Delineating the Relationship Between Leptin, Fat Mass, and Bone Mineral Density: A Mediation Analysis.

abstract：:The purpose of the present study was to determine if the type of dietary fat can modify the fatty acid composition and arachidonic acid levels in the alveolar bone phospholipids. Three groups of rats were fed nutritionally adequate semipurified diets containing different lipids: 10% corn oil (control, group I, rich in...

journal_title：Calcified tissue international

authors： Alam SQ,Kokkinos PP,Alam BS

更新日期：1993-11-01 00:00:00

abstract：:The ultimate hope of researchers and patients is a pathway to development of treatments for osteoarthritis to modify the disease process in addition to the symptoms. However, development of disease modifying drugs requires objective endpoints such as measures of joint structure, joint tissue homeostasis and/or joint s...

journal_title：Calcified tissue international

authors： Kraus VB,Karsdal MA

更新日期：2020-05-04 00:00:00

abstract：:We studied the influence of age, gender, latitude, season, diet and ethnicity on plasma 25-hydroxyvitamin D 25 OHD, PTH, 1,25-dihydroxyvitamin D, vitamin D-binding protein, bone-specific alkaline phosphatase, and osteocalcin levels in 46 Greenlanders living in Nuuk (64 degrees N) on a traditional fare (group A), 45 Gr...

journal_title：Calcified tissue international

authors： Rejnmark L,Jørgensen ME,Pedersen MB,Hansen JC,Heickendorff L,Lauridsen AL,Mulvad G,Siggaard C,Skjoldborg H,Sørensen TB,Pedersen EB,Mosekilde L

更新日期：2004-03-01 00:00:00

abstract：:The aim of this work was to explore the reduction of fluoride concentrations in the skeleton after stopping experimental fluoride administration. Fluoride was administered to the rats at varying doses (0, 50, 100 ppm in drinking water) and for different lengths of time (4, 13, 25 weeks). A series of fluoride concentra...

journal_title：Calcified tissue international

authors： Li J,Nakagaki H,Kato K,Tsuboi S,Kato S,Morita I,Ohno N,Kameyama Y,Chen R,Robinson C

更新日期：1995-04-01 00:00:00

abstract：:To characterize osteopenic changes in ovariectomized (OVX) rats as a function of time, female Sprague Dawley rats (240 g body weight, 90 days old) were subjected to bilateral ovariectomy or sham surgery and killed at various times from 14-180 days postovariectomy. The proximal tibial metaphysis was processed undecalci...

journal_title：Calcified tissue international

authors： Wronski TJ,Cintrón M,Dann LM

更新日期：1988-09-01 00:00:00

abstract：:Sarcopenia and osteoporosis are two sides of the same coin. They represent different aspects of the same age-related process of musculoskeletal atrophy and together culminate in falls, fractures, deconditioning, and increased mortality in older individuals. However, the current therapeutic approach to the prevention o...

journal_title：Calcified tissue international

authors： Girgis CM

更新日期：2015-03-01 00:00:00

abstract：:In the past years, several epidemiological and clinical observations have underlined the importance of genetics in the pathogenesis of both female and male osteoporosis. It has been estimated that from 50 to 80% of the inter-individual variability in bone mass is genetically determined. In rare instances, osteoporosis...

journal_title：Calcified tissue international

authors： Gennari L,Brandi ML

更新日期：2001-10-01 00:00:00

abstract：:Amelogenins, the major protein components of the enamel extracellular matrix, are postulated to be involved in controlling the elongated and oriented growth of enamel carbonated apatite crystals. In order to clarify the functional role of amelogenin during the early stage of enamel biomineralization, octacalcium phosp...

journal_title：Calcified tissue international

authors： Iijima M,Moradian-Oldak J

更新日期：2004-06-01 00:00:00

abstract：:The effects of long-term running were studied in 20 beagle dogs. Ten dogs ran from the age of 15 weeks to the age of 70 weeks in a progressive program for up to 40 km/day. Ten sister dogs spent the same time in individual cages. At the age of 70 weeks the spines of the dogs were studied with regard to mineral density ...

journal_title：Calcified tissue international

authors： Puustjärvi K,Karjalainen P,Nieminen J,Helminen HJ,Soimakallio S,Kivimäki T,Arokoski J

更新日期：1991-01-01 00:00:00

abstract：:ELISAs for measuring the urinary excretion of collagen crosslinks and related peptides appear to show marked differences in sensitivity to anti-resorptive therapy. This presumably reflects variations in specificity of the anylate being detected in these assays, and the way in which they respond to treatment. To clarif...

journal_title：Calcified tissue international

authors： Tobias JH,Laversuch CV,Wilson N,Robins SP

更新日期：1996-11-01 00:00:00

abstract：:The goal of this study was to find out if bone can recover after long-term administration of bisphosphonate. Disodium pamidronate (APD) was given orally by gavage to mature beagle dogs at doses of 0, 2.5, 12.5, and 25 mg/kg/day for 1 year (0.1% concentration) and the animals were allowed to recover for another year. A...

