Hydrogen peroxide induces apoptosis of osteocytes: involvement of calcium ion and caspase activity.

abstract：:Various studies have investigated the serum sclerostin and bone morphogenetic protein-2 (BMP-2) levels in patients with ankylosing spondylitis (AS), but the results were inconsistent. The aim of this meta-analysis was to synthetically assess the associations of serum levels of sclerostin and BMP-2 with AS. Multiple el...

journal_title：Calcified tissue international

authors： Yang J,Xu S,Chen M,Yuan Y,Zhang X,Ma Y,Wu M,Han R,Hu X,Liu R,Deng J,Guan S,Gao X,Pan M,Xu S,Shuai Z,Jiang S,Guan S,Chen L,Pan F

更新日期：2019-07-01 00:00:00

abstract：:Alkaptonuria (AKU) is characterised by increased circulating homogentisic acid and deposition of ochronotic pigment in collagen-rich connective tissues (ochronosis), stiffening the tissue. This process over many years leads to a painful and severe osteoarthropathy, particularly affecting the cartilage of the spine and...

journal_title：Calcified tissue international

authors： Hughes JH,Keenan CM,Sutherland H,Edwards HR,Wilson PJM,Ranganath LR,Jarvis JC,Bou-Gharios G,Gallagher JA

更新日期：2021-02-01 00:00:00

abstract：:To evaluate the associations of sarcopenia and previous falls with 2-year major osteoporotic fractures (MOFs) in community-dwelling older adults. Four thousand Chinese men and women ≥ 65 years recruited from Hong Kong communities were prospectively followed up. Measures of muscle mass, grip strength, gait speed and fa...

journal_title：Calcified tissue international

authors： Su Y,Lam FMH,Leung J,Cheung WH,Ho SC,Kwok T

更新日期：2020-08-01 00:00:00

abstract：:Normal rat bone maturation has been studied using biochemical methods and hydrazine separation of matrix and mineral for X-ray diffraction. In the bone, the amount of mineral increases between 4 and 22 weeks of age, while in the matrix, the ratio of noncollagenous protein to collagen progressively decreases. In minera...

journal_title：Calcified tissue international

authors： Burnell JM,Teubner EJ,Miller AG

更新日期：1980-01-01 00:00:00

abstract：:The goals of internal fixation are an accurate reduction and stable fixation in the presence of adequate bony vascularity. This can be achieved by a variety of means including plate fixation. A certain amount of periosteal stripping is necessary for proper open reduction of a fracture and for proper plate application....

journal_title：Calcified tissue international

authors： Kowalski MJ,Schemitsch EH,Kregor PJ,Senft D,Swiontkowski MF

更新日期：1996-07-01 00:00:00

abstract：:We have examined the effect of the anti-tumor compound taxol, on osteoclastic bone resorption. In the bone slice assay, taxol (0.1-0.001 microM) dose-dependently inhibited bone resorption with an IC50 of 0.08 microM. Osteoclast survival on bone slices was unaffected by 0.01-1 microM taxol, but 10 microM was cytotoxic....

journal_title：Calcified tissue international

authors： Hall TJ,Jeker H,Schaueblin M

更新日期：1995-12-01 00:00:00

abstract：:To test the hypothesis that the relationship between fat mass (FM) and bone mineral density (BMD) is mediated by leptin. The study involved 611 individuals aged 20-89 years who were randomly sampled from Ho Chi Minh City (Vietnam). BMD at the femoral neck (FN), lumbar spine (LS), and whole body (WB) was measured by DX...

journal_title：Calcified tissue international

authors： Ho-Pham LT,Lai TQ,Nguyen UD,Bui QV,Nguyen TV

更新日期：2017-01-01 00:00:00

abstract：:The P2X7 nucleotide receptor (P2X7R) is an ATP-gated ion channel expressed in bone cells. Homozygous null P2X7R (P2X7R(-/-)) mice have reduced bone formation, so we hypothesized that P2X7R(-/-) mice have impaired fracture healing compared to P2X7R(+/+) control mice. To test the hypothesis, adult P2X7R(-/-) mice and P2...

journal_title：Calcified tissue international

authors： Li J,Meyer R,Duncan RL,Turner CH

更新日期：2009-05-01 00:00:00

abstract：:Primary cilia are responsible for sensing mechanical loading in osteocytes. However, the underlying working mechanism of cilia remains elusive. An osteocyte model is necessary to reveal the role of cilia. Furthermore, the osteocyte model should be with upregulated or downregulated primary cilium expression. Herein, we...

journal_title：Calcified tissue international

authors： Ding D,Yang X,Luan HQ,Wu XT,He C,Sun LW,Fan YB

更新日期：2020-12-01 00:00:00

abstract：:Atomic force microscopy (AFM) was used to obtain three-dimensional images of isolated mineralites extracted from young postnatal bovine bone. The mean mineralite size is 9 nm x 6 nm x 2.0 nm, significantly shorter and thicker than the mineralites of mature bovine bone measured by the same technique. Mineralites of the...

