Abstract：
:Yerba mate (Ilex paraguariensis) is a xanthine-containing beverage, which is also rich in caffeine. Because caffeine has a negative impact on bone mineral density (BMD) mainly associated with low calcium (Ca) diets, there would be expected a negative effect of yerba mate on bone. In this study, Sprague-Dawley rats were used and randomly assigned into four groups (n = 6/group): Control + Ca 0.2 g %; Control + Ca 0.9 g %; Yerba + Ca 0.2 g %; Yerba + Ca 0.9 g %. At the end of the experiment, tibias and femurs were obtained for BMD, morphometric, histomorphometric, and biomechanical analyses. While there was no difference in bone parameters between rats with and without yerba mate consumption, a negative effect of low Ca diet was observed in BMD, morphometric, histomorphometric, and biomechanical results. Interaction between Ca content in the diet and yerba mate was only found in trabecular bone volume, which would indicate that the negative effect of low Ca intake on bone volume is reversed in part by yerba mate infusion. However, yerba mate was not able to reverse the negative effect of low Ca content on biomechanical properties and trabecular connectivity. In summary, at least in our study, yerba mate would not have a negative effect on bone and would be safe for the bone health of consumers.
journal_name
Calcif Tissue Intjournal_title
Calcified tissue internationalauthors
Brun LR,Brance ML,Lombarte M,Maher MC,Di Loreto VE,Rigalli Adoi
10.1007/s00223-015-0043-0subject
Has Abstractpub_date
2015-11-01 00:00:00pages
527-34issue
5eissn
0171-967Xissn
1432-0827pii
10.1007/s00223-015-0043-0journal_volume
97pub_type
杂志文章abstract：:Osteocalcin, the gamma-carboxyglutamic acid-containing protein, which is the most abundant noncollagenous protein of bone and dentin, is considered to play roles in bone formation and remodeling. It is unclear how the gamma-carboxyglutamic acid side-chains in osteocalcin coordinate to Ca2+, since the X-ray structure o...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002230010042
更新日期：2001-12-01 00:00:00
abstract：:The peptide hormone calcitonin is a potent inhibitor of osteoclastic resorption, but it is unstable and poorly absorbed following oral administration. Conjugates of salmon calcitonin covalently linked to low-molecular-weight amphiphilic polymers show improved stability and absorption. The purpose of this study was to ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-002-1051-4
更新日期：2003-09-01 00:00:00
abstract：:During endochondral ossification, proliferative activity of chondrocytes is arrested and the cells undergo terminal hypertrophic differentiation. We examined the expression of the cyclin-dependent kinase inhibitor, p21(CIP1/WAF1) in permanent cartilage (xyphoid and articular cartilage) and in cartilage undergoing endo...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900323
更新日期：1997-09-01 00:00:00
abstract：:The solubilization of alkaline phosphatase (AP) from osteoblastic cell membranes obtained from human primary bone cell cultures was studied according to the age and sex of the donors (17 females, 11 males; age range: 2-77 years). Cell membranes were treated by non-ionic (n-octyl beta-D-glucopyranoside, OG), ionic or z...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002230050006
更新日期：2000-01-01 00:00:00
abstract：:Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) mRNA levels are commonly used as an internal control to normalize gene expression data based on the belief that this gene is constitutively expressed. However, GAPDH mRNA levels increased by more than 2.5-fold in tibiae of hindlimb unloaded female rats compared to L32 m...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-002-1098-2
更新日期：2004-02-01 00:00:00
abstract：:The aim of this work was a preliminary assessment of the feasibility of using in vivo measurements of mechanical properties of bones to detect mineral loss and further to relate them to the tendency of the bone to fracture in the case of loss of minerals, such as in osteoporosis. Previous studies of bone strength in v...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF00298727
更新日期：1993-03-01 00:00:00
abstract：:To assess the usefulness of the measurement of the os calcis by ultrasound, a method that probably reflects bone quality as well as density, we have studied 54 women with hip fracture of the proximal femur and a control group. Ultrasound evaluation of the os calcis [broadband ultrasound attenuation (BUA), speed of the...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF00310252
更新日期：1995-09-01 00:00:00
