Inhibition of calcium pyrophosphate dihydrate crystal formation: effects of carboxylate ions.

abstract：:To assess the reductions in bone mass, strength, and turnover in adjuvant-induced arthritic rats and to examine the effect of a new benzamide compound, DU-6712, on these parameters, a 28-day dosing experiment was performed using 8-week-old female Lewis rats. Arthritis was induced by injecting the adjuvant into the hin...

journal_title：Calcified tissue international

authors： Uchiyama Y,Takamori H,Miyama K,Takano E,Nakajima H,Sato T,Nakamura T

更新日期：1998-06-01 00:00:00

abstract：:Teriparatide (TPTD) is known to increase the cortical thickness and porosity. The purpose of the present study was to determine whether switching from TPTD to ibandronate (IBN) would be useful for improving cortical bone parameters as assessed using high-resolution quantitative computed tomography (HR-QCT) analyses in...

journal_title：Calcified tissue international

authors： Iwamoto J,Seki A,Nango N

更新日期：2016-11-01 00:00:00

abstract：:A resolution-enhanced Fourier Transform Infrared (FTIR) Spectroscopic study of the CO3(2-) ion in pig enamel of increasing age and maturity has demonstrated the existence of four different, main carbonate locations. The major CO3(2-) site arises as a result of the substitution of CO3(2-) ions in the positions occupied...

journal_title：Calcified tissue international

authors： Rey C,Renugopalakrishnan V,Shimizu M,Collins B,Glimcher MJ

更新日期：1991-10-01 00:00:00

abstract：:Urinary pyridinoline (pyr) and deoxypyridinoline (dpyr) are new markers for bone resorption, and serum osteocalcin reportedly indicates osteoblastic activity. Recently, a new ultrasound bone densitometer instrument has been developed that measures ultrasonic properties of the os calcis, namely, the speed of sound (SOS...

journal_title：Calcified tissue international

authors： Kawana K,Kushida K,Takahashi M,Ohishi T,Denda M,Yamazaki K,Inoue T

更新日期：1994-12-01 00:00:00

abstract：:High PTH levels increase bone turnover and decrease bone mineral density (BMD). Low plasma 25-hydroxyvitamin D (25OHD) levels cause secondary hyperparathyroidism, but the relative contribution of low 25OHD and high PTH levels on risk of fracture is largely unknown. Within the cohort of women (n = 2,016) included in th...

journal_title：Calcified tissue international

authors： Rejnmark L,Vestergaard P,Brot C,Mosekilde L

更新日期：2011-03-01 00:00:00

abstract：:The aim of this study was to follow the changes in bone mineral density (BMD) and biochemical markers of bone turnover in 10 children (7.5-17.5 years of age) with severe juvenile idiopathic arthritis (JIA), during a 3-year therapy with salmon calcitonin (100 IU/day 2 months on and 2 off for a year and 200 IU/day for 2...

journal_title：Calcified tissue international

authors： Siamopoulou A,Challa A,Kapoglou P,Cholevas V,Mavridis AK,Lapatsanis PD

更新日期：2001-07-01 00:00:00

abstract：:Previous observational studies have identified various risk factors associated with the development of osteoporosis, including sex hormone-binding globulin (SHBG). The aim of this study was to determine the potential causal effects of circulating SHBG concentrations on bone mineral density (BMD). Two-sample Mendelian ...

journal_title：Calcified tissue international

authors： Qu Z,Jiang J,Yang F,Huang J,Zhao J,Yan S

更新日期：2020-10-17 00:00:00

abstract：:It has been suggested that oxidative stress is associated with the pathogenesis of osteoporosis. The objective of this study was to explore the association between a marker of oxidative stress and either bone turnover markers or bone mineral density (BMD) in postmenopausal women. In addition, the effects of oxidative ...

journal_title：Calcified tissue international

authors： Baek KH,Oh KW,Lee WY,Lee SS,Kim MK,Kwon HS,Rhee EJ,Han JH,Song KH,Cha BY,Lee KW,Kang MI

更新日期：2010-09-01 00:00:00

abstract：:As tobacco smoking has been identified as a risk factor in the development of osteoporosis, possible deleterious effects of nicotine inhalation on bone mineral density (BMD) and mechanical properties of the femur in female rats were studied. Female Sprague Dawley rats were exposed to nicotine vapour 20 hours a day 5 d...

journal_title：Calcified tissue international

authors： Syversen U,Nordsletten L,Falch JA,Madsen JE,Nilsen OG,Waldum HL

更新日期：1999-09-01 00:00:00

abstract：:We have previously shown that cyclosporin A (CsA) produces high bone remodeling with resorption exceeding formation and loss of bone volume in the rat. This may have important clinical implications where CsA is widely used in organ transplantation. 1,25 dihydroxyvitamin D3 (1,25(OH)2D3) is a bone mineralizing hormone ...