journal_title：Calcified tissue international

authors： Tong W,Glimcher MJ,Katz JL,Kuhn L,Eppell SJ

更新日期：2003-05-01 00:00:00

abstract：:The five-year survival rate for primary bone cancers is ~ 70% while almost all cases of secondary metastatic bone cancer are terminal. Hypoxia, the deficiency of oxygen which occurs as the rate of tumour growth exceeds the supply of vascularisation, is a key promoter of tumour progression. Hypoxia-driven effects in th...

journal_title：Calcified tissue international

authors： Cox TR,Erler JT,Rumney RMH

更新日期：2018-02-01 00:00:00

abstract：:Insulin is a potent stimulator of collagen synthesis and other osteoblastic cell functions. In various insulin-sensitive tissues, stimulation of glucose transport and glycolytic metabolism are hallmarks of insulin action and may play a role in insulin regulation of cellular function. However, the effects of insulin on...

journal_title：Calcified tissue international

authors： Ituarte EA,Halstead LR,Iida-Klein A,Ituarte HG,Hahn TJ

更新日期：1989-07-01 00:00:00

abstract：:Diets with a high saturated fat content can produce deleterious effects on the absorption of dietary calcium and consequently an adverse effect on bone mineralization in growing animals. Hence dietary fat may have long-term consequences for skeletal health and skeletal pathologies such as osteoporosis. Whether a diet ...

journal_title：Calcified tissue international

authors： Wohl GR,Loehrke L,Watkins BA,Zernicke RF

更新日期：1998-07-01 00:00:00

abstract：:Targeted disruption of the c-src gene leads to a severe form of osteopetrosis in mice [2]. As the c-src gene is expressed in all tissues and cells tested, we have analyzed fibroblasts from three individuals with malignant, congenital osteopetrosis for the expression of c-src at the protein level. No differences could ...

journal_title：Calcified tissue international

authors： Meyerson G,Dahl N,Påhlman S

更新日期：1993-07-01 00:00:00

abstract：:To characterize osteopenic changes in ovariectomized (OVX) rats as a function of time, female Sprague Dawley rats (240 g body weight, 90 days old) were subjected to bilateral ovariectomy or sham surgery and killed at various times from 14-180 days postovariectomy. The proximal tibial metaphysis was processed undecalci...

journal_title：Calcified tissue international

authors： Wronski TJ,Cintrón M,Dann LM

更新日期：1988-09-01 00:00:00

abstract：:The recent advancement of high resolution magnetic resonance imaging has opened up new avenues for the determination of structural characteristics of the trabecular network, which may significantly improve the diagnosis of osteoporosis. An analysis of the calcaneus in healthy women has shown similar age-related change...

journal_title：Calcified tissue international

authors： Engelke K,Hahn M,Takada M,Vogel M,Ouyang X,Delling G,Genant HK

更新日期：2001-03-01 00:00:00

abstract：:Studies suggest that long-term use of proton pump inhibitors (PPIs) may be associated with an increased risk of fracture. However, the role of medication adherence in this association is not fully understood. A retrospective cohort study was conducted to examine the relationship between PPI use/adherence and fracture ...

journal_title：Calcified tissue international

authors： Ding J,Heller DA,Ahern FM,Brown TV

更新日期：2014-06-01 00:00:00

abstract：:The bone mineral status of 17 girls with Turner's syndrome was evaluated by single photon absorptiometry. Bone mineral content (BMC) was 25.4% below that predicted by normalization for age, sex, height, weight, and bone width. Only 25% of this demineralization could be attributed to delayed skeletal maturation. Bones ...

journal_title：Calcified tissue international

authors： Shore RM,Chesney RW,Mazess RB,Rose PG,Bargman GJ

更新日期：1982-01-01 00:00:00

abstract：:The effects of 5, 10, and 20% dietary xylitol supplementations on the resorption of bone were studied. The resorption was measured by the urinary excretion of [3H] radioactivity from [3H]tetracycline-prelabeled rats. The 10 and 20% oral xylitol administrations caused a significant decrease in the excretion of [3H] as ...

journal_title：Calcified tissue international

authors： Mattila P,Svanberg M,Knuuttila M

更新日期：1995-03-01 00:00:00

abstract：:Raman spectroscopy and imaging are known to be valuable tools for the analysis of bone, the determination of protein secondary structure, and the study of the composition of crystalline materials. We have utilized all of these attributes to examine how mechanical loading and the resulting deformation affects bone ultr...

journal_title：Calcified tissue international

authors： Carden A,Rajachar RM,Morris MD,Kohn DH

更新日期：2003-02-01 00:00:00

abstract：:Bone loss during advancing age in women and men is partly the result of sex steroid deficiency. As the contribution of circulating sex steroids and sex hormone-binding globulin (SHBG) to bone loss remains uncertain, we sought to determine whether levels of sex steroids or SHBG predict change in bone mineral density (B...