abstract：:Cytochemical staining of normal human bone cells in monolayer cultures for alkaline phosphatase (ALP) indicated that the cultures contained mixed-cell populations. Time course evaluations of the cytochemical staining revealed, in addition to the ALP-negative cell population, at least two subpopulations of ALP-positive...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02555909
更新日期：1990-11-01 00:00:00
abstract：:Plasma osteocalcin (BGP), growth hormone (GH), and somatomedin C(SmC) were measured in 12 patients with acromegaly [7 clinically active (aA), 5 cured (cA)] and 9 control subjects (C). Basal plasma values for the three parameters were higher in aA than in C and in cA. No significant difference was found between cA and ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02555167
更新日期：1988-07-01 00:00:00
abstract：:Octacalcium phosphate (Ca8H2(PO4)6 . 5H2O) is considered to be precursor in the formation of apatite in bones and teeth; a crucial step for incorporation of impurities appears to occur during its hydrolysis. The present study examines the role that octacalcium phosphate plays in the process of incorporation of carbona...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02408521
更新日期：1980-01-01 00:00:00
abstract：:Quantitative ultrasound measurement (QUS) and bone mineral density (BMD) have each been shown to predict fracture risk in women. The present study examined whether a combination of QUS and BMD could improve the predictive accuracy of fracture risk. This is a population-based prospective study which involved 454 women ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-011-9556-3
更新日期：2012-02-01 00:00:00
abstract：:Formalin fixation of hard tissues alters the levels of some, but not all, of the parameters routinely measured by bone researchers. Although mineral parameters (ash weight, particle size (beta 1/2 002) and Ca/PO4 ratio) and lipid parameters (total lipid content and composition, extractability, and Ca-acidic phospholip...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02411262
更新日期：1982-07-01 00:00:00
abstract：:Bone resorption and formation in terms of milligram of calcium deposited into and released from whole humerus of 15-23 weeks old male rats were assessed, via linear least-squares regression analysis of change in calcium content and 3H-tetracycline kinetics of the bone. The rate of resorption was 0.376 mg calcium per d...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02555009
更新日期：1990-04-01 00:00:00
abstract：:High impact loading is known to prevent some of the age-related bone loss but its effects on the density distribution of cortical bone are relatively unknown. This study examined the effects of age and habitual sprinting on tibial and fibular mid-shaft bone traits (structural, cortical radial and polar bone mineral de...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-014-9881-4
更新日期：2014-08-01 00:00:00
abstract：:Forty 5-week-old rats were randomly divided into 1 control group given a normal diet and water low in fluoride (0.026 mM/1) and experimental group receiving the same basic diet and a fluoride supplement of 2.6 mMol/l in the drinking water. After 30 weeks, half of the fluoride-supplemented and half of the nonsupplement...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02405089
更新日期：1983-07-01 00:00:00
abstract：:Glycogen storage disease type 1a (Von Gierke's disease) is one of the more common glycogen storage diseases (GSD). GSD 1a patients can have severe idiopathic osteopenia, often beginning at a young age. Since calcium tracer studies offer a sensitive probe of the bone microenvironment and of calcium deposition, kinetics...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF00369209
更新日期：1996-12-01 00:00:00
abstract：:Our knowledge of the developmental changes in the concentration of serum and bone osteocalcin (OC) is limited. To investigate the interrelationship between skeletal and circulatory OC during acquisition of peak bone density in mice, we examined the temporal changes in the concentration of serum and bone OC from 3 to 1...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-001-1106-y
更新日期：2002-11-01 00:00:00
abstract：:In order to determine whether the bacterial bone resorbing agents lipopolysaccharide (LPS) and muramyl dipeptide (MDP) interact with osteoblasts, their effect on the synthesis of collagenase and tissue inhibitor or metalloproteinases (TIMP) from monolayer cultures of mouse osteoblast-like cells was investigated. All c...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02556318
更新日期：1989-05-01 00:00:00
abstract：:The accuracy of a radiographic absorptiometry (RA) technique called digital image processing (DIP), discriminative ability of RA for osteoporotic fracture, and the relationship between RA and dual X-ray absorptiometry (DXA) of the spine and forearm were evaluated. We measured 16 cadaver hands, 32 healthy non-black pre...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900400
