Virally induced periosteal osteogenesis in mice.

Abstract:

:Inoculation of Moloney murine sarcoma virus (M-MSV) into shank muscles of adult NMRI mice resulted in localized sarcoma and periosteal membrane proliferation with subsequent periosteal bone formation. Newly formed bone arose from outer surface of shank bones. Two weeks after M-MSV inoculation the width of bone cortex increased nearly 4 times. The spaces between newly formed bone ossicles were filled with bone marrow. In the later stages these bone marrow cavities were merged with medullar cavities. No extraskeletal bone formation was observed. The regression of M-MSV-induced sarcomas coincides with cessation of the proliferation of bone therefore allowing the maturation and rebuilding of bone. Newly formed bone was not resorbed during a 6-month observation period.

journal_name

Calcif Tissue Int

authors

Włodarski K,Kobus M,Luczak M,Dołowy J

doi

10.1007/BF02409426

subject

Has Abstract

pub_date

1981-01-01 00:00:00

pages

135-42

issue

2

eissn

0171-967X

issn

1432-0827

journal_volume

33

pub_type

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