journal_title：Calcified tissue international

authors： Bjørnerem A,Emaus N,Berntsen GK,Joakimsen RM,Fønnebø V,Wilsgaard T,Oian P,Seeman E,Straume B

更新日期：2007-08-01 00:00:00

abstract：:Ossification of the posterior longitudinal ligament of the spine (OPLL) is characterized by ectopic bone formation in the spinal ligaments. Mechanical stress, which acts on the posterior ligaments, is thought to be an important factor in the progression of OPLL. To clarify this mechanism, we investigated the effects o...

journal_title：Calcified tissue international

authors： Iwasaki K,Furukawa KI,Tanno M,Kusumi T,Ueyama K,Tanaka M,Kudo H,Toh S,Harata S,Motomura S

更新日期：2004-05-01 00:00:00

abstract：:Calcium-acidic phospholipid-phosphate complexes (Ca-PL-PO4) cause hydroxyapatite (HA) deposition in vitro. The acidic phospholipids--phosphatidylserine (PS), phosphatidylinositol (PI), phosphatidylglycerol (PG), and diphosphatidylglycerol (DPG)--all form Ca-PL-PO4 complexes: Nonacidic phospholipids--sphingomyelin (SPL...

journal_title：Calcified tissue international

authors： Boskey AL,Posner AS

更新日期：1982-01-01 00:00:00

abstract：:In humans, gastric surgery results in in osteopenia via mechanisms that are insufficiently understood; surgery-induced changes in the hormonal axes involving the stomach, thyroid, and the parathyroids may play a role. To study this in more detail, we evaluated calcium (Ca), magnesium (Mg), and phosphorus (P) metabolis...

journal_title：Calcified tissue international

authors： Rümenapf G,Schwille PO,Erben RG,Schreiber M,Bergé B,Fries W,Schmiedl A,Koroma S,Hohenberger W

更新日期：1998-11-01 00:00:00

abstract：:Aluminum ions (Al) and chromium (III) ions (Cr), as they exist in aqueous solution at neutral pH, adsorb onto calcium hydroxyapatite crystals (HAP) and severely inhibit their dissolution process, when present in concentrations less than 1 microM. Iron (III) ions (Fe), at concentrations up to 10 microM, have no effect ...

journal_title：Calcified tissue international

authors： Christoffersen MR,Thyregod HC,Christoffersen J

更新日期：1987-07-01 00:00:00

abstract：:Periodic fringes corresponding to six different lattice planes have been observed in apatite crystals of human normal alveolar bone by transmission electron microscopy. Three of these sets of fringes have spacings less than 3.5 A corresponding to the Scherzer resolution of the microscope used. The (0002) lattice plane...

journal_title：Calcified tissue international

authors： Cuisinier F,Bres EF,Hemmerle J,Voegel JC,Frank RM

更新日期：1987-06-01 00:00:00

abstract：:1,25(OH)2D3 was found to regulate its own receptor levels via an increase in corresponding mRNA levels in human osteoblast-like osteosarcoma cells (MG-63). In addition, exposure of the cells for 24h to dexamethasone, estradiol, retinoic acid, or triiodothyronine resulted in a dose-dependent accumulation of hVDR mRNA. ...

journal_title：Calcified tissue international

authors： Mäenpää P,Mahonen A,Pirskanen A

更新日期：1991-01-01 00:00:00

abstract：:Human osteoblasts were obtained by migration and proliferation of cells from embryonic membranous bone on glass fragments. Light and electron microscopy analyses revealed a typical osteoblast-like appearance with high protein synthesis activity. The cells showed high alkaline phosphatase activity that was associated w...

journal_title：Calcified tissue international

authors： Oliva A,Marrone G,Della Ragione F,Riccio V,Palumbo R,Rossano F,Zappia V

更新日期：1992-11-01 00:00:00

abstract：:In this cross-sectional study, 91 healthy premenopausal women aged 20-39 years were investigated to determine the effect of physical activities during their teenage years on their current bone mineral densities (BMD). We measured whole-body BMD (WBMD), lumbar BMD (LBMD), and radial BMD (RBMD) with dual energy X-ray ab...

journal_title：Calcified tissue international

authors： Hara S,Yanagi H,Amagai H,Endoh K,Tsuchiya S,Tomura S

更新日期：2001-01-01 00:00:00

abstract：:The native human parathyroid hormone, hPTH-(1-84), and certain carboxyl truncated analogs such as hPTH-(1-34) and even smaller fragments such as hPTH-(1-31)NH2, [Leu27]cyclo(Glu22-Lys26)hPTH-(1-31)NH2, and hPTH-(1-30)NH2 stimulate femoral trabecular and cortical bone growth in ovariectomized (OVX) rats. Here we show t...

journal_title：Calcified tissue international

authors： Whitfield JF,Morley P,Fraher L,Hodsman AB,Holdsworth DW,Watson PH,Willick GE,Barbier JR,Gulam M,Isaacs RJ,MacLean S,Ross V

更新日期：2000-04-01 00:00:00