journal_title：Calcified tissue international

authors： Epstein S,Schlosberg M,Fallon M,Thomas S,Movsowitz C,Ismail F

更新日期：1990-09-01 00:00:00

abstract：:Doses of 8, 16 (low), 32, 48, 64 (medium), and 150 (high) mg/kg/day of cortisol were administered to groups of 8 growing rats each during 16 days, and their femurs were then submitted to 3-point bending tests at low strain rate. Low doses had no effect. Medium doses, previously shown to improve calcium (Ca) balance an...

journal_title：Calcified tissue international

authors： Ferretti JL,Vázquez SO,Delgado CJ,Capozza R,Cointry G

更新日期：1992-01-01 00:00:00

abstract：:Changes in the acidity of osteoclasts were evaluated by direct measurement of the fluorescent intensity of osteoclasts exposed to acridine orange, a fluorescent weak base which becomes concentrated in acid-containing subcellular compartments. Parathyroid hormone (PTH) produced dose-dependent increases in fluorescent i...

journal_title：Calcified tissue international

authors： Anderson RE,Jee WS,Woodbury DM

更新日期：1985-12-01 00:00:00

abstract：:Fracture healing is a natural process that recapitulates embryonic skeletal development. In the early phase after fracture, reactive oxygen species (ROS) are produced under inflammatory and ischemic conditions due to vessel injury and soft tissue damage, leading to cell death. Usually, such damage during the course of...

journal_title：Calcified tissue international

authors： Kubo Y,Wruck CJ,Fragoulis A,Drescher W,Pape HC,Lichte P,Fischer H,Tohidnezhad M,Hildebrand F,Pufe T,Jahr H

更新日期：2019-10-01 00:00:00

abstract：:Primary cilia are responsible for sensing mechanical loading in osteocytes. However, the underlying working mechanism of cilia remains elusive. An osteocyte model is necessary to reveal the role of cilia. Furthermore, the osteocyte model should be with upregulated or downregulated primary cilium expression. Herein, we...

journal_title：Calcified tissue international

authors： Ding D,Yang X,Luan HQ,Wu XT,He C,Sun LW,Fan YB

更新日期：2020-12-01 00:00:00

abstract：:The fossil record shows that bone remodeling has existed since the earliest large vertebrates became weight-bearing on land, but the functions of remodeling have long been debated. The principal protagonists in this debate have been those favoring a mechanical function and those asserting that remodeling serves to mov...

journal_title：Calcified tissue international

authors： Martin RB

更新日期：2003-08-01 00:00:00

abstract：:The aims of this study were to compare the response to therapy in disease activity in pagetic patients with and without skull involvement and the usefulness of bone markers in the evaluation of these patients. Forty patients with Paget's disease treated with tiludronate and 26 healthy controls were included. Serum tot...

journal_title：Calcified tissue international

authors： Peris P,Alvarez L,Vidal S,Kasper D,Leeming DJ,Monegal A,Angeles Martínez M,Pons F,Guañabens N

更新日期：2006-07-01 00:00:00

abstract：:Dickkopf-1 (DKK1) and sclerostin are antagonists of the Wnt/β-catenin pathway and decreased expression of either results in increased bone formation and mass. As both affect the same signaling pathway, we aimed to elucidate the redundancy and/or compensation of sclerostin and DKK1. Weekly sclerostin antibody (Scl-Ab) ...

journal_title：Calcified tissue international

authors： Morse A,Cheng TL,Schindeler A,McDonald MM,Mohanty ST,Kneissel M,Kramer I,Little DG

更新日期：2018-09-01 00:00:00

abstract：:Gallium nitrate (GaN) reduces cancer-related hypercalcemia and inhibits bone resorption in vitro. This study investigated the effects of chronic GaN administration on bone, kidney, and parathyroid gland activity of growing rats. Experimental animals received GaN (1.75 mg elemental gallium i.p. QOD X 8, Ga+), and contr...

journal_title：Calcified tissue international

authors： Cournot-Witmer G,Bourdeau A,Lieberherr M,Thil CL,Plachot JJ,Enault G,Bourdon R,Balsan S

更新日期：1987-05-01 00:00:00

abstract：:To investigate the effect of low doses of intranasal salmon calcitonin on plasma cyclic AMP (cAMP) and serum ionized calcium, 40 healthy postmenopausal women were randomized to receive a single dose of either placebo or 50, 100, or 200 IU of salmon calcitonin as a nasal spray. Blood samples were collected throughout a...

journal_title：Calcified tissue international

authors： Thamsborg G,Storm TL,Brinch E,Sykulski R,Fogh-Andersen N,Holmegaard SN,Sørensen OH

