ultrasound measurements of the calcaneus are related to incidence of osteoporotic fracture. Such measurements are generally made at fixed coordinates relative to a footplate. This study compares measurements at an anatomically located region of interest (ROIanat) and at fixed coordinates (ROIfixed), with bone mineral ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF00298991
更新日期：1995-07-01 00:00:00
abstract：:Treatment of large bone defects (LBDs) is technically demanding. Tissue engineering is an option. A bioactive graft may be produced by combining tissue scaffolds and healing promotive factors in order to accelerate bone repair. We investigated the role of Simvastatin (Sim)-embedded porous Gelapin (Gel) scaffold on exp...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-015-9981-9
更新日期：2015-06-01 00:00:00
abstract：:The aim of this study was to investigate bone mineral density (BMD) and bone turnover in patients with primary knee osteoarthritis (KOA) and to compare them with generalized OA (GOA) and nonGOA patients. A total of 88 postmenopausal primary KOA patients were studied. OA was graded by using knee radiographs. BMD of the...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002230010068
更新日期：2000-05-01 00:00:00
abstract：:The aim of this study was to investigate the effect of transplanted chondrocytes on endochondral bone formation in cartilage repair tissue. In the knee joint of miniature pigs, cartilage lesions were treated by microfracturing and were then either left empty, covered with a collagen membrane, or treated by matrix-asso...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-009-9288-9
更新日期：2009-11-01 00:00:00
abstract：:Cartilage oligomeric matrix protein (COMP) is a macromolecule of yet unknown function with restricted distribution among tissues. In the present study, the ultrastructural localization of COMP in porcine immature joint cartilage and growth plate cartilage was semiquantitatively delineated. Tissues were fixed in a mixt...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900278
更新日期：1997-06-01 00:00:00
abstract：:Magnetic resonance imaging (MRI) is commonly used in the assessment of the musculoskeletal system and associated pathology. The ability of MRI to measure the signals from water and lipid protons enables quantitative measurements of bone porosity. The goal of this investigation was to demonstrate that the density and c...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002230050015
更新日期：2000-01-01 00:00:00
abstract：:To test the hypothesis that the relationship between fat mass (FM) and bone mineral density (BMD) is mediated by leptin. The study involved 611 individuals aged 20-89 years who were randomly sampled from Ho Chi Minh City (Vietnam). BMD at the femoral neck (FN), lumbar spine (LS), and whole body (WB) was measured by DX...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-016-0196-5
更新日期：2017-01-01 00:00:00
abstract：:The present study further characterizes an extract from immature, human tooth apicies from which an intact dentin phosphoprotein has been identified. Third molar apicies from developing roots were decalcified in 10% EDTA until Ca2+ was undetectable in the decalcifying solution. The crude extract was run on 7.5% SDS-PA...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900101
更新日期：1996-09-01 00:00:00
abstract：:Octacalcium phosphate (Ca8H2(PO4)6 . 5H2O) is considered to be precursor in the formation of apatite in bones and teeth; a crucial step for incorporation of impurities appears to occur during its hydrolysis. The present study examines the role that octacalcium phosphate plays in the process of incorporation of carbona...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02408521
更新日期：1980-01-01 00:00:00
abstract：:Urinary pyridinoline (pyr) and deoxypyridinoline (dpyr) are new markers for bone resorption, and serum osteocalcin reportedly indicates osteoblastic activity. Recently, a new ultrasound bone densitometer instrument has been developed that measures ultrasonic properties of the os calcis, namely, the speed of sound (SOS...
journal_title：Calcified tissue international
pub_type： 临床试验,杂志文章
doi：10.1007/BF00298555
更新日期：1994-12-01 00:00:00
abstract：:The extractions of 85Sr2+, 18F-, sucrose-14C, EDTA-51Cr, and antipyrine-14C in bone were determined by the multiple indicator-dilution method. Fluoride and strontium extractions were 18 to 70% during a single transcapillary passage, and those of EDTA and sucrose were from 11 to 59%, whereas extraction of antipyrine wa...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02407178
更新日期：1980-01-01 00:00:00
