Abstract：
:The fossil record shows that bone remodeling has existed since the earliest large vertebrates became weight-bearing on land, but the functions of remodeling have long been debated. The principal protagonists in this debate have been those favoring a mechanical function and those asserting that remodeling serves to move calcium in and out of the skeleton. In recent years the arguments of the former school have included not only the adaptation of internal structure to specific kinds of stresses, but the need to remove fatigue damage. It has become clear that (1) physiologic strains continually produce fatigue damage in bone; (2) this damage weakens bone and is associated with both osteocyte apoptosis and the activation of remodeling; and (3) remodeling is the only means by which this damage can be removed. The significance of these observations is increased by the fact that fatigue failure is more likely in larger structures. This "volume effect," along with the advantages of enhanced mobility and metabolic efficiency, may have selected for bone remodeling as a means of controlling fatigue damage as it occurs, allowing larger vertebrates to maintain a relatively light skeleton over an extended lifetime. In this view, bone remodeling is not primarily a mechanism for calcium transport, but is intimately related to other inflammatory repair responses.
journal_name
Calcif Tissue Intjournal_title
Calcified tissue internationalauthors
Martin RBdoi
10.1007/s00223-002-1059-9subject
Has Abstractpub_date
2003-08-01 00:00:00pages
101-7issue
2eissn
0171-967Xissn
1432-0827journal_volume
73pub_type
杂志文章,评审abstract：:Age-related loss of skeletal muscle is associated with increased risk of functional limitation and cardiovascular (CV) mortality. In the elderly abdominal aortic calcification (AAC) can increase CV risk by altering aortic properties which may raise blood pressure and increase cardiac workload. This study investigated ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-016-0157-z
更新日期：2016-10-01 00:00:00
abstract：:The peptide hormone calcitonin is a potent inhibitor of osteoclastic resorption, but it is unstable and poorly absorbed following oral administration. Conjugates of salmon calcitonin covalently linked to low-molecular-weight amphiphilic polymers show improved stability and absorption. The purpose of this study was to ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-002-1051-4
更新日期：2003-09-01 00:00:00
abstract：:The definition of osteoporosis was based for several years on bone mineral density values, which were used by most guidelines for defining treatment thresholds. The availability of tools for the estimation of fracture risk, such as FRAX™ or its adapted Italian version, DeFRA, is providing a way to grade osteoporosis s...
journal_title：Calcified tissue international
pub_type： 社论
doi：10.1007/s00223-013-9748-0
更新日期：2013-09-01 00:00:00
abstract：:Osteocalcin, the gamma-carboxyglutamic acid-containing protein, which is the most abundant noncollagenous protein of bone and dentin, is considered to play roles in bone formation and remodeling. It is unclear how the gamma-carboxyglutamic acid side-chains in osteocalcin coordinate to Ca2+, since the X-ray structure o...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002230010042
更新日期：2001-12-01 00:00:00
abstract：:We describe here the activity of a novel selective estrogen receptor modulator, SP500263. When given to adult ovariectomized (OVX) rats for 28 days at doses of 0.3, 1, or 3 mg/kg/day, we found that SP500263 partially protected against OVX-induced loss of bone mineral content in the distal ends of femurs and in the who...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-002-1029-2
更新日期：2003-06-01 00:00:00
abstract：:Molybdenum (Mo), at high concentrations, induces changes in the epiphyseal growth plate through its effects on copper (Cu) metabolism but it is unclear whether or not Mo can induce changes independent of its effects on copper status. To this end, the effect of Mo on longitudinal bone growth was examined in rats. Dieta...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF01321835
更新日期：1993-09-01 00:00:00
abstract：:The effects of fluoride on human enamel and selachian enameloid in vitro were visualized in TEM and analyzed with electron diffraction. It is demonstrated that under precise pH conditions, inducing concentration balance between F-ions and apatite, calcium fluoride is no longer formed, and crystalline changes occur ins...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02409406
更新日期：1981-01-01 00:00:00
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journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02556318
更新日期：1989-05-01 00:00:00
abstract：:In vitro models of osteogenesis are essential for investigating bone biology and the effects of pharmaceutical, chemical, and physical cues on bone formation. Osteogenesis takes place in a complex three-dimensional (3D) environment with cells from both mesenchymal and hematopoietic origins. Existing in vitro models of...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-011-9467-3