更新日期：1998-02-01 00:00:00
abstract：:In 11 postmenopausal women with histologically proven osteoporosis and normal lactose tolerance, a direct correlation between calcium absorption and intestinal lactase activity was observed. The results suggest that varying degrees of relative deficiencies in intestinal lactase might contribute to the graded decrease ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02557688
更新日期：1985-01-01 00:00:00
abstract：:The increased uptake of bone-seeking radionuclides following a fracture has been stated to be due to an increase in bone blood flow, resulting in an increase in capillary surface area available for exchange. This paper examines the relationship between the maximum instantaneous extraction of 99mTc-MDP and blood flow i...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02405085
更新日期：1983-07-01 00:00:00
abstract：:The discriminating ability and relevance of clinical risk factors, quantitative ultrasound (QUS) variables, X-ray-based bone mineral density (BMD) and hip axis length (HAL) measurements to evaluate the risk of osteoporotic fracture in elderly Brazilian women were examined in this study. QUS at the calcaneus (Achilles ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-002-1096-4
更新日期：2003-12-01 00:00:00
abstract：:Inorganic phosphate (P(i)) can regulate the level of skeletal alkaline phosphatase (ALP) activity in human osteoblast-like cells, but not by means of changes in transcription or release from the cell surface. The current studies were intended to determine whether (1) P(i) affected the inactivation of ALP activity in h...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF00302073
更新日期：1995-11-01 00:00:00
abstract：:A resolution-enhanced Fourier Transform Infrared (FTIR) Spectroscopic study of the CO3(2-) ion in pig enamel of increasing age and maturity has demonstrated the existence of four different, main carbonate locations. The major CO3(2-) site arises as a result of the substitution of CO3(2-) ions in the positions occupied...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02556215
更新日期：1991-10-01 00:00:00
abstract：:Duffy antigen receptor for chemokines (DARC) binds to a number of pro-inflammatory chemokines, and since chemokines are known to regulate trafficking of osteoclast (OC) precursors, we predicted that DARC would regulate OC recruitment to sites of inflammation by modulating chemokine activity. To test this hypothesis, w...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-016-0170-2
更新日期：2016-11-01 00:00:00
abstract：:The purpose of this work was to extend to long bones the study on the ossification of human fetal skeleton in relation to conceptual age by a quantitative methodological approach. Postero-anterior scans were performed on 29 dried fetal femora (from 11.5 weeks of conceptual age to term) by a Hologic QDR 1000 X-ray dens...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900591
更新日期：1999-02-01 00:00:00
abstract：:Using both low microwave power and weak magnetic field modulation, we have shown that the asymmetric signal arising in X-irradiated tooth enamel as well as in A-type carbonated apatite exposed to X-rays or to excited oxygen has an orthorhombic character and must be attributed to CO2-. Effectively, the mean values foun...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02409421
更新日期：1981-01-01 00:00:00
abstract：:The aim of this study was to investigate bone mineral density (BMD) and bone turnover in patients with primary knee osteoarthritis (KOA) and to compare them with generalized OA (GOA) and nonGOA patients. A total of 88 postmenopausal primary KOA patients were studied. OA was graded by using knee radiographs. BMD of the...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002230010068
更新日期：2000-05-01 00:00:00
abstract：:Tartrate resistant acid phosphatase (TRAP) has been proposed as a new biochemical marker for bone resorption. We have compared this new marker, TRAP, with the classical biochemical markers of bone remodelling, serum alkaline phosphatase (sAP), serum osteocalcin (sBGP), and with the urinary hydroxyproline/creatinine ra...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02555896
更新日期：1991-07-01 00:00:00
abstract：:The drawbacks of estrogen restrict the clinical use of hormone replacement therapy, and it would be most helpful to explore new estrogenic substances that could prevent bone loss and be free from any adverse effects. We synthesized a new compound named bone-seeking estrogen (SE2) by combining 17β-estradiol (E2) with i...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-013-9739-1
更新日期：2013-08-01 00:00:00