更新日期：1990-01-01 00:00:00

abstract：:Considerable advances in oncology over recent decades have led to improved survival, while raising concerns about long-term consequences of anticancer treatments. In patients with breast or prostate malignancies, bone health is a major issue due to the high risk of bone metastases and the frequent prolonged use of hor...

journal_title：Calcified tissue international

authors： Handforth C,D'Oronzo S,Coleman R,Brown J

更新日期：2018-02-01 00:00:00

abstract：:Data on the association between dietary vitamin K intake and fracture risk are limited among Chinese. This study examined such an association in community-dwelling elderly in Hong Kong. We present data from 2,944 subjects (1,605 men, 1,339 women) who participated in a prospective cohort study. Baseline dietary intakes...

journal_title：Calcified tissue international

authors： Chan R,Leung J,Woo J

更新日期：2012-05-01 00:00:00

abstract：:The wedges of the mid-diaphyseal osteotomies carried out to correct the femoral and/or tibial native deformity in type III osteogenesis imperfecta (OI III) were used to study the remodeling patterns and lamellar organization at the level of the major deformity. Histology and scanning electron microscopy (SEM) morpholo...

journal_title：Calcified tissue international

authors： Pazzaglia UE,Congiu T,Brunelli PC,Magnano L,Benetti A

更新日期：2013-11-01 00:00:00

abstract：:We hypothesized that reactive oxygen species play an important role in avascular/ischemic osteonecrosis. When isolated chick osteocytes were cultured with hydrogen peroxide, annexin V binding, which is the earliest marker of apoptosis, increased in a dose-dependent fashion. Hydrogen peroxide also induced the activatio...

journal_title：Calcified tissue international

authors： Kikuyama A,Fukuda K,Mori S,Okada M,Yamaguchi H,Hamanishi C

更新日期：2002-09-01 00:00:00

abstract：:High impact loading is known to prevent some of the age-related bone loss but its effects on the density distribution of cortical bone are relatively unknown. This study examined the effects of age and habitual sprinting on tibial and fibular mid-shaft bone traits (structural, cortical radial and polar bone mineral de...

journal_title：Calcified tissue international

authors： Rantalainen T,Duckham RL,Suominen H,Heinonen A,Alén M,Korhonen MT

更新日期：2014-08-01 00:00:00

abstract：:This study examines the efficacy of using radiolabeled thymidine as a measure of bone cell DNA synthesis. The effect of a bone-active peptide on cell proliferation is assessed under different labeling conditions and it is shown that the apparent stimulation in DNA synthesis is due to an increase in participating cells...

journal_title：Calcified tissue international

authors： Puzas JE,Brand JS

更新日期：1986-08-01 00:00:00

abstract：:Hip fracture may cause and/or complicate institutionalization. We undertook this study to define its overall prevalence among the residents of four nursing homes in Central Italy as well as its latency and impact on mobility when it occurred within institutions. We also performed a case control analysis with the aim o...

journal_title：Calcified tissue international

authors： Maggio D,Ubaldi E,Simonelli G,Cenci S,Pedone C,Cherubini A

更新日期：2001-06-01 00:00:00

abstract：:The increased uptake of bone-seeking radionuclides following a fracture has been stated to be due to an increase in bone blood flow, resulting in an increase in capillary surface area available for exchange. This paper examines the relationship between the maximum instantaneous extraction of 99mTc-MDP and blood flow i...

journal_title：Calcified tissue international

authors： McCarthy ID,Hughes SP

更新日期：1983-07-01 00:00:00

abstract：:Using a histochemical method for demonstrating acid phosphatase activity, we have studied osteoclasts residing at two different bone sites in rat incisor alveolar bone, one at the endosteum and the other at the tooth socket, and compared the response of these osteoclasts to systemic changes. After 12 days of calcium (...

journal_title：Calcified tissue international

authors： Liu CC,Baylink DJ

更新日期：1984-03-01 00:00:00

abstract：:Vitamin D has long been known to be important for bone health, but there is currently no consensus on the amount of vitamin D needed or how it varies with age, race/ethnicity, body size, absorption efficiency, season, and other factors. This review describes the effects of vitamin D on calcium absorption, parathyroid ...

journal_title：Calcified tissue international

authors： Dawson-Hughes B

更新日期：2013-02-01 00:00:00

abstract：:Enamel of intact human teeth laser irradiated in vitro under certain conditions is known to have less subsurface demineralization than unirradiated enamel on exposure to acid; consequently, the potential use of laser irradiance to reduce caries is apparent. The laser-induced physical and/or chemical changes that cause...

journal_title：Calcified tissue international

authors： Fowler BO,Kuroda S

更新日期：1986-04-01 00:00:00