journal_title：Calcified tissue international

authors： Grynpas MD,Kasra M,Dumitriu M,Nespeca R,Very JM,Mertz BP

更新日期：1994-10-01 00:00:00

abstract：:Calcium deficiency is a major etiological determinant of rickets in Nigerian children and is accompanied by undermineralization of the developing bone matrix which is composed largely of type I collagen. We have assessed types I and III collagen metabolism by measuring the circulating concentrations of teh N- and C-te...

journal_title：Calcified tissue international

authors： Sharp CA,Oginni LM,Worsfold M,Oyelami OA,Risteli L,Risteli J,Davie MW

更新日期：1997-08-01 00:00:00

abstract：:The purpose of this study was to examine the influence of exercise on the serum concentrations of intact parathyroid hormone (PTH). Serum PTH and plasma lactate were measured in 15 well-trained men, 9 long-distance runners and 6 fire-fighters, during two running exercises. Test one consisted of 40-minute treadmill run...

journal_title：Calcified tissue international

authors： Salvesen H,Johansson AG,Foxdal P,Wide L,Piehl-Aulin K,Ljunghall S

更新日期：1994-04-01 00:00:00

abstract：:Cartilage oligomeric matrix protein (COMP) is a macromolecule of yet unknown function with restricted distribution among tissues. In the present study, the ultrastructural localization of COMP in porcine immature joint cartilage and growth plate cartilage was semiquantitatively delineated. Tissues were fixed in a mixt...

journal_title：Calcified tissue international

authors： Ekman S,Reinholt FP,Hultenby K,Heinegârd D

更新日期：1997-06-01 00:00:00

abstract：:In general, physical exercise appears to have favorable effects on the skeleton. However, a few recent reports have described negative effects, including reduced bone density (BMD) and high bone turnover in runners. The aim of our study was to compare endurance runners to controls with respect to BMD at different site...

journal_title：Calcified tissue international

authors： Brahm H,Ström H,Piehl-Aulin K,Mallmin H,Ljunghall S

更新日期：1997-12-01 00:00:00

abstract：:This article reviews the effects of restrictive eating disorders on bone health. The relationship between eating disorders and amenorrhea is discussed in detail. The pathologic impact of malnutrition on bone is explored by examining the results of studies using various available imaging techniques. The multiple hormon...

journal_title：Calcified tissue international

authors： Thornton D,Gordon CM

更新日期：2017-05-01 00:00:00

abstract：:Amelogenins are the most abundant secreted proteins in developing dental enamel. These evolutionarily-conserved proteins have important roles in enamel mineral formation, as mutations within the amelogenin gene coding region lead to defects in enamel thickness or mineral structure. Because of extensive alternative spl...

journal_title：Calcified tissue international

authors： Chen E,Yuan ZA,Wright JT,Hong SP,Li Y,Collier PM,Hall B,D'Angelo M,Decker S,Piddington R,Abrams WR,Kulkarni AB,Gibson CW

更新日期：2003-11-01 00:00:00

abstract：:1,25(OH)2D3 was found to regulate its own receptor levels via an increase in corresponding mRNA levels in human osteoblast-like osteosarcoma cells (MG-63). In addition, exposure of the cells for 24h to dexamethasone, estradiol, retinoic acid, or triiodothyronine resulted in a dose-dependent accumulation of hVDR mRNA. ...

journal_title：Calcified tissue international

authors： Mäenpää P,Mahonen A,Pirskanen A

更新日期：1991-01-01 00:00:00

abstract：:We compared indices of three-dimensional microstructure of iliac trabecular bone between 26 patients with vertebral compression fractures due to postmenopausal osteoporosis and 24 control subjects without vertebral fracture, who were matched for age, sex, race, menopausal status, and several densitometric and histolog...

journal_title：Calcified tissue international

authors： Kleerekoper M,Villanueva AR,Stanciu J,Rao DS,Parfitt AM

更新日期：1985-12-01 00:00:00

abstract：:Effects of a single dose of 200 IU of nasal salmon calcitonin (SCT) on calcium metabolism and biochemical markers of bone turnover were investigated in 12 healthy male volunteers in a randomized, placebo-controlled, cross-over design. The nasal spray was given in the morning, and subsequently blood and urine samples w...

journal_title：Calcified tissue international

authors： Thamsborg G,Skousgaard SG,Daugaard H,Schifter S,Kollerup G,Sørensen OH

更新日期：1993-10-01 00:00:00

abstract：:Long-term use of hydrochlorothiazide (HCTZ), a common diuretic agent for hypertension, has been associated with increased bone density and reduced hip fracture rates in patients. In this study, we sought to examine whether HCTZ has an anabolic effect on the proliferation of human osteoblasts (derived from either verte...