更新日期：2011-05-01 00:00:00
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journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900400
更新日期：1998-02-01 00:00:00
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journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-005-0271-9
更新日期：2006-12-01 00:00:00
abstract：:Inoculation of Moloney murine sarcoma virus (M-MSV) into shank muscles of adult NMRI mice resulted in localized sarcoma and periosteal membrane proliferation with subsequent periosteal bone formation. Newly formed bone arose from outer surface of shank bones. Two weeks after M-MSV inoculation the width of bone cortex ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02409426
更新日期：1981-01-01 00:00:00
abstract：:Quantitative computed tomography (QCT) was compared to dual X-ray absorptiometry (DXA) measured in the lumbar spine of 508 European women defined as normal without fracture (NoF), or osteoporotic (OP), with either vertebral fracture (VF), or peripheral fracture (PF). The correlations between QCT and DXA BMD measuremen...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02678144
更新日期：2001-02-01 00:00:00
abstract：:Arterial calcification leading to increased arterial stiffness, a powerful risk factor for cardiovascular disease, may underlie the association of osteoporosis with cardiovascular disease in postmenopausal women. Osteoprotegerin (OPG), an indirect inhibitor of osteoclastogenesis, may be involved in arterial calcificat...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-008-9153-2
更新日期：2008-08-01 00:00:00
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journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900533
更新日期：1998-10-01 00:00:00
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journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF00298583
更新日期：1995-06-01 00:00:00
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journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-013-9771-1
更新日期：2013-11-01 00:00:00
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journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-019-00528-x
更新日期：2019-06-01 00:00:00
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journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF00296220
更新日期：1992-07-01 00:00:00
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journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-002-0017-x
更新日期：2004-05-01 00:00:00
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journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-008-9197-3
更新日期：2009-02-01 00:00:00
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journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02556044
更新日期：1989-10-01 00:00:00
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journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02555226
更新日期：1987-11-01 00:00:00
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journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02407162
更新日期：1980-01-01 00:00:00
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journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02555980
更新日期：1990-09-01 00:00:00
abstract：:Prosected vertebrae and phalanges from 32 cadavera were examined using noninvasive methods commonly used for assessment of osteoporosis. Bone measures were then compared with a strength variable obtained by mechanically crushing or breaking the bones. All of the phalangeal density assessment techniques were found to b...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02555150
更新日期：1988-08-01 00:00:00
abstract：:The relationship between oral indicators and bone mineral density (BMD) has been studied by many investigators, with mixed and complex results. The purpose of the present cross-sectional study was to evaluate the associations of periodontal conditions and tooth loss with metacarpal BMD (m-BMD) in a community-based coh...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-004-0275-x
更新日期：2005-07-01 00:00:00
abstract：:Sarcopenia and osteoporosis are two sides of the same coin. They represent different aspects of the same age-related process of musculoskeletal atrophy and together culminate in falls, fractures, deconditioning, and increased mortality in older individuals. However, the current therapeutic approach to the prevention o...
journal_title：Calcified tissue international
pub_type： 杂志文章,评审
doi：10.1007/s00223-015-9956-x
更新日期：2015-03-01 00:00:00
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journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF00582169
更新日期：1992-06-01 00:00:00
abstract：:The objective of this study was to compare the bone mineral density (BMD) of men with Down syndrome (DS) to otherwise mentally retarded (MR) men and to investigate whether leg muscle strength of these patients is related to BMD. Two groups with MR (with and without DS) participated in the study, having met the followi...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002230010035
更新日期：2000-03-01 00:00:00