journal_title：Calcified tissue international

authors： Lau KH,Song XD,Ochi M,Wergedal JE

更新日期：1996-12-01 00:00:00

abstract：:Raman spectroscopy has been used to demonstrate, for the first time, that calcium mineralization in the core of the major lateral teeth of the chiton Acanthopleura echinata takes place as an ordered process, with crystalline carbonated apatite being the first mineral deposited. Deposition begins at the top of the toot...

journal_title：Calcified tissue international

authors： Lee AP,Brooker LR,Macey DJ,van Bronswijk W,Webb J

更新日期：2000-11-01 00:00:00

abstract：:A positional cloning effort in French Canadian families with Paget's disease of bone (PDB) resulted in the identification of a mutation in the sequestosome1 (SQSTM1) gene in a subset of both familial and sporadic PDB cases. This was confirmed in samples of mainly United Kingdom (UK) origin. In this study, we performed...

journal_title：Calcified tissue international

authors： Beyens G,Van Hul E,Van Driessche K,Fransen E,Devogelaer JP,Vanhoenacker F,Van Offel J,Verbruggen L,De Clerck L,Westhovens R,Van Hul W

更新日期：2004-08-01 00:00:00

abstract：:It has recently been demonstrated that calcium ionophore A23187 mimics certain of the effects of parathyroid hormone (PTH) on bone in vitro, including stimulation of 45Ca release and cAMP formation. To further examine the relative effects of these two agents on bone cell metabolism, we compared the effects of syntheti...

journal_title：Calcified tissue international

authors： DeBartolo TF,Pegg LE,Shasserre C,Hahn TJ

更新日期：1982-09-01 00:00:00

abstract：:We examined differences in patients' survival after hip fracture (HF) and risk for subsequent HF among patients treated with oral and intravenous bisphosphonates (oBPs, iBPs), denosumab (DMAB), and patients without therapy. We used data from all patients in Austria aged ≥ 50 who sustained a HF between 2012 and 2017 an...

journal_title：Calcified tissue international

authors： Behanova M,Reichardt B,Stamm TA,Zwerina J,Klaushofer K,Kocijan R

更新日期：2019-12-01 00:00:00

abstract：:High resolution transmission electron microscopy (Hr TEM) studies on biological and synthetic calcium phosphate have provided information on the dissolution process at the crystal level. The purpose of this study was to investigate the dissolution of ceramic hydroxyapatite (HA) after implantation using Hr TEM. Recover...

journal_title：Calcified tissue international

authors： Daculsi G,LeGeros RZ,Mitre D

更新日期：1989-08-01 00:00:00

abstract：:The purpose of the present work was to investigate the appearance of ossification centers in human femur by Dual-energy X-ray Absorptiometry (DXA), comparing densitometric data with morphogenetic events. Posteroanterior scans were performed on 31 dried femora (from 11.5 weeks of conceptual age to 1 year of postnatal l...

journal_title：Calcified tissue international

authors： Panattoni GL,D'Amelio P,Di Stefano M,Isaia GC

更新日期：2000-04-01 00:00:00

abstract：:High serum levels of IGFBP-1 are related both to low body mass index (BMI) and to low insulin-like growth factor 1 (IGF-I), which both in turn are related to low bone mineral density (BMD) and to increased fracture risk. However, we have found no previous prospective studies on IGFBP-1 and fracture risk. Despite its n...

journal_title：Calcified tissue international

authors： Lundin H,Sääf M,Strender LE,Nyren S,Johansson SE,Salminen H

更新日期：2016-10-01 00:00:00

abstract：:There is increasing interest in identifying new pathways and candidate genes that confer susceptibility to osteoporosis. There is evidence that adipogenesis and osteogenesis may be related, including a common bone marrow progenitor cell for both adipocytes and osteoblasts. Perilipin 1 (PLIN1) and Perilipin 4 (PLIN4) a...

journal_title：Calcified tissue international

authors： Cusano NE,Kiel DP,Demissie S,Karasik D,Adrienne Cupples L,Corella D,Gao Q,Richardson K,Yiannakouris N,Ordovas JM

更新日期：2012-02-01 00:00:00

abstract：:We describe here the activity of a novel selective estrogen receptor modulator, SP500263. When given to adult ovariectomized (OVX) rats for 28 days at doses of 0.3, 1, or 3 mg/kg/day, we found that SP500263 partially protected against OVX-induced loss of bone mineral content in the distal ends of femurs and in the who...

journal_title：Calcified tissue international

authors： Sutherland MK,Brady H,Gayo-Fung LM,Leisten J,Lipps SG,McKie JA,O'Leary E,Patnaik N,Anderson DW,Bhagwat SS,Stein B

更新日期：2003-06-01 00:00:00